Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies

Authors: Taha Azad, Reza Rezaei, Ragunath Singaravelu, Adrian Pelin, Stephen Boulton, Julia Petryk, Kemal Alper Onsu, Nikolas T. Martin, Victoria Hoskin, Mina Ghahremani, Marie Marotel, Ricardo Marius, Xiaohong He, Mathieu J. F. Crupi, Huy-Dung Hoang, Abolfazl Nik-Akhtar, Mahsa Ahmadi, Nika Kooshki Zamani, Ashkan Golshani, Tommy Alain, Peter Greer, Michele Ardolino, Bryan C. Dickinson, Lee-Hwa Tai, Carolina S. Ilkow, John C. Bell

Source: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ac9b0514948d4425b5c222c2feb15ba2

A T cell-targeted multi-antigen vaccine generates robust cellular and humoral immunity against SARS-CoV-2 infection

Authors: Stephen Boulton, Joanna Poutou, Rida Gill, Nouf Alluqmani, Xiaohong He, Ragunath Singaravelu, Mathieu J.F. Crupi, Julia Petryk, Bradley Austin, Leonard Angka, Zaid Taha, Iris Teo, Siddarth Singh, Rameen Jamil, Ricardo Marius, Nikolas Martin, Taylor Jamieson, Taha Azad, Jean-Simon Diallo, Carolina S. Ilkow, John C. Bell

Source: Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101110- (2023)

Subject Terms: COVID-19, SARS-CoV-2, vaccine, vaccinia virus, spike, nucleocapsid, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050123001493; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/3db94dba202d4816898f54399e85392a

Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy

Authors: Marie-Eve Wedge, Victoria A. Jennings, Mathieu J. F. Crupi, Joanna Poutou, Taylor Jamieson, Adrian Pelin, Giuseppe Pugliese, Christiano Tanese de Souza, Julia Petryk, Brian J. Laight, Meaghan Boileau, Zaid Taha, Nouf Alluqmani, Hayley E. McKay, Larissa Pikor, Sarwat Tahsin Khan, Taha Azad, Reza Rezaei, Bradley Austin, Xiaohong He, David Mansfield, Elaine Rose, Emily E. F. Brown, Natalie Crawford, Almohanad Alkayyal, Abera Surendran, Ragunath Singaravelu, Dominic G. Roy, Gemma Migneco, Benjamin McSweeney, Mary Lynn Cottee, Egon J. Jacobus, Brian A. Keller, Takafumi N. Yamaguchi, Paul C. Boutros, Michele Geoffrion, Katey J. Rayner, Avijit Chatterjee, Rebecca C. Auer, Jean-Simon Diallo, Derrick Gibbings, Benjamin R. tenOever, Alan Melcher, John C. Bell, Carolina S. Ilkow

Source: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4c63ee51ae0d403a99532dab542cb349

CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX

Authors: Jack T. Whelan, Ragunath Singaravelu, Fuan Wang, Adrian Pelin, Levi A. Tamming, Giuseppe Pugliese, Nikolas T. Martin, Mathieu J. F. Crupi, Julia Petryk, Bradley Austin, Xiaohong He, Ricardo Marius, Jessie Duong, Carter Jones, Emily E. F. Fekete, Nouf Alluqmani, Andrew Chen, Stephen Boulton, Michael S. Huh, Matt Y. Tang, Zaid Taha, Elena Scut, Jean-Simon Diallo, Taha Azad, Brian D. Lichty, Carolina S. Ilkow, John C. Bell

Source: Frontiers in Immunology, Vol 13 (2023)

Subject Terms: CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9), vaccinia virus (VACV), STING agonist, poxvirus, oncolytic virus, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1050250/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f7cfd3f77d384dec8678da5baade9481

Deletion of Apoptosis Inhibitor F1L in Vaccinia Virus Increases Safety and Oncolysis for Cancer Therapy

Authors: Adrian Pelin, Johann Foloppe, Julia Petryk, Ragunath Singaravelu, Marian Hussein, Florian Gossart, Victoria A. Jennings, Lawton J. Stubbert, Madison Foster, Christopher Storbeck, Antonio Postigo, Elena Scut, Brian Laight, Michael Way, Philippe Erbs, Fabrice Le Boeuf, John C. Bell

Source: Molecular Therapy: Oncolytics, Vol 14, Iss , Pp 246-252 (2019)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S237277051930066X; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/5d24d17ce15143d1abecc60ad4722916

MicroRNA-124 Regulates Fatty Acid and Triglyceride Homeostasis

Authors: Tyler A. Shaw, Ragunath Singaravelu, Megan H. Powdrill, Jordan Nhan, Nadine Ahmed, Dennis Özcelik, John Paul Pezacki

Source: iScience, Vol 10, Iss , Pp 149-157 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004218302189; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/dc36f477afbf46ada4b1a32be24a9813

A High-Throughput NanoBiT-Based Serological Assay Detects SARS-CoV-2 Seroconversion

Authors: Taha Azad, Reza Rezaei, Ragunath Singaravelu, Taylor R. Jamieson, Mathieu J. F. Crupi, Abera Surendran, Joanna Poutou, Parisa Taklifi, Juthaporn Cowan, Donald William Cameron, Carolina S. Ilkow

Source: Nanomaterials, Vol 11, Iss 3, p 807 (2021)

Subject Terms: SARS-CoV-2, COVID-19, NanoBiT, serological assay, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.mdpi.com/2079-4991/11/3/807; https://doaj.org/toc/2079-4991

Access URL: https://doaj.org/article/dbf4edeb645742b9b83eefd53ff8b3c4

Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization

Authors: Taha Azad, Ragunath Singaravelu, Mathieu J.F. Crupi, Taylor Jamieson, Jaahnavi Dave, Emily E.F. Brown, Reza Rezaei, Zaid Taha, Stephen Boulton, Nikolas T. Martin, Abera Surendran, Joanna Poutou, Mina Ghahremani, Kazem Nouri, Jack T. Whelan, Jessie Duong, Sarah Tucker, Jean-Simon Diallo, John C. Bell, Carolina S. Ilkow

Source: Membranes, Vol 10, Iss 9, p 215 (2020)

Subject Terms: trimerization, spike protein, receptor-binding domain, transmembrane domain, SARS-CoV-2, vaccine development, Chemical technology, TP1-1185, Chemical engineering, TP155-156

File Description: electronic resource

Relation: https://www.mdpi.com/2077-0375/10/9/215; https://doaj.org/toc/2077-0375

Access URL: https://doaj.org/article/66fe2e4e8f174a0392c1b44f91898b63

Fluorescence lifetime imaging of alterations to cellular metabolism by domain 2 of the hepatitis C virus core protein.

Authors: Nirmal Mazumder, Rodney K Lyn, Ragunath Singaravelu, Andrew Ridsdale, Douglas J Moffatt, Chih-Wei Hu, Han-Ruei Tsai, John McLauchlan, Albert Stolow, Fu-Jen Kao, John Paul Pezacki

Source: PLoS ONE, Vol 8, Iss 6, p e66738 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3691201?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f66f39a8d49b402983602a5bd2d119ab

Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter

Authors: Reza Rezaei, author^{1, 2}, Abera Surendran, author^{1, 2}, Ragunath Singaravelu, author^{1, 2}, Taylor R. Jamieson, author^{1, 2}, Parisa Taklifi, author³, Joanna Poutou, author^{1, 2}, Taha Azad, author^{1, 2}, Carolina S. Ilkow, author^{1, 2}

Source: Journal of Visualized Experiments. (174)

Availability: http://www.jove.com/video/62488

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