Discovery of 22(S)-23-phenyl-24-norchol-5-en-3β,22-diol (PFM046) as the first-in-class, steroidal, non-sulfated Liver X Receptor antagonist with anticancer activity

Authors: Pontini, Lorenzo ^{a, 1}, Angelini, Tommaso ^{a, 1}, Palazzoli, Pietro ^{a, 1}, Maggioni, Daniela ^b, Giorgi, Gianluca ^c, Raccosta, Laura ^b, Damiano, Giuseppe ^b, Mammoli, Valerio ^d, Fontana, Niccolò ^d, Russo, Vincenzo ^{b, ⁎⁎}, Marinozzi, Maura ^{a, ⁎}

Source: In European Journal of Medicinal Chemistry 5 February 2025 283

Mechanochemical Simmons–Smith cyclopropanation via ball-milling-enabled activation of zinc(0)Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3gc00649b

Authors: Pontini, Lorenzo, Leitch, Jamie A., Browne, Duncan L.

Source: Green chemistry. 25(11):4319-4325

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184623759.0x000001&indx=1&recIds=ETOCvdc_100184623759.0x000001

Identification of oxysterol synthetic analogs as a novel class of late-stage inhibitors of herpes simplex virus 2 replication

Authors: Civra, Andrea, Costantino, Matteo, Ronchi, Giulia, Pontini, Lorenzo, Poli, Giuseppe, Marinozzi, Maura, Lembo, David

Source: In Antiviral Research July 2023 215

In search for novel liver X receptors modulators by extending the structure–activity relationships of cholenamide derivatives

Authors: Pontini, Lorenzo, Palazzoli, Pietro, Maggioni, Daniela, Damiano, Giuseppe, Giorgi, Gianluca, Russo, Vincenzo, Marinozzi, Maura

Source: In Chemistry and Physics of Lipids November 2021 241

Cholesterol and oxysterol sulfates: Pathophysiological roles and analytical challenges

Authors: Sanchez, Lorena Diaz, Pontini, Lorenzo, Marinozzi, Maura, Sanchez‐Aranguren, Lissette Carolina, Reis, Ana, Dias, Irundika H.K.

Source: British journal of pharmacology. 178(16):3327-3341

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100124853820.0x000001&indx=1&recIds=ETOCvdc_100124853820.0x000001

Shedding light on the roles of liver X receptors in cancer by using chemical probes

Authors: Pontini, Lorenzo, Marinozzi, Maura

Source: British journal of pharmacology. 178(16):3261-3276

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100124853753.0x000001&indx=1&recIds=ETOCvdc_100124853753.0x000001

Novel Synthetic Access to 24a-Homochol-5-en-24a-oate Scaffold from Stigmasterol

Authors: Pontini, Lorenzo, Marinozzi, Maura

Source: Organic preparations and procedures international. 53(6):571-577

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133261596.0x000001&indx=1&recIds=ETOCvdc_100133261596.0x000001

Process Development for the First GMP Synthesis of SGD-9501-TFA, Part 2: Synthesis of the Payload, Linker, and Drug Linker.

Authors: Payne, Katherine, Tran, Jeremy C., Gill, Brooke, Guy, William, McNichol, Caitlyn, Bdeir, Kareem, Reider, Malcolm, Stair, Andrea, Pontini, Lorenzo, Cerai, Gabriele, Roletto, Jacopo, Whittaker, Aaron M.

Source: Organic Process Research & Development; 10/18/2024, Vol. 28 Issue 10, p3780-3790, 11p

Process Development for the First GMP Synthesis of SGD-9501-TFA, Part 1: Synthesis of Two Oligopeptide Fragments.

Authors: Porter, Noah, Guy, William, Gill, Brooke, Bdeir, Kareem, Nguyen, Minh, Abbruzzese, Jared, Reider, Malcolm, Pontini, Lorenzo, Cerai, Gabriele, Roletto, Jacopo, Whittaker, Aaron M.

Source: Organic Process Research & Development; 10/18/2024, Vol. 28 Issue 10, p3772-3779, 8p

Sulfated oxysterols in ageing and neurodegeneration

Authors: Dias, Irundika HK., Pontini, Lorenzo, Marinozzi, Maura

Source: In Free Radical Biology and Medicine 20 August 2022 189 Supplement 1