Atorvastatin favorably modulates a clinical hepatocellular carcinoma risk gene signature

Authors: Kim, Myung‐Ho, Kim, Mi‐Young, Salloum, Shadi, Qian, Tongqi, Wong, Lai Ping, Xu, Min, Lee, Yoojin, Shroff, Stuti G., Sadreyev, Ruslan I., Corey, Kathleen E., Baumert, Thomas F., Hoshida, Yujin, Chung, Raymond T.

Source: Hepatology communications. 6(9):2581-2593

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190649159.0x000001&indx=1&recIds=ETOCvdc_100190649159.0x000001

Molecular Signature Predictive of Long-Term Liver Fibrosis Progression to Inform Antifibrotic Drug Development

Authors: Qian, Tongqi, Fujiwara, Naoto, Koneru, Bhuvaneswari, Ono, Atsushi, Kubota, Naoto, Jajoriya, Arun K., Tung, Matthew G., Crouchet, Emilie, Song, Won-Min, Marquez, Cesia Ammi, Panda, Gayatri, Hoshida, Ayaka, Raman, Indu, Li, Quan-Zhen, Lewis, Cheryl, Yopp, Adam, Rich, Nicole E., Singal, Amit G., Nakagawa, Shigeki, Goossens, Nicolas, Higashi, Takaaki, Koh, Anna P., Bian, C. Billie, Hoshida, Hiroki, Tabrizian, Parissa, Gunasekaran, Ganesh, Florman, Sander, Schwarz, Myron E., Hiotis, Spiros P., Nakahara, Takashi, Aikata, Hiroshi, Murakami, Eisuke, Beppu, Toru, Baba, Hideo, Bhatia, Sangeeta, Kobayashi, Masahiro, Kumada, Hiromitsu, Fobar, Austin J., Parikh, Neehar D., Marrero, Jorge A., Rwema, Steve Hategekimana, Nair, Venugopalan, Patel, Manishkumar, Kim-Schulze, Seunghee, Corey, Kathleen, O'Leary, Jacqueline G., Klintmalm, Goran B., Thomas, David L., Dibas, Mohammed, Rodriguez, Gerardo, Zhang, Bin, Friedman, Scott L., Baumert, Thomas F., Fuchs, Bryan C., Chayama, Kazuaki, Zhu, Shijia, Chung, Raymond T., Hoshida, Yujin

Source: Gastroenterology. 162(4):1210-1225

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157533662.0x000001&indx=1&recIds=ETOCvdc_100157533662.0x000001

Peroxidasin Deficiency Re-programs Macrophages Toward Pro-fibrolysis Function and Promotes Collagen Resolution in Liver

Authors: Sojoodi, Mozhdeh, Erstad, Derek J., Barrett, Stephen C., Salloum, Shadi, Zhu, Shijia, Qian, Tongqi, Colon, Selene, Gale, Eric M., Jordan, Veronica Clavijo, Wang, Yongtao, Li, Shen, Ataeinia, Bahar, Jalilifiroozinezhad, Sasan, Lanuti, Michael, Zukerberg, Lawrence, Caravan, Peter, Hoshida, Yujin, Chung, Raymond T., Bhave, Gautam, Lauer, Georg M., Fuchs, Bryan C., Tanabe, Kenneth K.

Source: In Cellular and Molecular Gastroenterology and Hepatology 2022 13(5):1483-1509

A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis

Authors: Fujiwara, Naoto, Kobayashi, Masahiro, Fobar, Austin J., Hoshida, Ayaka, Marquez, Cesia A., Koneru, Bhuvaneswari, Panda, Gayatri, Taguri, Masataka, Qian, Tongqi, Raman, Indu, Li, Quan-Zhen, Hoshida, Hiroki, Sezaki, Hitomi, Kumada, Hiromitsu, Tateishi, Ryosuke, Yokoo, Takeshi, Yopp, Adam C., Chung, Raymond T., Fuchs, Bryan C., Baumert, Thomas F., Marrero, Jorge A., Parikh, Neehar D., Zhu, Shijia, Singal, Amit G., Hoshida, Yujin

Source: In Med 9 July 2021 2(7):836-850

Omics‐derived hepatocellular carcinoma risk biomarkers for precision care of chronic liver diseases

Authors: Fujiwara, Naoto, Qian, Tongqi, Koneru, Bhuvaneswari, Hoshida, Yujin

Source: Hepatology research. 50(7):817-830

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107538851.0x000001&indx=1&recIds=ETOCvdc_100107538851.0x000001

GIGSEA: genotype imputed gene set enrichment analysis using GWAS summary level data

Authors: Zhu, Shijia, Qian, Tongqi, Hoshida, Yujin, Shen, Yuan, Yu, Jing, Hao, Ke

Source: Bioinformatics. 35(1):160-163

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100077951975.0x000001&indx=1&recIds=ETOCvdc_100077951975.0x000001

Use of big data in drug development for precision medicine: an update

Authors: Qian, Tongqi, Zhu, Shijia, Hoshida, Yujin

Source: Expert review of precision medicine and drug development. 4(3):189-200

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107752832.0x000001&indx=1&recIds=ETOCvdc_100107752832.0x000001

Restricted immunological and cellular pathways are shared by murine models of chronic alcohol consumption

Authors: Vogle, Alyx, Qian, Tongqi, Zhu, Shijia, Burnett, Elizabeth, Fey, Holger, Zhu, Zhibin, Keshavarzian, Ali, Shaikh, Maliha, Hoshida, Yujin, Kim, Miran, Aloman, Costica

Source: Scientific reports. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161908494.0x000001&indx=1&recIds=ETOCvdc_100161908494.0x000001

Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease.

Authors: Fujiwara, Naoto, Kubota, Naoto, Crouchet, Emilie, Koneru, Bhuvaneswari, Marquez, Cesia A., Jajoriya, Arun K., Panda, Gayatri, Qian, Tongqi, Zhu, Shijia, Goossens, Nicolas, Wang, Xiaochen, Liang, Shuang, Zhong, Zhenyu, Lewis, Sara, Taouli, Bachir, Schwartz, Myron E., Fiel, Maria Isabel, Singal, Amit G., Marrero, Jorge A., Fobar, Austin J.

Source: Science Translational Medicine; 6/22/2022, Vol. 14 Issue 650, p1-12, 12p

Subject Terms: NON-alcoholic fatty liver disease, HEPATOCELLULAR carcinoma, BIOMARKERS, ALPHA fetoproteins, DRUG discovery

OS037 - Peroxidasin deficiency re-programs macrophages toward pro-fibrolysis function and promotes collagen resolution in liver

Authors: Sojoodi, Mozhdeh, Erstad, Derek J., Barrett, Stephen, Salloum, Shadi, Zhu, Shijia, Qian, Tongqi, Gale, Eric, Jordan, Veronica Clavijo, Wang, Yongtao, Li, Shen, Lanuti, Michael, Caravan, Peter, Hoshida, Yujin, Chung, Raymond, Bhave, Gautam, Lauer, Georg, Fuchs, Bryan C., Tanabe, Kenneth K.

Source: In Journal of Hepatology July 2022 77 Supplement 1:S36-S36

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery.

Authors: Crouchet, Emilie, Bandiera, Simonetta, Fujiwara, Naoto, Li, Shen, El Saghire, Hussein, Fernández-Vaquero, Mirian, Riedl, Tobias, Sun, Xiaochen, Hirschfield, Hadassa, Jühling, Frank, Zhu, Shijia, Roehlen, Natascha, Ponsolles, Clara, Heydmann, Laura, Saviano, Antonio, Qian, Tongqi, Venkatesh, Anu, Lupberger, Joachim, Verrier, Eloi R., Sojoodi, Mozhdeh

Source: Nature Communications; 9/17/2021, Vol. 12 Issue 1, p1-19, 19p

Subject Terms: PROGNOSTIC models, NON-alcoholic fatty liver disease, LIVER, LIVER cells, HISTAMINE receptors, LIVER diseases

MPIC: Molecular Prognostic Indicators in Cirrhosis Database for Clinical Context-Specific in Silico Prognostic Biomarker Validation.

Authors: Yip, Shun H., Fujiwara, Naoto, Burke, Jason, Shetler, Anand, Peralta, Celina, Qian, Tongqi, Hoshida, Hiroki, Zhu, Shijia, Hoshida, Yujin

Source: Frontiers in Genetics; 9/18/2019, p1-5, 5p

Subject Terms: USER interfaces, CIRRHOSIS of the liver, STATISTICAL power analysis, DATABASES, MEDICAL databases, LIVER diseases, CHRONIC diseases, EXPERIMENTAL design