Advances in Ultrahigh Throughput Hit Discovery with Tandem Mass Spectrometry Encoded Libraries

Authors: Mata, J. Miguel, van der Nol, Edith, Pomplun, Sebastian J.

Source: Journal of the American Chemical Society. 145(34):19129-19139

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633653924&indx=1&recIds=ETOCRN633653924

Development of DuoMYC: a synthetic cell penetrant miniprotein that efficiently inhibits the oncogenic transcription factor MYC.

Authors: Ellenbroek, Brecht D.^1,2, Kahler, Jan Pascal^1,2, Arella, Damiano^1,2, Lin, Cherina^1,2, Jespers, Willem^1,2, Züger, Eliane Ann‐Katrin^1,2, Drukker, Micha^1,2, Pomplun, Sebastian J.^1,2, s.j.pomplun@lacdr.leidenuniv.nl

Source: Angewandte Chemie; 1/21/2025, Vol. 137 Issue 4, p1-8, 8p

Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amidesElectronic supplementary information (ESI) available. See DOI: 10.1039/d1sc04638a

Authors: Kolos, Jürgen M., Pomplun, Sebastian, Jung, Sascha, Rieß, Benedikt, Purder, Patrick L., Voll, Andreas M., Merz, Stephanie, Gnatzy, Monika, Geiger, Thomas M., Quist-Løkken, Ingrid, Jatzlau, Jerome, Knaus, Petra, Holien, Toril, Bracher, Andreas, Meyners, Christian, Czodrowski, Paul, Krewald, Vera, Hausch, Felix

Source: Chemical science. 12(44):14758-14765

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134251829.0x000001&indx=1&recIds=ETOCvdc_100134251829.0x000001

Engineering Bioactive Dimeric Transcription Factor Analogs via Palladium Rebound Reagents

Authors: Jbara, Muhammad, Pomplun, Sebastian, Schissel, Carly K., Hawken, Susana Wilson, Boija, Ann, Klein, Isaac, Rodriguez, Jacob, Buchwald, Stephen L., Pentelute, Bradley L.

Source: Journal of the American Chemical Society. 143(30):11788-11798

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627351208&indx=1&recIds=ETOCRN627351208

Targeting the SARS-CoV-2-spike protein: from antibodies to miniproteins and peptides

Authors: Pomplun, Sebastian

Source: RSC medicinal chemistry. 12(2):197-202

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121147576.0x000001&indx=1&recIds=ETOCvdc_100121147576.0x000001

Trendbericht Biochemie 2022: Bioaktive Substanzen entdecken: von Display‐Methoden zu selbstkodierten Substanzbibliotheken

Authors: Pomplun, Sebastian J.

Source: Nachrichten aus der Chemie. 70(7-8):65-67

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154069962.0x000001&indx=1&recIds=ETOCvdc_100154069962.0x000001

Discovery of Nucleic Acid Binding Molecules from Combinatorial Biohybrid Nucleobase Peptide Libraries

Authors: Pomplun, Sebastian, Gates, Zachary P., Zhang, Genwei, Quartararo, Anthony J., Pentelute, Bradley L.

Source: Journal of the American Chemical Society. 142(46):19642-19651

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN625413964&indx=1&recIds=ETOCRN625413964

Secondary Amino Alcohols: Traceless Cleavable Linkers for Use in Affinity Capture and Release

Authors: Pomplun, Sebastian, Shugrue, Christopher R., Schmitt, Adeline M., Schissel, Carly K., Farquhar, Charlotte E., Pentelute, Bradley L.

Source: Angewandte Chemie. 132(28):11663-11669

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114593246.0x000001&indx=1&recIds=ETOCvdc_100114593246.0x000001

Efficient Pictet–Spengler Bioconjugation with N‐Substituted Pyrrolyl Alanine Derivatives

Authors: Pomplun, Sebastian, Mohamed, Mohamed Y. H., Oelschlaegel, Tobias, Wellner, Christian, Bergmann, Frank

Source: Angewandte Chemie international edition. 58(11):3542-3547

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087175604.0x000001&indx=1&recIds=ETOCvdc_100087175604.0x000001

Synthetic Peptides: Promising Modalities for the Targeting of Disease‐Related Nucleic Acids.

Authors: Ellenbroek, Brecht D.¹, Kahler, Jan Pascal¹, Evers, Sophie R.^1,2, Pomplun, Sebastian J.¹, s.j.pomplun@lacdr.leidenuniv.nl

Source: Angewandte Chemie International Edition; 5/13/2024, Vol. 63 Issue 20, p1-20, 20p

Chapter Two - Use of DNA forceps to measure receptor-ligand dissociation equilibrium constants in a single-molecule competition assay

Authors: Stransky, François, Kostrz, Dorota, Follenfant, Maryne, Pomplun, Sebastian, Meyners, Christian, Strick, Terence, Hausch, Felix, Gosse, Charlie

Source: In Methods in Enzymology 2024 694:51-82

Automated Flow Peptide Synthesis Enables Engineering of Proteins with Stabilized Transient Binding Pockets.

Authors: Charalampidou, Anna, Nehls, Thomas, Meyners, Christian, Gandhesiri, Satish, Pomplun, Sebastian, Pentelute, Bradley L., Lermyte, Frederik, Hausch, Felix

Source: ACS Central Science; 3/27/2024, Vol. 10 Issue 3, p649-657, 9p

Rationales Design und asymmetrische Synthese potenter neuritotropher Liganden für FK506‐bindende Proteine (FKBPs)

Authors: Pomplun, Sebastian, Wang, Yansong, Kirschner, Alexander, Kozany, Christian, Bracher, Andreas, Hausch, Felix

Source: Angewandte Chemie. 127(1):352-355

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128625855.0x000001&indx=1&recIds=ETOCvdc_100128625855.0x000001

Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506‐Binding Proteins (FKBPs)

Authors: Pomplun, Sebastian, Wang, Yansong, Kirschner, Alexander, Kozany, Christian, Bracher, Andreas, Hausch, Felix

Source: Angewandte Chemie international edition. 54(1):345-348

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128637424.0x000001&indx=1&recIds=ETOCvdc_100128637424.0x000001

De Novo Discovery of High-Affinity Peptide Binders for the SARS-CoV‑2 Spike Protein.

Authors: Pomplun, Sebastian, Jbara, Muhammad, Quartararo, Anthony J., Zhang, Genwei, Brown, Joseph S., Lee, Yen-Chun, Ye, Xiyun, Hanna, Stephanie, Pentelute, Bradley L.

Source: ACS Central Science; 1/27/2021, Vol. 7 Issue 1, p156-163, 8p

Parallel Automated Flow Synthesis of Covalent Protein Complexes That Can Inhibit MYC-Driven Transcription

Authors: Pomplun, Sebastian, Jbara, Muhammad, Schissel, Carly K., Wilson Hawken, Susana, Boija, Ann, Li, Charles, Klein, Isaac, Pentelute, Bradley L.

Source: ACS Central Science; August 2021, Vol. 7 Issue: 8 p1408-1418, 11p

De NovoDiscovery of High-Affinity Peptide Binders for the SARS-CoV-2 Spike Protein

Authors: Pomplun, Sebastian, Jbara, Muhammad, Quartararo, Anthony J., Zhang, Genwei, Brown, Joseph S., Lee, Yen-Chun, Ye, Xiyun, Hanna, Stephanie, Pentelute, Bradley L.

Source: ACS Central Science; January 2021, Vol. 7 Issue: 1 p156-163, 8p

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.