Triple combination targeting PI3K, ER, and CDK4/6 inhibits growth of ER‐positive breast cancer resistant to fulvestrant and CDK4/6 or PI3K inhibitor

Authors: Karimi, Leena, Alves, Carla L., Terp, Mikkel G., Tuttolomondo, Martina, Portman, Neil, Ehmsen, Sidse, Johansen, Lene E., Bak, Martin, Lim, Elgene, Ditzel, Henrik J.

Source: Cancer communications. 43(6):720-725

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184965312.0x000001&indx=1&recIds=ETOCvdc_100184965312.0x000001

DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity

Authors: Du, Qian, Smith, Grady C., Luu, Phuc Loi, Ferguson, James M., Armstrong, Nicola J., Caldon, C. Elizabeth, Campbell, Elyssa M., Nair, Shalima S., Zotenko, Elena, Gould, Cathryn M., Buckley, Michael, Chia, Kee-Ming, Portman, Neil, Lim, Elgene, Kaczorowski, Dominik, Chan, Chia-Ling, Barton, Kirston, Deveson, Ira W., Smith, Martin A., Powell, Joseph E., Skvortsova, Ksenia, Stirzaker, Clare, Achinger-Kawecka, Joanna, Clark, Susan J.

Source: In Cell Reports 21 September 2021 36(12)

Estrogen receptor positive breast cancer patient–derived xenograft models in translational research

Authors: Chia, KeeMing, Freelander, Allegra, Kumar, Sanjeev, Parker, Andrew, Segara, Davendra, Portman, Neil, Lim, Elgene

Source: In Current Opinion in Endocrine and Metabolic Research December 2020 15:31-36

Targeting CDK2 in cancer: challenges and opportunities for therapy

Authors: Tadesse, Solomon, Anshabo, Abel T., Portman, Neil, Lim, Elgene, Tilley, Wayne, Caldon, C. Elizabeth ^⁎, Wang, Shudong ^⁎

Source: In Drug Discovery Today February 2020 25(2):406-413

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer

Authors: Kennedy, Sean, Han, Jeremy, Portman, Neil, Nobis, Max, Hastings, Jordan, Murphy, Kendelle, Latham, Sharissa, Cadell, Antonia, Miladinovic, Dushan, Marriott, Gabriella, O'Donnell, Yolande, Shearer, Robert, Williams, James, Munoz, Amaya, Cox, Thomas, Watkins, D., Saunders, Darren, Timpson, Paul, Lim, Elgene, Kolch, Walter, Croucher, David

Source: Breast cancer research. 21(1):1-17

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186561690.0x000001&indx=1&recIds=ETOCvdc_100186561690.0x000001

A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation

Authors: Macer-Wright, Jessica L., Stanley, Naomi R., Portman, Neil, Tan, Joanne T., Bursill, Christina, Rayner, Benjamin S., Hawkins, Clare L.

Source: Chemical research in toxicology. 32(6):1223-1234

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631485180&indx=1&recIds=ETOCRN631485180

Protein diversity in discrete structures at the distal tip of the trypanosome flagellum

Authors: Varga, Vladimir, Moreira-Leite, Flavia, Portman, Neil, Gull, Keith

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Aug 01. 114(32), E6546-E6555.

Access URL: https://www.jstor.org/stable/26486949

The flagellar contribution to the apical complex: a new tool for the eukaryotic Swiss Army knife?

Authors: Portman, Neil, Šlapeta, Jan

Source: In Trends in Parasitology February 2014 30(2):58-64

The potential of epigenetic therapy to target the 3D epigenome in endocrine-resistant breast cancer

Authors: Achinger-Kawecka, Joanna, Stirzaker, Clare, Portman, Neil, Campbell, Elyssa, Chia, Kee-Ming, Du, Qian, Laven-Law, Geraldine, Nair, Shalima S., Yong, Aliza, Wilkinson, Ashleigh, Clifton, Samuel, Milioli, Heloisa H., Alexandrou, Sarah, Caldon, C. Elizabeth, Song, Jenny, Khoury, Amanda, Meyer, Braydon, Chen, Wenhan, Pidsley, Ruth, Qu, Wenjia, Gee, Julia M. W., Schmitt, Anthony, Wong, Emily S., Hickey, Theresa E., Lim, Elgene, Clark, Susan J.

Source: Nature Structural and Molecular Biology; March 2024, Vol. 31 Issue: 3 p498-512, 15p

MDM2 inhibition in combination with endocrine therapy and CDK4/6 inhibition for the treatment of ER-positive breast cancer

Authors: Portman, Neil, Milioli, Heloisa H., Alexandrou, Sarah, Coulson, Rhiannon, Yong, Aliza, Fernandez, Kristine J., Chia, Kee Ming, Halilovic, Ensar, Segara, Davendra, Parker, Andrew, Haupt, Sue, Haupt, Ygal, Tilley, Wayne D., Swarbrick, Alex, Caldon, C. Elizabeth, Lim, Elgene

Source: Breast cancer research. 22(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171990005.0x000001&indx=1&recIds=ETOCvdc_100171990005.0x000001

The paraflagellar rod of kinetoplastid parasites: From structure to components and function

Authors: Portman, Neil, Gull, Keith

Source: In International Journal for Parasitology February 2010 40(2):135-148

Combining RNA Interference Mutants and Comparative Proteomics to Identify Protein Components and Dependences in a Eukaryotic Flagellum

Authors: Portman, Neil, Lacomble, Sylvain, Thomas, Benjamin, McKean, Paul G., Gull, Keith

Source: In Journal of Biological Chemistry 27 February 2009 284(9):5610-5619

Analysis of the Trypanosome Flagellar Proteome Using a Combined Electron Transfer/Collisionally Activated Dissociation Strategy

Authors: Hart, Sarah R., Lau, King Wai, Hao, Zhiqi, Broadhead, Richard, Portman, Neil, Hühmer, Andreas, Gull, Keith, McKean, Paul G., Hubbard, Simon J., Gaskell, Simon J.

Source: In Journal of the American Society for Mass Spectrometry 2009 20(2):167-175

MDM2 as a Rational Target for Intervention in CDK4/6 Inhibitor Resistant, Hormone Receptor Positive Breast Cancer.

Authors: Portman, Neil, Chen, Julia, Lim, Elgene

Source: Frontiers in Oncology; 11/3/2021, Vol. 11, p1-11, 11p

Subject Terms: HORMONE receptor positive breast cancer, HORMONE receptors, ESTROGEN, CYCLIN-dependent kinases, BREAST cancer, ESTROGEN receptors

Co-targeting CDK4/6 and AKT with endocrine therapy prevents progression in CDK4/6 inhibitor and endocrine therapy-resistant breast cancer.

Authors: Alves, Carla L., Ehmsen, Sidse, Terp, Mikkel G., Portman, Neil, Tuttolomondo, Martina, Gammelgaard, Odd L., Hundebøl, Monique F., Kaminska, Kamila, Johansen, Lene E., Bak, Martin, Honeth, Gabriella, Bosch, Ana, Lim, Elgene, Ditzel, Henrik J.

Source: Nature Communications; 9/16/2021, Vol. 12 Issue 1, p1-15, 15p

Subject Terms: BREAST cancer, HORMONE therapy, METASTATIC breast cancer, TREATMENT effectiveness, CANCER cell growth

Synergistic targeting of BRCA1 mutated breast cancers with PARP and CDK2 inhibition.

Authors: Aziz, Diar, Portman, Neil, Fernandez, Kristine J., Lee, Christine, Alexandrou, Sarah, Llop-Guevara, Alba, Phan, Zoe, Yong, Aliza, Wilkinson, Ashleigh, Sergio, C. Marcelo, Ferraro, Danielle, Etemadmoghadam, Dariush, Bowtell, David D., Serra, Violeta, Waring, Paul, Lim, Elgene, Caldon, C. Elizabeth

Source: NPJ Breast Cancer; 8/31/2021, Vol. 7 Issue 1, p1-14, 14p

Identification of Paralogous Life-Cycle Stage Specific Cytoskeletal Proteins in the Parasite Trypanosoma brucei.

Authors: Portman, Neil^1,2 neil.portman@sydney.edu.au, Gull, Keith¹

Source: PLoS ONE. Sep2014, Vol. 9 Issue 9, p1-9. 9p.

Subject Terms: *CYTOSKELETAL proteins, *LIFE cycles (Biology), *TRYPANOSOMA brucei, *GENE expression, *GEL electrophoresis, *MICROBIAL proteins, *PROTOZOA

Serum Response Factor Cleavage by Caspases 3 and 7 Linked to Apoptosis in Human BJAB Cells

Authors: Drewett, Victoria ^{*, ‡}, Devitt, Andrew ^*, Saxton, Janice ^*, Portman, Neil ^*, Greaney, Peter ^*, Cheong, NaEun ^§, Alnemri, Teresa F. ^§, Alnemri, Emad ^§, Shaw, Peter E. ^{*, ¶}

Source: In Journal of Biological Chemistry 7 September 2001 276(36):33444-33451

Swimming with protists: perception, motility and flagellum assembly.

Authors: Ginger, Michael L.¹ m.ginger@lancaster.ac.uk, Portman, Neil², McKean, Paul G.¹

Source: Nature Reviews Microbiology. Nov2008, Vol. 6 Issue 11, p838-850. 13p. 3 Diagrams, 1 Chart.

Subject Terms: *PROTISTA, *CELL motility, *CELL membranes, *CILIARY body, *CYTOLOGY

Non-canonical AR activity facilitates endocrine resistance in breast cancer.

Authors: KeeMing Chia, Milioli, Heloisa, Portman, Neil, Laven-Law, Geraldine, Coulson, Rhiannon, Yong, Aliza, Segara, Davendra, Parker, Andrew, Caldon, Catherine E., Niantao Deng, Swarbrick, Alexander, Tilley, Wayne D., Hickey, Theresa E., Lim, Elgene

Source: Endocrine-Related Cancer; Feb2019, Vol. 26 Issue 2, p251-264, 14p

Subject Terms: ANDROGEN receptors, BREAST cancer, GENE expression profiling, CELL lines