Cirrhotic-extracellular matrix attenuates aPD-1 treatment response by initiating immunosuppressive neutrophil extracellular traps formation in hepatocellular carcinoma

Authors: Xiao-Tian Shen, Sun-Zhe Xie, Xin Zheng, Tian-Tian Zou, Bei-Yuan Hu, Jing Xu, Lu Liu, Yun-Feng Xu, Xu-Feng Wang, Hao Wang, Shun Wang, Le Zhu, Kang-Kang Yu, Wen-Wei Zhu, Lu Lu, Ju-Bo Zhang, Jin-Hong Chen, Qiong-Zhu Dong, Lu-Yu Yang, Lun-Xiu Qin

Source: Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-18 (2024)

Subject Terms: Hepatocellular carcinoma (HCC), Immune checkpoint inhibitor (ICI), Neutrophil extracellular traps (NETs), Extracellular matrix (ECM), Collagen type I (Col1), Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-3619

Access URL: https://doaj.org/article/11f20552fc3944ccb8a7f193cd109f08

Modulation of cellular metabolism by protein crotonylation regulates pancreatic cancer progression

Authors: Yan Zheng, Le Zhu, Zhao-Yu Qin, Yu Guo, Shun Wang, Min Xue, Ke-Yu Shen, Bei-Yuan Hu, Xu-Feng Wang, Chao-Qun Wang, Lun-Xiu Qin, Qiong-Zhu Dong

Source: Cell Reports, Vol 42, Iss 7, Pp 112666- (2023)

Subject Terms: CP: Cancer, CP: Molecular biology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723006770; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/20ea196dd601414789280bdba1d989ad

Characteristics of the cancer stem cell niche and therapeutic strategies

Authors: Feng Ju, Manar M. Atyah, Nellie Horstmann, Sheraz Gul, Razi Vago, Christiane J. Bruns, Yue Zhao, Qiong-Zhu Dong, Ning Ren

Source: Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-17 (2022)

Subject Terms: Cancer stem cells, Chemokines, Hypoxia, Metastasis, Niche/microenvironment, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/ad79497c5baf43548d6f3b249b40c58b

The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives

Authors: Shun Wang, Yan Zheng, Feng Yang, Le Zhu, Xiao-Qiang Zhu, Zhe-Fang Wang, Xiao-Lin Wu, Cheng-Hui Zhou, Jia-Yan Yan, Bei-Yuan Hu, Bo Kong, De-Liang Fu, Christiane Bruns, Yue Zhao, Lun-Xiu Qin, Qiong-Zhu Dong

Source: Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-23 (2021)

Subject Terms: Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2059-3635

Access URL: https://doaj.org/article/845ae541dfb74cc49141785ab1aeb2ab

Isolation and characterization of exosomes for cancer research

Authors: Le Zhu, Hao-Ting Sun, Shun Wang, Sheng-Lin Huang, Yan Zheng, Chao-Qun Wang, Bei-Yuan Hu, Wei Qin, Tian-Tian Zou, Yan Fu, Xiao-Tian Shen, Wen-Wei Zhu, Yan Geng, Lu Lu, Hu-liang Jia, Lun-Xiu Qin, Qiong-Zhu Dong

Source: Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-24 (2020)

Subject Terms: Exosomes, Cancer, Isolation, Characterization, Biomarker, Therapy, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13045-020-00987-y; https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/10abffa0188540d2943213fd26a615bc

PKM2 Drives Hepatocellular Carcinoma Progression by Inducing Immunosuppressive Microenvironment

Authors: Tian-En Li, Shun Wang, Xiao-Tian Shen, Ze Zhang, Mo Chen, Hao Wang, Ying Zhu, Da Xu, Bei-Yuan Hu, Ran Wei, Yan Zheng, Qiong-Zhu Dong, Lun-Xiu Qin

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: hepatocellular carcinoma, pyruvate kinase M2, progression, immune escape, immunosuppressive microenvironment, PD-L1, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.589997/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/42966a4e96e44c70ad617d760a2738c3

RA190, a Proteasome Subunit ADRM1 Inhibitor, Suppresses Intrahepatic Cholangiocarcinoma by Inducing NF-KB-Mediated Cell Apoptosis

Authors: Guang-Yang Yu, Xuan Wang, Su-Su Zheng, Xiao-Mei Gao, Qing-An Jia, Wen-Wei Zhu, Lu Lu, Hu-Liang Jia, Jin-Hong Chen, Qiong-Zhu Dong, Ming Lu, Lun-Xiu Qin

Source: Cellular Physiology and Biochemistry, Vol 47, Iss 3, Pp 1152-1166 (2018)

Subject Terms: Intrahepatic cholangiocarcinoma (ICC), Proteasome subunit ADRM1, RA190, Apoptosis, PDX, Physiology, QP1-981, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://www.karger.com/Article/FullText/490210; https://doaj.org/toc/1015-8987; https://doaj.org/toc/1421-9778

Access URL: https://doaj.org/article/9e40af8c5cf74011b1e8819e0ed3a34c

Therapeutic Strategies Targeting Cancer Stem Cells and Their Microenvironment

Authors: Hao-Ran Sun, Shun Wang, Shi-Can Yan, Yu Zhang, Peter J. Nelson, Hu-Liang Jia, Lun-Xiu Qin, Qiong-Zhu Dong

Source: Frontiers in Oncology, Vol 9 (2019)

Subject Terms: cancer stem cells, tumor microenvironments, therapeutic resistance, mechanism, strategy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2019.01104/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/e60619e240df47199c19a4c7d2ae485f

Bcl-2 expression is a poor predictor for hepatocellular carcinoma prognosis of andropause-age patients

Authors: Xiao-Fei Zhang, Xin Yang, Hu-Liang Jia, Wen-Wei Zhu, Lu Lu, Wei Shi, Hao Zhang, Jin-Hong Chen, Yi-Feng Tao, Zheng-Xin Wang, Jun Yang, Lian-Xin Wang, Ming Lu, Yan Zheng, Jing Zhao, Qiong-Zhu Dong, Lun-Xiu Qin

Source: Cancer Biology & Medicine, Vol 13, Iss 4, Pp 459-468 (2016)

Subject Terms: Hepatocellular carcinoma, andropause, Bcl-2, prognosis, androgen, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.cancerbiomed.org/index.php/cocr/article/view/982; https://doaj.org/toc/2095-3941

Access URL: https://doaj.org/article/e9f1dbf71ab7481d90b8ed13339f5b78

Properties and feasibility of using cancer stem cells in clinical cancer treatment

Authors: Xiao-Mei Gao, Rui Zhang, Qiong-Zhu Dong, Lun-Xiu Qin

Source: Cancer Biology & Medicine, Vol 13, Iss 4, Pp 489-495 (2016)

Subject Terms: Cancer stem cells, cancers, treatment failure, metastasis, cancer therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.cancerbiomed.org/index.php/cocr/article/view/987; https://doaj.org/toc/2095-3941

Access URL: https://doaj.org/article/76bceebd10084d1db2e0dfa12578ffaf

Genomic aberrations in the HTPAP promoter affect tumor metastasis and clinical prognosis of hepatocellular carcinoma.

Authors: Jin-Cai Wu, Hu-Liang Jia, Zhuo-Ri Li, Kai-Lun Zhou, Lun-Xiu Qin, Qiong-Zhu Dong, Ning Ren

Source: PLoS ONE, Vol 9, Iss 3, p e90528 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3946185?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/bc00fc886d1c471390636696556fa7c7

Erratum to Bcl-2 expression is a poor predictor for hepatocellular carcinoma prognosis of andropause-age patients

Authors: Xiao-Fei Zhang, Xin Yang, Hu-Liang Jia, Wen-Wei Zhu, Lu Lu, Wei Shi, Hao Zhang, Jin-Hong Chen, Yi-Feng Tao, Zheng-Xin Wang, Jun Yang, Lian-Xin Wang, Ming Lu, Yan Zheng, Jing Zhao, Qiong-Zhu Dong, Lun-Xiu Qin

Source: Cancer Biology & Medicine, Vol 14, Iss 1, Pp 108-108 (2017)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.cancerbiomed.org/index.php/cocr/article/view/1014; https://doaj.org/toc/2095-3941

Access URL: https://doaj.org/article/a83d9ef1b9724bd8b24535c5ea42fb72

MicroRNA-29a-5p is a novel predictor for early recurrence of hepatitis B virus-related hepatocellular carcinoma after surgical resection.

Authors: Hai-Tao Zhu, Qiong-Zhu Dong, Yuan-Yuan Sheng, Jin-Wang Wei, Guan Wang, Hai-Jun Zhou, Ning Ren, Hu-Liang Jia, Qing-Hai Ye, Lun-Xiu Qin

Source: PLoS ONE, Vol 7, Iss 12, p e52393 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3527523?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/234d0d455a594c6b9d8536cf695c3036

Driver mutations of intrahepatic cholangiocarcinoma shape clinically relevant genomic clusters with distinct molecular features and therapeutic vulnerabilities.

Authors: Xiang-Yu Wang, Wen-Wei Zhu, Zheng Wang, Jian-Bo Huang, Sheng-Hao Wang, Fu-Mao Bai, Tian-En Li, Ying Zhu, Jing Zhao, Xin Yang, Lu Lu, Ju-Bo Zhang, Hu-Liang Jia, Qiong-Zhu Dong, Jin-Hong Chen, Andersen, Jesper B., Dan Ye, Lun-Xiu Qin

Source: Theranostics; 2022, Vol. 12 Issue 1, p260-276, 17p

Organ-specific cholesterol metabolic aberration fuels liver metastasis of colorectal cancer.

Authors: Kai-Li Zhang, Wen-Wei Zhu, Sheng-Hao Wang, Chao Gao, Jun-Jie Pan, Zun-Guo Du, Lu Lu, Hu-Liang Jia, Qiong-Zhu Dong, Jin-Hong Chen, Ming Lu, Lun-Xiu Qin

Source: Theranostics; 2021, Vol. 11 Issue 13, p6560-6572, 13p

Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade.

Authors: Ying Zhu, Jing Yang, Da Xu, Xiao-Mei Gao, Ze Zhang, Hsu, Jennifer L., Chia-Wei Li, Seung-Oe Lim, Yuan-Yuan Sheng, Yu Zhang, Jian-Hua Li, Qin Luo, Yan Zheng, Yue Zhao, Lu Lu, Hu-Liang Jia, Mien-Chie Hung, Qiong-Zhu Dong, Lun-Xiu Qin

Source: Gut; Sep2019, Vol. 68 Issue 9, p1653-1666, 14p

Subject Terms: HEPATOCELLULAR carcinoma, SORAFENIB, MEDICAL sciences, KILLER cells, GRANULOCYTE-macrophage colony-stimulating factor

CXCR6 predicts poor prognosis in gastric cancer and promotes tumor metastasis through epithelial-mesenchymal transition.

Authors: JIE-JIE JIN, FA-XIANG DAI, ZI-WEN LONG, HONG CAI, XIAO-WEN LIU, YE ZHOU, QI HONG, QIONG-ZHU DONG, YA-NONG WANG, HUA HUANG

Source: Oncology Reports; Jun2017, Vol. 37 Issue 6, p3279-3286, 8p, 1 Color Photograph, 4 Charts, 3 Graphs

β-catenin mutation is correlated with a favorable prognosis in patients with hepatocellular carcinoma.

Authors: ZHENG WANG, YUAN-YUAN SHENG, XIAO-MEI GAO, CHAO-QUN WANG, XIANG-YU WANG, XU LU, JIN-WANG WEI, KAI-LI ZHANG, QIONG-ZHU DONG, LUN-XIU QIN

Source: Molecular & Clinical Oncology; 2015, Vol. 3 Issue 4, p196-200, 5p

Subject Terms: LIVER cancer, CATENIN genetics, META-analysis, HETEROGENEITY, CLINICAL pathology, HEPATITIS B virus, PROGNOSIS

TGF beta1 and related-Smads contribute to pulmonary metastasis of hepatocellular doi:10.1186/1756-9966-31-93carcinoma in mice model.

Authors: Guo-Cai Li, Qing-Hai Ye, Qiong-Zhu Dong, Ning Ren, Hu-Liang Jia, Lun-Xiu Qin

Source: Journal of Experimental & Clinical Cancer Research (17569966); 2012, Vol. 31 Issue 1, p93-99, 7p, 1 Diagram, 2 Charts, 2 Graphs

Subject Terms: CANCER invasiveness, LIVER cancer, CELL culture, MESSENGER RNA, CYTOKINES, ONCOLOGY

The prognostic significance of preoperative plasma levels of osteopontin in patients with TNM stage-I of hepatocellular carcinoma.

Authors: Jian Sun, Hong-Mei Xu, Hai-Jun Zhou, Qiong-Zhu Dong, Yue Zhao, Li-Yun Fu, Zhen-Yu Hei, Qing-Hai Ye, Ning Ren, Hu-Liang Jia, Lun-Xiu Qin

Source: Journal of Cancer Research & Clinical Oncology; Jan2010, Vol. 136 Issue 1, p1-7, 7p, 4 Charts, 3 Graphs

Subject Terms: CANCER patients, LIVER cancer, CANCER invasiveness, ENZYME-linked immunosorbent assay, BLOOD plasma