Safety and Biological Activity of Rozibafusp alfa, a Bispecific Inhibitor of Inducible Costimulator Ligand and B Cell Activating Factor, in Patients With Rheumatoid Arthritis: Results of a Phase 1b, Randomized, Double‐Blind, Placebo‐Controlled, Multiple Ascending Dose Study

Authors: Abuqayyas, Lubna, Cheng, Laurence E., Teixeira dos Santos, Marcia, Sullivan, Barbara A., Ruiz‐Santiago, Norma, Wang, Hui, Zhou, Yanchen, Chindalore, Vishala, Cohen, Stanley, Kivitz, Alan J., Posch, Maximilian G., Parnes, Jane R.

Source: ACR open rheumatology. 4(10):903-911

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181411540.0x000001&indx=1&recIds=ETOCvdc_100181411540.0x000001

Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, double-blind, placebo-controlled trial.

Authors: Walther, Niklas, Schultz-Heienbrok, Robert, Staß, Heino, Corman, Victor M., Gassen, Nils C., Müller, Marcel A., Drosten, Christian, Witzenrath, Martin, Lee, Hweeling, Posch, Maximilian G.

Source: PLoS ONE; 2/25/2025, Vol. 20 Issue 2, p1-20, 20p

Subject Terms: POLYETHYLENE glycol, VIRUS diseases, DRUG addiction, PHARMACOKINETICS, VOLUNTEERS

Phase 1 Trials of Gatralimab, a Next-Generation Humanized Anti-CD52 Monoclonal Antibody, in Participants with Progressive Multiple Sclerosis.

Authors: Albach, Fredrik N., Geier, Christian, Keicher, Christian, Posch, Maximilian G., Schreiber, Stephan J., Grütz, Gerald, Akyüz, Levent, Luo, Xiaodong, Le-Halpere, Annaig, Truffinet, Philippe, Wagner, Frank

Source: Neurology & Therapy; Dec2024, Vol. 13 Issue 6, p1607-1625, 19p

Subject Terms: GRAVES' disease, REGULATORY T cells, MULTIPLE sclerosis, LYMPHOCYTES, MONOCLONAL antibodies

An open-label phase 2a study investigating the efficacy and safety of a cathepsin S inhibitor in patients with moderate-to-severe psoriasis

Authors: Gadola, Stephan D., Färber, Petra, Posch, Maximilian G., Nagel, Sandra, Canducci, Filippo

Source: Journal of the American Academy of Dermatology. 87(5):1089-1091

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172556475.0x000001&indx=1&recIds=ETOCvdc_100172556475.0x000001

Assessment of the anti-CD40 antibody iscalimab in patients with primary Sjögren's syndrome: a multicentre, randomised, double-blind, placebo-controlled, proof-of-concept study

Authors: Fisher, Benjamin A, Szanto, Antonia, Ng, Wan-Fai, Bombardieri, Michele, Posch, Maximilian G, Papas, Athena S, Farag, Arwa M, Daikeler, Thomas, Bannert, Bettina, Kyburz, Diego, Kivitz, Alan J, Carsons, Steven E, Isenberg, David A, Barone, Francesca, Bowman, Simon J, Espié, Pascal, Floch, David, Dupuy, Cyrielle, Ren, Xiaohui ^*, Faerber, Petra M, Wright, Andrew M, Hockey, Hans-Ulrich, Rotte, Michael, Milojevic, Julie, Avrameas, Alexandre, Valentin, Marie-Anne, Rush, James S, Gergely, Peter ^*

Source: In The Lancet Rheumatology March 2020 2(3):e142-e152

MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study

Authors: Ambery, Philip, Parker, Victoria E, Stumvoll, Michael, Posch, Maximilian G, Heise, Tim, Plum-Moerschel, Leona, Tsai, Lan-Feng, Robertson, Darren, Jain, Meena, Petrone, Marcella, Rondinone, Cristina, Hirshberg, Boaz, Jermutus, Lutz

Source: In The Lancet 30 June-6 July 2018 391(10140):2607-2618

Efficacy, Safety, and Mechanistic Insights of Cotadutide, a Dual Receptor Glucagon-Like Peptide-1 and Glucagon Agonist

Authors: Parker, Victoria E R, Robertson, Darren, Wang, Tao, Hornigold, David C, Petrone, Marcella, Cooper, Aidan T, Posch, Maximilian G, Heise, Tim, Plum-Moerschel, Leona, Schlichthaar, Heike, Klaus, Beate, Ambery, Philip D, Meier, Juris J, Hirshberg, Boaz

Source: Journal of clinical endocrinology & metabolism. 105(3):803-820

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136536422.0x000001&indx=1&recIds=ETOCvdc_100136536422.0x000001

A novel dual glucagon‐like peptide and glucagon receptor agonist SAR425899: Results of randomized, placebo‐controlled first‐in‐human and first‐in‐patient trials

Authors: Tillner, Joachim, Posch, Maximilian G., Wagner, Frank, Teichert, Lenore, Hijazi, Youssef, Einig, Christine, Keil, Stefanie, Haack, Torsten, Wagner, Michael, Bossart, Martin, Larsen, Philip J.

Source: Diabetes, obesity & metabolism. 21(1):120-128

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100076273688.0x000001&indx=1&recIds=ETOCvdc_100076273688.0x000001

Depression, anxiety, and quality of life as predictors of rehospitalization in patients with chronic heart failure.

Authors: Veskovic, Jovan, Cvetkovic, Mina, Tahirovic, Elvis, Zdravkovic, Marija, Apostolovic, Svetlana, Kosevic, Dragana, Loncar, Goran, Obradovic, Danilo, Matic, Dragan, Ignjatovic, Aleksandra, Cvetkovic, Tatjana, Posch, Maximilian G., Radenovic, Sara, Ristić, Arsen D., Dokic, Danilo, Milošević, Nenad, Panic, Natasa, Düngen, Hans-Dirk

Source: BMC Cardiovascular Disorders; 10/27/2023, Vol. 23 Issue 1, p1-11, 11p

Subject Terms: PATIENT readmissions, HEART failure patients, QUALITY of life, CHRONIC obstructive pulmonary disease, ANXIETY

First-in-Human Study of the Safety, Pharmacokinetics, and Pharmacodynamics of MHV370, a Dual Inhibitor of Toll-Like Receptors 7 and 8, in Healthy Adults.

Authors: Shisha, Tamas, Posch, Maximilian G., Lehmann, Jeanette, Feifel, Roland, Junt, Tobias, Hawtin, Stuart, Schuemann, Jens, Avrameas, Alexandre, Danekula, Rambabu, Misiolek, Patrycja, Siegel, Richard, Gergely, Peter

Source: European Journal of Drug Metabolism & Pharmacokinetics; Sep2023, Vol. 48 Issue 5, p553-566, 14p

Genetic deletion of arginine 14 in phospholamban causes dilated cardiomyopathy with attenuated electrocardiographic R amplitudes

Authors: Posch, Maximilian G., Perrot, Andreas, Geier, Christian, Boldt, Leif-Hendrik, Schmidt, Gunther, Lehmkuhl, Hans B., Hetzer, Roland, Dietz, Rainer, Gutberlet, Matthias, Haverkamp, Wilhelm, Özcelik, Cemil

Source: In Heart Rhythm 2009 6(4):480-486

A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy

Authors: Posch, Maximilian G., Posch, Matthias J., Geier, Christian, Erdmann, Bettina, Mueller, Wolf, Richter, Anette, Ruppert, Volker, Pankuweit, Sabine, Maisch, Bernhard, Perrot, Andreas, Buttgereit, Jens, Dietz, Rainer, Haverkamp, Wilhelm, Özcelik, Cemil

Source: In Molecular Genetics and Metabolism 2008 95(1):74-80

Metabolic, Intestinal, and Cardiovascular Effects of Sotagliflozin Compared With Empagliflozin in Patients With Type 2 Diabetes: A Randomized, Double-Blind Study.

Authors: Posch, Maximilian G., Walther, Niklas niklas.walther@charite-research.org, Ferrannini, Ele, Powell, David R., Banks, Phillip, Wason, Suman, Dahmen, Raphael

Source: Diabetes Care. Sep2022, Vol. 45 Issue 9, p2118-2126. 9p.

Subject Terms: *KNEE osteoarthritis, *KNEE joint, *TOTAL knee replacement, *SYNOVITIS, *RESEARCH funding, *POSTOPERATIVE pain

Peroxisome proliferator-activated receptor γ ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia

Authors: Zang, Chuanbing, Liu, Hongyu, Posch, Maximilian G, Waechter, Maries, Facklam, Margit, Fenner, Martin H, Ruthardt, Martin, Possinger, Kurt, Phillip Koeffler, H, Elstner, Elena

Source: In Leukemia Research 2004 28(4):387-397

THE +49AG POLYMORPHISM IN EXON 1 OF THE CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED PROTEIN 4 IS ASSOCIATED WITH DILATED CARDIOMYOPATHY

Authors: Ruppert, Volker, Meyer, Thomas, Struwe, Clarissa, Petersen, Jana, Perrot, Andreas, Posch, Maximilian G., ö;zcelik, Cemil, Richter, Anette, Maisch, Bernhard, Pankuweit, Sabine

Source: Journal of the American College of Cardiology. 55(10):A27.E261-A27.E261

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100051085001.0x000001&indx=1&recIds=ETOCvdc_100051085001.0x000001

Cardiac Alpha-Myosin (MYH6) Is the Predominant Sarcomeric Disease Gene for Familial Atrial Septal Defects.

Authors: Posch, Maximilian G.^1,2 posch@dhzb.de, Waldmuller, Stephan³, Müller, Melanie³, Scheffold, Thomas³, Fournier, David⁴, Andrade-Navarro, Miguel A.⁴, Geeter, Bernard De⁵, Guillaumont, Sophie⁶, Dauphin, Claire⁷, Yousseff, Dany⁸, Schmitt, Katharina R.⁹, Perrot, Andreas², Berger, Felix⁹, Hetzer, Roland¹, Bouvagnet, Patrice¹⁰, Özcelik, Cemil²

Source: PLoS ONE. 2011, Vol. 6 Issue 12, p1-7. 7p.

Subject Terms: *MYOSIN, *ATRIAL septal defects, *CONGENITAL heart disease, *GENETIC mutation, *CARDIOMYOPATHIES

Connective Tissue Growth Factor Overexpression in Cardiomyocytes Promotes Cardiac Hypertrophy and Protection against Pressure Overload.

Authors: Panek, Anna N.¹, Posch, Maximilian G.^2,3, Alenina, Natalia¹, Ghadge, Santhosh K.¹, Erdmann, Bettina¹, Popova, Elena¹, Perrot, Andreas^2,3, Geier, Christian^2,3, Morano, Rainer Dietz Ingo^1,2,3, Bader, Michael¹, Özcelik, Cemil^1,2,3 cemil.oezcelik@charite.de

Source: PLoS ONE. 2009, Vol. 4 Issue 8, p1-10. 10p. 5 Graphs.

Subject Terms: *CONNECTIVE tissue growth factor, *HEART cells, *CYTOKINES, *RODENTS, *GENE expression, *TRANSGENIC animals, *HEART failure, *MURIDAE, *OLIGOPEPTIDES, *TISSUE banks

Efficacy, Safety, and Mechanistic Insights of Cotadutide, a Dual Receptor Glucagon-Like Peptide-1 and Glucagon Agonist

Authors: Parker, Victoria E R, Robertson, Darren, Wang, Tao, Hornigold, David C, Petrone, Marcella, Cooper, Aidan T, Posch, Maximilian G, Heise, Tim, Plum-Moerschel, Leona, Schlichthaar, Heike, Klaus, Beate, Ambery, Philip D, Meier, Juris J, Hirshberg, Boaz

Source: The Journal of Clinical Endocrinology & Metabolism; March 2020, Vol. 105 Issue: 3 p803-820, 18p

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Mutations in the cardiac transcription factor GATA4 in patients with lone atrial fibrillation

Authors: Posch, Maximilian G., Boldt, Leif-Hendrik, Polotzki, Michael, Richter, Silke, Rolf, Sascha, Perrot, Andreas, Dietz, Rainer, Özcelik, Cemil, Haverkamp, Wilhelm

Source: In European Journal of Medical Genetics 2010 53(4):201-203