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Prediction of clinical pharmacokinetics of AMG 181, a human anti- α4 β7 monoclonal antibody for treating inflammatory bowel diseases.

Authors: Li, Hong, Köck, Kathleen, Wisler, John A., Rees, William A., Prince, Peter J., Reynhardt, Kai O., Hsu, Hailing, Yu, Zhigang, Borie, Dominic C., Salinger, David H., Pan, Wei ‐ Jian

Source: Pharmacology Research & Perspectives; Feb2015, Vol. 3 Issue 1, pn/a-N.PAG, 13p

Subject Terms: THERAPEUTIC use of monoclonal antibodies, INFLAMMATORY bowel disease treatment, PHARMACOKINETICS, PHARMACODYNAMICS, KRA, PHARMACEUTICAL research

Clinical pharmacology of AMG 181, a gut-specific human anti-α4β7 monoclonal antibody, for treating inflammatory bowel diseases.

Authors: Pan, Wei‐Jian, Köck, Kathleen, Rees, William A., Sullivan, Barbara A., Evangelista, Christine M., Yen, Mark, Andrews, Jane M., Radford‐Smith, Graham L., Prince, Peter J., Reynhardt, Kaz O., Doherty, David R., Patel, Sonal K., Krill, Christine D., Zhou, Kefei, Shen, Jing, Smith, Lynn E., Gow, Jason M., Lee, Jonathan, Treacy, Anthony M., Yu, Zhigang

Source: British Journal of Clinical Pharmacology; Dec2014, Vol. 78 Issue 6, p1315-1333, 19p, 4 Charts, 8 Graphs

Subject Terms: CLINICAL pharmacology, MONOCLONAL antibodies, INFLAMMATORY bowel diseases, PHARMACOKINETICS, PHARMACODYNAMICS

Sa1207 Pharmacokinetics/Pharmacodynamics (PK/PD), Efficacy, and Safety of AMG 181 in Subjects With Active, Mild to Moderate Ulcerative Colitis - An Initial Assessment

Authors: Pan, Wei-Jian, Radford-Smith, Graham, Andrews, Jane M., Schwartz, Howard I., Sullivan, Barbara A., Evangelista, Christine M., Rees, William A., Doherty, David R., Prince, Peter J., Reynhardt, Kai O., Zhou, Kefei, Johnson, Justo Sierra, Treacy, Anthony M., Lee, Jonathan, Yu, Zhigang, Borie, Dominique C.

Source: In Gastroenterology May 2013 144(5) Supplement 1:S

Sa1206 Multiple-Dose Pharmacokinetics (PK), Pharmacodynamics (PD), and Safety of AMG 181, a Human Anti-a4β7 Antibody for Treating Inflammatory Bowel Diseases (IBD)

Authors: Pan, Wei-Jian, Sullivan, Barbara A., Rees, William A., Evangelista, Christine M., Doherty, David R., Prince, Peter J., Reynhardt, Kai O., Zhou, Kefei, Yen, Mark, Hooper, Michele M., Lee, Jonathan, Yu, Zhigang, Hsu, Hailing, Borie, Dominique C.

Source: In Gastroenterology May 2013 144(5) Supplement 1:S

Su2082 Pharmacokinetics (PK), Pharmacodynamics (PD), and Safety of Amg 181, a Fully Human Anti-α4β7 Antibody for Treating Inflammatory Bowel Diseases (IBD)

Authors: Pan, Wei-Jian, Sullivan, Barbara A., Evangelista, Christine M., Doherty, David R., Tam, Chi-Yan J., Patel, Sonal K., Prince, Peter J., Reynhardt, Kai O., Rees, William A., Hsu, Hailing, Zhou, Kefei, Gu, Wen, Yen, Mark, Haller, Christine A., Dodson, Susanna, Yu, Zhigang, Wienkers, Larry C., Borie, Dominique C.

Source: In Gastroenterology May 2012 142(5) Supplement 1:S

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