Effect of chronic alcohol feeding using the Lieber-DeCarli diet on Alzheimer’s disease pathology in Tg2576 mice

Authors: Devaraj V. Chandrashekar, Nataraj Jagadeesan, Tamara Abdullah, Rudy Chang, Ross A. Steinberg, Frankey Sanchez, Elias Khal, Joshua Yang, David H. Cribbs, Derick Han, Rachita K. Sumbria

Source: Frontiers in Aging Neuroscience, Vol 17 (2025)

Subject Terms: alcohol, Aβ, Tg2576, LRP-1, Alzheimer’s disease, Lieber-DeCarli, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnagi.2025.1526571/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/9acf418c1ebf4f058c6908c27f909322

Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer's disease mice: Potential role in chronic heavy alcohol feeding

Authors: Devaraj V. Chandrashekar, G. Chuli Roules, Nataraj Jagadeesan, Urvashi R. Panchal, Adenike Oyegbesan, Oghenetega E. Imiruaye, Hai Zhang, Jerome Garcia, Kamaljit Kaur, Sanda Win, Tin A. Than, Neil Kaplowitz, Moom R. Roosan, Derick Han, Rachita K. Sumbria

Source: Neurobiology of Disease, Vol 199, Iss , Pp 106570- (2024)

Subject Terms: Intragastric feeding, Aβ, APP/PS1 mice, LRP-1, Liver, Alcohol, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996124001700; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/15f5f13e08d54a588a4da11e1312920d

Modulation of hippocampal protein expression by a brain penetrant biologic TNF-α inhibitor in the 3xTg Alzheimer’s disease mice

Authors: Nataraj Jagadeesan, G. Chuli Roules, Devaraj V. Chandrashekar, Joshua Yang, Sanjana Kolluru, Rachita K. Sumbria

Source: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)

Subject Terms: Biologic TNF-α inhibitor, Transferrin receptor antibody, Spatial proteomics, Alzheimer’s disease, Tau, Amyloid beta, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/9c7d4ce603b74672a7572a0c179d092c

Erythrocyte–brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo

Authors: Hai Zhang, Rachita K. Sumbria, Rudy Chang, Jiahong Sun, David H. Cribbs, Todd C. Holmes, Mark J. Fisher, Xiangmin Xu

Source: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-19 (2023)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/348c92fd4f674ca2add361badcf21756

Chronic kidney disease promotes cerebral microhemorrhage formation

Authors: Chuo Fang, Wei Ling Lau, Jiahong Sun, Rudy Chang, Adrian Vallejo, Donghy Lee, Jihua Liu, Han Liu, Yu-Han Hung, Yitong Zhao, Annlia Paganini-Hill, Rachita K. Sumbria, David H. Cribbs, Mark Fisher

Source: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-16 (2023)

Subject Terms: Cerebral microhemorrhages/microbleeds, Aging, Chronic kidney disease, Microglial activation, Brain endothelial cells, Blood–brain barrier, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/eafbdb1c3aab482e8b83e11404389a92

Biologic TNF-α inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy

Authors: Weijun Ou, Joshua Yang, Juste Simanauskaite, Matthew Choi, Demi M. Castellanos, Rudy Chang, Jiahong Sun, Nataraj Jagadeesan, Karen D. Parfitt, David H. Cribbs, Rachita K. Sumbria

Source: Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-19 (2021)

Subject Terms: Biologic TNF-α inhibitor, Alzheimer’s disease, Tau, Microgliosis, Transferrin receptor, Molecular Trojan Horse, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/6e93ff10e37147479a9c27eeeef00f70

Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: Potential link between liver steatosis and amyloid-β

Authors: Jerome Garcia, Rudy Chang, Ross A. Steinberg, Aldo Arce, Joshua Yang, Peter Van Der Eb, Tamara Abdullah, Devaraj V. Chandrashekar, Sydney M. Eck, Pablo Meza, Zhang-Xu Liu, Enrique Cadenas, David H. Cribbs, Neil Kaplowitz, Rachita K. Sumbria, Derick Han

Source: Frontiers in Physiology, Vol 13 (2022)

Subject Terms: amyloid precursor protein, lipoprotein receptor-related protein 1, liver, alcohol, Alzheimer’s disease, beta-amyloid, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2022.930402/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/978cff4effb34625aa5b7e8bf5da6b13

The Effects of a Blood–Brain Barrier Penetrating Erythropoietin in a Mouse Model of Tauopathy

Authors: Joshua Yang, Weijun Ou, Nataraj Jagadeesan, Juste Simanauskaite, Jiahong Sun, Demi Castellanos, David H. Cribbs, Rachita K. Sumbria

Source: Pharmaceuticals, Vol 16, Iss 4, p 558 (2023)

Subject Terms: Alzheimer’s disease, blood–brain barrier, erythropoietin, microglia, molecular Trojan horse, monoclonal antibody, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/4/558; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/e5bc714831ce42149e79fdfeee5744f6

Comparative studies between the murine immortalized brain endothelial cell line (bEnd.3) and induced pluripotent stem cell-derived human brain endothelial cells for paracellular transport

Authors: Jiahong Sun, Weijun Ou, Derick Han, Annlia Paganini-Hill, Mark J. Fisher, Rachita K. Sumbria

Source: PLoS ONE, Vol 17, Iss 5 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132315/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/69bebfdf3e6b42af8b968ba58111d409

Efficacy and Safety of a Brain-Penetrant Biologic TNF-α Inhibitor in Aged APP/PS1 Mice

Authors: Weijun Ou, Yuu Ohno, Joshua Yang, Devaraj V. Chandrashekar, Tamara Abdullah, Jiahong Sun, Riley Murphy, Chuli Roules, Nataraj Jagadeesan, David H. Cribbs, Rachita K. Sumbria

Source: Pharmaceutics, Vol 14, Iss 10, p 2200 (2022)

Subject Terms: Alzheimer’s disease, transferrin receptor, TNF-α inhibitor, blood–brain barrier, molecular Trojan horse, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/10/2200; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/34dca426638a4e159188d71b07ae587d

Insights Into the Mechanisms of Brain Endothelial Erythrophagocytosis

Authors: Jiahong Sun, Prema Vyas, Samar Mann, Annlia Paganini-Hill, Ane C. F. Nunes, Wei Ling Lau, David H. Cribbs, Mark J. Fisher, Rachita K. Sumbria

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: red blood cell, phosphatidylserine, oxidative stress, brain endothelial erythrophagocytosis, iron deposits, cerebral microhemorrhages, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.672009/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/a6482de1687d4718a9dae55e4aaf94fa

The concentration of brain homogenates with the Amicon Ultra Centrifugal filters

Authors: Joshua Yang, Rachita K. Sumbria

Source: MethodsX, Vol 8, Iss , Pp 101584- (2021)

Subject Terms: Brain concentration, Pharmacokinetics, Blood-Brain Barrier (BBB), Enzyme-linked immunosorbent assay (ELISA), Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2215016121003745; https://doaj.org/toc/2215-0161

Access URL: https://doaj.org/article/2b15fcb42d1443af8720d69815bb034a

Aging exacerbates development of cerebral microbleeds in a mouse model

Authors: Rachita K. Sumbria, Mher Mahoney Grigoryan, Vitaly Vasilevko, Annlia Paganini-Hill, Kelley Kilday, Ronald Kim, David H. Cribbs, Mark J. Fisher

Source: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-7 (2018)

Subject Terms: Animal models, Cerebral microhemorrhage, Cerebral microbleeds, Inflammation, Hemosiderin, Aging, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-018-1092-x; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/517c9a145ed4476fafe8379ce8c3fbec

Effects of phosphodiesterase 3A modulation on murine cerebral microhemorrhages

Authors: Rachita K. Sumbria, Vitaly Vasilevko, Mher Mahoney Grigoryan, Annlia Paganini-Hill, Ronald Kim, David H. Cribbs, Mark J. Fisher

Source: Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-14 (2017)

Subject Terms: Phosphodiesterase 3A, Cerebral microhemorrhage, Cerebral microbleeds, Cilostazol, Cerebral amyloid angiopathy, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-017-0885-7; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/72032a4bb513475783ac8d5850e4eeb9

Effects of Dabigatran in Mouse Models of Aging and Cerebral Amyloid Angiopathy

Authors: Neethu Michael, Mher Mahoney Grigoryan, Kelley Kilday, Rachita K. Sumbria, Vitaly Vasilevko, Joanne van Ryn, David H. Cribbs, Annlia Paganini-Hill, Mark J. Fisher

Source: Frontiers in Neurology, Vol 10 (2019)

Subject Terms: aging, cerebral amyloid angiopathy, cerebral microhemorrhage, dabigatran, direct thrombin inhibitor, intracerebral hemorrhage, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fneur.2019.00966/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/49803a3e15444c319536e3719b202b9e

Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice

Authors: Demi M. Castellanos, Jiahong Sun, Joshua Yang, Weijun Ou, Alexander C. Zambon, William M. Pardridge, Rachita K. Sumbria

Source: Pharmaceutics, Vol 12, Iss 9, p 852 (2020)

Subject Terms: transferrin receptor, transferrin receptor monoclonal antibody, iron, blood-brain barrier, pharmacokinetics, reticulocytes, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/12/9/852; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/8f463c21a27244dab2efc4ebff07a2c8

Brain Endothelial Erythrophagocytosis and Hemoglobin Transmigration Across Brain Endothelium: Implications for Pathogenesis of Cerebral Microbleeds

Authors: Rudy Chang, Juan Castillo, Alexander C. Zambon, Tatiana B. Krasieva, Mark J. Fisher, Rachita K. Sumbria

Source: Frontiers in Cellular Neuroscience, Vol 12 (2018)

Subject Terms: erythrophagocytosis, cerebral microbleeds, brain endothelial cells, hemoglobin, red blood cells, transmigration, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fncel.2018.00279/full; https://doaj.org/toc/1662-5102

Access URL: https://doaj.org/article/bfc0583c94234745863ca774eb85528d

Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections

Authors: Yuu Ohno, author¹, Riley Murphy, author², Matthew Choi, author³, Weijun Ou, author⁴, Rachita K. Sumbria, author^{4, 5}

Source: Journal of Visualized Experiments. (183)

Availability: http://www.jove.com/video/63669

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Targeting the transferrin receptor to develop erythropoietin for Alzheimer's disease

Authors: Rachita K Sumbria

Source: Neural Regeneration Research, Vol 15, Iss 12, Pp 2251-2252 (2020)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=12;spage=2251;epage=2252;aulast=Sumbria; https://doaj.org/toc/1673-5374

Access URL: https://doaj.org/article/bdcb76bce84c40daa3abef4a42e2a100