Monoclonal antibodies against GFRα3 are efficacious against evoked hyperalgesic and allodynic responses in mouse join pain models but, one of these, REGN5069, was not effective against pain in a randomized, placebo-controlled clinical trial in patients with osteoarthritis pain

Authors: Somersan-Karakaya, Selin, Turner, Kenneth C., Cortes-Burgos, Luz, Miller, Jutta, LaCroix-Fralish, Michael, Logovinsky, Veronika, Patel, Yamini, Torres, Richard, Ganguly, Samit, Breazna, Aurora, DeVeaux, Michelle, Bhore, Rafia, Gao, Min, Delfino, Frank J., Rafique, Ashique, Fairhurst, Jeanette L., Hunt, Charleen, Babb, Robert, Badithe, Ashok, Poueymirou, William T., Surowitz, Ronald, Rottey, Sylvie, Murphy, Andrew J., Harari, Olivier, Macdonald, Lynn E., Croll, Susan D.

Source: In Neurobiology of Pain August-December 2023 14

Detection and Transmission of Proteus mirabilis in Immunodeficient Mice

Authors: Tierce, Rebecca K., Winn, Adrienne A., Albers, Theresa M., Poueymirou, William T., Levee, Ellen M., Woods, Stephanie E., Reddyjarugu, Balu

Source: Journal of the American Association for Laboratory Animal Science. 61(3):256-269

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629516851&indx=1&recIds=ETOCRN629516851

Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties

Authors: Macdonald, Lynn E., Meagher, Karoline A., Franklin, Matthew C., Levenkova, Natasha, Hansen, Johanna, Badithe, Ashok T., Zhong, Maggie, Krueger, Pamela, Rafique, Ashique, Tu, Naxin, Shevchuk, James, Wadhwa, Saurabh, Ehrlich, George, Bautista, Joannie, Grant, Craig, Esau, Lakeisha, Poueymirou, William T., Auerbach, Wojtek, Morton, Lori, Babb, Robert, Chen, Gang, Huang, Tammy, MacDonald, Douglas, Graham, Kenneth, Gurer, Cagan, Voronina, Vera A., McWhirter, John R., Guo, Chunguang, Yancopoulos, George D., Murphy, Andrew J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Jan 01. 117(1), 292-299.

Access URL: https://www.jstor.org/stable/26897465

Resistance to Diet-Induced Obesity in Mice Globally Overexpressing OGH/GPB5

Authors: MacDonald, Lynn E., Wortley, Katherine E., Gowen, Lori C., Anderson, Keith D., Murray, Jane D., Poueymirou, William T., Simmons, Mary V., Barber, Dianna, Valenzuela, David M., Economides, Aris N., Wiegand, Stanley J., Yancopoulos, George D., Sleeman, Mark W., Murphy, Andrew J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Feb . 102(7), 2496-2501.

Access URL: https://www.jstor.org/stable/3374644

Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

Authors: Bodine, Sue C., Latres, Esther, Baumhueter, Susanne, Nunez, Lorna, Clarke, Brian A., Poueymirou, William T., Panaro, Frank J., Na, Erqian, Dharmarajan, Kumar, Pan, Zhen-Qiang, Valenzuela, David M., DeChiara, Thomas M., Stitt, Trevor N., Yancopoulos, George D., Glass, David J.

Source: Science, 2001 Nov . 294(5547), 1704-1708.

Access URL: https://www.jstor.org/stable/3085298

Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes

Authors: Macdonald, Lynn E., Karow, Margaret, Stevens, Sean, Auerbach, Wojtek, Poueymirou, William T., Yasenchak, Jason, Frendewey, David, Valenzuela, David M., Giallourakis, Cosmas C., Alt, Frederick W., Yancopoulos, George D., Murphy, Andrew J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Apr 01. 111(14), 5147-5152.

Access URL: https://www.jstor.org/stable/23771379

Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice

Authors: Murphy, Andrew J., Macdonald, Lynn E., Stevens, Sean, Karow, Margaret, Dore, Anthony T., Pobursky, Kevin, Huang, Tammy T., Poueymirou, William T., Esau, Lakeisha, Meola, Melissa, Mikulka, Warren, Krueger, Pamela, Fairhurst, Jeanette, Valenzuela, David M., Papadopoulos, Nicholas, Yancopoulos, George D.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Apr 01. 111(14), 5153-5158.

Access URL: https://www.jstor.org/stable/23771380

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

Authors: Rathinam, Chozhavendan, Poueymirou, William T., Rojas, Jose, Murphy, Andrew J., Valenzuela, David M., Yancopoulos, George D., Rongvaux, Anthony, Eynon, Elizabeth E., Manz, Markus G., Flavell, Richard A.

Source: In Blood 15 September 2011 118(11):3119-3128

Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth.

Authors: DeChiara, Thomas M., Vejsada, Richard, Poueymirou, William T.

Source: Cell; October 20 1995, Vol. 83, p313-322, 10p

F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses.

Authors: Poueymirou, William T., Auerbach, Wojtek, Frendewer, David

Source: Nature Biotechnology; January 2007, Vol. 25 Issue 1, p91-99, 9p

Differential effects of activators of cAMP-dependent protein kinase and protein kinase C on cleavage of one-cell mouse embryos and protein synthesis and phosphorylation in one- and two-cell embryos.

Authors: Poueymirou, William T., Schultz, Richard M.

Source: Developmental Biology; June 1987, Vol. 121, p489-498, 10p

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis.

Authors: Valenzuela, David M, Murphy, Andrew J, Frendewey, David, Gale, Nicholas W, Economides, Aris N, Auerbach, Wojtek, Poueymirou, William T, Adams, Niels C, Rojas, Jose, Yasenchak, Jason, Chernomorsky, Rostislav, Boucher, Marylene, Elsasser, Andrea L, Esau, Lakeisha, Zheng, Jenny, Griffiths, Jennifer A, Wang, Xiaorong, Su, Hong, Xue, Yingzi

Source: Nature Biotechnology; Jun2003, Vol. 21 Issue 6, p652, 8p

Chapter 16 - Producing Fully ES Cell-Derived Mice from Eight-Cell Stage Embryo Injections

Authors: DeChiara, Thomas M., Poueymirou, William T., Auerbach, Wojtek, Frendewey, David, Yancopoulos, George D., Valenzuela, David M.

Source: In Methods in Enzymology 2010 476:285-294

Deletion of Adam6in Mus musculusleads to male subfertility and deficits in sperm ascent into the oviduct

Authors: Voronina, Vera A, Harris, Faith M, Schmahl, Jennifer, Galligan, Caryn, Oristian, Daniel, Zamfirova, Ralica, Gong, Guochun, Bai, Yu, Fury, Wen, Rajamani, Saathyaki, Walls, Johnathon R, Poueymirou, William T, Esau, Lakeisha, Gale, Nicholas W, Auerbach, Wojtek, Murphy, Andrew J, Macdonald, Lynn E

Source: Biology of Reproduction; March 2019, Vol. 100 Issue: 3 p686-696, 11p

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

VelociMouse: Fully ES Cell-Derived F0-Generation Mice Obtained from the Injection of ES Cells into Eight-Cell-Stage Embryos.

Authors: DeChiara, Thomas M., Poueymirou, William T., Auerbach, Wojtek, Frendewey, David, Yancopoulos, George D., Valenzuela, David M.

Source: Gene Knockout Protocols (9781934115268); 2009, p311-324, 14p

Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy.

Authors: Lai, Ka-Man V., Gonzalez, Michael, Poueymirou, William T., Kline, William O., Na, Erqian, Zlotchenko, Elizabeth, Stitt, Trevor N., Economides, Aris N., Yancopoulos, George D., Glass, David J.

Source: Molecular & Cellular Biology; Nov2004, Vol. 24 Issue 21, p9295-9304, 10p, 4 Color Photographs, 1 Black and White Photograph, 1 Diagram, 5 Graphs

Subject Terms: MUSCULAR atrophy, HYPERTROPHY, TRANSGENIC mice, PROTEIN kinases, ADIPOSE tissues, NEUROMUSCULAR diseases, CYTOLOGY

Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development.

Authors: DeChiara, Thomas M., Kimble, Robert B., Poueymirou, William T., Rojas, Jose, Masiakowski, Piotr, Valenzuela, David M., Yancopoulos, George D.

Source: Nature Genetics; Mar2000, Vol. 24 Issue 3, p271, 4p

Subject Terms: PROTEIN-tyrosine kinases, CELL lines

Regulation of mouse preimplantation development: Inhibitory effect of the calmodulin antagonist W-7 on the first cleavage.

Authors: Poueymirou, William T., Schultz, Richard M.

Source: Molecular Reproduction & Development; 1990, Vol. 26 Issue 3, p211-216, 6p