Precise correction of a spectrum of β-thalassemia mutations in coding and non-coding regions by base editors

Authors: Kirti Prasad, Nivedhitha Devaraju, Anila George, Nithin Sam Ravi, Joshua Paul, Gokulnath Mahalingam, Vignesh Rajendiran, Lokesh Panigrahi, Vigneshwaran Venkatesan, Kartik Lakhotiya, Yogapriya Periyasami, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Shaji R. Velayudhan, Gregory A. Newby, Srujan Marepally, Alok Srivastava, Kumarasamypet M. Mohankumar

Source: Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102205- (2024)

Subject Terms: MT: RNA/DNA Editing, genome editing, base editor, β-thalassemia mutations, HbE/CD26(G>A), gene correction, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253124000921; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/1c5f0f013cfe4f2da711f4e85aae51fa

Efficient deletion of microRNAs using CRISPR/Cas9 with dual guide RNAs

Authors: Smitha Ijee, Karthik Chambayil, Anurag Dutta Chaudhury, Abhirup Bagchi, Kirti Modak, Saswati Das, Esther Sathya Bama Benjamin, Sonam Rani, Daniel Zechariah Paul, Aneesha Nath, Debanjan Roy, Dhavapriya Palani, Sweety Priyanka, Rakshini Ravichandran, Betty K. Kumary, Yazhini Sivamani, Vijayanand S., Dinesh Babu, Yukio Nakamura, Vasanth Thamodaran, Poonkuzhali Balasubramanian, Shaji R. Velayudhan

Source: Frontiers in Molecular Biosciences, Vol 10 (2024)

Subject Terms: miRNA, CRISPR-Cas9, dual-gRNA, iPSCs, erythroid, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2023.1295507/full; https://doaj.org/toc/2296-889X

Access URL: https://doaj.org/article/5312775f75e844e48f5507f1e9c2a7d8

Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies

Authors: Vigneshwaran Venkatesan, Abisha Crystal Christopher, Manuel Rhiel, Manoj Kumar K. Azhagiri, Prathibha Babu, Kaivalya Walavalkar, Bharath Saravanan, Geoffroy Andrieux, Sumathi Rangaraj, Saranya Srinivasan, Karthik V. Karuppusamy, Annlin Jacob, Abhirup Bagchi, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Rekha Pai, Srujan Kumar Marepally, Kumarasamypet Murugesan Mohankumar, Shaji R. Velayudhan, Melanie Boerries, Dimple Notani, Toni Cathomen, Alok Srivastava, Saravanabhavan Thangavel

Source: Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 671-688 (2023)

Subject Terms: MT: RNA/DNA Editing, deletional HPFH, sickle cell diseases, beta-thalassemia, gene editing, gene therapy, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253123001105; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/444686798a7c40d7a355be2ff089b162

Intracranial bleeding in acute promyelocytic leukemia treated with arsenic trioxide based regimens is associated with induction mortality but not with relapse

Authors: Uday Prakash Kulkarni, Sushil Selvarajan, N. A. Fouzia, Sharon Lionel, Sukesh Chandran Nair, Poonkuzhali Balasubramanian, Thenmozhi Mani, Aby Abraham, Biju George, Vikram Mathews

Source: Blood Cancer Journal, Vol 13, Iss 1, Pp 1-3 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2044-5385

Access URL: https://doaj.org/article/bc2f7a9ed64a4ad794afb96b27359654

Haploidentical Natural Killer Cell Therapy as an Adjunct to Stem Cell Transplantation for Treatment of Refractory Acute Myeloid Leukemia

Authors: Uday Kulkarni, Arun Kumar Arunachalam, Hamenth Kumar Palani, Reeshma Radhakrishnan Nair, Nithya Balasundaram, Arvind Venkatraman, Anu Korula, Sushil Selvarajan, Sharon Lionel, Poonkuzhali Balasubramanian, Madhavi Maddali, Aby Abraham, Biju George, Vikram Mathews

Source: Cell Transplantation, Vol 32 (2023)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1555-3892

Access URL: https://doaj.org/article/d4492367022c464e9341fd1d7b0aea08

Erythroid lineage-specific lentiviral RNAi vectors suitable for molecular functional studies and therapeutic applications

Authors: Abhirup Bagchi, Nivedhitha Devaraju, Karthik Chambayil, Vignesh Rajendiran, Vigneshwaran Venkatesan, Nilofer Sayed, Aswin Anand Pai, Aneesha Nath, Ernest David, Yukio Nakamura, Poonkuzhali Balasubramanian, Alok Srivastava, Saravanabhavan Thangavel, Kumarasamypet M. Mohankumar, Shaji R. Velayudhan

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/63d72c82f4d747819d0e40736513dbbc

Modulating retinoid-X-receptor alpha (RXRA) expression sensitizes chronic myeloid leukemia cells to imatinib in vitro and reduces disease burden in vivo

Authors: Bharathi M. Rajamani, Raveen Stephen Stallon Illangeswaran, Esther Sathya Bama Benjamin, Balaji Balakrishnan, Daniel Zechariah Paul Jebanesan, Saswati Das, Aswin Anand Pai, Rakhi Thalayattu Vidhyadharan, Ajith Mohan, Sreeja Karathedath, Aby Abraham, Vikram Mathews, Shaji R. Velayudhan, Poonkuzhali Balasubramanian

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: chronic myeloid leukemia (CML), imatinib, RXRA, RXRA ligands, resistance, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1187066/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/819afb142194448295ce19c5008ae927

Real world data with concurrent retinoic acid and arsenic trioxide for the treatment of acute promyelocytic leukemia

Authors: Uday P. Kulkarni, Sushil Selvarajan, Sharon Lionel, Mithun A. Prakash, Hamenth Kumar Palani, Nithya Balasundaram, Arvind Venkataraman, Anu Korula, Anup J. Devasia, N. A. Fouzia, Nancy Beryl Janet, Sukesh Chandran Nair, Aby Abraham, Thenmozhi Mani, Jeyaseelan Lakshmanan, Arun Kumar Arunachalam, Poonkuzhali Balasubramanian, Biju George, Vikram Mathews

Source: Blood Cancer Journal, Vol 12, Iss 1, Pp 1-4 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2044-5385

Access URL: https://doaj.org/article/25cb0d759bef4dba8c63d0c125449bb1

Calreticulin Immunohistochemistry in Myeloproliferative Neoplasms - Evolution of a New Cost-Effective Diagnostic Tool: A Retrospective Study with Histological and Molecular Correlation

Authors: Sanjeet ROY, Marie Therese MANIPADAM, Poonkuzhali BALASUBRAMANIAN

Source: Türk Patoloji Dergisi, Vol 38, Iss 1, Pp 025-033 (2022)

Subject Terms: immunohistochemistry, cal2, calreticulin, myeloproliferative neoplasm, calr, Pathology, RB1-214

File Description: electronic resource

Relation: http://www.turkjpath.org/pdf.php3?id=1988; https://doaj.org/toc/1018-5615; https://doaj.org/toc/1309-5730

Access URL: https://doaj.org/article/9b6c57cf8cba4570936e1a9c174d4052

Biomarkers for early complications post hematopoietic cell transplantation: Insights and challenges

Authors: Balaji Balakrishnan, Uday Prakash Kulkarni, Aswin Anand Pai, Raveen Stephen Stallon Illangeswaran, Ezhilpavai Mohanan, Vikram Mathews, Biju George, Poonkuzhali Balasubramanian

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: biomarker, GVHD, endothelial, SOS, HSCT, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1100306/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/40636592f0bb439b94d150821c626b10

Metformin pretreatment ameliorates busulfan-induced liver endothelial toxicity during haematopoietic stem cell transplantation

Authors: Balaji Balakrishnan, Raveen Stephen Stallon Illangeswaran, Bharathi Murugan Rajamani, Arun Kumar Arunachalam, Aswin Anand Pai, Ezhilpavai Mohanan, Alok Srivastava, Vikram Mathews, Poonkuzhali Balasubramanian

Source: PLoS ONE, Vol 18, Iss 10 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602364/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/8abb634a628e4006ae689cc31db1bfce

Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2

Authors: Anila George, Nithin Sam Ravi, Kirti Prasad, Lokesh Panigrahi, Sanya Koikkara, Vignesh Rajendiran, Nivedhitha Devaraju, Joshua Paul, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Srujan Marepally, Shaji R. Velayudhan, Alok Srivastava, Kumarasamypet M. Mohankumar

Source: Frontiers in Genome Editing, Vol 4 (2022)

Subject Terms: prime editing, sickle cell anaemia, CRISPR, haemoglobinopathies, beta-globin, Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgeed.2022.1085111/full; https://doaj.org/toc/2673-3439

Access URL: https://doaj.org/article/5c7fcda3597440939586146c2d46906f

Prognostic plasma biomarkers of early complications and graft‐versus‐host disease in patients undergoing allogeneic hematopoietic stem cell transplantation

Authors: Balaji Balakrishnan, Raveen Stephen Stallon Illangeswaran, Bharathi M Rajamani, Aswin Anand Pai, Infencia Xavier Raj, Daniel Zechariah Paul, Kavitha Lakshmi, Thenmozhi Mani, Ezhilpavai Mohanan, Uday Kulkarni, Anup Joseph Devasia, Fouzia NA, Anu Korula, Aby Abraham, Alok Srivastava, Vikram Mathews, Sophie Paczesny, Biju George, Poonkuzhali Balasubramanian

Source: eJHaem, Vol 1, Iss 1, Pp 219-229 (2020)

Subject Terms: GVHD, HSC transplantation, prognostic, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2688-6146

Access URL: https://doaj.org/article/22f625e9d97d4f0298a2106c70e13e93

A phase II study evaluating the role of bortezomib in the management of relapsed acute promyelocytic leukemia treated upfront with arsenic trioxide

Authors: Uday Kulkarni, Saravanan Ganesan, Ansu Abu Alex, Hamenth Palani, Sachin David, Nithya Balasundaram, Arvind Venkatraman, Mani Thenmozhi, Lakshmanan Jeyaseelan, Anu Korula, Anup Devasia, Aby Abraham, Nancy Beryl Janet, Poonkuzhali Balasubramanian, Biju George, Vikram Mathews

Source: Cancer Medicine, Vol 9, Iss 8, Pp 2603-2610 (2020)

Subject Terms: arsenic trioxide, PML mutations, proteasome inhibitor, relapsed acute promyelocytic leukemia, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/7479df91ae71429881fbed1ef7615da6

Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin

Authors: Nithin Sam Ravi, Beeke Wienert, Stacia K Wyman, Henry William Bell, Anila George, Gokulnath Mahalingam, Jonathan T Vu, Kirti Prasad, Bhanu Prasad Bandlamudi, Nivedhitha Devaraju, Vignesh Rajendiran, Nazar Syedbasha, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Muthuraman Narayanasamy, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Srujan Marepally, Shaji R Velayudhan, Alok Srivastava, Mark A DeWitt, Merlin Crossley, Jacob E Corn, Kumarasamypet M Mohankumar

Source: eLife, Vol 11 (2022)

Subject Terms: base editing, globin regulation, HPFH mutations, beta-hemoglobinopathies, fetal hemoglobin, CRISPR/Cas9, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/65421; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/4e7c9ae5baf449a09c47d7d306218410

Adult Acute Lymphoblastic Leukemia: Limitations of Intensification of Therapy in a Developing Country

Authors: Punit Jain, Anu Korula, Prashant Deshpande, Nisham PN, Ansu Abu Alex, Aby Abraham, Alok Srivastava, Nancy Beryl Janet, Kavitha M. Lakshmi, Poonkuzhali Balasubramanian, Biju George, Vikram Mathews

Source: Journal of Global Oncology, Vol 4, Iss 1, Pp 1-12 (2018)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2378-9506

Access URL: https://doaj.org/article/9e03d352c9ba4a03b06d77a5f72ec922

Allogeneic stem cell transplantation for thalassemia major in India

Authors: Vikram Mathews, Poonkuzhali Balasubramanian, Aby Abraham, Biju George, Alok Srivastava

Source: Pediatric Hematology Oncology Journal, Vol 2, Iss 4, Pp 114-120 (2017)

Subject Terms: Thalassemia major, Allogeneic stem cell transplant, Conditioning regimens, Regimen related toxicity, Alternative donors, Pediatrics, RJ1-570

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2468124517300979; https://doaj.org/toc/2468-1245

Access URL: https://doaj.org/article/3c55b34e04914e1a83fe1bbb9fed7216

Allogeneic Stem Cell Transplant for Acute Myeloid Leukemia: Evolution of an Effective Strategy in India

Authors: Abhijeet Ganapule, Sandeep Nemani, Anu Korula, Kavitha M. Lakshmi, Aby Abraham, Alok Srivastava, Poonkuzhali Balasubramanian, Biju George, Vikram Mathews

Source: Journal of Global Oncology, Vol 3, Iss 6, Pp 773-781 (2017)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2378-9506

Access URL: https://doaj.org/article/028ebafe4cfe4c75a20796534884f5be

Cholesterol Sequestration from Caveolae/Lipid Rafts Enhances Cationic Liposome-Mediated Nucleic Acid Delivery into Endothelial Cells

Authors: Santhosh Chandar Maddila, Chandrashekhar Voshavar, Porkizhi Arjunan, Rashmi Prakash Chowath, Hari Krishna Reddy Rachamalla, Balaji Balakrishnan, Poonkuzhali Balasubramanian, Rajkumar Banerjee, Srujan Marepally

Source: Molecules, Vol 26, Iss 15, p 4626 (2021)

Subject Terms: cationic lipids, clathrin-mediated endocytosis, caveolae-mediated endocytosis, macropinocytosis, transfection, endothelial cells, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/15/4626; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/5c00d46f065e4f6f99ad3e3920769b82

Direct Generation of Immortalized Erythroid Progenitor Cell Lines from Peripheral Blood Mononuclear Cells

Authors: Abhirup Bagchi, Aneesha Nath, Vasanth Thamodaran, Smitha Ijee, Dhavapriya Palani, Vignesh Rajendiran, Vigneshwaran Venkatesan, Phaneendra Datari, Aswin Anand Pai, Nancy Beryl Janet, Poonkuzhali Balasubramanian, Yukio Nakamura, Alok Srivastava, Kumarasamypet Murugesan Mohankumar, Saravanabhavan Thangavel, Shaji R. Velayudhan

Source: Cells, Vol 10, Iss 3, p 523 (2021)

Subject Terms: erythroid, differentiation, immortalization, peripheral blood, HPV E6/E7, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/10/3/523; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/cc913110f5c44221bd81e68c4de7504b