Integrating integrins with the hallmarks of cancer

Authors: Haake, Scott M., Rios, Brenda L., Pozzi, Ambra, Zent, Roy

Source: In Matrix Biology June 2024 130:20-35

Depleting transforming growth factor beta receptor 2 signalling in the cartilage of itga1-null mice attenuates spontaneous knee osteoarthritis

Authors: St Amant, Jennifer, Michaud, Jana, Hinds, Daniel, Coyle, Madison, Pozzi, Ambra, Clark, Andrea L.

Source: In Osteoarthritis and Cartilage Open December 2023 5(4)

The 5-lipoxygenase/cyclooxygenase-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis

Authors: Nakashima, Fumie, Giménez-Bastida, Juan A., Luis, Paula B., Presley, Sai H., Boer, Robert E., Chiusa, Manuel, Shibata, Takahiro, Sulikowski, Gary A., Pozzi, Ambra, Schneider, Claus

Source: In Journal of Biological Chemistry April 2023 299(4)

The soluble epoxide hydrolase inhibitor GSK2256294 decreases the proportion of adipose pro-inflammatory T cells

Authors: Mashayekhi, Mona ^*, Wanjalla, Celestine N., Warren, Christian M., Simmons, Joshua D., Ghoshal, Kakali, Pilkinton, Mark, Bailin, Samuel S., Gabriel, Curtis L., Pozzi, Ambra, Koethe, John R., Brown, Nancy J., Kalams, Spyros A., Luther, J. Matthew

Source: In Prostaglandins and Other Lipid Mediators February 2022 158

Disruption of the integrin-linked kinase (ILK) pseudokinase domain affects kidney development in mice

Authors: Bulus, Nada, Brown, Kyle L., Mernaugh, Glenda, Böttcher, Anika, Dong, Xinyu, Sanders, Charles R., Pozzi, Ambra, Fässler, Reinhard, Zent, Roy

Source: In Journal of Biological Chemistry January-June 2021 296

Treatment of Primary Aldosteronism Increases Plasma Epoxyeicosatrienoic Acids

Authors: Luther, James M., Wei, Dawei S., Ghoshal, Kakali, Peng, Dungeng, Adler, Gail K., Turcu, Adina F., Nian, Hui, Yu, Chang, Solorzano, Carmen C., Pozzi, Ambra, Brown, Nancy J.

Source: Hypertension. 77(4):1323-1331

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176821710.0x000001&indx=1&recIds=ETOCvdc_100176821710.0x000001

Endothelial β1-integrins are necessary for microvascular function and glucose uptake.

Authors: Winn, Nathan C., Roby, Deborah A., McClatchey, P. Mason, Williams, Ian M., Bracy, Deanna P., Bedenbaugh, Michelle N., Lantier, Louise, Plosa, Erin J., Pozzi, Ambra, Zent, Roy, Wasserman, David H.

Source: American Journal of Physiology: Endocrinology & Metabolism; Dec2024, Vol. 327 Issue 6, pE746-E759, 14p

Subject Terms: CAPILLARY flow, EXERCISE tolerance, INSULIN resistance, GENE knockout, EMBRYOLOGY

The laminin binding α3 and α6 integrins cooperate to promote epithelial cell adhesion and growth

Authors: Yazlovitskaya, Eugenia M., Viquez, Olga M., Tu, Tianxiang, De Arcangelis, Adele, Georges-Labouesse, Elisabeth, Sonnenberg, Arnoud, Pozzi, Ambra, Zent, Roy

Source: In Matrix Biology April 2019 77:101-116

Cytochrome P450 epoxygenases and cancer: A genetic and a molecular perspective

Authors: Sausville, Lindsay N., Williams, Scott M., Pozzi, Ambra

Source: In Pharmacology and Therapeutics April 2019 196:183-194

Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCδ Axis.

Authors: Ghoshal, Kakali, Luther, James M., Pakala, Suman B., Chetyrkin, Sergei, Falck, John R., Zent, Roy, Wasserman, David H., Pozzi, Ambra

Source: Diabetes; Aug2024, Vol. 73 Issue 8, p1229-1243, 15p

Subject Terms: LIPID metabolism, INSULIN, UNSATURATED fatty acids, GLUCOSE intolerance, INSULIN sensitivity, OXYGENASES

Sulfenylation of Human Liver and Kidney Microsomal Cytochromes P450 and Other Drug-Metabolizing Enzymes as a Response to Redox Alteration

Authors: Albertolle, Matthew E. ^‡, Phan, Thanh T.N. ^‡, Pozzi, Ambra ^{§, ¶}, Guengerich, F. Peter ^{‡, ‖}

Source: In Molecular & Cellular Proteomics May 2018 17(5):889-900

Heme–thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition

Authors: Albertolle, Matthew E., Kim, Donghak, Nagy, Leslie D., Yun, Chul-Ho, Pozzi, Ambra ^**, Savas, Üzen, Johnson, Eric F., Guengerich, F. Peter

Source: In Journal of Biological Chemistry 7 July 2017 292(27):11230-11242

Elevated Matrix Metalloprotease and Angiostatin Levels in Integrin α 1 Knockout Mice Cause Reduced Tumor Vascularization

Authors: Pozzi, Ambra, Moberg, Philip E., Miles, Lindsey A., Wagner, Simone, Soloway, Paul, Gardner, Humphrey A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2000 Feb . 97(5), 2202-2207.

Access URL: https://www.jstor.org/stable/122020

Progression of chronic kidney disease: too much cellular talk causes damage

Authors: Gewin, Leslie, Zent, Roy, Pozzi, Ambra

Source: In Kidney International March 2017 91(3):552-560

The nature and biology of basement membranes

Authors: Pozzi, Ambra, Yurchenco, Peter D., Iozzo, Renato V.

Source: In Matrix Biology January 2017 57-58:1-11

Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis

Authors: Borza, Corina M., Su, Yan, Tran, Truc-Linh, Yu, Ling, Steyns, Nick, Temple, Kayla J., Skwark, Marcin J., Meiler, Jens, Lindsley, Craig W., Hicks, Brennan R., Leitinger, Birgit, Zent, Roy, Pozzi, Ambra

Source: In Matrix Biology January 2017 57-58:258-271

Integrin alpha6 maintains the structural integrity of the kidney collecting system

Authors: Viquez, Olga M., Yazlovitskaya, Eugenia M., Tu, Tianxiang, Mernaugh, Glenda, Secades, Pablo, McKee, Karen K., Georges-Labouesse, Elizabeth, De Arcangelis, Adele, Quaranta, Vito, Yurchenco, Peter, Gewin, Leslie C., Sonnenberg, Arnoud, Pozzi, Ambra, Zent, Roy

Source: In Matrix Biology January 2017 57-58:244-257

Integrin α1β1 Mediates a Unique Collagen-Dependent Proliferation Pathway in vivo

Authors: Pozzi, Ambra, Wary, Kishore K., Giancotti, Filippo G., Gardner, Humphrey A.

Source: The Journal of Cell Biology, 1998 Jul . 142(2), 587-594.

Access URL: https://www.jstor.org/stable/1618805

Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains

Authors: Brown, Kyle, Banerjee, Surajit, Feigley, Andrew, Abe, Hanna, Blackwell, Timothy, Pozzi, Ambra, Hudson, Billy, Zent, Roy

Source: Scientific reports. 8(1):1-14

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112267088.0x000001&indx=1&recIds=ETOCvdc_100112267088.0x000001

p47phox contributes to albuminuria and kidney fibrosis in mice

Authors: Wang, Hongtao, Chen, Xiwu, Su, Yan, Paueksakon, Paisit, Hu, Wen, Zhang, Ming-Zhi, Harris, Raymond C., Blackwell, Timothy S., Zent, Roy, Pozzi, Ambra ^*

Source: In Kidney International May 2015 87(5):948-962