Tungsten enzymes play a role in detoxifying food and antimicrobial aldehydes in the human gut microbiome

Authors: Schut, Gerrit J., Thorgersen, Michael P., Poole, Farris L., Haja, Dominik K., Putumbaka, Saisuki, Adams, Michael W. W.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Oct . 118(43), 1-10.

Access URL: https://www.jstor.org/stable/27093546

Tungsten is utilized for lactate consumption and SCFA production by a dominant human gut microbe Eubacterium limosum.

Authors: Putumbaka, Saisuki¹, Schut, Gerrit J.¹, Thorgersen, Michael P.¹, Poole, Farris L.¹, Shao, Nana¹, Rodionov, Dmitry A.², Adams, Michael W. W.¹ adamsm@uga.edu

Source: Proceedings of the National Academy of Sciences of the United States of America. 1/7/2025, Vol. 122 Issue 1, p1-32. 42p.

Subject Terms: *SHORT-chain fatty acids, *HUMAN microbiota, *GUT microbiome, *LACTATE dehydrogenase, *METALLOENZYMES

Obligately aerobic human gut microbe expresses an oxygen resistant tungsten-containing oxidoreductase for detoxifying gut aldehydes.

Authors: Thorgersen, Michael P., Schut, Gerrit J., Poole II, Farris L., Haja, Dominik K., Putumbaka, Saisuki, Mycroft, Harriet I., de Vries, Willem J., Adams, Michael W. W.

Source: Frontiers in Microbiology; 8/16/2022, Vol. 13, p1-14, 14p

Subject Terms: ALDEHYDES, AEROBIC bacteria, OXIDOREDUCTASES, OXYGEN, PROPIONALDEHYDE, MICROORGANISMS, ARCHAEBACTERIA, FURFURAL