Blockade of mTORC1 via Rapamycin Suppresses 27-Hydroxycholestrol-Induced Inflammatory Responses.

Authors: Kang, Nakyung¹ (AUTHOR) ka776@naver.com, Kim, Jaesung¹ (AUTHOR) rlawotjd1029@naver.com, Kwon, Munju² (AUTHOR) gmj0226@naver.com, Son, Yonghae¹ (AUTHOR) squall0211@hanmail.net, Eo, Seong-Kug³ (AUTHOR) vetvirus@chonbuk.ac.kr, Baryawno, Ninib⁴ (AUTHOR) n.baryawno@ki.se, Kim, Byoung Soo⁵ (AUTHOR) bskim7@pusan.ac.kr, Yoon, Sik⁶ (AUTHOR) sikyoon@pusan.ac.kr, Oh, Sae-Ock⁶ (AUTHOR) hedgehog@pusan.ac.kr, Lee, Dongjun^2,7 (AUTHOR) lee.dongjun@pusan.ac.kr, Kim, Koanhoi¹ (AUTHOR) lee.dongjun@pusan.ac.kr

Source: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10381. 15p.

Subject Terms: *RAPAMYCIN, *BLOOD vessels, *CD14 antigen, *CELLULAR signal transduction, *IMMUNE response

Challenges with sirolimus experimental data to inform QSP model of post‐transplantation cyclophosphamide regimens.

Authors: Mohanan, Ezhilpavai¹ (AUTHOR), Shen, Guofang¹ (AUTHOR), Ren, Suping¹ (AUTHOR), Fan, Hsuan‐Hao² (AUTHOR), Moua, Kao Tang Ying³ (AUTHOR), Karolak, Aleksandra^1,4 (AUTHOR), Rockne, Russell C.⁴ (AUTHOR), Nakamura, Ryotaro^1,5 (AUTHOR), Horne, David A.⁶ (AUTHOR), Kanakry, Christopher G.⁷ (AUTHOR), Mager, Donald E.^2,8 (AUTHOR), McCune, Jeannine S.^1,5 (AUTHOR) jmccune@uw.edu

Source: CTS: Clinical & Translational Science. Aug2024, Vol. 17 Issue 8, p1-9. 9p.

Subject Terms: *REGULATORY T cells, *RAPAMYCIN, *IMMUNE system, *CYCLOPHOSPHAMIDE

Microglial AKAP8L: a key mediator in diabetes-associated cognitive impairment via autophagy inhibition and neuroinflammation triggering.

Authors: Zhang, Wen-yuan^1,2 (AUTHOR), Wei, Qian-qian^1,2 (AUTHOR), Zhang, Tao^3,4 (AUTHOR), Wang, Chang-shui⁵ (AUTHOR), Chen, Jing^6,7 (AUTHOR), Wang, Jian-hua^3,4 (AUTHOR), Xie, Xin^3,4 (AUTHOR), Jiang, Pei^3,4 (AUTHOR) jiangpeicsu@sina.com

Source: Journal of Neuroinflammation. 7/20/2024, Vol. 21 Issue 1, p1-19. 19p.

Subject Terms: *COGNITION disorders, *RAPAMYCIN, *MICROGLIA, *AUTOPHAGY, *NEUROINFLAMMATION, *ASTROCYTES

Preparation and in vivo and ex vivo studies of sirolimus nano-in-situ gel ophthalmic formulation.

Authors: Liu, Ye¹ (AUTHOR), Chen, Xu¹ (AUTHOR), Chen, Xinghao¹ (AUTHOR), Chen, Jie¹ (AUTHOR), Zhang, Han¹ (AUTHOR), Xu, Haonan¹ (AUTHOR), Jin, Lu¹ (AUTHOR), Wang, Qiao^1,2 (AUTHOR) wangqiao-1@163.com, Tang, Zhan^1,2 (AUTHOR) tangzhan1986@126.com

Source: Journal of Nanobiotechnology. 7/16/2024, Vol. 22 Issue 1, p1-17. 17p.

Subject Terms: *OPHTHALMIC drugs, *RAPAMYCIN, *AQUEOUS humor, *GELLAN gum, *DRUG delivery systems, *CORNEA

Coadministration of fluconazole to boost subtherapeutic sirolimus concentrations: A case report.

Authors: Scherkl, Camilo¹ (AUTHOR), Meid, Andreas D.¹ (AUTHOR), Cuntz, Sven E.² (AUTHOR), Classen, Laura² (AUTHOR), Weiss, Johanna¹ (AUTHOR), Czock, David¹ (AUTHOR), Haefeli, Walter E.¹ (AUTHOR) walter‐emil.haefeli@med.uni‐heidelberg.de

Source: Pharmacology Research & Perspectives. Jun2024, Vol. 12 Issue 3, p1-6. 6p.

Subject Terms: *RAPAMYCIN, *HEMATOPOIETIC stem cell transplantation, *BUSULFAN, *DRUG monitoring, *FLUCONAZOLE, *VORICONAZOLE, *CYTOCHROME P-450, *TACROLIMUS

Microfluidic nanoprecipitation of PEGylated PLGA nanoparticles with rapamycin and performance evaluation.

Authors: Guo, Jiahao¹ (AUTHOR), Dai, Wenjing² (AUTHOR), Wu, Weiqian¹ (AUTHOR), Zhuang, Shiya¹ (AUTHOR), Zhang, Huan¹ (AUTHOR), Cen, Lian¹ (AUTHOR) liancen@ecust.edu.cn

Source: Journal of Biomaterials Science -- Polymer Edition. Jun2024, Vol. 35 Issue 8, p1197-1213. 17p.

Subject Terms: *RAPAMYCIN, *SERUM albumin, *CANCER cell growth, *POLYETHYLENE glycol, *NANOPARTICLES, *ANTINEOPLASTIC agents, *BREAST cancer

mTOR signaling and Alzheimer's disease: What we know and where we are?

Authors: Davoody, Samin¹ (AUTHOR), Asgari Taei, Afsaneh² (AUTHOR), Khodabakhsh, Pariya³ (AUTHOR), Dargahi, Leila⁴ (AUTHOR) l.dargahi@sbmu.ac.ir

Source: CNS Neuroscience & Therapeutics. Apr2024, Vol. 30 Issue 4, p1-17. 17p.

Subject Terms: *ALZHEIMER'S disease, *RAPAMYCIN, *SERINE/THREONINE kinases, *NEUROFIBRILLARY tangles, *CELL physiology, *CELL size, *CHRONIC traumatic encephalopathy

Cost and effectiveness comparison of sirolimus versus standard treatment in Kasabach-Merritt phenomenon: a real-world evidence study in Thailand.

Authors: Tongruang, Chanikarn¹ (AUTHOR), Wananukul, Siriwan² (AUTHOR), Chatproedprai, Susheera² (AUTHOR), Narkbunnam, Nattee³ (AUTHOR), Nitiyarom, Rattanavalai⁴ (AUTHOR), Sirachainan, Nongnuch⁵ (AUTHOR), Natesirinilkul, Rungrote⁶ (AUTHOR), Chaweephisal, Phumin⁷ (AUTHOR), Sosothikul, Darintr^1,7 (AUTHOR) dsosothikul@hotmail.com

Source: Pediatric Hematology & Oncology. 2024, Vol. 41 Issue 3, p229-239. 11p.

Subject Terms: *RAPAMYCIN, *COST effectiveness, *MOSQUITO nets, *VINBLASTINE, *U.S. dollar

Geographic Terms: THAILAND

Unraveling the Role of Ras Homolog Enriched in Brain (Rheb1 and Rheb2): Bridging Neuronal Dynamics and Cancer Pathogenesis through Mechanistic Target of Rapamycin Signaling.

Authors: Rahman, Mostafizur¹ (AUTHOR) mostafizur@dgu.ac.kr, Nguyen, Tuan Minh¹ (AUTHOR) zxcvb2736@naver.com, Lee, Gi Jeong¹ (AUTHOR), Kim, Boram¹ (AUTHOR), Park, Mi Kyung² (AUTHOR) mkpark@hsmu.ac.kr, Lee, Chang Hoon¹ (AUTHOR) mkpark@hsmu.ac.kr

Source: International Journal of Molecular Sciences. Feb2024, Vol. 25 Issue 3, p1489. 30p.

Subject Terms: *CARCINOGENESIS, *RAPAMYCIN, *CELL proliferation, *SCIENTIFIC community, *INFLAMMATION, *BREAST

Rictor—A Mediator of Progression and Metastasis in Lung Cancer.

Authors: Szalai, Fatime¹ (AUTHOR) fatie.salay@gmail.com, Sztankovics, Dániel¹ (AUTHOR) sztankovics.daniel@gmail.com, Krencz, Ildikó¹ (AUTHOR) krencz.ildiko@gmail.com, Moldvai, Dorottya¹ (AUTHOR) moldvai.dorottya@gmail.com, Pápay, Judit¹ (AUTHOR) papayjudith@gmail.com, Sebestyén, Anna¹ (AUTHOR) hsebanna@gmail.com, Khoor, Andras² (AUTHOR) khoor.andras@mayo.edu

Source: Cancers. Feb2024, Vol. 16 Issue 3, p543. 16p.

Subject Terms: *DISEASE progression, *RAPAMYCIN, *LUNG tumors, *METASTASIS, *SIGNAL peptides, *EPITHELIAL-mesenchymal transition, *GENE expression, *CELL motility, *TUMOR markers

Successful Management of Retropharyngeal Lymphangioma with Stridor Using Sirolimus: A Case Report.

Authors: Razali, Siti Sarah Che Mohd^1,2 (AUTHOR), Mohd, Nik Khairani Nik¹ (AUTHOR), Ibrahim, Fairuz Mohd¹ (AUTHOR), Hamid, Suzina Sheikh Ab² (AUTHOR) suzina@usm.my

Source: Indian Journal of Otolaryngology & Head & Neck Surgery. Feb2024, Vol. 76 Issue 1, p1298-1301. 4p.

Subject Terms: *BRONCHIOLITIS, *RAPAMYCIN, *LYMPHATIC abnormalities, *LYMPHANGIOMAS, *MAGNETIC resonance imaging, *HUMAN abnormalities

Role of maraviroc and/or rapamycin in the liver of IL10 KO mice with frailty syndrome.

Authors: Pérez-Martínez, Laura¹ (AUTHOR) lperez@riojasalud.es, Romero, Lourdes¹ (AUTHOR), Verdugo-Sivianes, Eva M.^2,3 (AUTHOR), Muñoz-Galván, Sandra^2,3 (AUTHOR), Rubio-Mediavilla, Susana⁴ (AUTHOR), Amiama-Roig, Ana¹ (AUTHOR), Carnero, Amancio^2,3 (AUTHOR), Blanco, José-Ramón^1,5 (AUTHOR)

Source: PLoS ONE. 1/10/2024, Vol. 19 Issue 1, p1-14. 14p.

Subject Terms: *FRAILTY, *RAPAMYCIN, *CELLULAR aging, *LIVER, *GENE expression

Drug levels after sirolimus initiation and short‐term outcomes in ambulatory heart transplantation recipients.

Authors: Kancharla, Mihail^1,2 (AUTHOR), Kugathasan, Lakshmi¹ (AUTHOR), McDonald, Michael¹ (AUTHOR), Alba, Ana Carolina¹ (AUTHOR) carolina.alba@uhn.ca

Source: Clinical Transplantation. Jan2024, Vol. 38 Issue 1, p1-7. 7p.

Subject Terms: *HEART transplantation, *RAPAMYCIN, *GRAFT rejection, *VENTRICULAR ejection fraction, *GLOMERULAR filtration rate

Clear cell renal carcinoma essentially requires CDKL3 for oncogenesis.

Authors: Lanjing Ma¹, Zhongqiu Pang¹, Haijiao Zhang¹, Xueling Yang¹, Shaoqin Zheng¹, Yi Chen², Weijie Ding¹, Qing Han¹, Xi Zhang³, Liu Cao⁴, Teng Fei¹, Qiang Wang⁵, Daming Gao⁶, Aina He⁷, ainahe@sjtu.edu.cn, Ke-Bang Hu⁸, hukb@jlu.edu.cn, Xuexin Li^9,10,11,12, xuexin.li@ki.se, Ren Sheng¹, shengren@mail.neu.edu.cn

Source: Proceedings of the National Academy of Sciences of the United States of America; 2/18/2025, Vol. 122 Issue 7, p1-12, 42p

Topical sirolimus in dermatology: a systematic review.

Authors: Afzal, Usamah M¹ (AUTHOR), Alazemi, Mohammad² (AUTHOR), Ali, Omar³ (AUTHOR), Ali, Faisal R^4,5 (AUTHOR), Lear, John T^4,6 (AUTHOR)

Source: Clinical & Experimental Dermatology. Jan2025, Vol. 50 Issue 1, p1-11. 11p.

Subject Terms: *TOPICAL drug administration, *RAPAMYCIN, *TUBEROUS sclerosis, *DRUG efficacy, *RANDOMIZED controlled trials

AGING WITHOUT ILLNESS.

Authors: Willyard, Cassandra (AUTHOR)

Source: Science News. 1/13/2024, Vol. 205 Issue 1, p22-26. 5p. 3 Color Photographs, 1 Graph.

Subjects: OLDER people, AGING, OLD age, DOSAGE forms of drugs, AGING prevention, RAPAMYCIN

Efficacy of sirolimus in blue rubber bleb nevus syndrome.

Authors: Mouhsine, Z.¹ zineb.mouhsine23@gmail.com, El Fatoiki, F. E.¹, Hali, F.¹, Chiheb, S.¹

Source: European Journal of Pediatric Dermatology. 2024, Vol. 34 Issue 2, p85-87. 3p.

Subject Terms: *RAPAMYCIN, *RUBBER, *GASTROINTESTINAL system, *NEVUS, *SYNDROMES, *HUMAN abnormalities

Nuclear receptor subfamily 1 group D member 1 suppresses the proliferation, migration of adventitial fibroblasts, and vascular intimal hyperplasia via mammalian target of rapamycin complex 1/β-catenin pathway.

Authors: Ke Peng^1,2, Mingliang Wang², Jun Wang³, Qiang Wang², De Li², Xiongshan Sun² shan19910927@sina.com, Yongjian Yang^1,2 yyj10001@126.com, Dachun Yang² yangdc71@126.com

Source: Clinical & Experimental Hypertension. Dec2023, Vol. 45 Issue 1, p1-10. 10p.

Subject Terms: *HYPERPLASIA, *RAPAMYCIN, *GENE expression, *FIBROBLASTS, *CAROTID artery

Optimizing the therapeutic window of sirolimus by monitoring blood concentration for the treatment of immune thrombocytopenia.

Authors: Yun Zhang^1,2, Yao Quan¹, Dan Wang^1,3, Cassady, Kaniel⁴, Wenhang Zou⁵, Jingkang Xiong¹, Han Yao¹, Xiaojuan Deng¹, Ping Wang¹, Shijie Yang¹, Xi Zhang¹ zhangxxi@sina.com, Yimei Feng¹ yimeifeng@163.com

Source: Platelets. Dec2023, Vol. 34 Issue 1, p1-7. 7p.

Subject Terms: *IDIOPATHIC thrombocytopenic purpura, *RAPAMYCIN, *RECEIVER operating characteristic curves, *PLATELET count, *REGRESSION analysis

Rapamycin downregulates α-klotho in the kidneys of female rats with normal and reduced renal function.

Authors: Espartero, Azahara^1,2 (AUTHOR), Vidal, Angela^1,2 (AUTHOR), Lopez, Ignacio^1,2 (AUTHOR), Raya, Ana I.^1,2 (AUTHOR), Rodriguez, Mariano² (AUTHOR), Aguilera-Tejero, Escolastico^1,2 (AUTHOR) eaguilera@uco.es, Pineda, Carmen^1,2 (AUTHOR)

Source: PLoS ONE. 11/28/2023, Vol. 18 Issue 11, p1-15. 15p.

Subject Terms: *KIDNEY physiology, *RAPAMYCIN, *RATS, *KIDNEYS, *FIBROBLAST growth factors