Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complexElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3cc01143g

Authors: Datta, Dhrubajyoti, Theile, Christopher S., Wassarman, Kelly, Qin, June, Racie, Tim, Schmidt, Karyn, Jiang, Yongfeng, Sigel, Rachel, Janas, Maja M., Egli, Martin, Manoharan, Muthiah

Source: Chemical communications. 59(42):6347-6350

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183687743.0x000001&indx=1&recIds=ETOCvdc_100183687743.0x000001

In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.

Authors: De Giorgi, Marco, Park, So Hyun, Castoreno, Adam, Cao, Mingming, Hurley, Ayrea, Saxena, Lavanya, Chuecos, Marcel A., Walkey, Christopher J., Doerfler, Alexandria M., Furgurson, Mia N., Ljungberg, M. Cecilia, Patel, Kalyani R., Hyde, Sarah, Chickering, Tyler, Lefebvre, Stephanie, Wassarman, Kelly, Miller, Patrick, Qin, June, Schlegel, Mark K., Zlatev, Ivan

Source: Science Translational Medicine; 2/12/2025, Vol. 17 Issue 785, p1-13, 13p

Subject Terms: BLOOD coagulation factor IX, DNA repair, HIGH-protein diet, HEPATOTOXICOLOGY, GENOME editing

Improved In Vivo Metabolic Stability and Silencing Efficacy of siRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA Modifications.

Authors: Datta, Dhrubajyoti, Kumar, Pawan, Kundu, Jayanta, Qin, June, Gilbert, Jason A., Schofield, Sally, Donnelly, Daniel P., Liu, Ju, Degaonkar, Rohan, Egli, Martin, Manoharan, Muthiah

Source: Organic Letters; 11/29/2024, Vol. 26 Issue 47, p10061-10065, 5p

An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema

Authors: Liu, Jingxuan, Qin, June, Borodovsky, Anna, Racie, Timothy, Castoreno, Adam, Schlegel, Mark, Maier, Martin A., Zimmerman, Tracy, Fitzgerald, Kevin, Butler, James

Source: RNA. 25(2):255-263

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN618967201&indx=1&recIds=ETOCRN618967201

Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.

Authors: Yu, Mikyung, Qin, June, Liu, Xiumin, Ramsden, Diane, Williams, Brian, Zlatev, Ivan, Guenther, Dale, Matsuda, Shigeo, Tymon, Roxanne, Darcy, Justin, Wong, Catrina, Tsung, Jamie, Zawaneh, Peter, Chong, Saeho, Theile, Christopher S, Taneja, Nathan, Rogers, Arlin, Liu, Ju, Castellanos-Rizaldos, Elena, Bond, Sarah

Source: Nucleic Acids Research; 6/10/2024, Vol. 52 Issue 10, p5423-5437, 15p

Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy

Authors: Kumar, Varun, Qin, June, Jiang, Yongfeng, Duncan, Richard G, Brigham, Benjamin, Fishman, Shannon, Nair, Jayaprakash K, Akinc, Akin, Barros, Scott A, Kasperkovitz, Pia V

Source: In Molecular Therapy - Nucleic Acids January 2014 3

Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis

Authors: Butler, James S., Chan, Amy, Costelha, Susete, Fishman, Shannon, Willoughby, Jennifer L. S., Borland, Todd D., Milstein, Stuart, Foster, Donald J., Gonçalves, Paula, Chen, Qingmin, Qin, June, Bettencourt, Brian R., Sah, Dinah W., Alvarez, Rene, Rajeev, Kallanthottathil G., Manoharan, Muthiah, Fitzgerald, Kevin, Meyers, Rachel E., Nochur, Saraswathy V., Saraiva, Maria J., Zimmermann, Tracy S.

Source: Amyloid. 23(2):109-118

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097830192.0x000001&indx=1&recIds=ETOCvdc_100097830192.0x000001

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

Authors: Dong, Yizhou, Love, Kevin T., Dorkin, J. Robert, Sirirungruang, Sasilada, Zhang, Yunlong, Chen, Delai, Bogorad, Roman L., Yin, Hao, Chen, Yi, Vegas, Arturo J., Alabi, Christopher A., Sahay, Gaurav, Olejnik, Karsten T., Wang, Weiheng, Schroeder, Avi, Lytton-Jean, Abigail K. R., Siegwart, Daniel J., Akinc, Akin, Barnes, Carmen, Barros, Scott A., Carioto, Mary, Fitzgerald, Kevin, Hettinger, Julia, Kumar, Varun, Novobrantseva, Tatiana I., Qin, June, Querbes, William, Koteliansky, Victor, Langer, Robert, Anderson, Daniel G.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Mar . 111(11), 3955-3960.

Access URL: https://www.jstor.org/stable/23770965

Lipid-Like Materials for Low-Dose, in vivo Gene Silencing

Authors: Love, Kevin T., Mahon, Kerry P., Levins, Christopher G., Whitehead, Kathryn A., Querbes, William, Dorkin, J. Robert, Qin, June, Cantley, William, Qin, Liu Liang, Racie, Timothy, Frank-Kamenetsky, Maria, Yip, Ka Ning, Alvarez, Rene, Sah, Dinah W. Y., de Fougerolles, Antonin, Fitzgerald, Kevin, Koteliansky, Victor, Akinc, Akin, Langer, Robert, Anderson, Daniel G., Klibanov, Alexander

Source: Proceedings of the National Academy of Sciences of the United States of America, 2010 Feb 01. 107(5), 1864-1869.

Access URL: https://www.jstor.org/stable/40536500

Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells

Authors: Basha, Genc, Novobrantseva, Tatiana I, Rosin, Nicole, Tam, Yuen Yi C, Hafez, Ismail M, Wong, Matthew K, Sugo, Tsukasa, Ruda, Vera M, Qin, June, Klebanov, Boris, Ciufolini, Marco, Akinc, Akin, Tam, Ying K, Hope, Michael J, Cullis, Pieter R

Source: In Molecular Therapy December 2011 19(12):2186-2200

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

Authors: Maier, Martin A, Jayaraman, Muthusamy, Matsuda, Shigeo, Liu, Ju, Barros, Scott, Querbes, William, Tam, Ying K, Ansell, Steven M, Kumar, Varun, Qin, June, Zhang, Xuemei, Wang, Qianfan, Panesar, Sue, Hutabarat, Renta, Carioto, Mary, Hettinger, Julia, Kandasamy, Pachamuthu, Butler, David, Rajeev, Kallanthottathil G, Pang, Bo, Charisse, Klaus, Fitzgerald, Kevin, Mui, Barbara L, Du, Xinyao, Cullis, Pieter, Madden, Thomas D, Hope, Michael J, Manoharan, Muthiah, Akinc, Akin

Source: Molecular therapy. 21(8):1570-1578

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100056954230.0x000001&indx=1&recIds=ETOCvdc_100056954230.0x000001

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

Authors: Akinc, Akin, Querbes, William, De, Soma, Qin, June, Frank-Kamenetsky, Maria, Jayaprakash, K. Narayanannair, Jayaraman, Muthusamy, Rajeev, Kallanthottathil G, Cantley, William L, Dorkin, J Robert, Butler, James S, Qin, LiuLiang, Racie, Timothy, Sprague, Andrew, Fava, Eugenio, Zeigerer, Anja, Hope, Michael J, Zerial, Marino, Sah, Dinah WY, Fitzgerald, Kevin, Tracy, Mark A, Manoharan, Muthiah, Koteliansky, Victor, Fougerolles, Antonin de, Maier, Martin A

Source: In Molecular Therapy July 2010 18(7):1357-1364

Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor

Authors: Wada, Yumiko, Lu, Rongzhen, Zhou, Dan, Chu, John, Przewloka, Teresa, Zhang, Shijie, Li, Long, Wu, Yaming, Qin, June, Balasubramanyam, Vishwasenani, Barsoum, James, Ono, Mitsunori

Source: In Blood 1 February 2007 109(3):1156-1164

siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs.

Authors: Akabane-Nakata, Masaaki, Erande, Namrata D, Kumar, Pawan, Degaonkar, Rohan, Gilbert, Jason A, Qin, June, Mendez, Martha, Woods, Lauren Blair, Jiang, Yongfeng, Janas, Maja M, O'Flaherty, Derek K, Zlatev, Ivan, Schlegel, Mark K, Matsuda, Shigeo, Egli, Martin, Manoharan, Muthiah

Source: Nucleic Acids Research; 3/18/2021, Vol. 49 Issue 5, p2435-2449, 15p

Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates.

Authors: Brown, Christopher R, Gupta, Swati, Qin, June, Racie, Timothy, He, Guo, Lentini, Scott, Malone, Ryan, Yu, Mikyung, Matsuda, Shigeo, Shulga-Morskaya, Svetlana, Nair, Anil V, Theile, Christopher S, Schmidt, Karyn, Shahraz, Azar, Goel, Varun, Parmar, Rubina G, Zlatev, Ivan, Schlegel, Mark K, Nair, Jayaprakash K, Jayaraman, Muthusamy

Source: Nucleic Acids Research; 12/2/2020, Vol. 48 Issue 21, p11827-11844, 18p

Reactivity of Resident Immunocytes in Normal and Prepsoriatic Skin Using an Ex Vivo Skin-Explant Model System.

Authors: Curry, Jonathan L.¹, Jian-Zhong Qin, June¹, Robinson, Brian J.¹, Nickoloff, Brian J.¹ bnickol@lumc.edu

Source: Archives of Pathology & Laboratory Medicine. Mar2003, Vol. 127 Issue 3, p289-296. 8p. 2 Color Photographs, 4 Graphs.

Subject Terms: *IMMUNE response, *PSORIASIS, *SKIN diseases, *IMMUNOLOGY, *IMMUNE recognition

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Improved In VivoMetabolic Stability and Silencing Efficacy of siRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA Modifications

Authors: Datta, Dhrubajyoti, Kumar, Pawan, Kundu, Jayanta, Qin, June, Gilbert, Jason A., Schofield, Sally, Donnelly, Daniel P., Liu, Ju, Degaonkar, Rohan, Egli, Martin, Manoharan, Muthiah

Source: Organic Letters; 20240101, Issue: Preprints

An Investigational RNAi Therapeutic Targeting Factor XII (ALN-F12) for the Treatment of Hereditary Angioedema

Authors: Akinc, Akin, Liu, Jingxuan, Qin, June, Castoreno, Adam, Schlegel, Mark, Maier, Martin, Fitzgerald, Kevin, Meyers, Rachel

Source: In The Journal of Allergy and Clinical Immunology February 2016 137(2) Supplement:AB254-AB254