Anti-RGMa neutralizing antibody ameliorates vascular cognitive impairment in mice

Authors: Masaya Yamamoto, Takahide Itokazu, Hiroki Uno, Takakuni Maki, Nao Shibuya, Toshihide Yamashita

Source: Neurotherapeutics, Vol 22, Iss 2, Pp e00500- (2025)

Subject Terms: Chronic hypoperfusion, Neurogenesis, Cognitive impairment, Repulsive guidance molecule-a (RGMa), Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1878747924001879; https://doaj.org/toc/1878-7479

Access URL: https://doaj.org/article/3201deb7689e4a7ab658c9b125660540

RGMa and Neogenin control dendritic spine morphogenesis via WAVE Regulatory Complex-mediated actin remodeling

Authors: Kai Sempert, Belal Shohayeb, Vanessa Lanoue, Elizabeth A. O’Brien, Cecilia Flores, Helen M. Cooper

Source: Frontiers in Molecular Neuroscience, Vol 16 (2023)

Subject Terms: spine enlargement, actin cytoskeleton, synapse formation, Neogenin, RGMa, netrin receptor, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnmol.2023.1253801/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/e2b3b46e3f444a3b8e5af93d1eda494f

The CanonicalProducer: an instrument monitoring component of the Relational Grid Monitoring Architecture (R-GMA)

Authors: Byrom, R., Coghlan, B., Cooke, A., Cordenonsi, R., Cornwall, L., Datta, A., Djaoui, A., Field, L., Fisher, S., Hicks, S., Kenny, S., Magowan, J., Nutt, W., O'Callaghan, D., Oevers, M., Podhorszki, N., Ryan, J., Soni, M., Taylor, P., Wilson, A., Xiaomei Zhu

Source: Third International Symposium on Parallel and Distributed Computing/Third International Workshop on Algorithms, Models and Tools for Parallel Computing on Heterogeneous Networks Parallel computing on heterogeneous networks Parallel and Distributed Computing, 2004. Third International Symposium on/Algorithms, Models and Tools for Parallel Computing on Heterogeneous Networks, 2004. Third International Workshop on. :232-237 2004

Relation: ISPDC 2004. Third International Symposium on Parallel and Distributed Computing/HeteroPar '04. Third International Workshop on Algorithms, Models and Tools for Parallel Computing on Heterogeneous Networks

Delayed administration of elezanumab, a human anti-RGMa neutralizing monoclonal antibody, promotes recovery following cervical spinal cord injury

Authors: Andrea J. Mothe, Peer B. Jacobson, Mitchell Caprelli, Antigona Ulndreaj, Radmehr Rahemipour, Lili Huang, Philippe P. Monnier, Michael G. Fehlings, Charles H. Tator

Source: Neurobiology of Disease, Vol 172, Iss , Pp 105812- (2022)

Subject Terms: RGMa, Monoclonal antibody, Elezanumab, Cervical spinal cord injury, Axonal sprouting, Regeneration, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996122002042; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/a8245c7e74194fe69378e5a56161daca

RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro

Authors: Xiaofan Yuan, Hongmei Xiao, Qingzhe Hu, Guanru Shen, Xinyue Qin

Source: Journal of Lipid Research, Vol 63, Iss 10, Pp 100276- (2022)

Subject Terms: RGMa, Slug, atherosclerosis, carotid artery ligation, neointima, dedifferentiation, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227522001092; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/8674a3d753b74b94970e5c078f0e3e3d

Promoting functions of microRNA-29a/199B in neurological recovery in rats with spinal cord injury through inhibition of the RGMA/STAT3 axis

Authors: Weijie Yang, Ping Sun

Source: Journal of Orthopaedic Surgery and Research, Vol 15, Iss 1, Pp 1-10 (2020)

Subject Terms: MicroRNA-29a, MicroRNA-199B, RGMA, Spinal cord injury, STAT3 signaling pathway, Neurological recovery, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13018-020-01956-4; https://doaj.org/toc/1749-799X

Access URL: https://doaj.org/article/1d34b9b3ede54aa8bb52ce86554e1917

Humanized Anti-RGMa Antibody Treatment Promotes Repair of Blood-Spinal Cord Barrier Under Autoimmune Encephalomyelitis in Mice

Authors: Takeshi Hirata, Takahide Itokazu, Atsushi Sasaki, Fuminori Sugihara, Toshihide Yamashita

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: multiple sclerosis, EAE, blood-spinal cord barrier, blood-brain barrier, vascular pathology, rgma, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.870126/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f648c0ce4d6c4a43af026fa4b56675c5

Expression and Clinical Correlation Analysis Between Repulsive Guidance Molecule a and Neuromyelitis Optica Spectrum Disorders

Authors: Jinhua Tang, Xiaopeng Zeng, Jun Yang, Lei Zhang, Hang Li, Rui Chen, Shi Tang, Yetao Luo, Xinyue Qin, Jinzhou Feng

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: neuromyelitis optica spectrum disorders, repulsive Guidance Molecule a (RGMa), EDSS, AQP4, correlation analysis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.766099/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/fa4c624d9d9f4c14a9492e1781bd646b

Elezanumab, a clinical stage human monoclonal antibody that selectively targets repulsive guidance molecule A to promote neuroregeneration and neuroprotection in neuronal injury and demyelination models

Authors: Lili Huang, Emma Fung, Sahana Bose, Andreas Popp, Preethne Böser, John Memmott, Yuliya A. Kutskova, Renee Miller, Edit Tarcsa, Corinna Klein, Geertruida M. Veldman, Bernhard K. Mueller, Yi-Fang Cui

Source: Neurobiology of Disease, Vol 159, Iss , Pp 105492- (2021)

Subject Terms: RGMa, Elezanumab, ABT-555, ABT-207, Monoclonal antibody, BMP, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996121002412; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/97103df37b9d4f4e9f34440b5a477414

Common Polymorphisms in the RGMa Promoter Are Associated With Cerebrovascular Atherosclerosis Burden in Chinese Han Patients With Acute Ischemic Cerebrovascular Accident

Authors: Qingzhe Hu, Zhenlei Chen, Xiaofan Yuan, Shucheng Li, Rongrong Zhang, Xinyue Qin

Source: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

Subject Terms: RGMa, atherosclerosis, ischemic stroke, functional polymorphism, vasoprotection, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2021.743868/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/23c6a06b21224a8f8f5bde85849f721c

Delayed administration of the human anti-RGMa monoclonal antibody elezanumab promotes functional recovery including spontaneous voiding after spinal cord injury in rats

Authors: Andrea J. Mothe, Marlon Coelho, Lili Huang, Philippe P. Monnier, Yi-Fang Cui, Bernhard K. Mueller, Peer B. Jacobson, Charles H. Tator

Source: Neurobiology of Disease, Vol 143, Iss , Pp 104995- (2020)

Subject Terms: Repulsive Guidance Molecule A (RGMa), Spinal cord injury, Clip impact-compression, Neuronal survival, Axonal plasticity, Bladder function, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996120302709; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/0705e8cb2a934da099c36c454f69f541

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