SARS-CoV-2-ORF-3a Mediates Apoptosis Through Mitochondrial Dysfunction Modulated by the K + Ion Channel.

Authors: Qudus, Muhammad Suhaib¹ (AUTHOR), Afaq, Uzair^1,2 (AUTHOR), Liu, Siyu¹ (AUTHOR), Wu, Kailang^1,2 (AUTHOR), Yu, Chen¹ (AUTHOR) jwu@whu.edu.cn, Tian, Mingfu¹ (AUTHOR), Wu, Jianguo^1,2 (AUTHOR)

Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 4, p1575. 27p.

Subject Terms: *COVID-19, *POTASSIUM channels, *ION channels, *PYROPTOSIS, *PULMONARY edema, *POTASSIUM chloride

The Synergistic Impact of Glycolysis, Mitochondrial OxPhos, and PEP Cycling on ATP Production in Beta Cells.

Authors: Grubelnik, Vladimir¹ (AUTHOR), Zmazek, Jan² (AUTHOR), Marhl, Marko^2,3,4 (AUTHOR) marko.marhl@um.si

Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 4, p1454. 17p.

Subject Terms: *PANCREATIC beta cells, *POTASSIUM channels, *OXIDATIVE phosphorylation, *CYTOSOL, *SECRETION, *MITOCHONDRIA, *GLYCOLYSIS

Discovery of a Novel Insecticidal Peptide with a Cystine-Stabilized α-Helix/α-Helix Motif from the Venom of Scorpion Liocheles australasiae.

Authors: Miyashita, Masahiro¹ (AUTHOR) miyashita.masahiro.6e@kyoto-u.ac.jp, Mitani, Naoya¹ (AUTHOR), Iwamoto, Fuki¹ (AUTHOR), Hirota, Mitsuki¹ (AUTHOR), Nakagawa, Yoshiaki¹ (AUTHOR)

Source: Molecules. Jan2025, Vol. 30 Issue 1, p32. 12p.

Subject Terms: *AMINO acid residues, *POTASSIUM channels, *PEPTIDES, *SCORPION venom, *SPIDER venom, *SCORPIONS

Study of charmonium decays to KS⁰Kπ in the B → (KS⁰Kπ)K channels.

Authors: Palano, Antimo¹ antimo.palano@ba.infn.it

Source: EPJ Web of Conferences. 12/10/2024, Vol. 314, p1-7. 7p.

Subject Terms: *CHARMONIUM, *POTASSIUM channels, *PROTON-proton interactions, *ELASTICITY, *MASS spectrometry

Nitric Oxide and Small and Intermediate Calcium-Activated Potassium Channels Mediate the Vasodilation Induced by Apigenin in the Resistance Vessels of Hypertensive Rats.

Authors: Klider, Lislaine Maria^1,2 (AUTHOR) lis_klider19@hotmail.com, da Silva, Maria Luiza Fidelis² (AUTHOR), da Silva, Gustavo Ratti³ (AUTHOR) gustavo_ratti@hotmail.com, da Costa, João Ricardo Cray⁴ (AUTHOR) joao.cray@edu.unipar.br, Marques, Marcia Alessandra Arantes³ (AUTHOR) doutoramarciamarques@gmail.com, Lourenço, Emerson Luiz Botelho^3,4 (AUTHOR) emerson@prof.unipar.br, Lívero, Francislaine Aparecida dos Reis^1,3,4 (AUTHOR), Manfron, Jane⁵ (AUTHOR) janemanfron@hotmail.com, Gasparotto Junior, Arquimedes^1,2,4 (AUTHOR) arquimedesgasparotto@gmail.com

Source: Molecules. Nov2024, Vol. 29 Issue 22, p5425. 10p.

Subject Terms: *CALCIUM-dependent potassium channels, *POTASSIUM antagonists, *POTASSIUM channels, *VASCULAR resistance, *APIGENIN

Axons compensate for biophysical constraints of variable size to uniformize their action potentials.

Authors: Brunner, János¹ (AUTHOR), Arszovszki, Antónia¹ (AUTHOR), Tarcsay, Gergely¹ (AUTHOR), Szabadics, János¹ (AUTHOR) szabadics.janos@koki.hun-ren.hu

Source: PLoS Biology. 12/2/2024, Vol. 22 Issue 12, p1-21. 21p.

Subject Terms: *ACTION potentials, *POTASSIUM channels, *AXONS, *HIPPOCAMPUS (Brain), *NEURONS

Computational engineering of water-soluble human potassium ion channels through QTY transformation.

Authors: Smorodina, Eva¹ (AUTHOR), Tao, Fei² (AUTHOR), Qing, Rui² (AUTHOR), Yang, Steve³ (AUTHOR), Zhang, Shuguang⁴ (AUTHOR) shuguang@mit.edu

Source: Scientific Reports. 11/15/2024, Vol. 14 Issue 1, p1-24. 24p.

Subject Terms: *POTASSIUM channels, *ION channels, *ION transport (Biology), *MEMBRANE proteins, *POTASSIUM ions

A case of a 6-year-old girl with a rare compound heterozygous mutation of KCTD7 presenting with progressive myoclonic epilepsy.

Authors: Badv, Reza Shervin¹ (AUTHOR), Shariatmadari, Fakhreddin^1,2 (AUTHOR), Bayat, Shiva³ (AUTHOR), Memarian, Sara¹ (AUTHOR), Esteghamat Hanzae, Samaneh¹ (AUTHOR), Yousefimanesh, Hossein¹ (AUTHOR) Yousefimaneshhossein@gmail.com

Source: Egyptian Journal of Medical Human Genetics. 11/4/2024, Vol. 25 Issue 1, p1-4. 4p.

Subject Terms: *MYOCLONUS, *POTASSIUM channels, *ETIOLOGY of diseases, *GENETIC disorder diagnosis, *EPILEPSY

Toxicity of Flonicamid to Diaphorina citri (Hemiptera: Liviidae) and Its Identification and Expression of Kir Channel Genes.

Authors: Zhu, Jiangyue¹ (AUTHOR) zhujiangyue0612@163.com, Wang, Xinjing¹ (AUTHOR), Mo, Yunfei¹ (AUTHOR), Wu, Beibei¹ (AUTHOR), Yi, Tuyong¹ (AUTHOR) yituyong@hunau.net, Yang, Zhongxia¹ (AUTHOR) yituyong@hunau.net

Source: Insects (2075-4450). Nov2024, Vol. 15 Issue 11, p900. 12p.

Subject Terms: *INSECT genes, *POTASSIUM channels, *MOLECULAR cloning, *DRUG target, *INSECTICIDES, *CITRUS greening disease

Voltage-Gated Ion Channel Compensatory Effect in DEE: Implications for Future Therapies.

Authors: Shabani, Khadijeh¹ (AUTHOR) dania.shabani@gmail.com, Krupp, Johannes¹ (AUTHOR), Lemesre, Emilie¹ (AUTHOR), Lévy, Nicolas¹ (AUTHOR), Tran, Helene¹ (AUTHOR) dania.shabani@gmail.com

Source: Cells (2073-4409). Nov2024, Vol. 13 Issue 21, p1763. 15p.

Subject Terms: *SODIUM channels, *POTASSIUM channels, *CALCIUM channels, *PHENOTYPIC plasticity, *INTELLECTUAL disabilities, *VOLTAGE-gated ion channels, *ION channels

Functional characterization of KCNMA1 mutation associated with dyskinesia, seizure, developmental delay, and cerebellar atrophy.

Authors: Yucesan, Emrah¹ (AUTHOR) emrah.yucesan@iuc.edu.tr, Goncu, Beyza^2,3 (AUTHOR), Ozgul, Cemil⁴ (AUTHOR), Kebapci, Arda⁴ (AUTHOR), Aslanger, Ayca Dilruba⁵ (AUTHOR), Akyuz, Enes⁶ (AUTHOR), Yesil, Gozde⁵ (AUTHOR)

Source: International Journal of Neuroscience. Oct2024, Vol. 134 Issue 10, p1098-1103. 6p.

Subject Terms: *GAIN-of-function mutations, *CALCIUM-dependent potassium channels, *DEVELOPMENTAL delay, *CELL physiology, *CHROMOSOMES

Beta-adrenergic receptor stimulation, histamine receptor inhibition, and potassium channel opening contribute to the relaxant effects of crocetin on airway smooth muscle.

Authors: Behrouz, Sepideh^1,2, Memarzia, Arghavan^1,2, Eshaghi Ghalibaf, Mohammad Hossein^1,2,3, Boskabady, Mohammad Hossein^1,2 boskabadymh@mums.ac.ir

Source: Iranian Journal of Basic Medical Sciences. Oct2024, Vol. 27 Issue 10, p1317-1322. 6p.

Subject Terms: *HISTAMINE receptors, *POTASSIUM channels, *BETA adrenoceptors, *PROPRANOLOL, *SMOOTH muscle, *THEOPHYLLINE, *LABORATORY rats

Transcriptome analyses reveal common immune system dysregulation in PAH patients and Kcnk3‐deficient rats.

Authors: Ruffenach, Grégoire¹ (AUTHOR), Le Ribeuz, Hélène^2,3 (AUTHOR), Dutheil, Mary^2,3,4 (AUTHOR), El Jekmek, Kristell^2,3 (AUTHOR), Dumont, Florent^2,5 (AUTHOR), Willer, Anaïs Saint‐Martin^2,3 (AUTHOR), Humbert, Marc^2,3,6 (AUTHOR), Capuano, Véronique^2,3,4 (AUTHOR), Medzikovic, Lejla¹ (AUTHOR), Eghbali, Mansoureh¹ (AUTHOR), Montani, David^2,3,4,6 (AUTHOR), Antigny, Fabrice^2,3 (AUTHOR) fabrice.antigny@inserm.fr

Source: Pulmonary Circulation. Oct2024, Vol. 14 Issue 4, p1-11. 11p.

Subject Terms: *PULMONARY arterial hypertension, *POTASSIUM channels, *PROTEIN-tyrosine kinases, *PULMONARY circulation, *ARTERIAL occlusions

Shaker/Kv1 potassium channel SHK-1 protects against pathogen infection and oxidative stress in C. elegans.

Authors: Pu, Longjun^1,2,3, longjun.pu@umu.se, Wang, Jing^1,2,3, Nilsson, Lars^1,2,3, Zhao, Lina^1,2,3, Williams, Chloe⁴, Chi, Guanqiao⁵, Gilthorpe, Jonathan D⁴, Tuck, Simon⁴, Henriksson, Johan^1,6,7,8, Tang, Yi-Quan⁵, longjun.pu@umu.se, Nyunt Wai, Sun^1,6,8, yqtang@fudan.edu.cn, Chen, Changchun^1,2,3, sun.nyunt.wai@umu.se

Source: PLoS Genetics; 2/6/2025, Vol. 21 Issue 2, p1-24, 24p

Mechanisms and optogenetic control of rhythm slowing associated with Alzheimer's disease: some views from dynamical modeling.

Authors: Shen, Zhuan^1,2, Zhang, Honghui^1,2, Du, Lin^1,2, lindu@nwpu.edu.cn, Zhang, Ya^1,2, Sun, Xiaojuan³

Source: Nonlinear Dynamics; Jul2024, Vol. 112 Issue 13, p11637-11659, 23p

ACYP2 functions as an innovative nano-therapeutic target to impede the progression of hepatocellular carcinoma by inhibiting the activity of TERT and the KCNN4/ERK pathway.

Authors: Wu, Yixuan^1,2 (AUTHOR), Bao, Hongyi^1,2 (AUTHOR), Wu, Jinran^1,2 (AUTHOR), Chen, Bairong^1,2 (AUTHOR), Xu, Jing^1,2 (AUTHOR), Jin, Kangfeng^1,2 (AUTHOR), Chen, Lin³ (AUTHOR) xiaobei227@sina.com, Zhu, Guang⁴ (AUTHOR) gzhu@ust.hk, Wang, Feng^1,2 (AUTHOR) richardwangf@163.com

Source: Journal of Nanobiotechnology. 9/12/2024, Vol. 22 Issue 1, p1-22. 22p.

Subject Terms: *TELOMERASE reverse transcriptase, *CALCIUM-dependent potassium channels, *CELL nuclei, *HEPATOCELLULAR carcinoma, *CELL membranes, *CALCIUM channels

Identification of Shaker Potassium Channel Family Members and Functional Characterization of SsKAT1.1 in Stenotaphrum secundatum Suggest That SsKAT1.1 Contributes to Cold Resistance.

Authors: Hao, Dong-Li¹ (AUTHOR) haodongli@jib.ac.cn, Qu, Jia² (AUTHOR) 22220953000028@hainanu.edu.cn, Wang, Zhi-Yong² (AUTHOR) wangzhiyong@hainanu.edu.cn, Sun, Dao-Jin¹ (AUTHOR) sundaojin@jib.ac.cn, Yang, Sheng-Nan² (AUTHOR) 23210834000011@hainanu.edu.cn, Liu, Jian-Xiu¹ (AUTHOR) turfunit@cnbg.net, Zong, Jun-Qin¹ (AUTHOR) zongjunqin@jib.ac.cn, Lu, Hai-Long¹ (AUTHOR) zongjunqin@jib.ac.cn

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9480. 18p.

Subject Terms: *POTASSIUM channels, *FOXTAIL millet, *CELL membranes, *BLOOD proteins, *MEMBRANE proteins

Relaxing actions of carvacrol on isolated rat duodenum smooth muscles: Evidence for the role of potassium ion channels.

Authors: YUSUF, Muhammed¹ ecz.muhammed.yusuf@gmail.com, AYDIN, Süleyman¹

Source: Journal of Research in Pharmacy. 2024, Vol. 28 Issue 5, p1501-1507. 7p.

Subject Terms: *POTASSIUM channels, *POTASSIUM antagonists, *ION channels, *ACTION potentials, *SMOOTH muscle

Effect of aortic smooth muscle BK channels on mediating chronic intermittent hypoxia-induced vascular dysfunction.

Authors: Ping Zhang¹, Pengtao Zou², Xiao Huang², Xianghui Zeng³, Songtao Liu², Yuanyuan Liu², Liang Shao² shaojing@ncmc.edu.cn

Source: Korean Journal of Physiology & Pharmacology. Sep2024, Vol. 28 Issue 5, p469-478. 10p.

Subject Terms: *CALCIUM-dependent potassium channels, *DIASTOLIC blood pressure, *SYSTOLIC blood pressure, *ARTERIAL diseases, *ENDOTHELIUM diseases

Diversely evolved xibalbin variants from remipede venom inhibit potassium channels and activate PKA-II and Erk1/2 signaling.

Authors: Pinheiro-Junior, Ernesto Lopes¹ (AUTHOR), Alirahimi, Ehsan² (AUTHOR), Peigneur, Steve¹ (AUTHOR), Isensee, Jörg² (AUTHOR), Schiffmann, Susanne³ (AUTHOR), Erkoc, Pelin^4,5 (AUTHOR), Fürst, Robert^4,5 (AUTHOR), Vilcinskas, Andreas^5,6 (AUTHOR), Sennoner, Tobias⁷ (AUTHOR), Koludarov, Ivan⁷ (AUTHOR), Hempel, Benjamin-Florian⁸ (AUTHOR), Tytgat, Jan¹ (AUTHOR), Hucho, Tim² (AUTHOR), von Reumont, Björn M.^5,9 (AUTHOR) bmvr@reumont.net

Source: BMC Biology. 7/29/2024, Vol. 22 Issue 1, p1-27. 27p.

Subject Terms: *POTASSIUM channels, *VENOM, *SODIUM channels, *CALCIUM channels, *POTASSIUM antagonists, *SENSORY neurons