Design, synthesis, molecular docking and anticancer activity evaluation of methyl salicylate based thiazoles as PTP1B inhibitors

Authors: Dominika Kołodziej-Sobczak, Łukasz Sobczak, Wojciech Płaziński, Adrianna Sławińska-Brych, Magdalena Mizerska-Kowalska, Klaudia Hołub, Barbara Zdzisińska, Karol Jaroch, Barbara Bojko, Krzysztof Z. Łączkowski

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-15 (2025)

Subject Terms: Protein tyrosine phosphatase 1B, Enzyme inhibitor, Molecular docking, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/83fcfcae773f4cb38461c3e4ce0e6d2a

QSAR Model for Prediction PTP1B Inhibitor as Anti-diabetes Mellitus using Simulated Annealing-Support Vector Machine

Authors: Fadhlurrahman, Hanif, Khoirunnisa, Azka, Kurniawan, Isman

Source: 2022 International Conference on Data Science and Its Applications (ICoDSA) Data Science and Its Applications (ICoDSA), 2022 International Conference on. :109-113 Jul, 2022

Relation: 2022 International Conference on Data Science and Its Applications (ICoDSA)

New natural protein tyrosine phosphatase 1B inhibitors from Gynostemma pentaphyllum

Authors: Xianting Wang, Yidan Deng, Jianmei Wang, Lin Qin, Yimei Du, Qianru Zhang, Di Wu, Xingdong Wu, Jian Xie, Yuqi He, Daopeng Tan

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)

Subject Terms: Gynostemma pentaphyllum, protein tyrosine phosphatase 1B, α-glucosidase, α-amylase, phytochemistry, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/90a9861ff1dc48adbf2f64a8634f4947

Recent progress in chemistry and bioactivity of novel enzyme inhibitors from natural products: A comprehensive review

Authors: Pan, Chengqian ^{a, b}, Kakeya, Hideaki ^{b, ⁎}

Source: In European Journal of Medicinal Chemistry 5 May 2025 289

The Role of Natural Products on Diabetes Mellitus Treatment

Contributors: Aragon Novoa, Diana Marcela, Silva, Fátima Regina Mena Barreto

Subject Terms: narirutin, naringenin rutinoside, isonaringin, molecular docking, mechanism of action, enzyme, receptors, diabetes mellitus, neurotoxicity, curcumin nanoparticle, zinc oxide nanoparticle, metformin, inflammation, oxidative stress, apoptosis, acarbose, combination approach, Ecklonia radiata, fucoidan, type 2 diabetes management, Lavandula pedunculata (Mill.) Cav., Punica granatum L., Trigonella foenum-graecum L., diabetes, glucose intestinal absorption, oral glucose tolerance test, pregnancy, type 1 diabetes mellitus, beta-cell, insulin, C-peptide, hypoglycemia, n-3 PUFA, placenta, fetus, oleuropein, Mediterranean diet, metabolic syndrome, silymarin, combination therapy, liver steatosis, pre-diabetes, advanced glycation end products, polydatin, salivary gland, type 2, biological products, plants, antioxidants, therapeutics, natural products, phenols, ageing, diabetic cardiomyopathy, mitochondrial longevity, electron transport chain, BGP-15, nicotinic acid, NAD precursor, bioactive molecule, NA/STZ-induced diabetes mellitus, Balanitis aegyptiaca, fruit, seed, aqueous extracts, edible mushroom, insulin resistance, polysaccharide, vitamin D, α-glucosidase, α-amylase, Artemisia absinthium, antioxidant activity, phenolic compounds, hyperglycemia, pancreatic α-amylase, intestinal α-glucosidase, rosinidin, streptozotocin, lipid profile, proinflammatory cytokine, CXCL16, ADAM10, NF-κβ, pancreatic islets, resveratrol, T1D, sweeteners, D-Pinitol, carob fruit, pituitary hormones, type 2 diabetes, Chinese herbal medicine, YH1, gut microbiota, bile acids, elderberry, yarrow, cornelian cherry, bilberry, wild strawberry, rosehip, raspberry, blackberry, stinging nettle, Trigonella foenum-graecum, fenugreek, prediabetes, fasting blood glucose, post-prandial glucose, flavonoid, rutin, antioxidant, lipidosis, flavonoids, polyphenols, patent, marine natural products, Dysidea avara, sesquiterpene-type quinones, avarone, aldose reductase, protein tyrosine phosphatase 1B, dual target inhibitors, Orthosiphon stamineus, GLUT4, anti-oxidant, phytochemicals, Medicine and Nursing

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/137520
https://mdpi.com/books/pdfview/book/8680

Protein tyrosine phosphatase 1B in metabolic and cardiovascular diseases: from mechanisms to therapeutics

Authors: Yan Sun, Frank A. Dinenno, Peiyang Tang, Maria I. Kontaridis

Source: Frontiers in Cardiovascular Medicine, Vol 11 (2024)

Subject Terms: protein tyrosine phosphatase 1B (PTP1B), cardiovascular disease, insulin resistance, diabetes, obesity, therapeutics, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2024.1445739/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/6488faaef51e4ae78ef5e8a7180eed7d

Theoretical study on the design of allosteric inhibitors of diabetes associated protein PTP1B

Authors: Jiuyu Zhan, Zhenyang Liu, Hongwei Gao

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: protein tyrosine phosphatase 1B, inhibitor, MD simulations, rational design, LUDI, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1423029/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/d2f46cf4c1064482b593c54ae6ebdf24

In silico Analysis of Selected Four-Leaf Water Clover (Marsilea species) Constituents as Human Acetyl Cholinesterase (hAchE), Carbonic Anhydrase II (hCA-II), and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Agents

Authors: Rithanyaa Ramesh, Radhakrishnan Narayanaswamy

Source: Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss 6, Pp 1237-1241 (2024)

Subject Terms: docking, four-leaf water clover, good health and well-being, human acetylcholinesterase (hache), human carbonic anhydrase ii (hca-ii), human protein tyrosine phosphatase 1b (hptp-1b), marsilea species, Pharmacy and materia medica, RS1-441, Analytical chemistry, QD71-142

File Description: electronic resource

Relation: https://journals.lww.com/10.4103/jpbs.jpbs_549_23; https://doaj.org/toc/0976-4879; https://doaj.org/toc/0975-7406

Access URL: https://doaj.org/article/9a153863914847eb9ded1e4d1c8f5019

Pachymic acid exerts antitumor activities by modulating the Wnt/β-catenin signaling pathway via targeting PTP1B

Authors: Zhang Hao, Zhu Kun, Zhang Xue-Feng, Ding Yi-Hui, Zhu Bing, Meng Wen, Ding Qing-Song, Zhang Fan

Source: Asian Pacific Journal of Tropical Biomedicine, Vol 14, Iss 4, Pp 170-180 (2024)

Subject Terms: pachymic acid, lung adenocarcinoma, protein tyrosine phosphatase 1b, wnt/β-catenin signaling pathway, metastasis, angiogenesis, autophagy, Arctic medicine. Tropical medicine, RC955-962, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.lww.com/10.4103/apjtb.apjtb_857_23; https://doaj.org/toc/2221-1691; https://doaj.org/toc/2588-9222

Access URL: https://doaj.org/article/379b80a561ad4eb39c0ab3b9ba6bee1b

Functional Significance and Structure-Activity Relationship of Food-Derived Protein Tyrosine Phosphatase 1B Inhibitors

Authors: BAO Meili, WANG Zhenyu

Source: Shipin Kexue, Vol 44, Iss 17, Pp 258-277 (2023)

Subject Terms: food-derived, natural compounds, type 2 diabetes, protein tyrosine phosphatase 1b inhibitor, Food processing and manufacture, TP368-456

File Description: electronic resource

Relation: https://www.spkx.net.cn/fileup/1002-6630/PDF/2023-44-17-030.pdf; https://doaj.org/toc/1002-6630

Access URL: https://doaj.org/article/1e81d0c315a3427e8fc18e7f90997098

Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte

Authors: Hsu, Ming-Fo ^{a, 1}, Ito, Yoshihiro ^{a, 1, 2}, Singh, Jai Prakash ^b, Hsu, Shu-Fang ^b, Wells, Alan ^c, Jen, Kuang-Yu ^d, Meng, Tzu-Ching ^b, Haj, Fawaz G. ^{a, e, f, ⁎}

Source: In BBA - Molecular Cell Research January 2024 1871(1)

In silico extension on the antidiabetic potential of Euonymus laxiflorus natural compounds onto the inhibitability against protein tyrosine phosphatase 1B

Authors: Thanh Q. Bui, Vinh Phu Nguyen, Thi Thanh Hai Nguyen, Tu Quy Phan, Nguyen Thi Ai Nhung

Source: Tạp chí Khoa học Đại học Huế: Khoa học Tự nhiên, Vol 132, Iss 1D (2023)

Subject Terms: antidiabetics, Euonymus laxiflorus, in silico, protein tyrosine phosphatase 1B, Science, Science (General), Q1-390

File Description: electronic resource

Relation: https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/7237; https://doaj.org/toc/1859-1388; https://doaj.org/toc/2615-9678

Access URL: https://doaj.org/article/58f0703290d148d19a0e9d4006a4bdb8

New dammarane-type triterpenoids from hydrolyzate of total Gynostemma pentaphyllum saponins with protein tyrosine phosphatase 1B inhibitory activity

Authors: Daopeng Tan, Jianmei Wang, Xianting Wang, Lin Qin, Yimei Du, Changkuo Zhao, Peijun Liu, Qianru Zhang, Feifei Ma, Jian Xie, Di Wu, Yuqi He

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Subject Terms: Gynostemma pentaphyllum, dammarane triterpenoids, protein tyrosine phosphatase 1B, phytochemistry, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/d3f54107b425428d9482f32c6a87ecf8

Ameliorative effect of black raspberry anthocyanins on diabetes retinopathy by inhibiting axis protein tyrosine phosphatase 1B-endoplasmic reticulum stress

Authors: Ting Xiao, Yuan Zhi, Fangfang Tian, Feilong Huang, Xingyan Cheng, Ai Wu, Ling Tao, Zhenghong Guo, Xiangchun Shen

Source: Journal of Functional Foods, Vol 107, Iss , Pp 105696- (2023)

Subject Terms: Black raspberry, Anthocyanins, Endoplasmic reticulum stress, Protein tyrosine phosphatase 1B, Diabetes retinopathy, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1756464623002967; https://doaj.org/toc/1756-4646

Access URL: https://doaj.org/article/6cba104d912c46f4bea05f1e672608ad

Melanoxetin: A Hydroxylated Flavonoid Attenuates Oxidative Stress and Modulates Insulin Resistance and Glycation Pathways in an Animal Model of Type 2 Diabetes Mellitus

Authors: Sónia Rocha, Andreia Amaro, Marcos D. Ferreira-Junior, Carina Proença, Artur M. S. Silva, Vera M. Costa, Sara Oliveira, Diogo A. Fonseca, Sónia Silva, Maria Luísa Corvo, Marisa Freitas, Paulo Matafome, Eduarda Fernandes

Source: Pharmaceutics, Vol 16, Iss 2, p 261 (2024)

Subject Terms: flavonoid, type 2 diabetes, oxidative stress, advanced glycation end products, prostaglandin E2, protein tyrosine phosphatase 1B, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/2/261; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/762fab5305bf416b80d0a1d509abf7ba

Crude extract and isolated bioactive compounds from Notholirion thomsonianum (Royale) Stapf as multitargets antidiabetic agents: in-vitro and molecular docking approaches

Authors: Mater H. Mahnashi, Yahya S. Alqahtani, Ali O. Alqarni, Bandar A. Alyami, Muhammad Saeed Jan, Muhammad Ayaz, Farhat Ullah, Umer Rashid, Abdul Sadiq

Source: BMC Complementary Medicine and Therapies, Vol 21, Iss 1, Pp 1-13 (2021)

Subject Terms: Notholirion thomsonianum, Bioactive compounds, α-Glucosidase, α-Amylase, Protein tyrosine phosphatase 1B (PTP1B), Antioxidant, Other systems of medicine, RZ201-999

File Description: electronic resource

Relation: https://doaj.org/toc/2662-7671

Access URL: https://doaj.org/article/3874b7a91dc946f5aba4e25e2b88fc67

Effects of sleeve gastrectomy on bone mass, microstructure of femurs and bone metabolism associated serum factors in obese rats

Authors: Ying Xue, Ran Li, Yong Zhao, Ling Li, Yun Zhou

Source: BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-14 (2021)

Subject Terms: Sleeve gastrectomy (SG), Bone metabolism, Adipokines, Protein tyrosine phosphatase 1B (PTP1B), Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://doaj.org/toc/1472-6823

Access URL: https://doaj.org/article/9a256a73b45e41e2b1eafd475e10e024

Association of protein tyrosine phosphatase 1B gene polymorphism with the effects of weight reduction therapy on bodyweight and glycolipid profiles in obese patients

Authors: Hajime Yamakage, Yousuke Konishi, Kazuya Muranaka, Kikuko Hotta, Yoshihiro Miyamoto, Hiroko Morisaki, Takayuki Morisaki, Noriko Satoh‐Asahara

Source: Journal of Diabetes Investigation, Vol 12, Iss 8, Pp 1462-1470 (2021)

Subject Terms: Obesity, Protein tyrosine phosphatase 1B, Weight reduction therapy, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://doaj.org/toc/2040-1116; https://doaj.org/toc/2040-1124

Access URL: https://doaj.org/article/3ac3560632e64164bdc41c46f81b08e8

The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response

Authors: Shinrye Lee, Seyeon Kim, Ha-Young Kang, Hye Ryeong Lim, Younghwi Kwon, Myungjin Jo, Yu-Mi Jeon, Sang Ryong Kim, Kiyoung Kim, Chang Man Ha, Seongsoo Lee, Hyung-Jun Kim

Source: Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-22 (2020)

Subject Terms: Neurodegenerative disease, Neuroinflammation, Astrocytes, Tar DNA-binding protein 43, Protein tyrosine phosphatase 1B, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-020-01963-6; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/c7b701015c05417c8041f989cf386104

Role of Protein Tyrosine Phosphatase 1B Inhibitor in Early Brain Injury of Subarachnoid Hemorrhage in Mice

Authors: Zhong-Hua Zhang, Xiao-Ming Zhou, Xin Zhang

Source: Brain Sciences, Vol 13, Iss 5, p 816 (2023)

Subject Terms: protein tyrosine phosphatase 1B, subarachnoid hemorrhage, early brain injury, apoptosis, inflammation factors, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3425/13/5/816; https://doaj.org/toc/2076-3425

Access URL: https://doaj.org/article/35df17d4c004487f98cecb97cbc13565