Epimaps of the SARS-CoV-2 Receptor-Binding Domain Mutational Landscape: Insights into Protein Stability, Epitope Prediction, and Antibody Binding.

Authors: Pitsillou, Eleni^1,2 (AUTHOR), El-Osta, Assam^{3,4,5,6,7,8,9} (AUTHOR), Hung, Andrew² (AUTHOR), Karagiannis, Tom C.^1,3,4,10 (AUTHOR) karat@unimelb.edu.au

Source: Biomolecules (2218-273X). Feb2025, Vol. 15 Issue 2, p301. 23p.

Subject Terms: *SARS-CoV-2, *PROTEIN stability, *SARS-CoV-2 Omicron variant, *VACCINE effectiveness, *IMMUNOTECHNOLOGY

Phi-Value and NMR Structural Analysis of a Coupled Native-State Prolyl Isomerization and Conformational Protein Folding Process.

Authors: Weininger, Ulrich¹ (AUTHOR) ulrich.weininger@physik.uni-halle.de, von Delbrück, Maximilian² (AUTHOR) delbrueck@knauer.net, Schmid, Franz X.² (AUTHOR) fx.schmid@uni-bayreuth.de, Jakob, Roman P.³ (AUTHOR) roman.jakob@unibas.ch

Source: Biomolecules (2218-273X). Feb2025, Vol. 15 Issue 2, p259. 16p.

Subject Terms: *PROTEIN folding, *PROTEIN stability, *NUCLEAR magnetic resonance spectroscopy, *ISOMERIZATION, *HYDROGEN bonding

Exploring Bovine Serum Albumin (BSA) as a Facile Substrate for Testing of Osmolytes as Cosmetic Ingredients.

Authors: Sinesi, Giulia¹ (AUTHOR), Salvioni, Lucia¹ (AUTHOR), Ronchi, Elisabetta² (AUTHOR), Barbuzzi, Elena Maria Gabriella² (AUTHOR), Prosperi, Davide^1,3 (AUTHOR), Colombo, Miriam^1,3 (AUTHOR) miriam.colombo@unimib.it, Giustra, Marco Davide^1,3 (AUTHOR) marco.giustra@unimib.it

Source: Molecules. Feb2025, Vol. 30 Issue 3, p664. 19p.

Subject Terms: *SKIN care products, *PROTEIN stability, *HAIR care products, *SERUM albumin, *PROTEIN folding

Impact of choline choride and sugar natural deep eutectic solvents on structure and functionality of treebean (Parkia timoriana) seed protein.

Authors: Chakravorty, Prostuti¹ (AUTHOR), Das, Amit Baran^1,2 (AUTHOR) amitbaran84@gmail.com

Source: Scientific Reports. 1/29/2025, Vol. 15 Issue 1, p1-10. 10p.

Subject Terms: *SEED proteins, *PROTEIN stability, *EUTECTIC structure, *PROTEIN structure, *PLANT proteins, *PSEUDOPLASTIC fluids

Investigating the functional and structural effect of non-synonymous single nucleotide polymorphisms in the cytotoxic T-lymphocyte antigen-4 gene: An in-silico study.

Authors: Kamal, Md. Mostafa¹ (AUTHOR), Shantanu, Kazi Fahmida Haque² (AUTHOR), Teeya, Shamiha Tabassum¹ (AUTHOR), Rahman, Md. Motiar³ (AUTHOR), Hasan, A. K. M. Munzurul⁴ (AUTHOR) munzurul.hasan@usask.ca, Chivers, Douglas P.⁴ (AUTHOR), Wani, Tanveer A.⁵ (AUTHOR), Alshammari, Atekah Hazzaa⁶ (AUTHOR), Rachamalla, Mahesh⁴ (AUTHOR), da Silva Junior, Francisco Carlos⁷ (AUTHOR), Hossen, Md. Munnaf⁸ (AUTHOR) munnafpstu@gmail.com

Source: PLoS ONE. 1/24/2025, Vol. 20 Issue 1, p1-20. 20p.

Subject Terms: *SINGLE nucleotide polymorphisms, *PROTEIN stability, *MUTANT proteins, *MISSENSE mutation, *AMINO acid sequence

The Y44 residue point mutation in CXCL14 reveals the significance of CXCL14 protein stability in anti-tumor activity.

Authors: Kamal, Shah¹ (AUTHOR), Ullah, Najeeb¹ (AUTHOR), Kong, Xianglin¹ (AUTHOR), Amanullah, Amanullah¹ (AUTHOR), Dai, Ao¹ (AUTHOR), Kamal, Mohammad Amjad^2,3,4,5,6 (AUTHOR), Deng, Cheng^1,7 (AUTHOR) dengcheng2014@126.com, Shanshan, Lai¹ (AUTHOR) lss7259@163.com

Source: Oncologie (De Gruyter). Jan2025, Vol. 27 Issue 1, p79-94. 16p.

Subject Terms: *PROTEIN stability, *HELA cells, *TERTIARY structure, *ANTINEOPLASTIC agents, *CELL migration

Fabrication and characterization of maltodextrin-microporous starch microcapsules including mackerel protein hydrolysates.

Authors: Ma, Jiawen¹ (AUTHOR), He, Luyao¹ (AUTHOR), Cai, Jinxiu² (AUTHOR), Zhang, Wu² (AUTHOR), Yang, Hua¹ (AUTHOR), Cao, Shaoqian¹ (AUTHOR) shaoqiancao@sina.com, Qi, Xiangyang¹ (AUTHOR) qixiangyang85@sina.com

Source: CyTA: Journal of Food. 2024, Vol. 22 Issue 1, p1-10. 10p.

Subject Terms: *PROTEIN hydrolysates, *PROTEIN stability, *MACKERELS, *SPRAY drying, *STARCH, *MALTODEXTRIN

Functional and pathogenic insights into CNNM4 variants in Jalili syndrome.

Authors: Rattanapornsompong, Khanti¹ (AUTHOR), Rinkrathok, Mawika¹ (AUTHOR), Sriwattanapong, Kanokwan^1,2 (AUTHOR), Shotelersuk, Vorasuk^3,4 (AUTHOR), Porntaveetus, Thantrira^1,5 (AUTHOR) thantrira.p@chula.ac.th

Source: Scientific Reports. 11/23/2024, Vol. 14 Issue 1, p1-11. 11p.

Subject Terms: *PROTEIN stability, *RETINAL degeneration, *AMELOGENESIS imperfecta, *MISSENSE mutation, *MUTANT proteins

DAPK enhances DDX20 protein stability via suppression of TRIM25-mediated ubiquitination-based DDX20 degradation.

Authors: Ye, Yan^1,2,3 (AUTHOR), Zhang, Xiuli^1,2 (AUTHOR), Wang, Chenyi⁴ (AUTHOR), Huang, Yide⁴ (AUTHOR), Xu, Luyun⁴ (AUTHOR), Liu, Hongxia⁴ (AUTHOR), Li, Ke⁴ (AUTHOR), Liu, Nannan⁵ (AUTHOR), Wang, Qingshui^1,2 (AUTHOR) wangqingshui@fjtcm.edu.cn, Zhang, Tao⁵ (AUTHOR) jamesl55@foxmail.com, Assaraf, Yehuda G.⁶ (AUTHOR) assaraf@technion.ac.il, Lin, Yao^1,2 (AUTHOR) yaolin@fjtcm.edu.cn

Source: Cancer Cell International. 11/18/2024, Vol. 24 Issue 1, p1-15. 15p.

Subject Terms: *PROTEIN stability, *CELL cycle proteins, *LIVER cancer, *HEPATOCELLULAR carcinoma, *CELL migration

Phase Separation of FUS with Poly(ADP-ribosyl)ated PARP1 Is Controlled by Polyamines, Divalent Metal Cations, and Poly(ADP-ribose) Structure.

Authors: Sukhanova, Maria V.¹ (AUTHOR) mary@niboch.nsc.ru, Anarbaev, Rashid O.¹ (AUTHOR) anarbaev@niboch.nsc.ru, Naumenko, Konstantin N.¹ (AUTHOR) k-naumenko@mail.ru, Hamon, Loic² (AUTHOR) loic.hamon@univ-evry.fr, Singatulina, Anastasia S.¹ (AUTHOR) nastsing@yandex.ru, Pastré, David² (AUTHOR) david.pastre@univ-evry.fr, Lavrik, Olga I.¹ (AUTHOR) david.pastre@univ-evry.fr

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p12445. 19p.

Subject Terms: *ATOMIC force microscopy, *PROTEIN stability, *FLUORESCENCE microscopy, *LIGHT scattering, *PHASE separation, *POLYAMINES

TPGPred: A Mixed-Feature-Driven Approach for Identifying Thermophilic Proteins Based on GradientBoosting.

Authors: Zhao, Cuihuan¹ (AUTHOR) zhaocuihuan@mail.tsinghua.edu.cn, Yan, Shuan² (AUTHOR), Li, Jiahang³ (AUTHOR) jiahangli@nankai.edu.cn

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p11866. 25p.

Subject Terms: *RECEIVER operating characteristic curves, *PROTEIN stability, *AMINO acid sequence, *BIOTECHNOLOGY, *INDUSTRIALIZATION

The impact of androgen-induced translation in modulating androgen receptor activity.

Authors: Israel, Justus S.¹ (AUTHOR), Marcelin, Laura-Maria¹ (AUTHOR), Mehralivand, Sherif¹ (AUTHOR), Scholze, Jana¹ (AUTHOR), Hofmann, Jörg¹ (AUTHOR), Stope, Matthias B.^2,3 (AUTHOR), Puhr, Martin⁴ (AUTHOR), Thomas, Christian^1,5 (AUTHOR) christian.thomas@uniklinikum-dresden.de, Erb, Holger H. H.^1,2,5,6 (AUTHOR) holger.erb@uniklinikum-dresden.de

Source: Biology Direct. 11/11/2024, Vol. 19 Issue 1, p1-17. 17p.

Subject Terms: *ANDROGEN deprivation therapy, *PROTEIN stability, *GENETIC translation, *GENETIC transcription, *CELLULAR signal transduction

Detectability of cytokine and chemokine using ELISA, following sample-inactivation using Triton X-100 or heat.

Authors: Labossiere, Erica Hofer¹ (AUTHOR), Gonzalez-Diaz, Sandra^1,2 (AUTHOR), Enns, Stephanie³ (AUTHOR), Lopez, Paul¹ (AUTHOR), Yang, Xuefen¹ (AUTHOR), Kidane, Biniam^3,4,5 (AUTHOR), Vazquez-Grande, Gloria⁶ (AUTHOR), Siddik, Abu Bakar^1,2 (AUTHOR), Kung, Sam Kam-Pun⁷ (AUTHOR), Sandstrom, Paul^1,2 (AUTHOR), Ravandi, Amir⁸ (AUTHOR), Ball, T. Blake^1,2 (AUTHOR), Su, Ruey-Chyi^1,2 (AUTHOR) ruey.c.su@phac-aspc.gc.ca

Source: Scientific Reports. 11/5/2024, Vol. 14 Issue 1, p1-11. 11p.

Subject Terms: *TRITON X-100, *PROTEIN stability, *LUNGS, *CYTOKINES, *SAMPLING methods

Linking Protein Stability to Pathogenicity: Predicting Clinical Significance of Single-Missense Mutations in Ocular Proteins Using Machine Learning.

Authors: Majid, Iyad¹ (AUTHOR), Sergeev, Yuri V.¹ (AUTHOR) sergeevy@nei.nih.gov

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11649. 15p.

Subject Terms: *PROTEIN stability, *DENATURATION of proteins, *MACHINE learning, *COMPUTATIONAL biology, *RANDOM forest algorithms

Computational Approach to Identifying New Chemical Entities as Elastase Inhibitors with Potential Antiaging Effects.

Authors: Pitasi, Giovanna¹ (AUTHOR) giovanna.pitasi@studenti.unime.it, Brancale, Andrea² (AUTHOR) andrea.brancale@vscht.cz, Floris, Sonia³ (AUTHOR) s.floris@unica.it, Fais, Antonella³ (AUTHOR) fais@unica.it, Gitto, Rosaria¹ (AUTHOR) ldeluca@unime.it, De Luca, Laura¹ (AUTHOR)

Source: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 20, p11174. 16p.

Subject Terms: *PROTEIN stability, *CARRIER proteins, *CONNECTIVE tissues, *ELASTIN, *CHEMICAL libraries, *ELASTASES, *WRINKLES (Skin)

A new amino acid substitution in the MvALS1 gene of metsulfuron-methyl resistant biotypes Monochoria vaginalis (Burm. f.) C. Presl from West Java, Indonesia.

Authors: Putri, Kansa Dianti¹ (AUTHOR) kansadianti@apps.ipb.ac.id, Guntoro, Dwi¹ (AUTHOR) dwi_guntoro@apps.ipb.ac.id, Ardie, Sintho Wahyuning¹ (AUTHOR), Hariyadi¹ (AUTHOR)

Source: PLoS ONE. 10/4/2024, Vol. 19 Issue 10, p1-14. 14p.

Subject Terms: *PROTEIN stability, *PLANT containers, *PADDY fields, *AQUATIC plants, *HERBACEOUS plants

Glypican-3 knockdown inhibits the cell growth, stemness, and glycolysis development of hepatocellular carcinoma cells under hypoxic microenvironment through lactylation.

Authors: Yao, Gebing¹ (AUTHOR), Yang, Zihua¹ (AUTHOR) dryangzihua@hotmail.com

Source: Archives of Physiology & Biochemistry. Oct2024, Vol. 130 Issue 5, p546-554. 9p.

Subject Terms: *HEPATOCELLULAR carcinoma, *PROTEIN stability, *GENE expression, *POLYMERASE chain reaction, *PROTEIN expression

Effect of onion skin powder on color, lipid, and protein oxidative stability of premade beef patty during cold storage.

Authors: Wang, Cuntang^1,2 wangcuntang1980@163.com, Wang, Yuqing^1,2, Song, Yang^1,2, Ren, Manni^1,2, Gao, Zengming^1,2, Ren, Jian^1,2 renjian1970789@163.com

Source: Scientific Reports. 9/6/2024, Vol. 14 Issue 1, p1-11. 11p.

Subject Terms: *PROTEIN stability, *COLD storage, *HUMAN skin color, *CARBONYL group, *MEAT quality, *ONIONS, *LIPIDS

Structural and biochemical investigation into stable FGF2 mutants with novel mutation sites and hydrophobic replacements for surface-exposed cysteines.

Authors: An, Young Jun¹ (AUTHOR), Jung, Ye-Eun² (AUTHOR), Lee, Kyeong Won¹ (AUTHOR), Kaushal, Prashant³ (AUTHOR), Ko, In Young⁴ (AUTHOR), Shin, Seung Min¹ (AUTHOR), Ji, Sangho⁵ (AUTHOR), Yu, Wookyung⁵ (AUTHOR), Lee, Cheolju³ (AUTHOR), Lee, Won-Kyu⁴ (AUTHOR), Cha, Kiweon⁴ (AUTHOR), Lee, Jung-Hyun¹ (AUTHOR) jlee@kiost.ac.kr, Cha, Sun-Shin² (AUTHOR) chajung@ewha.ac.kr, Yim, Hyung-Soon¹ (AUTHOR) yimh@kiost.ac.kr

Source: PLoS ONE. 9/5/2024, Vol. 19 Issue 9, p1-22. 22p.

Subject Terms: *FIBROBLAST growth factor 2, *PROTEIN stability, *ATOMIC structure, *STRUCTURAL engineering, *THERMAL stability

Thermal Stabilisation of Lysozyme through Ensilication.

Authors: Abdulkareem, Reveng A.^1,2 (AUTHOR), Doekhie, Aswin³ (AUTHOR), Fotaki, Nikoletta¹ (AUTHOR), Koumanov, Francoise⁴ (AUTHOR), Dodson, Charlotte A.¹ (AUTHOR) c.a.dodson@bath.ac.uk, Sartbaeva, Asel^3,5 (AUTHOR) c.a.dodson@bath.ac.uk

Source: Molecules. Sep2024, Vol. 29 Issue 17, p4207. 12p.

Subject Terms: *BIOCOMPATIBILITY, *PROTEIN stability, *THERAPEUTIC use of proteins, *ENZYMES, *PROTEINS