Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months (COVID-OUT): a multicentre, randomised, quadruple-blind, parallel-group, phase 3 trial

Authors: Anderson, Blake, Atwater, Riannon C, Avula, Nandini, Beckman, Kenny B, Belani, Hrishikesh K, Boulware, David R, Bramante, Carolyn T, Brea, Jannis, Broedlow, Courtney A, Buse, John B, Campora, Paula, Challa, Anup, Charles, Jill, Christensen, Grace, Christiansen, Theresa, Cohen, Ken, Connelly, Bo, Datta, Srijani, Deng, Nikita, Dunn, Alex T, Erickson, Spencer M, Fairbairn, Faith M, Fenno, Sarah L, Fraser, Daniel J, Fricton, Regina D, Griffiths, Gwen, Hagen, Aubrey A, Hartman, Katrina M, Hendrickson, Audrey F, Huling, Jared D, Ingraham, Nicholas E, Jeng, Arthur C, Johnson, Darrell M, Karger, Amy B, Klatt, Nichole R, Kuehl, Erik A, LaBar, Derek D, Lee, Samuel, Liebovitz, David M, Lindberg, Sarah, Luke, Darlette G, Machicado, Rosario, Mohamud, Zeinab, Murray, Thomas A, Ngonyama, Rumbidzai, Nicklas, Jacinda M, Odde, David J, Parrens, Elliott, Parra, Daniela, Patel, Barkha, Proper, Jennifer L, Pullen, Matthew F, Puskarich, Michael A, Rao, Via, Reddy, Neha V, Reddy, Naveen, Rypka, Katelyn J, Saveraid, Hanna G, Seloadji, Paula, Shahriar, Arman, Sherwood, Nancy, Siegart, Jamie L, Siegel, Lianne K, Simmons, Lucas, Sinelli, Isabella, Singh, Palak, Snyder, Andrew, Stauffer, Maxwell T, Thompson, Jennifer, Tignanelli, Christopher J, Tople, Tannon L, Tordsen, Walker J, Watson, Ray HB, Wu, Beiqing, Zaman, Adnin, Zolik, Madeline R, Zinkl, Lena, Anderson, Blake J, Thompson, Jennifer L, Pullen, Matthew, Wirtz, Esteban Lemus, Sherwood, Nancy E, Lindberg, Sarah M, Beckman, Kenneth B, Rose, Michael R, Mehta, Tanvi, Griffiths, Gwendolyn, Bhat, Neeta S

Source: In The Lancet Infectious Diseases October 2023 23(10):1119-1129

Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study

Authors: Sahner, David, Tierney, John, Vogel, Susan E., Herpin, Betsey R., Smolskis, Mary C., McKay, Laura A., Cahill, Kelly, Crew, Page, Sardana, Ratna, Raim, Sharon Segal, Hensely, Lisa, Lorenzo, Johsua, Mock, Rebecca, Zuckerman, Judith, Atri, Negin, Miller, Mark, Vallee, David, Chung, Lucy, Kang, Nayon, Barrett, Kevin, Adam, Stacey J., Read, Sarah, Draghia-Akli, Ruxandra, Currier, Judy, Hughes, Eric, Harrigan, Rachel H., Amos, Laura, Carlsen, Amy, Carter, Anita, Collins, Gary, Davis, Bionca, Denning, Eileen, DuChene, Alain, Eckroth, Kate, Engen, Nicole, Frase, Alex, Gandits, Greg, Grund, Birgit, Harrison, Merrie, Hurlbut, Nancy, Kaiser, Payton, Koopmeiners, Joseph, Larson, Gregg, Meger, Sue, Mistry, Shweta Sharma, Murray, Thomas, Nelson, Ray, Quan, Kien, Quan, Siu Fun, Reilly, Cavan, Siegel, Lianne, Thompson, Greg, Vock, David, Walski, Jamie, Gelijns, Annetine C., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, O'Sullivan, Karen, Marks, Mary E., Accardi, Evan, Kinzel, Emily, Burris, Sarah, Bedoya, Gabriela, Gupta, Lola, Overbey, Jessica R., Santos, Milerva, Gillinov, Marc A., Miller, Marissa A., Taddei-Peters, Wendy C., Fenton, Kathleen, Sandkovsky, Uriel, Gottlieb, Robert L., Mack, Michael, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Bettacchi, Christopher, Golden, Kevin, Duhaime, Erin, Ryan, Madison, Tallmadge, Catherine, Estrada, Lorie, Jones, Felecia, Villa, Samatha, Wang, Samatha, Robert, Raven, Coleman, Tanquinisha, Clariday, Laura, Baker, Rebecca, Hurutado-Rodriguez, Mariana, Iram, Nazia, Fresnedo, Michelle, Davis, Allyson, Leonard, Kiara, Ramierez, Noelia, Thammavong, Jon, Duque, Krizia, Turner, Emma, Fisher, Tammy, Robinson, Dianna, Ransom, Desirae, Maldonado, Nicholas, Lusk, Erica, Killian, Aaron, Palacious, Adriana, Solis, Edilia, Jerrow, Janet, Watts, Matthew, Whitacre, Heather, Cothran, Elizabeth, Smith, Peter K., Barkauskas, Christina E., Vekstein, Andrew M., Ko, Emily R., Dreyer, Grace R., Stafford, Neil, Brooks, Megan, Der, Tatyana, Witte, Marie, Gamarallage, Ruwan, Franzone, John, Ivey, Noel, Lumsden, Rebecca H., Mosaly, Nilima, Mourad, Ahmaad, Holland, Thomas L., Motta, Mary, Lane, Kathleen, McGowan, Lauren M., Stout, Jennifer, Aloor, Heather, Bragg, Kennesha M., Toledo, Barvina, McLendon-Arvik, Beth, Bussadori, Barbara, Hollister, Beth A., Griffin, Michelle, Giangiacomo, Dana M., Rodriguez, Vicente, Bokhart, Gordon, Eichman, Sharon M., Parrino, Patrick E., Spindel, Stephen, Bansal, Aditya, Baumgarten, Katherine, Hand, Johnathan, Vonderhaar, Derek, Nossaman, Bobby, Sylvia Laudun, Ames, DeAnna, Broussard, Shane, Hernandez, Nilmo, Isaac, Geralyn, Dinh, Huan, Zheng, Yiling, Tran, Sonny, McDaniel, Hunter, Crovetto, Nicolle, Perin, Emerson, Costello, Briana, Manian, Prasad, Sohail, M. Rizwan, Postalian, Alexander, Hinsu, Punit, Watson, Carolyn, Chen, James, Fink, Melyssa, Sturgis, Lydia, Walker, Kim, Mahon, Kim, Parenti, Jennifer, Kappenman, Casey, Knight, Aryn, Sturek, Jeffrey M., Barros, Andrew, Enfield, Kyle B., Kadl, Alexandra, Green, China J., Simon, Rachel M., Fox, Ashley, Thornton, Kara, Adams, Amy, Badhwar, Vinay, Sharma, Sunil, Peppers, Briana, McCarthy, Paul, Krupica, Troy, Sarwari, Arif, Reece, Rebecca, Fornaresico, Lisa, Glaze, Chad, Evans, Raquel, Di, Fang, Carlson, Shawn, Aucremanne, Tanja, Tennant, Connie, Sutton, Lisa Giblin, Buterbaugh, Sabrina, Williams, Roger, Bunner, Robin, Traverse, Jay H., Rhame, Frank, Huelster, Joshua, Kethireddy, Rajesh, Davies, Irena, Salamanca, Julianne, Majeski, Christine, Skelton, Paige, Zarambo, Maria, Sarafolean, Andrea, Bowdish, Michael E., Borok, Zea, Wald-Dickler, Noah, Hutcheon, Douglass, Towfighi, Amytis, Lee, Mary, Lewis, Meghan R., Spellberg, Brad, Sher, Linda, Sharma, Aniket, Olds, Anna P., Justino, Chris, Loxano, Edward, Romero, Chris, Leong, Janet, Rodina, Valentina, Quesada, Christine, Hamilton, Luke, Escobar, Jose, Leshnower, Brad, Bender, William, Sharifpour, Milad, Miller, Jeffrey, Farrington, Woodrow, Baio, Kim T., McBride, Mary, Fielding, Michele, Mathewson, Sonya, Porte, Kristina, Maton, Missy, Ponder, Chari, Haley, Elisabeth, Spainhour, Christine, Rogers, Susan, Tyler, Derrick, Madathil, Ronson J., Rabin, Joseph, Levine, Andrea, Saharia, Kapil, Tabatabai, Ali, Lau, Christine, Gammie, James S., Peguero, Maya-Loren, McKernan, Kimberly, Audette, Mathew, Fleischmann, Emily, Akbari, Kreshta, Lee, Myounghee, Chi, Andrew, Salehi, Hanna, Pariser, Alan, Nyguyen, Phuong Tran, Moore, Jessica, Gee, Adrienne, Vincent, Shelika, Zuckerman, Richard A., Iribarne, Alexander, Metzler, Sara, Shipman, Samantha, Johnson, Haley, Newton, Crystallee, Parr, Doug, Miller, Leslie, Schelle, Beth, McLean, Sherry, Rothbaum, Howard R., Alvarez, Michael S., Kalan, Shivam P., Germann, Heather H., Hendershot, Jennifer, Moroney, Karen, Herring, Karen, Cook, Sharri, Paul, Pam, Walker-Ignasiak, Rebecca, North, Crystal, Oldmixon, Cathryn, Ringwood, Nancy, Muzikansky, Ariela, Morse, Richard, Fitzgerald, Laura, Morin, Haley D., Brower, Roy G., Reineck, Lora A., Bienstock, Karen, Steingrub, Jay H., Hou, Peter K., Steingrub, Jay S., Tidswell, Mark A., Kozikowski, Lori-Ann, Kardos, Cynthia, DeSouza, Leslie, Romain, Sarah, Thornton-Thompson, Sherell, Talmor, Daniel, Shapiro, Nathan, Andromidas, Konstantinos, Banner-Goodspeed, Valerie, Bolstad, Michael, Boyle, Katherine L., Cabrera, Payton, deVilla, Arnaldo, Ellis, Joshua C., Grafals, Ana, Hayes, Sharon, Higgins, Conor, Kurt, Lisa, Kurtzman, Nicholas, Redman, Kimberly, Rosseto, Elinita, Scaffidi, Douglas, Filbin, Michael R., Hibbert, Kathryn A., Parry, Blair, Margolin, Justin, Hillis, Brooklynn, Hamer, Rhonda, Brait, Kelsey, Beakes, Caroline, McKaig, Brenna, Kugener, Eleonore, Jones, Alan E., Galbraith, James, Nandi, Utsav, Peacock, Rebekah, Hendey, Gregory, Kangelaris, Kirsten, Ashktorab, Kimia, Gropper, Rachel, Agrawal, Anika, Yee, Kimberley J., Jauregui, Alejandra E., Zhuo, Hanjing, Almasri, Eyad, Fayed, Mohamed, Hubel, Kinsley A., Hughes, Alyssa R., Garcia, Rebekah L., Lim, George W., Chang, Steven Y., Lin, Michael Y., Vargas, Julia, Sihota, Hena, Beutler, Rebecca, Agarwal, Trisha, Wilson, Jennifer G., Vojnik, Rosemary, Perez, Cynthia, McDowell, Jordan H., Roque, Jonasel, Wang, Henry, Huebinger, Ryan M., Patel, Bela, Vidales, Elizabeth, Albertson, Timothy, Hardy, Erin, Harper, Richart, Moss, Marc A., Baduashvili, Amiran, Chauhan, Lakshmi, Douin, David J., Martinez, Flora, Finck, Lani L., Bastman, Jill, Howell, Michelle, Higgins, Carrie, McKeehan, Jeffrey, Finigan, Jay, Stubenrauch, Peter, Janssen, William J., Griesmer, Christine, VerBurg, Olivia, Hyzy, Robert C., Park, Pauline K., Nelson, Kristine, McSparron, Jake I., Co, Ivan N., Wang, Bonnie R., Jimenez, Jose, Olbrich, Norman, McDonough, Kelli, Jia, Shijing, Hanna, Sinan, Gong, Michelle N., Richardson, Lynne D., Nair, Rahul, Lopez, Brenda, Amosu, Omowunmi, Offor, Obiageli, Tzehaie, Hiwet, Nkemdirim, William, Boujid, Sabah, Mosier, Jarrod M., Hypes, Cameron, Campbell, Elizabeth Salvagio, Bixby, Billie, Gilson, Boris, Lopez, Anitza, Bime, Christian, Parthasarathy, Sairam, Cano, Ariana M., Hite, R. 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Scott, Marquez, Adrienna, Chu, Hanh, Lee, Kia, Quillin, Kimberly, Garcia, Andrea, Lew, Pauline, Rogers, Ralph, Shehadeh, Fadi, Mylona, Evangelia K., Kaczynski, Matthew, Tran, Quynh-Lam, Benitez, Gregorio, Mishra, Biswajit, Felix, Lewis Oscar, Vafea, Maria Tsikala, Atalla, Eleftheria, Davies, Robin, Hedili, Salma, Monkeberg, Maria Andrea, Tabler, Sandra, Harrington, Britt, Meegada, Sreenath, Koripalli, Venkata Sandeep, Muddana, Prithvi, Jain, Lakshay, Undavalli, Chaitanya, Kavya, Parasa, Ibiwoye, Mofoluwaso, Akilo, Hameed, Lovette, Bryce D., Wylie, Jamie-Crystal, Smith, Diana M., Poon, Kenneth, Eckardt, Paula, Heysu, Rubio-Gomez, Sundararaman, Nithya, Alaby, Doris, Sareli, Candice, Sánchez, Adriana, Popielski, Laura, Kambo, Amy, Viens, Kimberley, Turner, Melissa, Vjecha, Michael J., Weintrob, Amy, Brar, Indira, Markowitz, Norman, Pastor, Erika, Corpuz, Roweena, Alangaden, George, McKinnon, John, Ramesh, Mayur, Herc, Erica, Yared, Nicholas, Lanfranco, Odaliz Abreu, Rivers, Emanuel, 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Theresa, Lopez, Jessica, Tan, Susanna Yu, Lee, Robert H., Asghar, Aliya, Karyn Isip, Tasadduq Karim, Le, Katherine, Nguyen, Thao, Wong, Shinn, Raben, Dorthe, Murray, Daniel D., Jensen, Tomas O., Peters, Lars, Aagaard, Bitten, Nielsen, Charlotte B., Krapp, Katharina, Nykjær, Bente Rosdahl, Olsson, Christina, Kanne, Katja Lisa, Grevsen, Anne Louise, Joensen, Zillah Maria, Bruun, Tina, Bojesen, Ane, Woldbye, Frederik, Normand, Nick E., Esman, Frederik V.L., Benfield, Thomas, Clausen, Clara Lundetoft, Hovmand, Nichlas, Israelsen, Simone Bastrup, Iversen, Katrine, Leding, Caecilie, Pedersen, Karen Brorup, Thorlacius-Ussing, Louise, Tinggaard, Michaela, Tingsgard, Sandra, Krohn-Dehli, Louise, Pedersen, Dorthe, Villadsen, Signe, Staehr Jensen, Jens-Ulrik, Overgaard, Rikke, Rastoder, Ema, Heerfordt, Christian, Hedsund, Caroline, Ronn, Christian Phillip, Kamstrup, Peter Thobias, Hogsberg, Dorthe Sandbaek, Bergsoe, Christina, Søborg, Christian, Hissabu, Nuria M.S., Arp, Bodil C., Ostergaard, 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Miquel, Carratalà, Jordi, Videla, Sebastià, Günthard, Huldrych, Braun, Dominique L., West, Emily, M’Rabeth-Bensalah, Khadija, Eichinger, Mareile L., Grüttner-Durmaz, Manuela, Grube, Christina, Zink, Veronika, pharmacist, Goes pharmacist, Josefine, Fätkenheuer, Gerd, Malin, Jakob J., Tsertsvadze, Tengiz, Abutidze, Akaki, Chkhartishvili, Nikoloz, Metchurtchlishvili, Revaz, Endeladze, Marina, Paciorek, Marcin, Bursa, Dominik, Krogulec, Dominika, Pulik, Piotr, Ignatowska, Anna, Horban, Andrzej, Bakowska, Elzbieta, Kowaska, Justyna, Bednarska, Agnieszka, Jurek, Natalia, Skrzat-Klapaczynska, Agata, Bienkowski, Carlo, Hackiewicz, Malgorzata, Makowiecki, Michal, Platowski, Antoni, Fishchuk, Roman, Kobrynska, Olena, Levandovska, Khrystyna, Kirieieva, Ivanna, Kuziuk, Mykhailo, Naucler, Pontus, Perlhamre, Emma, Mazouch, Lotta, Kelleher, Anthony, Polizzotto, Mark, Carey, Catherine, Chang, Christina C., Hough, Sally, Virachit, Sophie, Davidson, Sarah, Bice, Daniel J., Ognenovska, Katherine, Cabrera, Gesalit, Flynn, Ruth, Young, Barnaby E., Chia, Po Ying, Lee, Tau Hong, Lin, Ray J., Lye, David C., Ong, Sean W.X., Puah, Ser Hon, Yeo, Tsin Wen, Diong, Shiau Hui, Ongko, Juwinda, Yeo, He Ping, Eriobu, Nnakelu, Kwaghe, Vivian, Zaiyad, Habib, Idoko, Godwin, Uche, Blessing, Selvamuthu, Poongulali, Kumarasamy, Nagalingeswaran, Beulah, Faith Ester, Govindarajan, Narayan, Mariyappan, Kowsalya, Losso, Marcelo H., Abela, Cecilia, Moretto, Renzo, Belloc, Carlos G., Ludueña, Jael, Amar, Josefina, Toibaro, Javier, Macias, Laura Moreno, Fernandez, Lucia, Frare, Pablo S., Chaio, Sebastian R., Pachioli, Valeria, Timpano, Stella M., Sanchez, Marisa del Lujan, de Paz Sierra, Mariana, Stanek, Vanina, Belloso, Waldo, Cilenti, Flavia L., Valentini, Ricardo N., Stryjewski, Martin E., Locatelli, Nicolas, Soler Riera, Maria C., Salgado, Clara, Baeck, Ines M., Di Castelnuovo, Valentina, Zarza, Stella M., Hudson, Fleur, Parmar, Mahesh K.B., Goodman, Anna L., Dphil, Badrock, Jonathan, Gregory, Adam, Goodall, Katharine, Harris, Nicola, Wyncoll, James, Bhagani, S., Rodger, A., Luntiel, A., Patterson, C., Morales, J., Witele, E., Preston, A.-M., Nandani, A., Price, D.A., Hanrath, Aiden, Nell, Jeremy, Patel, Bijal, Hays, Carole, Jones, Geraldine, Davidson, Jade, Bawa, T., Mathews, M., Mazzella, A., Bisnauthsing, K., Aguilar-Jimenez, L., Borchini, F., Hammett, S., Touloumi, Giota, Pantazis, Nikos, Gioukari, Vicky, Souliou, Tania, Antoniadou, A., Protopapas, K., Kavatha, D., Grigoropoulou, S., Oikonomopoulo, C., Moschopoulos, C., Koulouris, N.G., Tzimopoulos, K., Koromilias, A., Argyraki, K., Lourida, P., Bakakos, P., Kalomenidis, I., Vlachakos, V., Barmparessou, Z., Balis, E., Zakynthinos, S., Sigala, I., Gianniou, N., Dima, E., Magkouta, S., Synolaki, E., Konstanta, S., Vlachou, M., Stathopoulou, P., Panagopoulos, P., Petrakis, V., Papazoglou, D., Tompaidou, E., Isaakidou, E., Poulakou, G., Rapti, V., Leontis, K., Nitsotolis, T., Athanasiou, K., Syrigos, K., Kyriakoulis, K., Trontzas, I., Arfara-Melanini, M., Kolonis, V., Kityo, Cissy, Mugerwa, Henry, Kiweewa, Francis, Kimuli, Ivan, Lukaakome, Joseph, Nsereko, Christoher, Lubega, Gloria, Kibirige, Moses, Nakahima, William, Wangi, Deus, Aguti, Evelyne, Generous, Lilian, Massa, Rosemary, Nalaki, Margaret, Magala, Felix, Nabaggala, Phiona Kaweesi, Kidega, Robert, Faith, Oryem Daizy, Florence, Apio, Emmanuel, Ocung, Beacham, Mugoonyi Paul, Geoffrey, Amone, Nakiboneka, Dridah, Apiyo, Paska, Kirenga, Bruce, Atukunda, Angella, Muttamba, Winters, Remmy, Kyeyume, Segawa, Ivan, Pheona, Nsubuga, Kigere, David, Mbabazi, Queen Lailah, Boersalino, Ledra, Nyakoolo, Grace, Fred, Aniongo, Alupo, Alice, Ebong, Doryn, Monday, Edson, Nalubwama, Ritah Norah, Kainja, Milton, Ambrose, Munu, Kwehayo, Vanon, Nalubega, Mary Grace, Ongoli, Augustine, Obbo, Stephen, Sebudde, Nicholus, Alaba, Jeniffer, Magombe, Geoffrey, Tino, Harriet, Obonya, Emmanuel, Lutaakome, Joseph, Kitonsa, Jonathan, Onyango, Martin, Naboth, Tukamwesiga, Naluyinda, Hadijah, Nanyunja, Regina, Irene, Muttiibwa, Jane, Biira, Wimfred, Kyobejja, Leonard, Ssemazzi, Deus, Tkiinomuhisha, Babra, Namasaba, Taire, Paul, Nabankema, Evelyn, Ogavu, Joseph, Mugerwa, Oscar, Okoth, Ivan, Mwebaze, Raymond, Mugabi, Timothy, Makhoba, Anthony, Arikiriza, Phiona, Theresa, Nabuuma, Nakayima, Hope, Frank, Kisuule, Ramgi, Patrícia, Pereira, Kássia, Osinusi, Anu, Cao, Huyen, Klekotka, Paul, Price, Karen, Nirula, Ajay, Osei, Suzette, Tipple, Craig, Wills, Angela, Peppercorn, Amanda, Watson, Helen, Gupta, Rajesh, Alexander, Elizabeth, Mogalian, Erik, Lin, Leo, Ding, Xiao, Margolis, David, Yan, Li, Girardet, Jean-Luc, Ma, Ji, Hong, Zhi, Zhu, Quing, Seegobin, Seth, Gibbs, Michael, Latchman, Mickel, Hasior, Katarzyna, Bouquet, Jerome, Wei, Jianxin, Streicher, Katie, Schmelzer, Albert, Brooks, Dennis, Butcher, Jonny, Tonev, Dimitar, Arbetter, Douglas, Damstetter, Philippe, Legenne, Philippe, Stumpp, Michael, Goncalves, Susana, Ramanathan, Krishnan, Chandra, Richa, Baseler, Beth, Teitelbaum, Marc, Schechner, Adam, Holley, H. Preston, Jankelevich, Shirley, Becker, Nancy, Dolney, Suzanne, Hissey, Debbie, Simpson, Shelly, Kim, Mi Ha, Beeler, Joy, Harmon, Liam, Asomah, Mabel, Jato, Yvonne, Stottlemyer, April, Tang, Olivia, Vanderpuye, Sharon, Yeon, Lindsey, Buehn, Molly, Eccard-Koons, Vanessa, Frary, Sadie, MacDonald, Leah, Cash, Jennifer, Hoopengardner, Lisa, Linton, Jessica, Schaffhauser, Marylu, Nelson, Michaela, Spinelli-Nadzam, Mary, Proffitt, Calvin, Lee, Christopher, Engel, Theresa, Fontaine, Laura, Osborne, C.K., Hohn, Matt, Galcik, Michael, Thompson, DeeDee, Kopka, Stacey, Shelley, Denise M., Mendez, Gregg, Brown, Shawn, Albert, Sara, Balde, Abby, Baracz, Michelle, Bielica, Mona, Billouin-Frazier, Shere, Choudary, Jay, Dixon, Mary, Eyler, Carolyn, Frye, Leanne, Gertz, Jensen, Giebeig, Lisa, Gulati, Neelam, Hankinson, Liz, Hogarty, Debi, Huber, Lynda, Krauss, Gary, Lake, Eileen, Manandhar, Meryan, Rudzinski, Erin, Sandrus, Jen, Suders, Connie, Natarajan, Ven, Rupert, Adam W., Baseler, Michael, Lynam, Danielle, Imamichi, Tom, Laverdure, Sylvain, McCormack, Ashley, Paudel, Sharada, Cook, Kyndal, Haupt, Kendra, Khan, Ayub, Hazen, Allison, Badralmaa, Yunden, Smith, Kenneth, Patel, Bhakti, Kubernac, Amanda, Kubernac, Robert, Hoover, Marie L., Solomon, Courtney, Rashid, Marium, Murphy, Joseph, Brown, Craig, DuChateau, Nadine, Ellis, Sadie, Flosi, Adam, Fox, Lisa, Johnson, Les, Nelson, Rich, Stojanovic, Jelena, Treagus, Amy, Wenner, Christine, Williams, Richard, Jensen, Tomas O, Murray, Thomas A, Grandits, Greg A, Jain, Mamta K, Shaw-Saliba, Kathryn, Matthay, Michael A, Baker, Jason V, Dewar, Robin L, Goodman, Anna L, Hatlen, Timothy J, Highbarger, Helene C, Lallemand, Perrine, Leshnower, Bradley G, Looney, David, Moschopoulos, Charalampos D, Murray, Daniel D, Mylonakis, Eleftherios, Rehman, M Tauseef, Rupert, Adam, Stevens, Randy, Turville, Stuart, Wick, Katherine, Lundgren, Jens, Ko, Emily R

Source: In The Lancet Microbe June 2024 5(6):e559-e569

A Comparison of Recruitment Methods for a Remote, Nationwide Clinical Trial for COVID-19 Treatment.

Authors: Hartman, Katrina M, Patel, Barkha, Rao, Via, Hagen, Aubrey A, Saveraid, Hanna G, Fricton, Regina, Lee, Samuel, Snyder, Andrew T, Pullen, Matthew F, Boulware, David R, Liebovitz, David M, Belani, Hrishikesh K, Niklas, Jacinda M, Murray, Thomas A, Cohen, Ken, Thompson, Jennifer L, Erickson, Spencer M, Bramante, Carolyn T

Source: Open Forum Infectious Diseases; Jul2024, Vol. 11 Issue 7, p1-5, 5p

Subject Terms: CLINICAL trial registries, COVID-19 treatment, ELECTRONIC health records, NATIONAL competency-based educational tests, SEARCH engines

The STOP COVID 2 Study: Fluvoxamine vs Placebo for Outpatients With Symptomatic COVID-19, a Fully Remote Randomized Controlled Trial.

Authors: Reiersen, Angela M, Mattar, Caline, Ignacio, Rachel A Bender, Boulware, David R, Lee, Todd C, Hess, Rachel, Lankowski, Alexander J, McDonald, Emily G, Miller, J Philip, Powderly, William G, Pullen, Matthew F, Rado, Jeffrey T, Rich, Michael W, Schiffer, Joshua T, Schweiger, Julie, Spivak, Adam M, Stevens, Angela, Vigod, Simone N, Agarwal, Payal, Yang, Lei

Source: Open Forum Infectious Diseases; Aug2023, Vol. 10 Issue 8, p1-9, 9p

Subject Terms: SARS-CoV-2, RANDOMIZED controlled trials, CLINICAL trial registries, COVID-19, CLINICAL deterioration

Geographic Terms: CANADA

Patient-facing job role is associated with SARS-CoV-2 positivity among healthcare workers in long term care facilities in Minnesota, August–December, 2020

Authors: Bakare, R. Adetunji, Mulcahy, John F., Pullen, Matthew F., Demmer, Ryan T., Cox, Sara L., Thurn, Julie A., Galdys, Alison L.

Source: Infection Control & Hospital Epidemiology; September 2023, Vol. 44 Issue: 9 p1467-1471, 5p

The Geographic Distribution of Dimorphic Mycoses in the United States for the Modern Era.

Authors: Mazi, Patrick B, Sahrmann, John M, Olsen, Margaret A, Coler-Reilly, Ariella, Rauseo, Adriana M, Pullen, Matthew, Zuniga-Moya, Julio C, Powderly, William G, Spec, Andrej

Source: Clinical Infectious Diseases; Apr2023, Vol. 76 Issue 7, p1295-1301, 7p

Subject Terms: COCCIDIOIDOMYCOSIS, RETROSPECTIVE studies, MYCOSES, DESCRIPTIVE statistics, BLASTOMYCOSIS, RESEARCH funding, DATA analysis software, HISTOPLASMOSIS

Geographic Terms: UNITED States

Blastomycosis—Some Progress but Still Much to Learn.

Authors: Pullen, Matthew F.¹ (AUTHOR), Alpern, Jonathan D.^2,3 (AUTHOR), Bahr, Nathan C.⁴ (AUTHOR) nbahr@kumc.edu

Source: Journal of Fungi. Aug2022, Vol. 8 Issue 8, p824-824. 16p.

Subject Terms: *BLASTOMYCOSIS, *THERAPEUTICS, *MYCOSES, *SYMPTOMS, *CENTRAL nervous system

Cerebrospinal Fluid Bacillary Load by Xpert MTB/RIF Ultra Polymerase Chain Reaction Cycle Threshold Value Predicts 2-Week Mortality in Human Immunodeficiency Virus–Associated Tuberculous Meningitis.

Authors: Martyn, Emily M, Bangdiwala, Ananta S, Kagimu, Enock, Rutakingirwa, Morris K, Kasibante, John, Okirwoth, Michael, Stead, Gavin, Wadda, Vincent, Pullen, Matthew F, Bold, Tyler D, Meya, David B, Boulware, David R, Bahr, Nathan C, Cresswell, Fiona V

Source: Clinical Infectious Diseases; 11/1/2021, Vol. 73 Issue 9, pe3505-e3510, 6p

Subject Terms: HIV infection complications, MYCOBACTERIUM, PREDICTIVE tests, MOLECULAR diagnosis, VIRAL load, LACTATES, CEREBROSPINAL fluid, POLYMERASE chain reaction, LONGITUDINAL method

Feasibility of SARS-CoV-2 Antibody Testing in Remote Outpatient Trials.

Authors: Lofgren, Sarah M, Okafor, Elizabeth C, Colette, Alanna A, Pastick, Katelyn A, Skipper, Caleb P, Pullen, Matthew F, Nicol, Melanie R, Bold, Tyler D, Bangdiwala, Ananta S, Engen, Nicole W, Collins, Lindsey B, Williams, Darlisha A, Axelrod, Margaret L, Thielen, Beth K, Hullsiek, Kathy H, Boulware, David R, Rajasingham, Radha

Source: Open Forum Infectious Diseases; Nov2021, Vol. 8 Issue 11, p1-7, 7p

Subject Terms: ANTIBODY titer, COVID-19, COVID-19 testing, OUTPATIENTS, ENZYME-linked immunosorbent assay

Company/Entity: CENTERS for Disease Control & Prevention (U.S.)

Hydroxychloroquine as Pre-exposure Prophylaxis for Coronavirus Disease 2019 (COVID-19) in Healthcare Workers: A Randomized Trial.

Authors: Rajasingham, Radha, Bangdiwala, Ananta S, Nicol, Melanie R, Skipper, Caleb P, Pastick, Katelyn A, Axelrod, Margaret L, Pullen, Matthew F, Nascene, Alanna A, Williams, Darlisha A, Engen, Nicole W, Okafor, Elizabeth C, Rini, Brian I, Mayer, Ingrid A, McDonald, Emily G, Lee, Todd C, Li, Peter, MacKenzie, Lauren J, Balko, Justin M, Dunlop, Stephen J, Hullsiek, Katherine H

Source: Clinical Infectious Diseases; 6/1/2021, Vol. 72 Issue 11, pe835-e843, 9p

Subject Terms: INTENSIVE care units, COVID-19, HOSPITAL emergency services, CONFIDENCE intervals, TREATMENT effectiveness, RANDOMIZED controlled trials, BLIND experiment, HYDROXYCHLOROQUINE, PREVENTIVE medicine

Geographic Terms: UNITED States, CANADA

Lessons Learned From Conducting Internet-Based Randomized Clinical Trials During a Global Pandemic.

Authors: Pullen, Matthew F¹ (AUTHOR) pullen@umn.edu, Pastick, Katelyn A¹ (AUTHOR), Williams, Darlisha A¹ (AUTHOR), Nascene, Alanna A¹ (AUTHOR), Bangdiwala, Ananta S² (AUTHOR), Okafor, Elizabeth C¹ (AUTHOR), Hullsiek, Katherine Huppler² (AUTHOR), Skipper, Caleb P¹ (AUTHOR), Lofgren, Sarah M¹ (AUTHOR), Engen, Nicole² (AUTHOR), Abassi, Mahsa¹ (AUTHOR), McDonald, Emily G³ (AUTHOR), Lee, Todd C³ (AUTHOR), Rajasingham, Radha¹ (AUTHOR), Boulware, David R^1,2 (AUTHOR)

Source: Open Forum Infectious Diseases. Feb2021, Vol. 8 Issue 2, p1-9. 9p.

Subject Terms: *CLINICAL trials, *COVID-19 pandemic, *PANDEMICS, *EXPERIMENTAL design, *DISEASE prevalence, *HEALTH care reminder systems

Safety of Hydroxychloroquine Among Outpatient Clinical Trial Participants for COVID-19.

Authors: Lofgren, Sarah M, Nicol, Melanie R, Bangdiwala, Ananta S, Pastick, Katelyn A, Okafor, Elizabeth C, Skipper, Caleb P, Pullen, Matthew F, Engen, Nicole W, Abassi, Mahsa, Williams, Darlisha A, Nascene, Alanna A, Axelrod, Margaret L, Lother, Sylvain A, MacKenzie, Lauren J, Drobot, Glen, Marten, Nicole, Cheng, Matthew P, Zarychanski, Ryan, Schwartz, Ilan S, Silverman, Michael

Source: Open Forum Infectious Diseases; Nov2020, Vol. 7 Issue 11, p1-7, 7p

Subject Terms: DRUG side effects, COVID-19, HYDROXYCHLOROQUINE, COVID-19 treatment, ATRIAL arrhythmias, CLINICAL trials

Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19 : A Randomized Trial.

Authors: Skipper, Caleb P., Pastick, Katelyn A., Engen, Nicole W., Bangdiwala, Ananta S., Abassi, Mahsa, Lofgren, Sarah M., Williams, Darlisha A., Okafor, Elizabeth C., Pullen, Matthew F., Nicol, Melanie R., Nascene, Alanna A., Hullsiek, Kathy H., Cheng, Matthew P., Luke, Darlette, Lother, Sylvain A., MacKenzie, Lauren J., Drobot, Glen, Kelly, Lauren E., Schwartz, Ilan S., Zarychanski, Ryan

Source: Annals of Internal Medicine; 10/20/2020, Vol. 173 Issue 8, p623-631, 9p, 2 Diagrams, 1 Chart, 3 Graphs

Subject Terms: VIRAL pneumonia, RESEARCH, COVID-19, TIME, RESEARCH methodology, RETROSPECTIVE studies, EVALUATION research, MEDICAL cooperation, COMPARATIVE studies, RANDOMIZED controlled trials, EPIDEMICS, BLIND experiment, RESEARCH funding, HYDROXYCHLOROQUINE, ANTIMALARIALS, LONGITUDINAL method

Cerebrospinal Fluid Early Fungicidal Activity as a Surrogate Endpoint for Cryptococcal Meningitis Survival in Clinical Trials.

Authors: Pullen, Matthew F¹ pullen@umn.edu, Hullsiek, Katherine Huppler¹, Rhein, Joshua^1,2, Musubire, Abdu K², Tugume, Lillian², Nuwagira, Edwin³, Abassi, Mahsa¹, Ssebambulidde, Kenneth², Mpoza, Edward², Kiggundu, Ruben², Akampurira, Andrew², Nabeta, Henry W², Schutz, Charlotte⁴, Evans, Emily E³, Rajasingham, Radha¹, Skipper, Caleb P¹, Pastick, Katelyn A¹, Williams, Darlisha A^1,2, Morawski, Bozena M¹, Bangdiwala, Ananta S¹

Source: Clinical Infectious Diseases. Oct2020, Vol. 71 Issue 7, pe45-e49. 5p.

Subject Terms: *CEREBROSPINAL fluid examination, *AMPHOTERICIN B, *ANTIFUNGAL agents, *CLINICAL trials, *CRYPTOCOCCUS neoformans, *CULTURES (Biology), *FUNGI, *MENINGITIS, *REGRESSION analysis, *SURVIVAL, *SECONDARY analysis, *PROPORTIONAL hazards models, *DESCRIPTIVE statistics, *FLUCONAZOLE, *COLONY-forming units assay, *PHARMACODYNAMICS

Post-exposure prophylaxis or pre-emptive therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): study protocol for a pragmatic randomized-controlled trial.

Alternate Title: Prophylaxie post-exposition ou traitement préventif pour le syndrome respiratoire aigu sévère du coronavirus 2 (SARS-CoV-2) : protocole d'étude pour une étude randomisée contrôlée pragmatique. (French)

Authors: Lother, Sylvain A., Abassi, Mahsa, Agostinis, Alyssa, Bangdiwala, Ananta S., Cheng, Matthew P., Drobot, Glen, Engen, Nicole, Hullsiek, Kathy H., Kelly, Lauren E., Lee, Todd C., Lofgren, Sarah M., MacKenzie, Lauren J., Marten, Nicole, McDonald, Emily G., Okafor, Elizabeth C., Pastick, Katelyn A., Pullen, Matthew F., Rajasingham, Radha, Schwartz, Ilan, Skipper, Caleb P.

Source: Canadian Journal of Anaesthesia / Journal Canadien d'Anesthésie; Sep2020, Vol. 67 Issue 9, p1201-1211, 11p

Symptoms of COVID-19 Outpatients in the United States.

Authors: Pullen, Matthew F¹ (AUTHOR) pullen@umn.edu, Skipper, Caleb P¹ (AUTHOR), Hullsiek, Kathy H² (AUTHOR), Bangdiwala, Ananta S² (AUTHOR), Pastick, Katelyn A¹ (AUTHOR), Okafor, Elizabeth C¹ (AUTHOR), Lofgren, Sarah M¹ (AUTHOR), Rajasingham, Radha¹ (AUTHOR), Engen, Nicole W² (AUTHOR), Galdys, Alison¹ (AUTHOR), Williams, Darlisha A¹ (AUTHOR), Abassi, Mahsa¹ (AUTHOR), Boulware, David R^1,2 (AUTHOR)

Source: Open Forum Infectious Diseases. Jul2020, Vol. 7 Issue 7, p1-4. 4p.

Subject Terms: *SYMPTOMS, *COVID-19, *SARS-CoV-2, *CLINICAL trials, *OUTPATIENTS

Geographic Terms: UNITED States

A 66-Year-Old Man With Progressive Chest Pain, Dyspnea, and Incomplete Paraplegia of the Lower Extremities.

Authors: Babcock, Corey P¹ babco095@umn.edu, Pullen, Matthew F², Manivel, Juan C³, Yamanaka, Bradley M⁴, Kaka, Anjum⁵

Source: Clinical Infectious Diseases. 6/15/2020, Vol. 70 Issue 12, p2743-2746. 4p.

Subject Terms: *ACTINOMYCOSIS, *CHEST diseases, *CHEST pain, *COMPUTED tomography, *DYSPNEA, *PARAPLEGIA

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Tuberculosis at the animal-human interface in the Ugandan cattle corridor using a third-generation sequencing platform: a cross-sectional analysis study.

Authors: Pullen, Matthew Flinn, Boulware, David R., Sreevatsan, Srinand, Bazira, Joel

Source: BMJ Open; Apr2019, Vol. 9 Issue 4, p1-7, 7p

Increased Foxo3a Nuclear Translocation and Activity is an Early Neuronal Response to βγ-Secretase-Mediated Processing of the Amyloid-β Protein Precursor: Utility of an AβPP-GAL4 Reporter Assay.

Authors: Law, Bernard M., Guest, Amy L., Pullen, Matthew W. J., Perkinton, Michael S., Williams, Robert J.

Source: Journal of Alzheimer's Disease; 2018, Vol. 61 Issue 2, p673-688, 16p

Subject Terms: ALZHEIMER'S disease, SECRETASES, AMYLOID, INTERFERON gamma release tests, INTRACELLULAR membranes, ANIMAL experimentation, BIOLOGICAL models, BIOLOGICAL transport, CELLULAR signal transduction, COMPARATIVE studies, RESEARCH methodology, MEDICAL cooperation, MICE, GENETIC mutation, NEURONS, PHOSPHORYLATION, PROTEIN precursors, PROTEOLYTIC enzymes, RESEARCH, EVALUATION research