The lethal K18-hACE2 knock-in mouse model mimicking the severe pneumonia of COVID-19 is practicable for antiviral development

Authors: Zhen Zhang, Li Zhou, Qianyun Liu, Yucheng Zheng, Xue Tan, Zhixiang Huang, Ming Guo, Xin Wang, Xianying Chen, Simeng Liang, Wenkang Li, Kun Song, Kun Yan, Jiali Li, Qiaohong Li, Yuzhen Zhang, Shimin Yang, Zeng Cai, Ming Dai, Qiaoyang Xian, Zheng-Li Shi, Ke Xu, Ke Lan, Yu Chen

Source: Emerging Microbes and Infections, Vol 13, Iss 1 (2024)

Subject Terms: SARS-CoV-2, mouse model, K18-hACE2 knock-in mouse, severe pneumonia, Omicron, antivirals, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/fa17329035b44d72b792b36985b71803

A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug

Authors: Qianyun Liu, Yuchi Lu, Chenguang Cai, Yanyan Huang, Li Zhou, Yanbin Guan, Shiying Fu, Youyou Lin, Huan Yan, Zhen Zhang, Xiang Li, Xiuna Yang, Haitao Yang, Hangtian Guo, Ke Lan, Yu Chen, Shin-Chen Hou, Yi Xiong

Source: Cell Death and Disease, Vol 15, Iss 6, Pp 1-9 (2024)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/e6d50b2d38bb4d22bdf8e9052c17481d

Longitudinal changes in the volume of residual lung lobes after lobectomy for lung cancer: a retrospective cohort study

Authors: De-Hao Tu, Chong Yi, Qianyun Liu, Lingmei Huang, Guang Yang, Rirong Qu

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Subject Terms: Lung cancer, Lobectomy, Pulmonary function, Lung volume, Video-assisted thoracic surgery, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/ca697b2d69424453a9bf1bd75d95666a

Natural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding

Authors: Jikai Deng, Shimin Yang, Yingjian Li, Xue Tan, Jiejie Liu, Yanying Yu, Qiang Ding, Chengpeng Fan, Hongyun Wang, Xianyin Chen, Qianyun Liu, Xiao Guo, Feiyu Gong, Li Zhou, Yu Chen

Source: Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-16 (2024)

Subject Terms: Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2059-3635

Access URL: https://doaj.org/article/6340717067474531ba925d6cd9225a1c

A Double Extended Kalman Filter Algorithm for Weakening Non-Line-of-Sight Errors in Complex Indoor Environments Based on Ultra-Wideband Technology

Authors: Sheng Xu, Qianyun Liu, Min Lin, Qing Wang, Kaile Chen

Source: Sensors, Vol 25, Iss 3, p 740 (2025)

Subject Terms: ultra-wideband (UWB), non-line-of-sight (NLOS), time of arrival (TOA), Kalman filter (KF), residual classification, covariance adjustment, Chemical technology, TP1-1185

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8220/25/3/740; https://doaj.org/toc/1424-8220

Access URL: https://doaj.org/article/7d7b8b577c244dda97e502ebdc34dc08

Radio-immunomics in hepatocellular carcinoma: Unraveling the tumor immune microenvironment

Authors: Qianyun Liu, Wenwei Zhu, Fulong Song, Tuo Lou, Lei He, Wenming Zhou, Zhichao Feng

Source: Meta-Radiology, Vol 2, Iss 3, Pp 100098- (2024)

Subject Terms: Radio-immunomics, Hepatocellular carcinoma, Tumor immune microenvironment, Spatiotemporal molecular medicine, Immunotherapy, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2950162824000523; https://doaj.org/toc/2950-1628

Access URL: https://doaj.org/article/7d13e6f2c4ba4ad7947967704d3fa858

Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge

Authors: Qianyun Liu, Haiyan Zhao, Zhiqiang Li, Zhen Zhang, Rui Huang, Mengxue Gu, Ke Zhuang, Qing Xiong, Xianying Chen, Weiyi Yu, Shengnan Qian, Yuzhen Zhang, Xue Tan, Muyi Zhang, Feiyang Yu, Ming Guo, Zhixiang Huang, Xin Wang, Wenjie Xiang, Bihao Wu, Fanghua Mei, Kun Cai, Limin Zhou, Li Zhou, Ying Wu, Huan Yan, Sheng Cao, Ke Lan, Yu Chen

Source: Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-13 (2023)

Subject Terms: Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2059-3635

Access URL: https://doaj.org/article/345c5753c1e8444fa2d3ce94a8205b2d

A long-term cohort study: the immune evasion and decreasing neutralization dominated the SARS-CoV-2 breakthrough infection

Authors: Qianyun Liu, Meihua Jin, Fanghua Mei, Hui Fan, Mengxue Gu, Yuzhen Zhang, Shengnan Qian, Xue Tan, Lei Ji, Zhen Zhang, Guozhong Chen, Huan Yan, Yu Chen, Ke Lan, Qing Geng, Kun Cai, Li Zhou

Source: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Subject Terms: SARS-CoV-2, omicron subvariants, immune evasion, immune imprint, long-tracked cohort, JN.1, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2024.1381877/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/bc0e5dc2a97548779a4780657a967d57

Drastic decline in sera neutralization against SARS-CoV-2 Omicron variant in Wuhan COVID-19 convalescents

Authors: Chengbao Ma, Xianying Chen, Fanghua Mei, Qing Xiong, Qianyun Liu, Lianghui Dong, Chen Liu, Wenjing Zou, Faxian Zhan, Bing Hu, Yingle Liu, Fang Liu, Li Zhou, Junqiang Xu, Yongzhong Jiang, Ke Xu, Kun Cai, Yu Chen, Huan Yan, Ke Lan

Source: Emerging Microbes and Infections, Vol 11, Iss 1, Pp 567-572 (2022)

Subject Terms: sars-cov-2, omicron variant, delta variant, immune escape, fusion, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/f79fddb058334f33985e226298695c48

Quadratic Auto-Step Least Mean Square Equalization for High-Data-Rate IR-UWB Wireless Communication Systems

Authors: Gang Wang, Min Lin, Qianyun Liu

Source: IEEE Access, Vol 10, Pp 53909-53917 (2022)

Subject Terms: Intersymbol interference (ISI), adaptive equalization, auto-step least mean square (A-LMS), quadratic, ultra-wideband (UWB), Electrical engineering. Electronics. Nuclear engineering, TK1-9971

File Description: electronic resource

Relation: https://ieeexplore.ieee.org/document/9777993/; https://doaj.org/toc/2169-3536

Access URL: https://doaj.org/article/7d17fdd1f6384095b34b7e2c4b7270a0

Exploring early warning and forecasting of meteorological risk of landslide and rockfall induced by meteorological factors by the approach of machine learning

Authors: Yangchun LI, Qianyun LIU, Xiao LI, Tianhong GU, Nan ZHANG

Source: Zhongguo dizhi zaihai yu fangzhi xuebao, Vol 32, Iss 3, Pp 118-123 (2021)

Subject Terms: machine learning, geological hazard, landslide, rockfall, meteorological risk, early warning and forecastin, Geology, QE1-996.5

File Description: electronic resource

Relation: https://doaj.org/toc/1003-8035

Access URL: https://doaj.org/article/6bfedbb3b88846c2b295ad4a20378d76

Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in mice

Authors: Zhen Zhang, Qianyun Liu, Ying Sun, Jiali Li, Jiejie Liu, Ruangang Pan, Liu Cao, Xianying Chen, Yingjian Li, Yuzhen Zhang, Ke Xu, Deyin Guo, Li Zhou, Ke Lan, Yu Chen

Source: Emerging Microbes and Infections, Vol 10, Iss 1, Pp 1626-1637 (2021)

Subject Terms: Coronavirus, vaccine, N7-Methyltransferase, nsp14, cap structure, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/451f4a6e0bba483aa6e4c80a49c1bb5f

Neurodevelopmental Toxicity of Polystyrene Nanoplastics in Caenorhabditis elegans and the Regulating Effect of Presenilin

Authors: Qianyun Liu, Chunxiang Chen, Mengting Li, Jia Ke, Yichen Huang, Yuefeng Bian, Shufen Guo, Yang Wu, Yan Han, Mingyuan Liu

Source: ACS Omega, Vol 5, Iss 51, Pp 33170-33177 (2020)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2470-1343

Access URL: https://doaj.org/article/f1e4b69195354cc089c9144c808c6861

Emerging SARS-CoV-2 variants: Why, how, and what's next?

Authors: Yu Chen, Qianyun Liu, Li Zhou, You Zhou, Huan Yan, Ke Lan

Source: Cell Insight, Vol 1, Iss 3, Pp 100029- (2022)

Subject Terms: SARS-CoV-2 variants, Mutation rate, Omicron, Deltacron, Mutations in the Spike, Biology (General), QH301-705.5, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772892722000268; https://doaj.org/toc/2772-8927

Access URL: https://doaj.org/article/47617474f7294154bf6f7c4f49f975b1

Assessment of Solid Pulmonary Nodules or Masses Using Zero Echo Time MR Lung Imaging: A Prospective Head-to-Head Comparison With CT

Authors: Qianyun Liu, Zhichao Feng, Weiyin Vivian Liu, Weidong Fu, Lei He, Xiaosan Cheng, Zhongliang Mao, Wenming Zhou

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: magnetic resonance imaging, zero echo time sequence, pulmonary nodule, comparison, computed tomography, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.812014/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/776efc76dda54f26838ac17d6c9f65a9

N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition

Authors: Ruangang Pan, Eveline Kindler, Liu Cao, Yu Zhou, Zhen Zhang, Qianyun Liu, Nadine Ebert, Roland Züst, Ying Sun, Alexander E. Gorbalenya, Stanley Perlman, Volker Thiel, Yu Chen, Deyin Guo

Source: mBio, Vol 13, Iss 1 (2022)

Subject Terms: coronavirus, nonstructural protein 14 (nsp14), RNA cap structure, N7-methylation, type I interferon, SARS-CoV-2, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/841cb6336f9f44e5a3a759faac211544

Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan, China

Authors: Qianyun Liu, Qing Xiong, Fanghua Mei, Chengbao Ma, Zhen Zhang, Bing Hu, Junqiang Xu, Yongzhong Jiang, Faxian Zhan, Suhua Zhou, Li Tao, Xianying Chen, Ming Guo, Xin Wang, Yaohui Fang, Shu Shen, Yingle Liu, Fang Liu, Li Zhou, Ke Xu, Changwen Ke, Fei Deng, Kun Cai, Huan Yan, Yu Chen, Ke Lan

Source: The Innovation, Vol 3, Iss 1, Pp 100181- (2022)

Subject Terms: SARS-CoV-2, antibody, variant, B.1.617.2, convalescent, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666675821001065; https://doaj.org/toc/2666-6758

Access URL: https://doaj.org/article/1b86bffd4295484e8c86ee9a5d452e51

Cohort protocol: Guangzhou High-Risk Infant Cohort study

Authors: Yuan Yuan, Yan Hu, Huayan Zhang, Pian Hu, Azhu Han, Yuqi Wen, Jingjing Liang, Wanqi Xiao, Suifang Lin, Yanyan Song, Xuying Tan, Xiaopeng Zhao, Haipeng Dong, Qianyun Liu, Li Tao

Source: BMJ Open, Vol 10, Iss 10 (2020)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/10/10/e037829.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/f1dc0e2b873c41d68d29423b5d577058

B-Cell-Epitope-Based Fluorescent Quantum Dot Biosensors for SARS-CoV-2 Enable Highly Sensitive COVID-19 Antibody Detection

Authors: Yucheng Zheng, Kun Song, Kun Cai, Linlin Liu, Dixiao Tang, Wenbo Long, Bohui Zhai, Jianjun Chen, Yanbing Tao, Yunong Zhao, Simeng Liang, Qing Huang, Qianyun Liu, Qi Zhang, Yu Chen, Yingle Liu, Huayao Li, Ping Wang, Ke Lan, Huan Liu, Ke Xu

Source: Viruses, Vol 14, Iss 5, p 1031 (2022)

Subject Terms: SARS-CoV-2 diagnosis, nanometer-scale fluorescent biosensors, B-cell epitopes, quantum dots, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/14/5/1031; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/e07497108a8149559ca26a582e4ff7ed

P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus.

Authors: Liu Cao, Yanxi Ji, Lanyi Zeng, Qianyun Liu, Zhen Zhang, Shuting Guo, Xiaolong Guo, Yongjia Tong, Xiaolu Zhao, Chun-Mei Li, Yu Chen, Deyin Guo

Source: PLoS Pathogens, Vol 15, Iss 10, p e1008079 (2019)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/1be18a2dcfdf4ac6a6db8f2c67b89f68