Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity

Authors: Panarello, Silvia ^{1, 2, 4}, González-Díez, Aleix ^{1, 2, 5}, Berizzi, Alice E. ^{3, 5}, Malhaire, Fanny ³, Borràs-Tudurí, Roser ¹, Rovira, Xavier ¹, Serra, Carme ¹, Prézeau, Laurent ³, Pin, Jean-Philippe ³, Goudet, Cyril ³, Llebaria, Amadeu ^{1, ∗}, Gómez-Santacana, Xavier ^{1, 3, 6, ∗∗}

Source: In iScience 21 June 2024 27(6)

Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists

Authors: Staudt, Markus, Liu, Na, Malhaire, Fanny, Doroudian, Yasaman, Prézeau, Laurent, Renard, Emma, Hasanpour, Zahra, Pin, Jean-Philippe, Bunch, Lennart

Source: In European Journal of Medicinal Chemistry 15 February 2024 266

Heterodimers Revolutionize the Field of Metabotropic Glutamate Receptors

Authors: Belkacemi, Kawthar, Rondard, Philippe, Pin, Jean-Philippe, Prézeau, Laurent

Source: In Neuroscience June 2024

A nanobody activating metabotropic glutamate receptor 4 discriminates between homoand heterodimers

Authors: Haubrich, Jordi, Font, Joan, Quast, Robert B., Goupil-Lamy, Anne, Scholler, Pauline, Nevoltris, Damien, Acher, Francine, Chames, Patrick, Rondard, Philippe, Prézeau, Laurent, Pin, Jean-Philippe

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Aug . 118(33), 1-6.

Access URL: https://www.jstor.org/stable/27074848

Nonclassical Ligand-Independent Regulation of Go Protein by an Orphan Class C G-Protein–Coupled Receptor

Authors: Hajj, Mariana, De Vita, Teresa, Vol, Claire, Renassia, Charlotte, Bologna, Jean-Charles, Brabet, Isabelle, Cazade, Magali, Pastore, Manuela, Blahos, Jaroslav, Labesse, Gilles, Pin, Jean-Philippe, Prézeau, Laurent ^*

Source: In Molecular Pharmacology August 2019 96(2):233-246

GPCR interaction as a possible way for allosteric control between receptors

Authors: Pin, Jean-Philippe, Kniazeff, Julie, Prézeau, Laurent, Liu, Jiang-Feng, Rondard, Philippe

Source: In Molecular and Cellular Endocrinology 15 April 2019 486:89-95

The urotensin II receptor triggers an early meningeal response and a delayed macrophage-dependent vasospasm after subarachnoid hemorrhage in male mice.

Authors: Pedard, Martin, Prevost, Lucie, Carpena, Camille, Holleran, Brian, Desrues, Laurence, Dubois, Martine, Nicola, Celeste, Gruel, Roxane, Godefroy, David, Deffieux, Thomas, Tanter, Mickael, Ali, Carine, Leduc, Richard, Prézeau, Laurent, Gandolfo, Pierrick, Morin, Fabrice, Wurtz, Olivier, Bonnard, Thomas, Vivien, Denis, Castel, Hélène

Source: Nature Communications; 9/29/2024, Vol. 15 Issue 1, p1-27, 27p

Subject Terms: CEREBRAL vasospasm, SUBARACHNOID hemorrhage, CEREBRAL ischemia, COGNITION disorders, TREATMENT effectiveness

The EBI2 receptor is coexpressed with CCR5 in CD4⁺ T cells and boosts HIV-1 R5 replication.

Authors: Guigues, Adeline, Gimenez, Sandrine, Mettling, Clément, Maurel, Damien, Doumazane, Etienne, Prézeau, Laurent, François, Vincent, Corbeau, Pierre

Source: AIDS (02699370); 8/1/2024, Vol. 38 Issue 10, p1449-1459, 11p

Heptahelical Domain of Metabotropic Glutamate Receptor 5 Behaves Like Rhodopsin-like Receptors

Authors: Goudet, Cyril, Gaven, Florence, Kniazeff, Julie, Vol, Claire, Liu, Jiangfeng, Cohen-Gonsaud, Martin, Acher, Francine, Prézeau, Laurent, Pin, Jean Philippe

Source: Proceedings of the National Academy of Sciences of the United States of America, 2004 Jan 01. 101(1), 378-383.

Access URL: https://www.jstor.org/stable/3148428

The EBI2 receptor is coexpressed with CCR5 in CD4+T cells and boosts HIV-1 R5 replication

Authors: Guigues, Adeline, Gimenez, Sandrine, Mettling, Clément, Maurel, Damien, Doumazane, Etienne, Prézeau, Laurent, François, Vincent, Corbeau, Pierre

Source: AIDS; August 2024, Vol. 38 Issue: 10 p1449-1459, 11p

Closure of the Venus Flytrap Module of mGlu8 Receptor and the Activation Process: Insights from Mutations Converting Antagonists into Agonists

Authors: Bessis, Anne-Sophie, Rondard, Philippe, Gaven, Florence, Brabet, Isabelle, Triballeau, Nicolas, Prézeau, Laurent, Acher, Francine, Pin, Jean-Philippe

Source: Proceedings of the National Academy of Sciences of the United States of America, 2002 Aug . 99(17), 11097-11102.

Access URL: https://www.jstor.org/stable/3059528

Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics

Authors: Møller, Thor, Hottin, Jerome, Clerté, Caroline, Zwier, Jurriaan, Durroux, Thierry, Rondard, Philippe, Prézeau, Laurent, Royer, Catherine, Pin, Jean-Philippe, Margeat, Emmanuel, Kniazeff, Julie

Source: Scientific reports. 8(1):1-15

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171373497.0x000001&indx=1&recIds=ETOCvdc_100171373497.0x000001

SGIP1 alters internalization and modulates signaling of activated cannabinoid receptor 1 in a biased manner

Authors: Hájková, Alena, Techlovská, Šárka, Dvořáková, Michaela, Chambers, Jayne Nicole, Kumpošt, Jiří, Hubálková, Pavla, Prezeau, Laurent, Blahos, Jaroslav

Source: In Neuropharmacology August 2016 107:201-214

Post-endocytotic Deubiquitination and Degradation of the Metabotropic γ-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14

Authors: Lahaie, Nicolas, Kralikova, Michaela, Prézeau, Laurent, Blahos, Jaroslav, Bouvier, Michel

Source: In Journal of Biological Chemistry 25 March 2016 291(13):7156-7170

Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)‑2-((S)‑Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu2 Receptor Agonist.

Authors: Liu, Na, Eshak, Floriane, Malhaire, Fanny, Brabet, Isabelle, Prézeau, Laurent, Renard, Emma, Pin, Jean-Philippe, Acher, Francine C., Staudt, Markus, Bunch, Lennart

Source: Journal of Medicinal Chemistry; 1/25/2024, Vol. 67 Issue 2, p1314-1326, 13p

Different EGF‐induced receptor dimer conformations for signaling and internalization.

Authors: Haubrich, Jordi, Zwier, Jurriaan M., Charrier‐Savournin, Fabienne, Prézeau, Laurent, Pin, Jean‐Philippe

Source: FASEB Journal; Jan2024, Vol. 38 Issue 1, p1-14, 14p

G protein‐coupled receptors can control the Hippo/YAP pathway through Gq signaling

Authors: Zindel, Diana, Mensat, Patrick, Vol, Claire, Homayed, Zeinab, Charrier‐Savournin, Fabienne, Trinquet, Eric, Banères, Jean‐Louis, Pin, Jean‐Philippe, Pannequin, Julie, Roux, Thomas, Dupuis, Elodie, Prézeau, Laurent

Source: FASEB journal. 35(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140054821.0x000001&indx=1&recIds=ETOCvdc_100140054821.0x000001

Reversing HIV latency via sphingosine-1-phosphate receptor 1 signaling

Authors: Duquenne, Charline, Gimenez, Sandrine, Guigues, Adeline, Viala, Benjamin, Boulouis, Caroline, Mettling, Clément, Maurel, Damien, Campos, Noëlie, Doumazane, Etienne, Comps-Agrar, Laetitia, Tazi, Jamal, Prézeau, Laurent, Psomas, Christina, Corbeau, Pierre, François, Vincent

Source: AIDS. 31(18):2443-2454

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100050818488.0x000001&indx=1&recIds=ETOCvdc_100050818488.0x000001

Metabotropic glutamate receptor 1 splice variants mGluR1a and mGluR1b combine in mGluR1a/b dimers in vivo

Authors: Techlovská, Šárka, Chambers, Jayne Nicole, Dvořáková, Michaela, Petralia, Ronald S., Wang, Ya-Xian, Hájková, Alena, Nová, Alice, Franková, Daniela, Prezeau, Laurent, Blahos, Jaroslav

Source: In Neuropharmacology November 2014 86:329-336

Quantitative Phosphoproteomics Unravels Biased Phosphorylation of Serotonin 2A Receptor at Ser280 by Hallucinogenic versus Nonhallucinogenic Agonists

Authors: Karaki, Samah, Becamel, Carine, Murat, Samy, Mannoury la Cour, Clotilde ^**, Millan, Mark J. ^**, Prézeau, Laurent, Bockaert, Joël, Marin, Philippe, Vandermoere, Franck

Source: In Molecular & Cellular Proteomics May 2014 13(5):1273-1285