Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin

Authors: Burke, Ryan M., Dirkx, Ronald A., Quijada, Pearl, Lighthouse, Janet K., Mohan, Amy, O'Brien, Meghann, Wojciechowski, Wojciech, Woeller, Collynn F., Phipps, Richard P., Alexis, Jeffrey D., Ashton, John M., Small, Eric M.

Source: Circulation research. 128(11):1663-1678

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190155122.0x000001&indx=1&recIds=ETOCvdc_100190155122.0x000001

Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease.

Authors: Li, Zhen, Gu, Min, Zaparte, Aline, Fu, Xiaoming, Mahen, Kala, Mrdjen, Marko, Li, Xinmin S., Yang, Zhihong, Ma, Jing, Thoudam, Themis, Chandler, Kristina, Hesler, Maggie, Heathers, Laura, Gorse, Kiersten, Van, Thanh Trung, Wong, David, Gibson, Aaron M., Wang, Zeneng, Taylor, Christopher M., Quijada, Pearl

Source: Nature Communications; 12/30/2024, Vol. 15 Issue 1, p1-23, 23p

Subject Terms: ALCOHOLISM, VASCULAR endothelial cells, FECAL microbiota transplantation, ENDOTHELIUM diseases, ENDOTHELIAL cells

Pre-existing fibroblasts of epicardial origin are the primary source of pathological fibrosis in cardiac ischemia and aging

Authors: Quijada, Pearl, Misra, Adwiteeya, Velasquez, Lissette S., Burke, Ryan M., Lighthouse, Janet K., Mickelsen, Deanne M., Dirkx, Ronald A., Jr., Small, Eric M.

Source: In Journal of Molecular and Cellular Cardiology April 2019 129:92-104

Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling

Authors: Ebeid, David E, Khalafalla, Farid G, Broughton, Kathleen M, Monsanto, Megan M, Esquer, Carolina Y, Sacchi, Veronica, Hariharan, Nirmala, Korski, Kelli I, Moshref, Maryam, Emathinger, Jacqueline, Cottage, Christopher T, Quijada, Pearl J, Nguyen, Jonathan H, Alvarez, Roberto, Völkers, Mirko, Konstandin, Mathias H, Wang, Bingyan J, Firouzi, Fareheh, Navarrete, Julian M, Gude, Natalie A, Goumans, Marie-Jose, Sussman, Mark A

Source: Cardiovascular research. 117(1):201-211

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100113447696.0x000001&indx=1&recIds=ETOCvdc_100113447696.0x000001

Exploring the Function of Epicardial Cells Beyond the Surface.

Authors: Wong, David, Martinez, Julie, Quijada, Pearl

Source: Circulation Research; 7/5/2024, Vol. 135 Issue 2, p353-371, 19p

Cardiomyocyte cell cycle dynamics and proliferation revealed through cardiac-specific transgenesis of fluorescent ubiquitinated cell cycle indicator (FUCCI)

Authors: Alvarez, Roberto, Jr, Wang, Bingyan J., Quijada, Pearl J., Avitabile, Daniele, Ho, Thi, Shaitrit, Maya, Chavarria, Monica, Firouzi, Fareheh, Ebeid, David, Monsanto, Megan M., Navarrete, Natalie, Moshref, Maryam, Siddiqi, Sailay, Broughton, Kathleen M., Bailey, Barbara A., Gude, Natalie A., Sussman, Mark A.

Source: In Journal of Molecular and Cellular Cardiology February 2019 127:154-164

Small proline-rich protein 2B drives stress-dependent p53 degradation and fibroblast proliferation in heart failure

Authors: Burke, Ryan M., Lighthouse, Janet K., Quijada, Pearl, Dirkx, Ronald A., Rosenberg, Alexander, Moravec, Christine S., Alexis, Jeffrey D., Small, Eric M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Apr 01. 115(15), E3436-E3445.

Access URL: https://www.jstor.org/stable/26508509

Cardiac interstitial tetraploid cells can escape replicative senescence in rodents but not large mammals

Authors: Broughton, Kathleen, Khieu, Tiffany, Nguyen, Nicky, Rosa, Michael, Mohsin, Sadia, Quijada, Pearl, Wang, Bingyan, Echeagaray, Oscar, Kubli, Dieter, Kim, Taeyong, Firouzi, Fareheh, Monsanto, Megan, Gude, Natalie, Adamson, Robert, Dembitsky, Walter, Davis, Michael, Sussman, Mark

Source: Communications biology. 2(1):1-14

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179727446.0x000001&indx=1&recIds=ETOCvdc_100179727446.0x000001

Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy

Authors: Trembley, Michael A., Quijada, Pearl, Agullo-Pascual, Esperanza, Tylock, Kevin M., Colpan, Mert, Dirkx, Ronald A., Myers, Jason R., Mickelsen, Deanne M., de Mesy Bentley, Karen, Rothenberg, Eli, Moravec, Christine S., Alexis, Jeffrey D., Gregorio, Carol C., Dirksen, Robert T., Delmar, Mario, Small, Eric M.

Source: Circulation. 138(17):1864-1878

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100069518104.0x000001&indx=1&recIds=ETOCvdc_100069518104.0x000001

S100A4 protects the myocardium against ischemic stress

Authors: Doroudgar, Shirin, Quijada, Pearl, Konstandin, Mathias, Ilves, Kelli, Broughton, Kathleen, Khalafalla, Farid G., Casillas, Alexandria, Nguyen, Kristine, Gude, Natalie, Toko, Haruhiro, Ornelas, Luis, Thuerauf, Donna J., Glembotski, Christopher C., Sussman, Mark A., Völkers, Mirko

Source: In Journal of Molecular and Cellular Cardiology November 2016 100:54-63

Nuclear Calcium/Calmodulin-dependent Protein Kinase II Signaling Enhances Cardiac Progenitor Cell Survival and Cardiac Lineage Commitment

Authors: Quijada, Pearl, Hariharan, Nirmala, Cubillo, Jonathan D., Bala, Kristin M., Emathinger, Jacqueline M., Wang, Bingyan J., Ormachea, Lucia, Bers, Donald M., Sussman, Mark A., Poizat, Coralie

Source: In Journal of Biological Chemistry 16 October 2015 290(42):25411-25426

Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells

Authors: Samse, Kaitlen, Emathinger, Jacqueline, Hariharan, Nirmala, Quijada, Pearl, Ilves, Kelli, Völkers, Mirko, Ormachea, Lucia, De La Torre, Andrea, Orogo, Amabel M., Alvarez, Roberto, Din, Shabana, Mohsin, Sadia, Monsanto, Megan, Fischer, Kimberlee M., Dembitsky, Walter P., Gustafsson, Åsa B., Sussman, Mark A.

Source: In Journal of Biological Chemistry 29 May 2015 290(22):13935-13947

Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1

Authors: Völkers, Mirko, Toko, Haruhiro, Doroudgar, Shirin, Din, Shabana, Quijada, Pearl, Joyo, Anya Y., Ornelas, Luis, Joyo, Eri, Thuerauf, Donna J., Konstandin, Mathias H., Gude, Natalie, Glembotski, Christopher C., Sussman, Mark A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Jul . 110(31), 12661-12666.

Access URL: https://www.jstor.org/stable/42712663

Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation

Authors: Din, Shabana, Mason, Matthew, Völkers, Mirko, Johnson, Bevan, Cottage, Christopher T., Wang, Zeping, Joyo, Anya Y., Quijada, Pearl, Erhardt, Peter, Magnuson, Nancy S., Konstandin, Mathias H., Sussman, Mark A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Apr 01. 110(15), 5969-5974.

Access URL: https://www.jstor.org/stable/42590338

Cardiac Stem Cell Hybrids Enhance Myocardial Repair

Authors: Quijada, Pearl, Salunga, Hazel T., Hariharan, Nirmala, Cubillo, Jonathan D., El-Sayed, Farid G., Moshref, Maryam, Bala, Kristin M., Emathinger, Jacqueline M., De La Torre, Andrea, Ormachea, Lucia, Alvarez, Roberto, Gude, Natalie A., Sussman, Mark A.

Source: Circulation research. 117(8):695-706

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100037135873.0x000001&indx=1&recIds=ETOCvdc_100037135873.0x000001

Pim-1 Kinase Antagonizes Aspects of Myocardial Hypertrophy and Compensation to Pathological Pressure Overload

Authors: Muraski, John A., Fischer, Kimberlee M., Wu, Weitao, Cottage, Christopher T., Quijada, Pearl, Mason, Matt, Din, Shabana, Gude, Natalie, Alvarez,, Roberto, Rota, Marcello, Kajstura, Jan, Wang, Zeping, Schaefer, Erik, Chen, Xiongen, MacDonnel, Scott, Magnuson, Nancy, Houser, Stephen R., Anversa, Piero, Sussman, Mark A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2008 Sep . 105(37), 13889-13894.

Access URL: https://www.jstor.org/stable/25464146

Making it stick: chasing the optimal stem cells for cardiac regeneration

Authors: Quijada, Pearl, Sussman, Mark A

Source: Expert review of cardiovascular therapy. 12(11):1275-1288

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103027887.0x000001&indx=1&recIds=ETOCvdc_100103027887.0x000001

Cardiac pericytes mediate the remodeling response to myocardial infarction.

Authors: Quijada, Pearl^1,2,3,4, Park, Shuin^4,5, Peng Zhao^2,5, Kolluri, Kamal S. S.⁵, Wong, David^1,4, Shih, Kevin D.¹, Kai Fang⁵, Pezhouman, Arash^6,7, Lingjun Wang^5,8, Daraei, Ali⁵, Tran, Matthew D.¹, Rathbun, Elle M.⁹, Burgos Villar, Kimberly N.^10,11, Garcia-Hernandez, Maria L.¹², Pham, Thanh T. D.⁹, Lowenstein, Charles J.¹³, Iruela-Arispe, M.Luisa¹⁴, Carmichael, S.Thomas^2,9, Small, Eric M.^11,15,16 eric_small@urmc.rochester.edu, Ardehali, Reza^6,7 rardehali@mednet.ucla.edu

Source: Journal of Clinical Investigation. 5/15/2023, Vol. 133 Issue 10, p1-16. 16p.

Subject Terms: *PERICYTES, *MYOCARDIAL infarction, *CHONDROITIN sulfate proteoglycan, *BASAL lamina, *EXTRACELLULAR matrix, *VENTRICULAR remodeling

Human Cardiac Progenitor Cells Engineered With Pim-I Kinase Enhance Myocardial Repair

Authors: Mohsin, Sadia, Khan, Mohsin, Toko, Haruhiro, Bailey, Brandi, Cottage, Christopher T., Wallach, Kathleen, Nag, Divya, Lee, Andrew, Siddiqi, Sailay, Lan, Feng, Fischer, Kimberlee M., Gude, Natalie, Quijada, Pearl, Avitabile, Daniele, Truffa, Silvia, Collins, Brett, Dembitsky, Walter, Wu, Joseph C., Sussman, Mark A.

Source: Journal of the American College of Cardiology. 60(14):1278-1287

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116207426.0x000001&indx=1&recIds=ETOCvdc_100116207426.0x000001

Circulating Around the Tissue

Authors: Quijada, Pearl, Sussman, Mark A.

Source: Circulation research. 116(4):563-565

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100037135221.0x000001&indx=1&recIds=ETOCvdc_100037135221.0x000001