α‐Triazolylboronic Acids: A Novel Scaffold to Target FLT3 in AML.

Authors: Introvigne, Maria Luisa, Destro, Lorenza, Mologni, Luca, Crippa, Valentina, Zardi, Paolo, Fini, Francesco, Prati, Fabio, Caselli, Emilia, Zambon, Alfonso

Source: ChemMedChem; 1/2/2025, Vol. 20 Issue 1, p1-10, 10p

Straightforward synthesis of chiral non-racemic α-boryl isocyanidesElectronic supplementary information (ESI) available: Experimental details, analytical data, characterisation data and NMR spectra. See DOI: 10.1039/d1ob00616a

Authors: Fini, Francesco, Zanni, Alessandro, Introvigne, Maria Luisa, Stucchi, Mattia, Caselli, Emilia, Prati, Fabio

Source: Organic & biomolecular chemistry. 19(30):6687-6691

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100124782471.0x000001&indx=1&recIds=ETOCvdc_100124782471.0x000001

Α‐Triazolylboronic Acids: A Promising Scaffold for Effective Inhibitors of KPCs

Authors: Introvigne, Maria Luisa, Taracila, Magdalena A., Prati, Fabio, Caselli, Emilia, Bonomo, Robert A.

Source: ChemMedChem. 15(14):1283-1288

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107440729.0x000001&indx=1&recIds=ETOCvdc_100107440729.0x000001

Synthesis, characterization and metal coordination of a potential β-lactamase inhibitor: 5-Methyl-2-phenoxymethyl-3-H-imidazole-4-carboxylic acid (PIMA)

Authors: Romagnoli, Chiara, Prati, Fabio, Benassi, Rois, Orteca, Giulia, Saladini, Monica, Ferrari, Erika

Source: In Arabian Journal of Chemistry December 2017 10(8):1061-1069

Negative Epistasis and Evolvability in TEM-1 β-Lactamase—The Thin Line between an Enzyme's Conformational Freedom and Disorder

Authors: Dellus-Gur, Eynat, Elias, Mikael, Caselli, Emilia, Prati, Fabio, Salverda, Merijn L.M., de Visser, J. Arjan G.M., Fraser, James S., Tawfik, Dan S.

Source: In Journal of Molecular Biology 17 July 2015 427(14):2396-2409

A comprehensive and contemporary 'snapshot' of β-lactamases in carbapenem resistant Acinetobacter baumannii

Authors: Hujer, Andrea M., Hujer, Kristine M., Leonard, David A., Powers, Rachel A., Wallar, Bradley J., Mack, Andrew R., Taracila, Magdalena A., Rather, Philip N., Higgins, Paul G., Prati, Fabio, Caselli, Emilia, Marshall, Steven H., Clarke, Thomas, Greco, Christopher, Venepally, Pratap, Brinkac, Lauren, Kreiswirth, Barry N., Fouts, Derrick E., Bonomo, Robert A.

Source: Diagnostic microbiology and infectious disease. 99(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132782648.0x000001&indx=1&recIds=ETOCvdc_100132782648.0x000001

An Easy Route to Enantiomerically Enriched 7- and 8-Hydroxy­stearic Acids by Olefin-Metathesis-Based Approach

Authors: Boga, Carla, Drioli, Sara, Forzato, Cristina, Micheletti, Gabriele, Nitti, Patrizia, Prati, Fabio

Source: Synlett. 27(9):1354-1358

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178979289.0x000001&indx=1&recIds=ETOCvdc_100178979289.0x000001

Paternò–Büchi reaction versus hydrogen abstraction in the photochemical reactivity of alkenyl boronates with benzophenone

Authors: D'Annibale, Andrea, D'Auria, Maurizio, Prati, Fabio, Romagnoli, Chiara, Stoia, Sonia, Racioppi, Rocco, Viggiani, Licia

Source: In Tetrahedron 13 May 2013 69(19):3782-3795

Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography

Authors: Nichols, Derek A., Hargis, Jacqueline C., Sanishvili, Ruslan, Jaishankar, Priyadarshini, Defrees, Kyle, Smith, Emmanuel W., Wang, Kenneth K., Prati, Fabio, Renslo, Adam R., Woodcock, H. Lee

Source: Journal of the American Chemical Society. 137(25):8086-8095

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN601802774&indx=1&recIds=ETOCRN601802774

Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum.

Authors: Powers, Rachel A., June, Cynthia M., Fernando, Micah C., Fish, Erin R., Maurer, Olivia L., Baumann, Rachelle M., Beardsley, Trevor J., Taracila, Magdalena A., Rudin, Susan D., Hujer, Kristine M., Hujer, Andrea M., Santi, Nicolò, Villamil, Valentina, Introvigne, Maria Luisa, Prati, Fabio, Caselli, Emilia, Bonomo, Robert A., Wallar, Bradley J.

Source: Journal of Medicinal Chemistry; 7/13/2023, Vol. 66 Issue 13, p8510-8525, 16p

Fragment-guided design of subnanomolar β-lactamase inhibitors active in vivo

Authors: Eidam, Oliv, Romagnoli, Chiara, Dalmasso, Guillaume, Barelier, Sarah, Caselli, Emilia, Bonnet, Richard, Shoichet, Brian K., Prati, Fabio

Source: Proceedings of the National Academy of Sciences of the United States of America, 2012 Oct . 109(43), 17448-17453.

Access URL: https://www.jstor.org/stable/41829690

Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates.

Authors: Lu, Peggy, Alletto, Francesco, Lee, Bosul, Burk, Elizabeth, Martinez, Jasmine, Prati, Fabio, Caselli, Emilia, Spellberg, Brad, Luna, Brian

Source: PLoS ONE; 6/13/2023, Vol. 18 Issue 6, p1-6, 6p

Subject Terms: KLEBSIELLA pneumoniae, IRON, RIFAMYCINS, ESCHERICHIA coli, ACINETOBACTER baumannii

Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii.

Authors: Introvigne, Maria Luisa, Beardsley, Trevor J., Fernando, Micah C., Leonard, David A., Wallar, Bradley J., Rudin, Susan D., Taracila, Magdalena A., Rather, Philip N., Colquhoun, Jennifer M., Song, Shaina, Fini, Francesco, Hujer, Kristine M., Hujer, Andrea M., Prati, Fabio, Powers, Rachel A., Bonomo, Robert A., Caselli, Emilia

Source: Antibiotics (2079-6382); Apr2023, Vol. 12 Issue 4, p644, 19p

Subject Terms: ACINETOBACTER baumannii, BETA lactamases, CEFTAZIDIME, CARBAPENEMASE, STRUCTURE-activity relationships, GRAM-negative bacteria

Company/Entity: WORLD Health Organization

Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors

Authors: Forghieri, Marco, Laggner, Christian, Paoli, Paolo, Langer, Thierry, Manao, Giampaolo, Camici, Guido, Bondioli, Lucia, Prati, Fabio, Costantino, Luca

Source: In Bioorganic & Medicinal Chemistry 2009 17(7):2658-2672

Structure-based optimization of cephalothin-analogue boronic acids as β-lactamase inhibitors

Authors: Morandi, Stefania, Morandi, Federica, Caselli, Emilia, Shoichet, Brian K., Prati, Fabio

Source: In Bioorganic & Medicinal Chemistry 2008 16(3):1195-1205

Total synthesis of a dienynone from Echinacea pallida

Authors: Morandi, Stefania, Pellati, Federica, Benvenuti, Stefania, Prati, Fabio

Source: In Tetrahedron 2008 64(27):6324-6328

Structure and Dynamics of CTX-M Enzymes Reveal Insights into Substrate Accommodation by Extended-spectrum β-Lactamases

Authors: Delmas, Julien, Chen, Yu, Prati, Fabio, Robin, Frédéric, Shoichet, Brian K., Bonnet, Richard

Source: In Journal of Molecular Biology 2008 375(1):192-201

Probing Active Site Chemistry in SHV β-Lactamase Variants at Ambler Position 244: UNDERSTANDING UNIQUE PROPERTIES OF INHIBITOR RESISTANCE

Authors: Thomson, Jodi M., Distler, Anne M., Prati, Fabio, Bonomo, Robert A.

Source: In Journal of Biological Chemistry 8 September 2006 281(36):26734-26744

Nanomolar β-lactamase inhibitors

Enantiomeric excess of 1,2-diols by formation of cyclic boronates: an improved method

Authors: Morandi, Stefania, Caselli, Emilia, Forni, Arrigo, Bucciarelli, Maria, Torre, Giovanni, Prati, Fabio

Source: In Tetrahedron: Asymmetry 2005 16(17):2918-2926