Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab

Authors: Wu, Meng ^{1, †}, Fulgenzi, Claudia A.M. ^{2, †}, D’Alessio, Antonio ^{2, 3}, Cortellini, Alessio ^{2, 4}, Celsa, Ciro ^{2, 5}, Manfredi, Giulia F. ^{2, 3}, Stefanini, Bernardo ^{2, 6}, Wu, Y. Linda ⁷, Huang, Yi-Hsiang ^{8, 9, 10}, Saeed, Anwaar ¹¹, Pirozzi, Angelo ^{12, 13}, Pressiani, Tiziana ¹³, Rimassa, Lorenza ^{12, 13}, Schoenlein, Martin ¹⁴, Schulze, Kornelius ¹⁵, von Felden, Johann ¹⁵, Mohamed, Yehia ¹⁶, Kaseb, Ahmed O. ¹⁶, Vogel, Arndt ^{17, 18}, Roehlen, Natascha ^{19, 20}, Silletta, Marianna ⁴, Nishida, Naoshi ²¹, Kudo, Masatoshi ²¹, Vivaldi, Caterina ^{22, 23}, Balcar, Lorenz ²⁴, Scheiner, Bernhard ²⁴, Pinter, Matthias ²⁴, Singal, Amit G. ²⁵, Glover, Joshua ²⁶, Ulahannan, Susanna ²⁶, Foerster, Fredrich ²⁷, Weinmann, Arndt ²⁷, Galle, Peter R. ²⁷, Parikh, Neehar D. ²⁸, Hsu, Wei-Fan ²⁹, Parisi, Alessandro ³⁰, Chon, Hong Jae ³¹, Pinato, David J. ^{2, 3}, Ang, Celina ^{1, ⁎}

Source: In JHEP Reports February 2025 7(2)

Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer: A large real-life worldwide population

Authors: Rimini, Margherita, Fornaro, Lorenzo, Rizzato, Mario Domenico, Antonuzzo, Lorenzo, Rossari, Federico, Satake, Tomoyuki, Vandeputte, Hanne, Vivaldi, Caterina, Pressiani, Tiziana, Lucchetti, Jessica, Kim, Jin Won, Abidoye, Oluseyi, Rapposelli, Ilario Giovanni, Tamberi, Stefano, Finkelmeier, Fabian, Giordano, Guido, Nichetti, Federico, Chon, Hong Jae, Braconi, Chiara, Pirrone, Chiara, Castet, Florian, Tamburini, Emiliano, Yoo, Changhoon, Parisi, Alessandro, Diana, Anna, Scartozzi, Mario, Prager, Gerald W., Avallone, Antonio, Schirripa, Marta, Kim, Il Hwan, Perkhofer, Lukas, Oneda, Ester, Verrico, Monica, Adeva, Jorge, Chan, Stephen L., Spinelli, Gian Paolo, Personeni, Nicola, Garajova, Ingrid, Rodriquenz, Maria Grazia, Leo, Silvana, Salani, Francesca, De Rosa, Antonio, Lavacchi, Daniele, Foti, Silvia, Ikeda, Masafumi, Dekervel, Jeroen, Niger, Monica, Balsano, Rita, Tonini, Giuseppe, Kang, Minsu, Bekaii-Saab, Tanios, Esposito, Luca, Boccaccino, Alessandra, Himmelsbach, Vera, Landriscina, Matteo, Djaballah, Selma Ahcene, Zanuso, Valentina, Masi, Gianluca, Lonardi, Sara, Rimassa, Lorenza, Casadei-Gardini, Andrea

Source: In European Journal of Cancer September 2024 208

Multicenter phase I/II trial of gemcitabine, oxaliplatin and nab-paclitaxel as first-line treatment for patients with advanced biliary tract cancer

Authors: Pressiani, Tiziana, Balsano, Rita, Giordano, Laura, Milella, Michele, Bergamo, Francesca, Bozzarelli, Silvia, Noventa, Silvia, Ferrrari, Daris, Scartozzi, Mario, Parra, Hector Soto, Auriemma, Alessandra, Soldà, Caterina, Zaniboni, Alberto, Zecchetto, Camilla, Rizzato, Mario Domenico, Rimassa, Lorenza, Santoro, Armando

Source: In European Journal of Cancer August 2024 207

A meta-analysis and real-world cohort study on the sex-related differences in efficacy and safety of immunotherapy for hepatocellular carcinoma

Authors: Balcar, Lorenz, Scheiner, Bernhard, Fulgenzi, Claudia Angela Maria, D’Alessio, Antonio, Pomej, Katharina, Roig, Marta Bofill, Meyer, Elias Laurin, Che, Jaekyung, Nishida, Naoshi, Lee, Pei-Chang, Wu, Linda, Ang, Celina, Krall, Anja, Saeed, Anwaar, Stefanini, Bernardo, Cammarota, Antonella, Pressiani, Tiziana, Abugabal, Yehia I., Chamseddine, Shadi, Wietharn, Brooke, Parisi, Alessandro, Huang, Yi-Hsiang, Phen, Samuel, Vivaldi, Caterina, Salani, Francesca, Masi, Gianluca, Bettinger, Dominik, Vogel, Arndt, von Felden, Johann, Schulze, Kornelius, Silletta, Marianna, Trauner, Michael, Samson, Adel, Wege, Henning, Piscaglia, Fabio, Galle, Peter R., Stauber, Rudolf, Kudo, Masatoshi, Singal, Amit G., Itani, Aleena, Ulahannan, Susanna V., Parikh, Neehar D., Cortellini, Alessio, Kaseb, Ahmed, Rimassa, Lorenza, Chon, Hong Jae, Pinato, David J., Pinter, Matthias

Source: In JHEP Reports February 2024 6(2)

Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer: An early exploratory analysis of real‐world data

Authors: Rimini, Margherita, Fornaro, Lorenzo, Lonardi, Sara, Niger, Monica, Lavacchi, Daniele, Pressiani, Tiziana, Lucchetti, Jessica, Giordano, Guido, Pretta, Andrea, Tamburini, Emiliano, Pirrone, Chiara, Rapposelli, Ilario Giovanni, Diana, Anna, Martinelli, Erika, Garajová, Ingrid, Simionato, Francesca, Schirripa, Marta, Formica, Vincenzo, Vivaldi, Caterina, Caliman, Enrico, Rizzato, Mario Domenico, Zanuso, Valentina, Nichetti, Federico, Angotti, Lorenzo, Landriscina, Matteo, Scartozzi, Mario, Ramundo, Matteo, Pastorino, Alessandro, Daniele, Bruno, Cornara, Noemi, Persano, Mara, Gusmaroli, Eleonora, Cerantola, Riccardo, Salani, Francesca, Ratti, Francesca, Aldrighetti, Luca, Cascinu, Stefano, Rimassa, Lorenza, Antonuzzo, Lorenzo, Casadei‐Gardini, Andrea

Source: Liver international. 43(8):1803-1812

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187930936.0x000001&indx=1&recIds=ETOCvdc_100187930936.0x000001

Outcomes of Sorafenib for Recurrent Hepatocellular Carcinoma After Liver Transplantation in the Era of Combined and Sequential Treatments

Authors: Tovoli, Francesco, Pallotta, Dante Pio, Sansone, Vito, Iavarone, Massimo, De Giorgio, Massimo, Ielasi, Luca, Di Costanzo, Giovan Giuseppe, Giuffrida, Paolo, Sacco, Rodolfo, Pressiani, Tiziana, Di Donato, Maria Francesca, Trevisani, Franco, Fagiuoli, Stefano, Piscaglia, Fabio, Granito, Alessandro

Source: Transplantation. 107(1):156-161

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185047553.0x000001&indx=1&recIds=ETOCvdc_100185047553.0x000001

Atezolizumab plus bevacizumab versus lenvatinib for unresectable hepatocellular carcinoma: a large real-life worldwide population

Authors: Casadei-Gardini, Andrea, Rimini, Margherita, Tada, Toshifumi, Suda, Goki, Shimose, Shigeo, Kudo, Masatoshi, Cheon, Jaekyung, Finkelmeier, Fabian, Lim, Ho Yeong, Rimassa, Lorenza, Presa, José, Masi, Gianluca, Yoo, Changhoon, Lonardi, Sara, Tovoli, Francesco, Kumada, Takashi, Sakamoto, Naoya, Iwamoto, Hideki, Aoki, Tomoko, Chon, Hong Jae, Himmelsbach, Vera, Pressiani, Tiziana, Montes, Margarida, Vivaldi, Caterina, Soldà, Caterina, Piscaglia, Fabio, Hiraoka, Atsushi, Sho, Takuya, Niizeki, Takashi, Nishida, Naoshi, Steup, Christoph, Iavarone, Massimo, Di Costanzo, Giovanni, Marra, Fabio, Scartozzi, Mario, Tamburini, Emiliano, Cabibbo, Giuseppe, Foschi, Francesco Giuseppe, Silletta, Marianna, Hirooka, Masashi, Kariyama, Kazuya, Tani, Joji, Atsukawa, Masanori, Takaguchi, Koichi, Itobayashi, Ei, Fukunishi, Shinya, Tsuji, Kunihiko, Ishikawa, Toru, Tajiri, Kazuto, Ochi, Hironori, Yasuda, Satoshi, Toyoda, Hidenori, Ogawa, Chikara, Nishimura, Takashi, Hatanaka, Takeshi, Kakizaki, Satoru, Shimada, Noritomo, Kawata, Kazuhito, Tada, Fujimasa, Ohama, Hideko, Nouso, Kazuhiro, Morishita, Asahiro, Tsutsui, Akemi, Nagano, Takuya, Itokawa, Norio, Okubo, Tomomi, Arai, Taeang, Imai, Michitaka, Kosaka, Hisashi, Naganuma, Atsushi, Koizumi, Yohei, Nakamura, Shinichiro, Kaibori, Masaki, Iijima, Hiroko, Hiasa, Yoichi, Burgio, Valentina, Persano, Mara, Della Corte, Angelo, Ratti, Francesca, De Cobelli, Francesco, Aldrighetti, Luca, Cascinu, Stefano, Cucchetti, Alessandro

Source: European journal of cancer. 180:9-20

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180271567.0x000001&indx=1&recIds=ETOCvdc_100180271567.0x000001

Progression patterns and therapeutic sequencing following immune checkpoint inhibition for hepatocellular carcinoma: An international observational study

Authors: Talbot, Thomas, D'Alessio, Antonio, Pinter, Matthias, Balcar, Lorenz, Scheiner, Bernhard, Marron, Thomas U., Jun, Tomi, Dharmapuri, Sirish, Ang, Celina, Saeed, Anwaar, Hildebrand, Hannah, Muzaffar, Mahvish, Fulgenzi, Claudia A. M., Amara, Suneetha, Naqash, Abdul Rafeh, Gampa, Anuhya, Pillai, Anjana, Wang, Yinghong, Khan, Uqba, Lee, Pei‐Chang, Huang, Yi‐Hsiang, Bengsch, Bertram, Bettinger, Dominik, Mohamed, Yehia I., Kaseb, Ahmed, Pressiani, Tiziana, Personeni, Nicola, Rimassa, Lorenza, Nishida, Naoshi, Kudo, Masatoshi, Weinmann, Arndt, Galle, Peter R., Muhammed, Ambreen, Cortellini, Alessio, Vogel, Arndt, Pinato, David J.

Source: Liver international. 43(3):695-707

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175270933.0x000001&indx=1&recIds=ETOCvdc_100175270933.0x000001

Reproducible safety and efficacy of atezolizumab plus bevacizumab for HCC in clinical practice: Results of the AB-real study

Authors: Fulgenzi, Claudia Angela Maria, Cheon, Jaekyung, D'Alessio, Antonio, Nishida, Naoshi, Ang, Celina, Marron, Thomas U., Wu, Linda, Saeed, Anwaar, Wietharn, Brooke, Cammarota, Antonella, Pressiani, Tiziana, Personeni, Nicola, Pinter, Matthias, Scheiner, Bernhard, Balcar, Lorenz, Napolitano, Andrea, Huang, Yi-Hsiang, Phen, Samuel, Naqash, Abdul Rafeh, Vivaldi, Caterina, Salani, Francesca, Masi, Gianluca, Bettinger, Dominik, Vogel, Arndt, Schönlein, Martin, von Felden, Johann, Schulze, Kornelius, Wege, Henning, Galle, Peter R., Kudo, Masatoshi, Rimassa, Lorenza, Singal, Amit G., Sharma, Rohini, Cortellini, Alessio, Gaillard, Vincent E., Chon, Hong Jae, Pinato, David James

Source: In European Journal of Cancer November 2022 175:204-213

Preliminary evidence of safety and tolerability of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma and Child‐Pugh A and B cirrhosis: A real‐world study

Authors: D'Alessio, Antonio, Fulgenzi, Claudia Angela Maria, Nishida, Naoshi, Schönlein, Martin, von Felden, Johann, Schulze, Kornelius, Wege, Henning, Gaillard, Vincent E., Saeed, Anwaar, Wietharn, Brooke, Hildebrand, Hannah, Wu, Linda, Ang, Celina, Marron, Thomas U., Weinmann, Arndt, Galle, Peter R., Bettinger, Dominik, Bengsch, Bertram, Vogel, Arndt, Balcar, Lorenz, Scheiner, Bernhard, Lee, Pei‐Chang, Huang, Yi‐Hsiang, Amara, Suneetha, Muzaffar, Mahvish, Naqash, Abdul Rafeh, Cammarota, Antonella, Personeni, Nicola, Pressiani, Tiziana, Sharma, Rohini, Pinter, Matthias, Cortellini, Alessio, Kudo, Masatoshi, Rimassa, Lorenza, Pinato, David J.

Source: Hepatology. 76(4):1000-1012

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191468160.0x000001&indx=1&recIds=ETOCvdc_100191468160.0x000001

Impact of older age in patients receiving atezolizumab and bevacizumab for hepatocellular carcinoma

Authors: Vithayathil, Mathew, D'Alessio, Antonio, Fulgenzi, Claudia A. M., Nishida, Naoshi, Schönlein, Martin, Felden, Johann, Schulze, Kornelius, Wege, Henning, Saeed, Anwaar, Wietharn, Brooke, Hildebrand, Hannah, Wu, Linda, Ang, Celina, Marron, Thomas U., Weinmann, Arndt, Galle, Peter R., Bettinger, Dominik, Bengsch, Bertram, Vogel, Arndt, Balcar, Lorenz, Scheiner, Bernhard, Lee, Pei‐Chang, Huang, Yi‐Hsiang, Amara, Suneetha, Muzaffar, Mahvish, Naqash, Abdul Rafeh, Cammarota, Antonella, Personeni, Nicola, Pressiani, Tiziana, Pinter, Matthias, Cortellini, Alessio, Kudo, Masatoshi, Rimassa, Lorenza, Pinato, David J., Sharma, Rohini

Source: Liver international. 42(11):2538-2547

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164982678.0x000001&indx=1&recIds=ETOCvdc_100164982678.0x000001

Patterns and outcomes of subsequent therapy after immune checkpoint inhibitor discontinuation in HCC

Authors: Sharma, Rohini, Pillai, Anjana, Marron, Thomas Urban, Fessas, Petros, Saeed, Anwaar, Jun, Tomi, Dharmapuri, Sirish, Szafron, David, Naqash, Abdul Rafeh, Gampa, Anuhya, Wang, Yinghong, Khan, Uqba, Muzaffar, Mahvish, Lee, Chieh‐Ju, Lee, Pei‐Chang, Bulumulle, Anushi, Paul, Sonal, Bettinger, Dominic, Hildebrand, Hannah, Yehia, Mohammed, Pressiani, Tiziana, Kaseb, Ahmed, Huang, Yi‐Hsiang, Ang, Celina, Kudo, Masatoshi, Nishida, Naoshi, Personeni, Nicola, Rimassa, Lorenza, Pinato, David James

Source: Hepatology communications. 6(7):1776-1785

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154052157.0x000001&indx=1&recIds=ETOCvdc_100154052157.0x000001

Tumour burden score and immune‐related hepatotoxicity in patients with hepatocellular carcinoma or liver metastases treated with immune checkpoint inhibitors

Authors: Di Carlo, Eleonora, D'Alessio, Antonio, Cammarota, Antonella, Zanuso, Valentina, Pressiani, Tiziana, Bozzarelli, Silvia, Ferrillo, Giuseppe, Vatteroni, Giulia, Pedicini, Vittorio, Giordano, Laura, Personeni, Nicola, Rimassa, Lorenza

Source: Liver Cancer International. 3(2):63-71

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154067885.0x000001&indx=1&recIds=ETOCvdc_100154067885.0x000001

Prognosis of patients with hepatocellular carcinoma treated with immunotherapy – development and validation of the CRAFITY score

Authors: Scheiner, Bernhard, Pomej, Katharina, Kirstein, Martha M., Hucke, Florian, Finkelmeier, Fabian, Waidmann, Oliver, Himmelsbach, Vera, Schulze, Kornelius, von Felden, Johann, Fründt, Thorben W., Stadler, Marc, Heinzl, Harald, Shmanko, Kateryna, Spahn, Stephan, Radu, Pompilia, Siebenhüner, Alexander R., Mertens, Joachim C., Rahbari, Nuh N., Kütting, Fabian, Waldschmidt, Dirk-Thomas, Ebert, Matthias P., Teufel, Andreas, De Dosso, Sara, Pinato, David J., Pressiani, Tiziana, Meischl, Tobias, Balcar, Lorenz, Müller, Christian, Mandorfer, Mattias, Reiberger, Thomas, Trauner, Michael, Personeni, Nicola, Rimassa, Lorenza, Bitzer, Michael, Trojan, Jörg, Weinmann, Arndt, Wege, Henning, Dufour, Jean-François, Peck-Radosavljevic, Markus, Vogel, Arndt, Pinter, Matthias

Source: Journal of hepatology. 76(2):353-363

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153315580.0x000001&indx=1&recIds=ETOCvdc_100153315580.0x000001

The dual checkpoint blockade in unresectable hepatocellular carcinoma: opportunities emerging in clinical trials

Authors: Cammarota, Antonella, Zanuso, Valentina, D'Alessio, Antonio, Pressiani, Tiziana, Bozzarelli, Silvia, Personeni, Nicola, Rimassa, Lorenza

Source: Expert opinion on investigational drugs. 31(4):425-435

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100145919696.0x000001&indx=1&recIds=ETOCvdc_100145919696.0x000001

Cabozantinib plus atezolizumab for the treatment of advanced hepatocellular carcinoma: shedding light on the preclinical rationale and clinical trials

Authors: Cammarota, Antonella, Zanuso, Valentina, D'Alessio, Antonio, Pressiani, Tiziana, Personeni, Nicola, Rimassa, Lorenza

Source: Expert opinion on investigational drugs. 31(4):401-413

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100145919671.0x000001&indx=1&recIds=ETOCvdc_100145919671.0x000001

Hepatic decompensation is the major driver of mortality in patients with HCC treated with atezolizumab plus bevacizumab: The impact of successful antiviral treatment.

Authors: Celsa, Ciro, Cabibbo, Giuseppe, Fulgenzi, Claudia Angela Maria, Battaglia, Salvatore, Enea, Marco, Scheiner, Bernhard, D'Alessio, Antonio, Manfredi, Giulia F., Stefanini, Bernardo, Nishida, Naoshi, Galle, Peter R., Schulze, Kornelius, Wege, Henning, Ciccia, Roberta, Hsu, Wei-Fan, Vivaldi, Caterina, Wietharn, Brooke, Lin, Ryan Po-Ting, Pirozzi, Angelo, Pressiani, Tiziana

Source: Hepatology (02709139); Mar2025, Vol. 81 Issue 3, p837-852, 16p

Expanded biomarker analysis of an international, open-label phase 2 study of regorafenib plus pembrolizumab in patients with advanced hepatocellular carcinoma (HCC) previously treated with immune checkpoint inhibitors (ICI).

Authors: El-Khoueiry, Anthony B., Balli, David, Blanc, Jean-Frédéric, Rosmorduc, Olivier, Decaens, Thomas, Mathurin, Philippe, Merle, Philippe, Dayyani, Farshid, Masi, Gianluca, Pressiani, Tiziana, Galle, Peter Robert, Hatogai, Ken, Mueller, Udo, Kalambakas, Stacey Anastasia, Weispfenning, Anke, Ishii, Yuko, Bouattour, Mohamed

Source: Journal of Clinical Oncology; 2025 Supplement 4, Vol. 43, p635-635, 132p

The Immune–Genomics of Cholangiocarcinoma: A Biological Footprint to Develop Novel Immunotherapies.

Authors: Cammarota, Antonella, Balsano, Rita, Pressiani, Tiziana, Bozzarelli, Silvia, Rimassa, Lorenza, Lleo, Ana

Source: Cancers; Jan2025, Vol. 17 Issue 2, p272, 21p

Subject Terms: GENOMICS, CANCER, CHOLANGIOCARCINOMA, IMMUNOTHERAPY, ANTINEOPLASTIC agents, IMMUNE checkpoint inhibitors, FIBROBLASTS, DRUG development

Treatment-related toxicity and improved outcome from immunotherapy in hepatocellular cancer: Evidence from an FDA pooled analysis of landmark clinical trials with validation from routine practice

Authors: Pinato, David J., Marron, Thomas U., Mishra-Kalyani, Pallavi Shruti, Gong, Yutao, Wei, Guo, Szafron, David, Sharon, Elad, Saeed, Anwaar, Jun, Tomi, Dharmapuri, Sirish, Naqash, Abdul R., Peeraphatdit, Thoetchai, Gampa, Anuhya, Wang, Yinghong, Khan, Uqba, Muzaffar, Mahvish, Navaid, Musharraf, Lee, Chieh J., Lee, Pei-Chang, Bulumulle, Anushi, Yu, Bo, Paul, Sonal, Nimkar, Neil, Bettinger, Dominik, Hildebrand, Hannah, Abugabal, Yehia I., Pressiani, Tiziana, Personeni, Nicola, D'Alessio, Antonio, Kaseb, Ahmed O., Huang, Yi-Hsiang, Ang, Celina, Schneider, Julie, Pillai, Anjana, Rimassa, Lorenza, Goldberg, Kirsten B., Pazdur, Richard, Theoret, Marc, Lemery, Steven, Fashoyin-Aje, ‘Lola, Cortellini, Alessio, Pelosof, Lorraine

Source: In European Journal of Cancer November 2021 157:140-152