Death-associated protein kinase 1 prevents hypoxia-induced metabolic shift and pulmonary arterial smooth muscle cell proliferation in PAH

Authors: Seidel, Laura-Marie ^a, Thudium, Jana ^a, Smith, Caroline ^a, Sapehia, Vandna ^a, Sommer, Natascha ^a, Wujak, Magdalena ^{a, b}, Weissmann, Norbert ^a, Seeger, Werner ^{a, c, d}, Schermuly, Ralph T. ^{a, 1}, Novoyatleva, Tatyana ^{a, 1, ⁎}

Source: In Cellular Signalling March 2025 127

NUPR1 modulates pulmonary embolism progression via smooth muscle cells phenotypic transformation

Authors: Shu Wang, Aizhen Xu, Maoqing Chen, Yue Wu

Source: Heliyon, Vol 10, Iss 21, Pp e38918- (2024)

Subject Terms: Pulmonary embolism, Pulmonary artery smooth muscle cells, NUPR1, Phenotypic shift, Glycolysis, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024149493; https://doaj.org/toc/2405-8440

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Exonic CircGUCY1A2 inhibits pulmonary artery smooth muscle cells phenotypic switching via regulating O-glycosylation of COL3A1 in pulmonary hypertension

Authors: Bai, June ^{a, b, 1}, Gao, Danni ^{a, b, 1}, Mei, Jian ^{a, d}, Yuan, Hao ^{a, b}, Wang, Xiaoying ^{a, e}, Zhang, Lixin ^{a, d}, Ma, Cui ^{a, d}, Yu, Hang ^f, Guan, Xiaoyu ^{a, b}, Liu, Huiyu ^{a, b}, Wang, Hongdan ^{a, b}, Wan, Kuiyu ^{a, d}, Zhu, Daling ^{a, b, c, ⁎}

Source: In European Journal of Pharmacology 5 April 2025 992

Neutrophil extracellular traps promote proliferation of pulmonary smooth muscle cells mediated by CCDC25 in pulmonary arterial hypertension

Authors: Hongxiao Sun, Zhanhui Du, Xu Zhang, Shuai Gao, Zhixian Ji, Gang Luo, Silin Pan

Source: Respiratory Research, Vol 25, Iss 1, Pp 1-16 (2024)

Subject Terms: Coiled-coil domain containing 25, Neutrophil extracellular traps, Pulmonary arterial hypertension, Pulmonary artery smooth muscle cells, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/e8df8cf88fe3482a8f9389efb5ed2d6a

Cited2 inhibited hypoxia-induced proliferation and migration of PASMCs via the TGF-β1/Cited2/PPARγ pathway

Authors: Hongjuan Wang, Lan Ma, Qin Yu

Source: Iranian Journal of Basic Medical Sciences, Vol 27, Iss 4, Pp 509-517 (2024)

Subject Terms: cited2, hypoxia-induced pulmonary hypertension, migration, proliferation, pulmonary artery smooth muscle cells, Medicine

File Description: electronic resource

Relation: https://ijbms.mums.ac.ir/article_23509_631c1fe5fe648fcea5de8d5e58dbcac7.pdf; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874

Access URL: https://doaj.org/article/4f2b2c34e69943e7a68417600d1f54bd

SOX9 promotes hypoxic pulmonary hypertension through stabilization of DPP4 in pulmonary artery smooth muscle cells

Authors: Guo, Yan-Zi ^a, Cui, Han-Yu ^a, Cai, Ming-Yuan ^a, Wang, Di ^a, Deng, Wei-Ping ^a, Hu, Chang-Ping ^{a, b, ⁎}

Source: In Experimental Cell Research 1 October 2024 442(2)

Fluorinated perhexiline derivative attenuates vascular proliferation in pulmonary arterial hypertension smooth muscle cells

Authors: Griffiths, Kayleigh ^{a, 1}, Grand, Roger J. ^{b, 1}, Horan, Ian ^c, Certo, Michelangelo ^d, Keeler, Ross C. ^a, Mauro, Claudio ^d, Tseng, Chih-Chung ^e, Greig, Iain ^e, Morrell, Nicholas W. ^c, Zanda, Matteo ^f, Frenneaux, Michael P. ^g, Madhani, Melanie ^{a, ⁎}

Source: In Vascular Pharmacology September 2024 156

NEK2 inhibition reverses vascular remodeling in pulmonary arterial hypertension associated with congenital heart disease

Authors: Zhou, Jing-jing ^{a, 1}, Jing-Li ^{a, 1}, Luo, Chun-lei ^b, He, Yi-hua ^{a, ⁎}, Qian, Yu-ling ^{c, d, ⁎}

Source: In Cellular Signalling July 2025 131

A role of TRIM59 in pulmonary hypertension: modulating the protein ubiquitylation modification

Authors: Yingli Liu, Li Zhu, Yue Ming, Zhuhua Wu, Lili Zhang, Qi Chen, Yong Qi

Source: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-22 (2023)

Subject Terms: TRIM59, Pulmonary hypertension, Ubiquitylation modification, YAP1/TEAD4, Pulmonary artery smooth muscle cells, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/79389e7e3c0b4883ba801590f73e996b

Non‐canonical IKB kinases regulate YAP/TAZ and pathological vascular remodeling behaviors in pulmonary artery smooth muscle cells

Authors: Aja Aravamudhan, Paul B. Dieffenbach, Kyoung Moo Choi, Patrick A. Link, Jeffrey A. Meridew, Andrew J. Haak, Laura E. Fredenburgh, Daniel J. Tschumperlin

Source: Physiological Reports, Vol 12, Iss 7, Pp n/a-n/a (2024)

Subject Terms: non‐canonical IKB kinases, pulmonary arterial hypertension, pulmonary artery smooth muscle cells, YAP and TAZ, Physiology, QP1-981

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Relation: https://doaj.org/toc/2051-817X

Access URL: https://doaj.org/article/aebdd8312bac4e3da3890b481db20877

Effect of IL‐17 on pulmonary artery smooth muscle cells and connective tissue disease‐associated pulmonary arterial hypertension

Authors: Tian‐Yan Shi, Xiao‐Hong Wen, Juan Meng, Yue‐Wu Lu

Source: Immunity, Inflammation and Disease, Vol 12, Iss 4, Pp n/a-n/a (2024)

Subject Terms: connective tissue disease‐associated pulmonary arterial hypertension (CTD‐PAH), ICAM, IL‐17, MAPK signal pathway, pulmonary artery smooth muscle cells (PASMCs), Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2050-4527

Access URL: https://doaj.org/article/ffdd861fa0a0466fb172ee3077e73300

Differential responses of pulmonary vascular cells from PAH patients and controls to TNFα and the effect of the BET inhibitor JQ1

Authors: Sharon Mumby, Frederic Perros, Julien Grynblat, Gregoire Manaud, Alberto Papi, Paolo Casolari, Gaetano Caramori, Marc Humbert, S. John Wort, Ian M. Adcock

Source: Respiratory Research, Vol 24, Iss 1, Pp 1-16 (2023)

Subject Terms: Bromodomain and extra‐terminal proteins, Human pulmonary microvascular endothelial cells, Human pulmonary artery smooth muscle cells, Inflammation, Pulmonary arterial hypertension, Diseases of the respiratory system, RC705-779

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Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/c329a62700014b68975999176cca51b6

Study on the Regulatory Mechanism of the PDK1-Mediated TGF-β/Smad Signaling Pathway in Hypoxia-Induced Yak Lungs

Authors: Yiyang Zhang, Jun Wang, Meng Zhang, Xiaoyun Li, Fan Zhang, Manlin Zhou, Kun Yang, Weiji Chen, Haie Ding, Xiao Tan, Qian Zhang, Zilin Qiao

Source: Animals, Vol 14, Iss 16, p 2422 (2024)

Subject Terms: yak, yellow cattle, pulmonary artery smooth muscle cells (PASMCs), hypoxia, pyruvate dehydrogenase kinase 1 (PDK1), TGF-β/Smad signaling pathway, Veterinary medicine, SF600-1100, Zoology, QL1-991

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2615/14/16/2422; https://doaj.org/toc/2076-2615

Access URL: https://doaj.org/article/7f1950bf22c14444b81e599b6ba772a3

Effect of the TGF-β/BMP Signaling Pathway on the Proliferation of Yak Pulmonary Artery Smooth Muscle Cells under Hypoxic Conditions

Authors: Junfeng He, Kejin Wang, Biao Wang, Yan Cui, Qian Zhang

Source: Animals, Vol 14, Iss 14, p 2072 (2024)

Subject Terms: yak, hypoxia, pulmonary artery smooth muscle cells, proliferation, Veterinary medicine, SF600-1100, Zoology, QL1-991

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2615/14/14/2072; https://doaj.org/toc/2076-2615

Access URL: https://doaj.org/article/48b7a05874a5429084655d8be4b37515

Pressure stress delays cyclooxygenase-2 expression induced by interleukin-1β in cultured human pulmonary artery smooth muscle cells

Authors: Hiraide, Sachiko, Machida, Takuji ^∗, Takihana, Shota, Ohshita, Mikoto, Iizuka, Kenji

Source: In Heliyon October 2023 9(10)

Restoration of miR-328a-5p function curtails hypoxic pulmonary hypertension through a mechanism involving PIN1/GSK3β/β-catenin axis

Authors: Yuan, Jieqing ^{a, 1}, Li, Shanshan ^{a, 1}, Han, Yu ^a, Li, Fujun ^b, Shi, Hai ^a, Shi, Weitao ^c, Cui, Wenjie ^{a, ⁎}

Source: In International Immunopharmacology October 2023 123

Ferritinophagy inhibition regulates hypoxia-induced proliferation of pulmonary artery smooth muscle cells

Authors: YIN Chengyang, CHEN Dewei, ZHANG Erlong

Source: 陆军军医大学学报, Vol 45, Iss 12, Pp 1249-1258 (2023)

Subject Terms: hypoxic pulmonary hypertension, ferritinophagy, pulmonary artery smooth muscle cells, iron homeostasis, cell proliferation, Medicine (General), R5-920

File Description: electronic resource

Relation: http://aammt.tmmu.edu.cn/html/202303076.htm; https://doaj.org/toc/2097-0927

Access URL: https://doaj.org/article/d2a4ce277f9d402092f7018689f527a7

Alleviating experimental pulmonary hypertension via co-delivering FoxO1 stimulus and apoptosis activator to hyperproliferating pulmonary arteries

Authors: Bingbing Li, Chao Teng, Huiling Yu, Xiaohong Jiang, Xuyang Xing, Qi Jiang, Chenshi Lin, Zongmin Zhao, Ruifeng Zhang, Wei He

Source: Acta Pharmaceutica Sinica B, Vol 13, Iss 6, Pp 2369-2382 (2023)

Subject Terms: Pulmonary hypertension, Pulmonary artery smooth muscle cells, Fork-head box transcriptional factor O1, Caspase 3, Co-delivery, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383522004968; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/c756bad29a564623a85a1cbb1220f150

Traditional Chinese medicine monomers: Targeting pulmonary artery smooth muscle cells proliferation to treat pulmonary hypertension

Authors: Yang, Xiuli ¹, Yang, Yang ¹, Liu, Ke, Zhang, Chuantao ^∗

Source: In Heliyon April 2023 9(4)

CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells

Authors: Weimin Yu, Qian Zhang, Yixiang Qiu, Hui Chen, Xiaoyang Huang, Li Xiao, Gang Xu, Siqi Li, Pingping Hu, Xiaoyong Tong

Source: Clinical and Experimental Hypertension, Vol 45, Iss 1 (2023)

Subject Terms: Pulmonary hypertension, SERCA2, pulmonary vascular remodeling, pulmonary artery smooth muscle cells, phenotypic transition, calcineurin, nuclear factor of activated T-lymphocytes, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/1064-1963; https://doaj.org/toc/1525-6006

Access URL: https://doaj.org/article/82cb8c579cb24d77b415bf8c95879f10