Structural Plasticity of Plasmodium falciparum Plasmepsin X to Accommodate Binding of Potent Macrocyclic Hydroxyethylamine Inhibitors

Authors: Withers-Martinez, Chrislaine ^{1, ⁎}, George, Roger ², Ogrodowicz, Roksana ², Kunzelmann, Simone ², Purkiss, Andrew G. ², Kjaer, Svend ², Walker, Philip A. ², Kovada, Vadims ³, Jirgensons, Aigars ³, Blackman, Michael J. ^{1, 4, ⁎}

Source: In Journal of Molecular Biology 15 May 2025 437(10)

Structural and functional characterization of the extended-diKH domain from the antiviral endoribonuclease KHNYN

Authors: Youle, Rebecca L. ^{1, 2, ‡}, Lista, María José ^{1, ‡}, Bouton, Clement ¹, Kunzelmann, Simone ³, Wilson, Harry ¹, Cottee, Matthew A. ², Purkiss, Andrew G. ³, Morris, Elizabeth R. ², Neil, Stuart J.D. ^{1, ∗}, Taylor, Ian A. ^{2, ∗}, Swanson, Chad M. ^{1, ∗}

Source: In Journal of Biological Chemistry April 2025 301(4)

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

Authors: Adams, Sarah E., Purkiss, Andrew G., Knowles, Phillip P., Nans, Andrea, Briggs, David C., Borg, Annabel, Earl, Christopher P., Goodman, Kerry M., Nawrotek, Agata, Borg, Aaron J., McIntosh, Pauline B., Houghton, Francesca M., Kjær, Svend, McDonald, Neil Q.

Source: In Structure 1 July 2021 29(7):694-708

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity

Authors: Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.

Source: In European Journal of Medicinal Chemistry 13 April 2016 112:20-32

RET Recognition of GDNF-GFRα1 Ligand by a Composite Binding Site Promotes Membrane-Proximal Self-Association

Authors: Goodman, Kerry M., Kjær, Svend, Beuron, Fabienne, Knowles, Phillip P., Nawrotek, Agata, Burns, Emily M., Purkiss, Andrew G., George, Roger, Santoro, Massimo, Morris, Edward P., McDonald, Neil Q.

Source: In Cell Reports 25 September 2014 8(6):1894-1904

Explosive Expansion of βγ-Crystallin Genes in the Ancestral Vertebrate.

Authors: Kappé, Guido, Purkiss, Andrew G., van Genesen, Siebe T.

Source: Journal of Molecular Evolution; September 2010, Vol. 71 Issue 3, p219-230, 12p

Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1.

Authors: Rzechorzek, Neil J., Kunzelmann, Simone, Purkiss, Andrew G., Silva Dos Santos, Mariana, MacRae, James I., Taylor, Ian A., Fugger, Kasper, West, Stephen C.

Source: Nature Communications; 10/27/2023, Vol. 14 Issue 1, p1-11, 11p

Subject Terms: POLY ADP ribose, HYDROLYSIS, SMALL molecules, SCISSION (Chemistry), CRYSTAL structure, POLY(ADP-ribose) polymerase

Biophysical Properties of γC-Crystallin in Human and Mouse Eye Lens: The Role of Molecular Dipoles

Authors: Purkiss, Andrew G. ^†, Bateman, Orval A. ^†, Wyatt, Keith, Wilmarth, Phillip A., David, Larry L., Wistow, Graeme J., Slingsby, Christine

Source: In Journal of Molecular Biology 2007 372(1):205-222

Deamidation in human γS-crystallin from cataractous lenses is influenced by surface exposure.

Authors: Lapko, Veniamin N., Purkiss, Andrew G., Smith, David L.

Source: Biochemistry; July 9 2002, Vol. 41 Issue 27, p8638-8648, 11p

Sulfur in human crystallins

Authors: Srikanthan, Durga, Bateman, Orval A., Purkiss, Andrew G., Slingsby, Christine ^∗

Source: In Experimental Eye Research 2004 79(6):823-831

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The X-ray Crystal Structure of Human γS-crystallin C-terminal Domain

Authors: Purkiss, Andrew G. ^{‡, §}, Bateman, Orval A. ^‡, Goodfellow, Julia M. ^‡, Lubsen, Nicolette H. ^¶, Slingsby, Christine ^‡

Source: In Journal of Biological Chemistry 8 February 2002 277(6):4199-4205

Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp‑dNTPαS Diastereomers.

Authors: Morris, Elizabeth R.¹, Kunzelmann, Simone², Caswell, Sarah J.¹, Purkiss, Andrew G.², Kelly, Geoff³, Taylor, Ian A.¹ ian.taylor@crick.ac.uk

Source: Biochemistry. 6/1/2021, Vol. 60 Issue 21, p1682-1698. 17p.

Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization.

Authors: Gori, Ilaria, George, Roger, Purkiss, Andrew G., Strohbuecker, Stephanie, Randall, Rebecca A., Ogrodowicz, Roksana, Carmignac, Virginie, Faivre, Laurence, Joshi, Dhira, Kjær, Svend, Hill, Caroline S.

Source: eLife; 1/25/2021, p1-40, 40p

Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Authors: Morris, Elizabeth R., Caswell, Sarah J., Kunzelmann, Simone, Arnold, Laurence H., Purkiss, Andrew G., Kelly, Geoff, Taylor, Ian A.

Source: Nature Communications; 6/23/2020, Vol. 11 Issue 1, p1-14, 14p

Subject Terms: CRYSTAL structure, BINDING sites, HYDROLYSIS, DNA repair, NUCLEIC acids

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IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties.

Authors: Dagil, Robert, Ball, Neil J, Ogrodowicz, Roksana W, Hobor, Fruzsina, Purkiss, Andrew G, Kelly, Geoff, Martin, Stephen R, Taylor, Ian A, Ramos, Andres

Source: Nucleic Acids Research; 5/7/2019, Vol. 47 Issue 8, p4334-4348, 15p

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Urochordate βγ-Crystallin and the Evolutionary Origin of the Vertebrate Eye Lens

Authors: Shimeld, Sebastian M. ^*, Purkiss, Andrew G., Dirks, Ron P.H., Bateman, Orval A., Slingsby, Christine, Lubsen, Nicolette H.

Source: In Current Biology 2005 15(18):1684-1689