Evaluation of prognostic scores in patients with HCC undergoing first-line immunotherapy with atezolizumab and bevacizumab

Authors: Gairing, Simon Johannes ¹, Mildenberger, Philipp ², Gile, Jennifer ³, Artusa, Fabian ⁴, Scheiner, Bernhard ⁵, Leyh, Catherine ⁶, Lieb, Sabine ⁷, Sinner, Friedrich ⁸, Jörg, Vincent ⁹, Fruendt, Thorben ⁹, Himmelsbach, Vera ¹⁰, Abedin, Nada ¹⁰, Sahin, Cennet ¹¹, Böttcher, Katrin ¹², Schuhbaur, Jasmin ¹³, Labuhn, Simon ¹⁴, Korolewicz, James ¹⁵, Fulgenzi, Claudia A.M. ¹⁵, D'Alessio, Antonio ¹⁵, Zanuso, Valentina ^{16, 17}, Hucke, Florian ¹⁸, Röhlen, Natascha ¹⁹, Ben Khaled, Najib ²⁰, Ramadori, Eleonora ²¹, Müller, Lukas ²², Weinmann, Arndt ¹, Kloeckner, Roman ²³, Galle, Peter Robert ¹, Tran, Nguyen H. ³, Venkatesh, Sudhakar K. ²⁴, Teufel, Andreas ^{25, 26}, Ebert, Matthias ^{26, 27}, De Toni, Enrico N. ²⁰, Waldschmidt, Dirk-Thomas ²¹, Marquardt, Jens U. ²⁸, Bettinger, Dominik ¹⁹, Peck-Radosavljevic, Markus ¹⁸, Geier, Andreas ²⁹, Reiter, Florian P. ²⁹, Rimassa, Lorenza ^{16, 17}, Pinato, David J. ^{15, 30}, Roderburg, Christoph ¹⁴, Ettrich, Thomas ¹³, Bitzer, Michael ³¹, Scheble, Veit ³¹, Ehmer, Ursula ¹², Berres, Marie-Luise ¹¹, Finkelmeier, Fabian ¹⁰, Gonzalez-Carmona, Maria Angeles ³², von Felden, Johann ⁹, Schulze, Kornelius ⁹, Venerito, Marino ⁸, van Bömmel, Florian ⁷, Jochheim, Leonie S. ⁶, Pinter, Matthias ⁵, Mohr, Raphael ⁴, Ilyas, Sumera I. ³³, Schmidtmann, Irene ², Foerster, Friedrich ^{1, ⁎}

Source: In JHEP Reports March 2025 7(3)

Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab

Authors: Wu, Meng ^{1, †}, Fulgenzi, Claudia A.M. ^{2, †}, D’Alessio, Antonio ^{2, 3}, Cortellini, Alessio ^{2, 4}, Celsa, Ciro ^{2, 5}, Manfredi, Giulia F. ^{2, 3}, Stefanini, Bernardo ^{2, 6}, Wu, Y. Linda ⁷, Huang, Yi-Hsiang ^{8, 9, 10}, Saeed, Anwaar ¹¹, Pirozzi, Angelo ^{12, 13}, Pressiani, Tiziana ¹³, Rimassa, Lorenza ^{12, 13}, Schoenlein, Martin ¹⁴, Schulze, Kornelius ¹⁵, von Felden, Johann ¹⁵, Mohamed, Yehia ¹⁶, Kaseb, Ahmed O. ¹⁶, Vogel, Arndt ^{17, 18}, Roehlen, Natascha ^{19, 20}, Silletta, Marianna ⁴, Nishida, Naoshi ²¹, Kudo, Masatoshi ²¹, Vivaldi, Caterina ^{22, 23}, Balcar, Lorenz ²⁴, Scheiner, Bernhard ²⁴, Pinter, Matthias ²⁴, Singal, Amit G. ²⁵, Glover, Joshua ²⁶, Ulahannan, Susanna ²⁶, Foerster, Fredrich ²⁷, Weinmann, Arndt ²⁷, Galle, Peter R. ²⁷, Parikh, Neehar D. ²⁸, Hsu, Wei-Fan ²⁹, Parisi, Alessandro ³⁰, Chon, Hong Jae ³¹, Pinato, David J. ^{2, 3}, Ang, Celina ^{1, ⁎}

Source: In JHEP Reports February 2025 7(2)

A patient-derived HCC spheroid system to model the tumor microenvironment and treatment response

Authors: Crouchet, Emilie ^{1, ⁎}, Almeida, Nuno ¹, Durand, Sarah C. ¹, Parnot, Marie ¹, Oudot, Marine A. ¹, Giannone, Fabio ^{1, 2}, Gadenne, Cloé ¹, Roehlen, Natascha ¹, Saviano, Antonio ^{1, 3}, Felli, Emanuele ^{1, 4}, Pessaux, Patrick ^{1, 5}, Duong, Hong Tuan ¹, Ohdan, Hideki ⁶, Aikata, Hiroshi ⁷, Chayama, Kazuaki ^{8, 9}, Baumert, Thomas F. ^{1, 3, 5, 10, ⁎}, Schuster, Catherine ^{1, ⁎}

Source: In JHEP Reports February 2025 7(2)

Targeting the liver clock improves fibrosis by restoring TGF-β signaling

Authors: Crouchet, Emilie, Dachraoui, Mayssa, Jühling, Frank, Roehlen, Natascha, Oudot, Marine A., Durand, Sarah C., Ponsolles, Clara, Gadenne, Cloé, Meiss-Heydmann, Laura, Moehlin, Julien, Martin, Romain, Brignon, Nicolas, Del Zompo, Fabio, Teraoka, Yuji, Aikata, Hiroshi, Abe-Chayama, Hiromi, Chayama, Kazuaki, Saviano, Antonio, Heide, Danijela, Onea, Mihaela, Geyer, Lucas, Wolf, Thibaut, Felli, Emanuele, Pessaux, Patrick, Heikenwälder, Mathias, Chambon, Pierre, Schuster, Catherine, Lupberger, Joachim, Mukherji, Atish, Baumert, Thomas F.

Source: In Journal of Hepatology January 2025 82(1):120-133

AI-derived body composition parameters as prognostic factors in patients with HCC undergoing TACE in a multicenter study

Authors: Müller, Lukas, Mähringer-Kunz, Aline, Auer, Timo Alexander, Fehrenbach, Uli, Gebauer, Bernhard, Haubold, Johannes, Schaarschmidt, Benedikt Michael, Kim, Moon-Sung, Hosch, René, Nensa, Felix, Kleesiek, Jens, Diallo, Thierno D., Eisenblätter, Michel, Kuzior, Hanna, Roehlen, Natascha, Bettinger, Dominik, Steinle, Verena, Mayer, Philipp, Zopfs, David, Pinto Dos Santos, Daniel, Kloeckner, Roman

Source: In JHEP Reports August 2024 6(8)

Characteristics and outcomes of immunotherapy-related liver injury in patients with hepatocellular carcinoma versus other advanced solid tumours

Authors: Celsa, Ciro ^{1, 2, †}, Cabibbo, Giuseppe ^{2, †}, Fulgenzi, Claudia A.M. ^{1, 3}, Scheiner, Bernhard ^{1, 4}, D’Alessio, Antonio ^{1, 5}, Manfredi, Giulia F. ^{1, 5}, Nishida, Naoshi ⁶, Ang, Celina ⁷, Marron, Thomas U. ⁷, Saeed, Anwaar ⁸, Wietharn, Brooke ⁹, Pinter, Matthias ⁴, Cheon, Jaekyung ¹⁰, Huang, Yi-Hsiang ¹¹, Lee, Pei-Chang ¹², Phen, Samuel ¹³, Gampa, Anuhya ¹⁴, Pillai, Anjana ¹⁵, Vivaldi, Caterina ¹⁶, Salani, Francesca ^{15, 16}, Masi, Gianluca ¹⁵, Roehlen, Natascha ¹⁷, Thimme, Robert ¹⁷, Vogel, Arndt ^{18, 19}, Schönlein, Martin ²⁰, von Felden, Johann ²¹, Schulze, Kornelius ²¹, Wege, Henning ²¹, Galle, Peter R. ²², Kudo, Masatoshi ⁶, Rimassa, Lorenza ^{23, 24}, Singal, Amit G. ¹³, El Tomb, Paul ²⁵, Ulahannan, Susanna ²⁵, Parisi, Alessandro ²⁶, Chon, Hong Jae ¹⁰, Hsu, Wei-Fan ²⁷, Stefanini, Bernardo ²⁸, Verzoni, Elena ²⁹, Giusti, Raffaele ³⁰, Veccia, Antonello ³¹, Catino, Annamaria ³², Aprile, Giuseppe ³³, Guglielmini, Pamela Francesca ³⁴, Di Napoli, Marilena ³⁵, Ermacora, Paola ³⁶, Antonuzzo, Lorenzo ³⁷, Rossi, Ernesto ³⁸, Verderame, Francesco ³⁹, Zustovich, Fable ⁴⁰, Ficorella, Corrado ⁴¹, Di Pietro, Francesca Romana ⁴², Battelli, Nicola ⁴³, Negrini, Giorgia ⁴⁴, Grossi, Francesco ⁴⁵, Bordonaro, Roberto ⁴⁶, Pipitone, Stefania ⁴⁷, Banzi, Maria ⁴⁸, Ricciardi, Serena ⁴⁹, Laera, Letizia ⁵⁰, Russo, Antonio ⁵¹, De Giorgi, Ugo ⁵², Cavanna, Luigi ⁵³, Sorarù, Mariella ⁵⁴, Montesarchio, Vincenzo ⁵⁵, Bordi, Paola ⁵⁶, Brunetti, Leonardo ³, Pinto, Carmine ⁴⁸, Bersanelli, Melissa ⁵⁶, Cammà, Calogero ², Cortellini, Alessio ^{1, 3, ‡}, Pinato, David J. ^{1, 5, ∗, ‡}

Source: In Journal of Hepatology March 2024 80(3):431-442

Treatment of HCC with claudin-1-specific antibodies suppresses carcinogenic signaling and reprograms the tumor microenvironment

Authors: Roehlen, Natascha, Muller, Marion, Nehme, Zeina, Crouchet, Emilie, Jühling, Frank, Del Zompo, Fabio, Cherradi, Sara, Duong, Francois H.T., Almeida, Nuno, Saviano, Antonio, Fernández-Vaquero, Mirian, Riedl, Tobias, El Saghire, Houssein, Durand, Sarah C., Ponsolles, Clara, Oudot, Marine A., Martin, Romain, Brignon, Nicolas, Felli, Emanuele, Pessaux, Patrick, Lallement, Antonin, Davidson, Irwin, Bandiera, Simonetta, Thumann, Christine, Marchand, Patrice, Moll, Solange, Nicolay, Brandon, Bardeesy, Nabeel, Hoshida, Yujin, Heikenwälder, Mathias, Iacone, Roberto, Toso, Alberto, Meyer, Markus, Elson, Greg, Schweighoffer, Tamas, Teixeira, Geoffrey, Zeisel, Mirjam B., Laquerriere, Patrice, Lupberger, Joachim, Schuster, Catherine, Mailly, Laurent, Baumert, Thomas F.

Source: In Journal of Hepatology February 2023 78(2):343-355

Impact of duodenal-jejunal bypass liner (DJBL) on NAFLD in patients with obesity and type 2 diabetes mellitus

Authors: Roehlen, Natascha, Laubner, Katharina, Nicolaus, Leonard, Schwacha, Henning, Bettinger, Dominik, Krebs, Andreas, Thimme, Robert, Seufert, Jochen

Source: In Nutrition November-December 2022 103-104

Akutes Leberversagen. (German)

Alternate Title: Acute Liver Failure. (English)

Authors: Röhlen, Natascha, Thimme, Robert

Source: DMW: Deutsche Medizinische Wochenschrift; Mar2025, Vol. 150 Issue 7, p371-384, 14p

Neuartiger Fettsäuresynthase-Hemmer: MASH-Fibrose: Neuartiger Fettsäuresynthase-Hemmer. (German)

Authors: Rohloff, Lukas, Röhlen, Natascha

Source: Gastro-News; Dec2024, Vol. 11 Issue 6, p31-33, 3p

OS-078-YI Hepatic decompensation as an aetiology-dependent determinant of mortality in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab

Authors: Celsa, Ciro, Cabibbo, Giuseppe, Fulgenzi, Claudia, Scheiner, Bernhard, Battaglia, Salvatore, D'Alessio, Antonio, Manfredi, Giulia, Stefanini, Bernardo, Nishida, Naoshi, Galle, Peter R., Schulze, Kornelius, Wege, Henning, Ciccia, Roberta, Hsu, Wei-Fan, Vivaldi, Caterina, Wietharn, Brooke, Lin, Po-Ting, Pirozzi, Angelo, Pressiani, Tiziana, Dalbeni, Andrea, Natola, Leonardo Antonio, Auriemma, Alessandra, Rigamonti, Cristina, Burlone, Michela Emma, Parisi, Alessandro, Huang, Yi-Hsiang, Lee, Pei-Chang, Ang, Celina, Marron, Thomas, Pinter, Matthias, Cheon, Jaekyung, Chon, Hong Jae, Phen, Samuel, Singal, Amit, Gampa, Anuhya, Pillai, Anjana, Thimme, Robert, Vogel, Arndt, Soror, Noha, Ulahannan, Susanna V., Sharma, Rohini, Sacerdoti, David, Pirisi, Mario, Rimassa, Lorenza, Lin, Chun-yen, Saeed, Anwaar, Röhlen, Natascha, Masi, Gianluca, Schoenlein, Martin, von Felden, Johann, Kudo, Masatoshi, Cortellini, Alessio, Camma, Calogero, Pinato, David J.

Source: In Journal of Hepatology June 2024 80 Supplement 1:S51-S52

OS-079-YI Development and validation of the CABLE score to estimate individual prognosis of patients with hepatocellular carcinoma treated with 1L atezolizumab and bevacizumab

Authors: Gairing, Simon Johannes, Mildenberger, Philipp, Gile, Jennifer, Artusa, Fabian, Scheiner, Bernhard, Leyh, Catherine, Lieb, Sabine, Sinner, Friedrich, Jörg, Vincent, Fruendt, Thorben, Himmelsbach, Vera, Abedin, Nada, Sahin, Cennet, Boettcher, Katrin, Schuhbaur, Jasmin, Labuhn, Simon, Korolewicz, James, Fulgenzi, Claudia, D'Alessio, Antonio, Zanuso, Valentina, Hucke, Florian, Röhlen, Natascha, Khaled, Najib Ben, Ramadori, Eleonora, Müller, Lukas, Weinmann, Arndt, Kloeckner, Roman, Galle, Peter R., Tran, Nguyen H., Venkatesh, Sudhakar, Teufel, Andreas, de Toni, Enrico, Waldschmidt, Dirk-Thomas, Marquardt, Jens U., Bettinger, Dominik, Peck-Radosavljevic, Markus, Geier, Andreas, Reiter, Florian P, Rimassa, Lorenza, Pinato, David J., Roderburg, Christoph, Ettrich, Thomas, Bitzer, Michael, Scheble, Veit, Ehmer, Ursula, Berres, Marie-Luise, Finkelmeier, Fabian, Gonzalez-Carmona, Maria Angeles, von Felden, Johann, Schulze, Kornelius, Venerito, Marino, van Bömmel, Florian, Jochheim, Leonie, Pinter, Matthias, Mohr, Raphael, Ilyas, Sumera I., Schmidtmann, Irene, Foerster, Friedrich

Source: In Journal of Hepatology June 2024 80 Supplement 1:S52-S52

OS-040-YI Claudin-1 is a mediator and therapeutic target of biliary fibrosis by modulating liver progenitor cell fate and signaling

Authors: Zompo, Fabio Del, Crouchet, Emilie, Ostyn, Tessa, Jühling, Frank, Moehlin, Julien, Roehlen, Natascha, Andrews, Tallulah, Nakib, Diana, Perciani, Catia, Chung, Sai, Bader, Gary L., Mcgilvray, Ian, MacParland, Sonya, Iacone, Roberto, Teixeira, Geoffrey, Heikenwälder, Mathias, Govaere, Olivier, Roskams, Tania, Schuster, Catherine, Mailly, Laurent, Baumert, Thomas

Source: In Journal of Hepatology June 2024 80 Supplement 1:S31-S32

OS-029 Claudin-1 is a driver for cholangiocarcinoma by modulating cancer cell plasticity and fate

Authors: Nehme, Zeina, Muller, Marion, Crouchet, Emilie, Jühling, Frank, Moehlin, Julien, Desert, Romain, Del Zompo, Fabio, Brochon-Toiser, Jade, Roehlen, Natascha, Thumann, Christine, Pessaux, Patrick, Felli, Emanuele, Venkatasamy, Aïna, Onea, Mihaela, Iacone, Roberto, Meyer, Markus, Toso, Alberto, Bardeesy, Nabeel, Goyal, Lipika, Ranvir, Vikas, Fernández-Vaquero, Mirian, Heikenwälder, Mathias, Ostyn, Tessa, Roskams, Tania, Laquerriere, Patrice, Schuster, Catherine, Mailly, Laurent, Baumert, Thomas

Source: In Journal of Hepatology June 2024 80 Supplement 1:S25-S26

Leberfibrose - Diagnostik und innovative Therapieansätze. (German)

Authors: Röhlen, Natascha, Thimme, Robert, Böttler, Tobias

Source: Gastro-News; Oct2022, Vol. 9 Issue 5, p40-50, 11p

OS-098 - Perturbation of rhythmicity of the circadian clock-oscillator in hepatic stellate cells is associated with liver fibrosis

Authors: Crouchet, Emilie, Dachraoui, Mayssa, Jühling, Frank, Oudot, Marine, Ponsolles, Clara, Heydmann, Laura, Gadenne, Cloé, Moehlin, Julien, Roehlen, Natascha, Martin, Romain, Brignon, Nicolas, Mailly, Laurent, Teraoka, Yuji, Aikata, Hiroshi, Imamura, Michio, Abe-Chayama, Hiromi, Chayama, Kazuaki, Del Zompo, Fabio, Saviano, Antonio, Durand, Sarah, Schuster, Catherine, Pessaux, Patrick, Lupberger, Joachim, Mukherji, Atish, Baumert, Thomas

Source: In Journal of Hepatology June 2023 78 Supplement 1:S77-S78

SAT160 - In vivo loss-of-function studies unravel protein tyrosine phosphatase delta as a regulator of liver regeneration during metabolic liver disease

Authors: Roca Suarez, Armando Andres, Mailly, Laurent, Roehlen, Natascha, Virzi, Alessia, Brignon, Nicolas, Jühling, Frank, Thumann, Christine, Durand, Sarah, Oudot, Marine, Schaeffer, Eugénie, Martin, Romain, Heydmann, Laura, Bach, Charlotte, Parent, Romain, Jamey, Carole, Brumaru, Daniel, Dali-Youcef, Nassim, Felli, Emanuele, Pessaux, Patrick, Mukherji, Atish, Schuster, Catherine, Baumert, Thomas, Lupberger, Joachim

Source: In Journal of Hepatology July 2022 77 Supplement 1:S738-S738

FRI583 - Single cell RNAsequencing derived signature of hepatocyte de-differentiation predicts development of hepatocellular carcinoma in patients with liver cirrhosis

Authors: Gromak, Mikhail, Luxenburger, Hendrik, Böttler, Tobias, Thimme, Robert, Hofmann, Maike, Röhlen, Natascha

Source: In Journal of Hepatology July 2022 77 Supplement 1:S657-S657

OS038 - Targeting the liver circadian clock by REV-ERB-alpha activation improves liver fibrosis by circadian gating of TGF-beta signaling

Authors: Dachraoui, Mayssa, Jühling, Frank, Roehlen, Natascha, Crouchet, Emilie, Martin, Romain, Brignon, Nicolas, Mailly, Laurent, Saviano, Antonio, Durand, Sarah, Schuster, Catherine, Felli, Emanuele, Pessaux, Patrick, Lupberger, Joachim, Mukherji, Atish, Baumert, Thomas

Source: In Journal of Hepatology July 2022 77 Supplement 1:S36-S36

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