The genomic and evolutionary landscapes of anaplastic thyroid carcinoma

Authors: Zeng, Peter Y.F. ^{1, 2, 3, 4, 47}, Prokopec, Stephenie D. ^{5, 45, 46, 47}, Lai, Stephen Y. ^{6, 47}, Pinto, Nicole ¹, Chan-Seng-Yue, Michelle A. ⁵, Clifton-Bligh, Roderick ⁷, Williams, Michelle D. ⁸, Howlett, Christopher J. ⁹, Plantinga, Paul ⁹, Cecchini, Matthew J. ¹⁰, Lam, Alfred K. ¹⁰, Siddiqui, Iram ¹¹, Wang, Jianxin ⁵, Sun, Ren X. ⁵, Watson, John D. ^{5, 45, 46}, Korah, Reju ¹², Carling, Tobias ¹², Agrawal, Nishant ¹³, Cipriani, Nicole ¹⁴, Ball, Douglas ¹⁵, Nelkin, Barry ¹⁶, Rooper, Lisa M. ¹⁷, Bishop, Justin A. ¹⁸, Garnis, Cathie ¹⁹, Berean, Ken ¹⁹, Nicolson, Norman G. ¹², Weinberger, Paul ^{20, 21}, Henderson, Ying C. ⁶, Lalansingh, Christopher M. ⁵, Tian, Mao ^{45, 46}, Yamaguchi, Takafumi N. ^{5, 45, 46}, Livingstone, Julie ^{5, 45, 46}, Salcedo, Adriana ^{5, 22, 42}, Patel, Krupal ^{1, 5}, Vizeacoumar, Frederick ²³, Datti, Alessandro ^{24, 25}, Xi, Liu ²⁶, Nikiforov, Yuri E. ²⁷, Smallridge, Robert ²⁸, Copland, John A. ²⁹, Marlow, Laura A. ²⁹, Hyrcza, Martin D. ³⁰, Delbridge, Leigh ^{31, 32}, Sidhu, Stan ^{31, 32}, Sywak, Mark ^{31, 32}, Robinson, Bruce ^{32, 33}, Fung, Kevin ^{1, 4}, Ghasemi, Farhad ¹, Kwan, Keith ⁹, MacNeil, S. Danielle ^{1, 4}, Mendez, Adrian ^{1, 4}, Palma, David A. ^{2, 3, 4}, Khan, Mohammed I. ¹, Shaikh, Mushfiq ¹, Ruicci, Kara M. ¹, Wehrli, Bret ⁹, Winquist, Eric ^{2, 3, 4}, Yoo, John ^{1, 4}, Mymryk, Joe S. ^{1, 2, 4, 34}, Rocco, James W. ³⁵, Wheeler, David ²⁶, Scherer, Steve ²⁶, Giordano, Thomas J. ³⁶, Barrett, John W. ¹, Faquin, William C. ³⁷, Gill, Anthony J. ^{32, 38, 39}, Clayman, Gary ^{40, 47}, Boutros, Paul C. ^{22, 41, 42, 43, 44, 45, 46, 47, ∗}, Nichols, Anthony C. ^{1, 2, 3, 4, 47, 48, ∗∗}

Source: In Cell Reports 26 March 2024 43(3)

Loss of LRP1B expression drives acquired chemo and radio-resistance in HPV-positive head and neck cancer

Authors: Shaikh, Mushfiq H., Dawson, Alice, Prokopec, Stephenie D., Barrett, John W., Y.F. Zeng, Peter, Khan, Mohammed I., Ryan, Sarah E.B., Cecchini, Matthew, Palma, David A., Mymryk, Joe S., Boutros, Paul C., Nichols, Anthony C.

Source: In Oral Oncology November 2023 146

Serological abnormalities that predict progression to systemic autoimmune rheumatic diseases in antinuclear antibody–positive individuals

Authors: Muñoz-Grajales, Carolina, Prokopec, Stephenie D, Johnson, Sindhu R, Touma, Zahi, Ahmad, Zareen, Bonilla, Dennisse, Hiraki, Linda, Bookman, Arthur, Boutros, Paul C, Chruscinski, Andrzej, Wither, Joan

Source: Rheumatology. 61(3):1092-1105

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100142886579.0x000001&indx=1&recIds=ETOCvdc_100142886579.0x000001

Sex disparities in head & neck cancer driver genes: An analysis of the TCGA dataset

Authors: Mundi, Neil, Ghasemi, Farhad, Zeng, Peter Y.F., Prokopec, Stephenie D., Patel, Krupal, Kim, Hugh Andrew Jinwook, Di Gravio, Eric, MacNeil, Danielle, Khan, Mohammed Imran, Han, Myung Woul, Shaikh, Mushfiq, Mendez, Adrian, Yoo, John, Fung, Kevin, Gameiro, Steven F., Palma, David A., Mymryk, Joe S., Barrett, John W., Boutros, Paul C., Nichols, Anthony C.

Source: In Oral Oncology May 2020 104

Transgenerational epigenetic and transcriptomic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin exposure in rat

Authors: Prokopec, Stephenie D., Viluksela, Matti, Miettinen, Hanna M., Boutros, Paul C., Pohjanvirta, Raimo

Source: Archives of toxicology. 94(5):1613-1624

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167727886.0x000001&indx=1&recIds=ETOCvdc_100167727886.0x000001

Comparative toxicoproteogenomics of mouse and rat liver identifies TCDD-resistance genes

Authors: Prokopec, Stephenie D., Lu, Aileen, Lee, Sandy Che-Eun S., Yao, Cindy Q., Sun, Ren X., Watson, John D., Soliymani, Rabah, de Borja, Richard, Wong, Ada, Sam, Michelle, Zuzarte, Philip, McPherson, John D., Okey, Allan B., Pohjanvirta, Raimo, Boutros, Paul C.

Source: Archives of toxicology. 93(10):2961-2978

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125619447.0x000001&indx=1&recIds=ETOCvdc_100125619447.0x000001

A readout of metabolic efficiency in arylamine N‐acetyltransferase‐deficient mice reveals minor energy metabolism changes

Authors: Denis, Raphaël G.P., Busi, Florent, Castel, Julien, Morel, Chloé, Zhang, Wenchao, Bui, Linh‐Chi, Sugamori, Kim S., Prokopec, Stephenie D., Boutros, Paul C., Grant, Denis M., Rodrigues‐Lima, Fernando, Luquet, Serge, Dupret, Jean‐Marie

Source: FEBS letters. 593(8):831-841

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100084040982.0x000001&indx=1&recIds=ETOCvdc_100084040982.0x000001

Transcriptional profiling of rat white adipose tissue response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin

Authors: Houlahan, Kathleen E., Prokopec, Stephenie D., Sun, Ren X., Moffat, Ivy D., Lindén, Jere, Lensu, Sanna, Okey, Allan B., Pohjanvirta, Raimo, Boutros, Paul C.

Source: In Toxicology and Applied Pharmacology 15 October 2015 288(2):223-231

Sex-related differences in murine hepatic transcriptional and proteomic responses to TCDD

Authors: Prokopec, Stephenie D., Watson, John D., Lee, Jamie, Pohjanvirta, Raimo, Boutros, Paul C.

Source: In Toxicology and Applied Pharmacology 15 April 2015 284(2):188-196

Transcriptional profiling of rat hypothalamus response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin

Authors: Houlahan, Kathleen E., Prokopec, Stephenie D., Moffat, Ivy D., Lindén, Jere, Lensu, Sanna, Okey, Allan B., Pohjanvirta, Raimo, Boutros, Paul C.

Source: In Toxicology 3 February 2015 328:93-101

Flavopiridol causes cell cycle inhibition and demonstrates anti-cancer activity in anaplastic thyroid cancer models.

Authors: Pinto, Nicole^1,2 (AUTHOR), Prokopec, Stephenie D.³ (AUTHOR), Ghasemi, Farhad¹ (AUTHOR), Meens, Jalna⁴ (AUTHOR), Ruicci, Kara M.¹ (AUTHOR), Khan, Imran M.¹ (AUTHOR), Mundi, Neil¹ (AUTHOR), Patel, Krupal¹ (AUTHOR), Han, Myung W.¹ (AUTHOR), Yoo, John^1,5 (AUTHOR), Fung, Kevin^1,5 (AUTHOR), MacNeil, Danielle^1,5 (AUTHOR), Mymryk, Joe S.^5,6 (AUTHOR), Datti, Alessandro^7,8 (AUTHOR), Barrett, John W.¹ (AUTHOR), Boutros, Paul C.^{3,9,10,11,12,13,14,15} (AUTHOR), Ailles, Laurie⁴ (AUTHOR), Nichols, Anthony C.^1,5 (AUTHOR) Anthony.Nichols@lhsc.on.ca

Source: PLoS ONE. 9/24/2020, Vol. 15 Issue 9, p1-13. 13p.

Subject Terms: *ANAPLASTIC thyroid cancer, *CELL cycle, *CELL cycle proteins, *CELL lines, *THYROID hormones, *TRIIODOTHYRONINE, *CELL cycle regulation

TCDD dysregulation of 13 AHR-target genes in rat liver

Authors: Watson, John D., Prokopec, Stephenie D., Smith, Ashley B., Okey, Allan B., Pohjanvirta, Raimo, Boutros, Paul C.

Source: In Toxicology and Applied Pharmacology 1 February 2014 274(3):445-454

Long-term hemodynamic and molecular effects persist after discontinued renin–angiotensin system blockade in patients with type 1 diabetes mellitus

Authors: Cherney, David Z.I. ^*, Zinman, Bernard, Kennedy, Christopher R.J., Moineddin, Rahim, Lai, Vesta, Yang, Stuart, Miller, Judith A., Prokopec, Stephenie D., Boutros, Paul C., Scholey, James W., Reich, Heather N.

Source: In Kidney International December 2013 84(6):1246-1253

Validating reference genes within a mouse model system of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity

Authors: Prokopec, Stephenie D., Buchner, Nicholas B., Fox, Natalie S., Chong, Lauren C., Mak, Denise Y.F., Watson, John D., Petronis, Arturas, Pohjanvirta, Raimo, Boutros, Paul C.

Source: In Chemico-Biological Interactions 5 September 2013 205(1):63-71

Sex differences in oncogenic mutational processes

Authors: Li, Constance H., Prokopec, Stephenie D., Sun, Ren X., Yousif, Fouad, Schmitz, Nathaniel, Boutros, Paul C.

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174562159.0x000001&indx=1&recIds=ETOCvdc_100174562159.0x000001

Transcriptional profiling of rat hypothalamus response to 2, 3, 7, 8-tetrachlorodibenzo-ρ-dioxin

Authors: Houlahan, Kathleen E., Prokopec, Stephenie D., Moffat, Ivy D., Lindén, Jere, Lensu, Sanna, Okey, Allan B., Pohjanvirta, Raimo, Boutros, Paul C.

Source: Toxicology. 328:93-101

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100065939385.0x000001&indx=1&recIds=ETOCvdc_100065939385.0x000001

Inter-strain heterogeneity in rat hepatic transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Authors: Yao, Cindy Q., Prokopec, Stephenie D., Watson, John D., Pang, Renee, P'ng, Christine, Chong, Lauren C., Harding, Nicholas J., Pohjanvirta, Raimo, Okey, Allan B., Boutros, Paul C.

Source: In Toxicology and Applied Pharmacology 15 April 2012 260(2):135-145

Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity

Authors: Boutros, Paul C., Yao, Cindy Q., Watson, John D., Wu, Alexander H., Moffat, Ivy D., Prokopec, Stephenie D., Smith, Ashley B., Okey, Allan B., Pohjanvirta, Raimo

Source: In Toxicology and Applied Pharmacology 2011 251(2):119-129

Genomic and human papillomavirus profiling of an oral cancer cohort identifies TP53 as a predictor of overall survival

Authors: Mundi, Neil, Prokopec, Stephenie D., Ghasemi, Farhad, Warner, Andrew, Patel, Krupal, MacNeil, Danielle, Howlett, Christopher, Stecho, William, Plantinga, Paul, Pinto, Nicole, Ruicci, Kara M., Khan, Mohammed Imran, Han, Myung Woul, Yoo, John, Fung, Kevin, Sahovaler, Axel, Palma, David A., Winquist, Eric, Mymryk, Joe S., Barrett, John W., Boutros, Paul C., Nichols, Anthony C.

Source: Cancers of the head & neck. 4(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129915189.0x000001&indx=1&recIds=ETOCvdc_100129915189.0x000001

BPG: Seamless, automated and interactive visualization of scientific data

Authors: P'ng, Christine, Green, Jeffrey, Chong, Lauren C., Waggott, Daryl, Prokopec, Stephenie D., Shamsi, Mehrdad, Nguyen, Francis, Mak, Denise Y. F., Lam, Felix, Albuquerque, Marco A., Wu, Ying, Jung, Esther H., Starmans, Maud H. W., Chan-Seng-Yue, Michelle A., Yao, Cindy Q., Liang, Bianca, Lalonde, Emilie, Haider, Syed, Simone, Nicole A., Sendorek, Dorota, Chu, Kenneth C., Moon, Nathalie C., Fox, Natalie S., Grzadkowski, Michal R., Harding, Nicholas J., Fung, Clement, Murdoch, Amanda R., Houlahan, Kathleen E., Wang, Jianxin, Garcia, David R., de Borja, Richard, Sun, Ren X., Lin, Xihui, Chen, Gregory M., Lu, Aileen, Shiah, Yu-Jia, Zia, Amin, Kearns, Ryan, Boutros, Paul C.

Source: BMC bioinformatics. 20(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127153249.0x000001&indx=1&recIds=ETOCvdc_100127153249.0x000001