P1030: SPLEEN VOLUME REDUCTION PREDICTS SURVIVAL IN MYELOFIBROSIS PATIENTS ON PACRITINIB BUT NOT BEST AVAILABLE THERAPY: PERSIST-2 LANDMARK OVERALL SURVIVAL ANALYSIS

Authors: Jan Bewersdorf, Helen Ajufo, Claire Harrison, Francesca Palandri, John Mascarenhas, Jeanne Palmer, Aaron T. Gerds, Jean-Jacques Kiladjian, Andrii Derkach, Karisse Roman-Torres, Sarah Buckley, Raajit K Rampal

Source: HemaSphere, Vol 7, p e44640da (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000971016.44640.da; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/80732606d0634d49b29d1472f618115f

S168: PELABRESIB (CPI-0610) MONOTHERAPY IN PATIENTS WITH HIGH-RISK ESSENTIAL THROMBOCYTHEMIA REFRACTORY OR INTOLERANT TO HYDROXYUREA: PRELIMINARY RESULTS FROM MANIFEST STUDY

Authors: Francesco Passamonti, Andrea Patriarca, Steven Knapper, Candido Rivera, Joseph M Scandura, Timothy Devos, Nikki Granacher, Adam Mead, Stephen Oh, Jeanne Palmer, Raajit K Rampal, Lino Teichmann, Qing LI, Jean-Pierre Eliane, Tzuu-Wang Chang, Sandra Klein, Gozde Colak, Claire Harrison

Source: HemaSphere, Vol 7, p e9927843 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000967584.99278.43; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/7ddf83147e984511807a01aa1e288684

P1024: MYLOX-1: A PHASE II STUDY EVALUATING THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF ORAL LOXL2 INHIBITOR GB2064 (WITH FOCUS ON BONE MARROW COLLAGEN) IN PATIENTS WITH MYELOFIBROSIS

Authors: Claire Harrison, John Mascarenhas, Daniela Cilloni, Richard Schlenk, Brian Jacoby, Robert J Slack, Vassilios Aslanis, Bhupinder Singh, Bertil Lindmark, Srdan Verstovsek, Raajit K Rampal

Source: HemaSphere, Vol 7, p e87048d4 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000970996.87048.d4; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/62f833fe9a3d493fa9bb83c9fd449bd4

P1027: UPDATED DURABILITY OF RESPONSE AND SAFETY IN MANIFEST ARM 3: PELABRESIB (CPI-0610) COMBINED WITH RUXOLITINIB FOR JAK INHIBITOR TREATMENT-NAÏVE PATIENTS WITH MYELOFIBROSIS

Authors: Claire Harrison, Andrea Patriarca, Vikas Gupta, Francesca Palandri, Timothy Devos, Raajit K Rampal, Moshe Talpaz, Alessandro Vannucchi, Andrew Kuykendall, Jean-Jacques Kiladjian, Srdan Verstovsek, Ruben Mesa, Gozde Colak, Soumik Dutta, Sandra Klein, Jie Cui, Tzuu-Wang Chang, John Mascarenhas

Source: HemaSphere, Vol 7, p e26914cb (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000971004.26914.cb; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/82025649e2084262b719c31611f22a1a

P1018: UPDATED RESULTS FROM MANIFEST ARM 2: EFFICACY AND SAFETY OF PELABRESIB (CPI-0610) AS ADD-ON TO RUXOLITINIB IN MYELOFIBROSIS

Authors: Marina Kremyanskaya, Claire Harrison, Prithviraj Bose, Vikas Gupta, Raajit K Rampal, Jonathan Lambert, Moshe Talpaz, Alessandro Vannucchi, Andrew Kuykendall, Jean-Jacques Kiladjian, Srdan Verstovsek, Ruben Mesa, Gozde Colak, Sandra Klein, Carmelita Alvero, John Mascarenhas

Source: HemaSphere, Vol 7, p e0578580 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000970976.05785.80; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/a6db7685a9614ba7ab9c0d665a227903

P1031: PRELIMINARY DATA FROM THE PHASE 1/2 STUDY OF TP-3654, AN INVESTIGATIONAL SELECTIVE PIM1 KINASE INHIBITOR, SHOWED CYTOKINE REDUCTION AND CLINICAL RESPONSES IN RELAPSED/REFRACTORY MYELOFIBROSIS

Authors: Firas El Chaer, Lindsay Rein, Kazuya Shimoda, Junichiro Yuda, Tamanna Haque, James Mccloskey, Akiyoshi Takami, Masafumi Fukaya, Shuichi Shirane, Sujan Kabir, Jian Mei, Zhonggai LI, Mark Wade, Claudia Lebedinsky, Raajit K Rampal

Source: HemaSphere, Vol 7, p e42358df (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000971020.42358.df; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/ef0764327e2144cb9246525a9d8831ba

P986: COMBINATION JAK1/2 AND CDK8/19 INHIBITION DEMONSTRATES ENHANCED EFFICACY IN MYELOPROLIFERATIVE NEOPLASMS

Authors: Zachary Zaroogian, Elżbieta Adamczyk, Adrianna Moszyńska, Marta Obacz, Urszula Pakulska, Benjamin Durham, Milena Mazan, Shoron Mowla, Katarzyna Wnęk, Amritha Varshini Hanasoge Somasundara, Beata Barczuk, Aniela Gołas, Ross Levine, Tomasz Rzymski, Raajit K Rampal

Source: HemaSphere, Vol 7, p e133428d (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000970848.13342.8d; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/512f19d4f82d4000871ea3e889e115ae

Treating accelerated and blast phase myeloproliferative neoplasms: progress and challenges

Authors: Helen O. Ajufo, Julian A. Waksal, John O. Mascarenhas, Raajit K. Rampal

Source: Therapeutic Advances in Hematology, Vol 14 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2040-6215

Access URL: https://doaj.org/article/ec6fb4abea7743a6a9319ac4596a0ddf

Characterization of disease-propagating stem cells responsible for myeloproliferative neoplasm–blast phase

Authors: Xiaoli Wang, Raajit K. Rampal, Cing Siang Hu, Joseph Tripodi, Noushin Farnoud, Bruce Petersen, Michael R. Rossi, Minal Patel, Erin McGovern, Vesna Najfeld, Camelia Iancu-Rubin, Min Lu, Andrew Davis, Marina Kremyanskaya, Rona Singer Weinberg, John Mascarenhas, Ronald Hoffman

Source: JCI Insight, Vol 7, Iss 8 (2022)

Subject Terms: Oncology, Stem cells, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/7d3e09d68f224b1fb0cde749aceeada5

Baseline risk of hematologic malignancy at initiation of frontline PARP inhibitor maintenance for BRCA1/2-associated ovarian cancer

Authors: Anastasia Navitski, Duaa H. Al-Rawi, Ying Liu, Maria M. Rubinstein, Claire F. Friedman, Raajit K. Rampal, Diana L. Mandelker, Karen Cadoo, Roisin E. O'Cearbhaill

Source: Gynecologic Oncology Reports, Vol 38, Iss , Pp 100873- (2021)

Subject Terms: Ovarian cancer, BRCA mutation, PARP inhibitors, Myelodysplastic syndrome, Acute myeloid leukemia, Gynecology and obstetrics, RG1-991, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352578921001776; https://doaj.org/toc/2352-5789

Access URL: https://doaj.org/article/5dec3a4009954488a69ec3bc6e83b29d

Cobimetinib‐induced 'dropped head syndrome' and subsequent disease management in an Erdheim‐Chester patient

Authors: Amber C. King, Eli L. Diamond, Jennifer S. Orozco, Hannah R. Morse, Linda L. Ouyang, Heiko Schöder, Raajit K. Rampal

Source: Clinical Case Reports, Vol 7, Iss 10, Pp 1989-1993 (2019)

Subject Terms: Erdheim‐Chester disease, hematology, neurology, pharmacology, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2050-0904

Access URL: https://doaj.org/article/9e1e6f10b4fd4244b1452a2eef66da91

Targeted therapies for myeloproliferative neoplasms

Authors: Bing Li, Raajit K. Rampal, Zhijian Xiao

Source: Biomarker Research, Vol 7, Iss 1, Pp 1-8 (2019)

Subject Terms: Targeting therapy, Myeloproliferative neoplasms, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40364-019-0166-y; https://doaj.org/toc/2050-7771

Access URL: https://doaj.org/article/e6b4d6190d854b8d8cac22be14914690

Prevention and treatment of transformation of myeloproliferative neoplasms to acute myeloid leukemia

Authors: Anand A. Patel, Raajit K. Rampal

Source: Haematologica, Vol 999, Iss 1 (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11795; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/ead6af08b798450baac79b6a279910e9

Interferons in the treatment of myeloproliferative neoplasms

Authors: Pankit Vachhani, John Mascarenhas, Prithviraj Bose, Gabriela Hobbs, Abdulraheem Yacoub, Jeanne M. Palmer, Aaron T. Gerds, Lucia Masarova, Andrew T. Kuykendall, Raajit K. Rampal, Ruben Mesa, Srdan Verstovsek

Source: Therapeutic Advances in Hematology, Vol 15 (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2040-6215

Access URL: https://doaj.org/article/f914014456cf435ebd924c6e619ff22a

Conventional interferon-α 2b versus hydroxyurea for newly-diagnosed patients with polycythemia vera in a real world setting: a retrospective study based on 286 patients from a single center

Authors: Dan Liu, Zefeng Xu, Peihong Zhang, Tiejun Qin, Xiujuan Sun, Shiqiang Qu, Lijuan Pan, Jiao Ma, Wenyu Cai, Jinqin Liu, Huijun Wang, Qi Sun, Zhongxun Shi, Huijun Huang, Gang Huang, Robert Peter Gale, Bing Li, Raajit K. Rampal, Zhijian Xiao

Source: Haematologica, Vol 107, Iss 4 (2022)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10493; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/bd6b9167748c48d5b416fb97f8f0e086

Atypical Presentation of Erythroid/Megakaryocytic Leukemic Transformation of a Myeloproliferative Neoplasm Associated with Mutation and Loss of TP53

Authors: Brian J. Chernak, Filiz Sen, Noushin Farnoud, Jad Bou Ayache, Yanming Zhang, Susan DeWolf, Raajit K. Rampal

Source: HemaSphere, Vol 4, Iss 4, p e411 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000411; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/4f291b955f004f3ba2e3bc40e7974a23

Hsp90 inhibition disrupts JAK-STAT signaling and leads to reductions in splenomegaly in patients with myeloproliferative neoplasms

Authors: Gabriela S. Hobbs, Amritha Varshini Hanasoge Somasundara, Maria Kleppe, Rivka Litvin, Maria Arcila, Jihae Ahn, Anna Sophia McKenney, Kristina Knapp, Ryan Ptashkin, Howard Weinstein, Murk-Hein Heinemann, Jasmine Francis, Suzanne Chanel, Ellin Berman, Michael Mauro, Martin S. Tallman, Mark L. Heaney, Ross L. Levine, Raajit K. Rampal

Source: Haematologica, Vol 103, Iss 1 (2018)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8338; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/562c84fe1892430fb07bda7a916c5530

Mutational correlates of response to hypomethylating agent therapy in acute myeloid leukemia

Authors: Catherine C. Coombs, David A. Sallman, Sean M. Devlin, Shweta Dixit, Abhinita Mohanty, Kristina Knapp, Najla H. Al Ali, Jeffrey E. Lancet, Alan F. List, Rami S. Komrokji, Eric Padron, Maria E. Arcila, Virginia M. Klimek, Marcel R. M. van den Brink, Martin S. Tallman, Ross L. Levine, Raajit K. Rampal, Franck Rapaport

Source: Haematologica, Vol 101, Iss 11 (2016)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/7895; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/164d8500288c4318ae19e0d3e8421161