Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease

Authors: Stefan Bräuer, Iñaki Schniewind, Elisabeth Dinter, Björn H. Falkenburger

Source: Acta Neuropathologica Communications, Vol 13, Iss 1, Pp 1-18 (2025)

Subject Terms: Seed amplification assay, Parkinson’s disease, Strains, RT-QuIC, Alpha-synuclein, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/dd0007f9800a46ff84527bbb23450a27

Seeding activity of skin misfolded tau as a biomarker for tauopathies

Authors: Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland, Zahid Syed Ali Shah, Evalynn Lomax, Yirong Yang, Steven A. Gunzler, Vincenzo Donadio, Rocco Liguori, Bin Xu, Wen-Quan Zou

Source: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-19 (2024)

Subject Terms: Tauopathies, Alzheimer’s disease, Seeding activity, Tau, Real-time quaking-induced conversion (RT-QuIC), Skin, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/1fa0ff5660ca40fa87bdb880b0cf5a95

A minimally invasive biomarker for sensitive and accurate diagnosis of Parkinson’s disease

Authors: Zerui Wang, Tricia Gilliland, Hyun Jo Kim, Maria Gerasimenko, Kailey Sajewski, Manuel V. Camacho, Gurkan Bebek, Shu G. Chen, Steven A. Gunzler, Qingzhong Kong

Source: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-12 (2024)

Subject Terms: Seeding activity, Alpha-synuclein, Parkinson’s disease, Biomarker, RT-QuIC, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/4c4934e62fea43468d3272fed2237ea8

Clinical, neuropathological, and molecular characteristics of rapidly progressive dementia with Lewy bodies: a distinct clinicopathological entity?

Authors: Giuseppe Mario Bentivenga, Simone Baiardi, Andrea Mastrangelo, Edoardo Ruggeri, Angela Mammana, Alice Ticca, Marcello Rossi, Sabina Capellari, Piero Parchi

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)

Subject Terms: Rapidly progressive dementia, Lewy body disease, RT-QuIC, Alpha-synuclein, GBA, Seeding amplification assay, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/ef9e0e17a9784355bde2bcad2168bd17

Aqueous extraction of formalin-fixed paraffin-embedded tissue and detection of prion disease using real-time quaking-induced conversion

Authors: Eric M. Nicholson, Justin J. Greenlee, Soyoun Hwang

Source: BMC Research Notes, Vol 17, Iss 1, Pp 1-4 (2024)

Subject Terms: Paraffin-embedded tissue, Prion, PrP, Spongiform encephalopathy, Transmissible spongiform encephalopathy, RT-QuIC, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390

File Description: electronic resource

Relation: https://doaj.org/toc/1756-0500

Access URL: https://doaj.org/article/84505ccba31f45bfa5fcaf895b085b62

A Systematic Review of Sporadic Creutzfeldt-Jakob Disease: Pathogenesis, Diagnosis, and Therapeutic Attempts

Authors: Maria Carolina Jurcau, Anamaria Jurcau, Razvan Gabriel Diaconu, Vlad Octavian Hogea, Vharoon Sharma Nunkoo

Source: Neurology International, Vol 16, Iss 5, Pp 1039-1065 (2024)

Subject Terms: Creutzfeldt-Jakob disease, prions, MRI, PMCA, RT-QuIC, WHO and EUROCJD diagnostic criteria, Medicine, Internal medicine, RC31-1245, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.mdpi.com/2035-8377/16/5/79; https://doaj.org/toc/2035-8377

Access URL: https://doaj.org/article/7272defe528b414bac67bdf6dafac377

Chaperone-mediated disaggregation of infectious prions releases particles that seed new prion formation in a strain-specific manner

Authors: Shoup, Daniel ^∗, Priola, Suzette A.

Source: In Journal of Biological Chemistry January 2025 301(1)

RT-QuIC detection of chronic wasting disease prion in platelet samples of white-tailed deer

Authors: Estela Kobashigawa, Sherri Russell, Michael Z. Zhang, Emily A. Sinnott, Michael Connolly, Shuping Zhang

Source: BMC Veterinary Research, Vol 20, Iss 1, Pp 1-10 (2024)

Subject Terms: CWD, Deer, Platelet, RT-QuIC, RAF, Sensitivity, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/1746-6148

Access URL: https://doaj.org/article/087aa0f949d94e368578e1dcb2790c32

Detection of skin α-synuclein using RT-QuIC as a diagnostic biomarker for Parkinson’s disease in the Chinese population

Authors: Jiaqi Li, Suying Duan, Jing Yang, Honglin Zheng, Yanpeng Yuan, Mibo Tang, Yanlin Wang, Yutao Liu, Zongping Xia, Haiyang Luo, Yuming Xu

Source: European Journal of Medical Research, Vol 29, Iss 1, Pp 1-10 (2024)

Subject Terms: α-synuclein, RT-QuIC, Skin, Parkinson’s disease, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2047-783X

Access URL: https://doaj.org/article/84446f3e54ee4e5e95f736e22d96f921

Evaluating the Diagnostic Efficacy of Using Pooled Samples for Chronic Wasting Disease Testing and Surveillance

Authors: Monica Hepker, Jianqiang Zhang, Vellareddy Anantharam, Anumantha G. Kanthasamy, Jue Yuan, Wenquan Zou, Rachel M. Ruden

Source: Pathogens, Vol 13, Iss 12, p 1133 (2024)

Subject Terms: chronic wasting disease, CWD, white-tailed deer, RT-QuIC, ELISA, monitoring, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-0817/13/12/1133; https://doaj.org/toc/2076-0817

Access URL: https://doaj.org/article/08e7243cde8e4df392dac67d8a640aa5

A Novel Detection of Biomarker Molecule of α-synuclein for Parkinson Disease by Phospholipid Liposome-Immobilized Cantilever Biosensor Using Real-Time Quaking-Induced Conversion Method

Authors: Kobayashi, R., Noda, M., Sawamura, M., Yamakado, H., Sohgawa, M.

Source: 2019 IEEE SENSORS SENSORS, 2019 IEEE. :1-3 Oct, 2019

Relation: 2019 IEEE SENSORS

Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain

Authors: Bryan Frey, David Holzinger, Keenan Taylor, Dagmar E. Ehrnhoefer, Andreas Striebinger, Sandra Biesinger, Laura Gasparini, Michael J. O’Neill, Florian Wegner, Stefan Barghorn, Günter U. Höglinger, Roland G. Heym

Source: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)

Subject Terms: Alzheimer’s disease, Tau seeding, Seed amplification assay (SAA), Real-time quaking induced conversion assay (RT-QuIC), Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/78bf1f0ec959455f9e1ccbfb0ccf720b

Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders

Authors: Stefan Bräuer, Marcello Rossi, Johann Sajapin, Thomas Henle, Thomas Gasser, Piero Parchi, Kathrin Brockmann, Björn H. Falkenburger

Source: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-9 (2023)

Subject Terms: Alpha-synuclein, Dementia with Lewy bodies, Parkinson’s disease, RT-QuIC, Seed amplification assay, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/179f7c1706ea4353babb1a925f2dfaeb

Novel histotypes of sporadic Creutzfeldt–Jakob disease linked to 129MV genotype

Authors: Laura Cracco, Gianfranco Puoti, Antonio Cornacchia, Katie Glisic, Seong‑Ki Lee, Zerui Wang, Mark L. Cohen, Brian S. Appleby, Ignazio Cali

Source: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-16 (2023)

Subject Terms: Prion protein, Prion, sCJD, Histotype, Codon 129, RT-QuIC, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/bb4511f0e0f649868b26b4cd035a5762

Pathological α-synuclein detected by real-time quaking-induced conversion in synucleinopathies

Authors: Juan Huang, Xingxing Yuan, Lin Chen, Binbin Hu, Hui Wang, Ye Wang, Wei Huang

Source: Experimental Gerontology, Vol 187, Iss , Pp 112366- (2024)

Subject Terms: Seed amplification assays, α-Syn RT-QuIC, Self-propagation, Aggregated α-synuclein, Synucleinopathies, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0531556524000081; https://doaj.org/toc/1873-6815

Access URL: https://doaj.org/article/873b9d9fc51647a28a51c50358d16450

Expanding CWD disease surveillance options using environmental contamination at deer signposts

Authors: Miranda H. J. Huang, Steve Demarais, Alejandro Banda, Bronson K. Strickland, Anna Grace Welch, Scoty Hearst, Stuart Lichtenberg, Allan Houston, Kim M. Pepin, Kurt C. VerCauteren

Source: Ecological Solutions and Evidence, Vol 5, Iss 1, Pp n/a-n/a (2024)

Subject Terms: chronic wasting disease, environmental contamination, environmental surveillance, prions, RT‐QuIC, scraping behaviour, Environmental sciences, GE1-350, Ecology, QH540-549.5

File Description: electronic resource

Relation: https://doaj.org/toc/2688-8319

Access URL: https://doaj.org/article/319a7f16902f43e99b5a33b94cff41f6

Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays

Authors: Giovanni Bellomo, Silvia Paciotti, Luis Concha-Marambio, Domenico Rizzo, Anna Lidia Wojdaƚa, Davide Chiasserini, Leonardo Gatticchi, Linda Cerofolini, Stefano Giuntini, Chiara Maria Giulia De Luca, Yihua Ma, Carly M. Farris, Giuseppe Pieraccini, Sara Bologna, Marta Filidei, Enrico Ravera, Moreno Lelli, Fabio Moda, Marco Fragai, Lucilla Parnetti, Claudio Luchinat

Source: Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-24 (2023)

Subject Terms: α-synuclein, Lipoproteins, Cerebrospinal fluid, Seed amplification assays, RT-QuIC, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/8a0abc545ac346ba9dc7517cc43c701f

α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies

Authors: Matthias Schmitz, Niccolò Candelise, Sezgi Canaslan, Hermann C. Altmeppen, Jakob Matschke, Markus Glatzel, Neelam Younas, Saima Zafar, Peter Hermann, Inga Zerr

Source: Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-11 (2023)

Subject Terms: α-synucleinopathies, α-synuclein, RT-QuIC, Protein strains, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9158

Access URL: https://doaj.org/article/6c54b68df0764b89832328706fb2e620

Editorial: Molecular determinants of protein assemblies in health and disease, Volume II

Authors: Verena Kohler, Anoop Arunagiri, Salvador Ventura, Sonja Kroschwald, Srivastav Ranganathan

Source: Frontiers in Molecular Biosciences, Vol 10 (2023)

Subject Terms: protein aggregation, amyloid, RT QuIC, disaggregation, chaperones, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2023.1343082/full; https://doaj.org/toc/2296-889X

Access URL: https://doaj.org/article/810de3a60e3a4ee2af0d2e2b2333bbb4

Identification of chronic wasting disease prions in decaying tongue tissues from exhumed white-tailed deer

Authors: Paulina Soto, Francisca Bravo-Risi, Rebeca Benavente, Stuart Lichtenberg, Mitch Lockwood, J. Hunter Reed, Rodrigo Morales

Source: mSphere, Vol 8, Iss 5 (2023)

Subject Terms: prions, chronic wasting disease, protein misfolding cyclic amplification (PMCA), real-time quaking induced conversion (RT-QuIC), white-tailed deer, exhumation, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/51f69dd5a3c740c495efdfd90981dbab