Gene editing of CD3 epsilon to redirect regulatory T cells for adoptive T cell transfer

Authors: Du, Weijie ^{1, 2}, Noyan, Fatih ³, McCallion, Oliver ⁴, Drosdek, Vanessa ^{1, 2}, Kath, Jonas ^{1, 2}, Glaser, Viktor ^{1, 2}, Fuster-Garcia, Carla ^{5, 6, 7}, Yang, Mingxing ², Stein, Maik ^{1, 2}, Franke, Clemens ^{1, 2}, Pu, Yaolin ^{1, 2}, Weber, Olaf ⁸, Polansky, Julia K. ^{2, 9}, Cathomen, Toni ^{5, 6, 7}, Jaeckel, Elmar ^{3, 10}, Hester, Joanna ⁴, Issa, Fadi ⁴, Volk, Hans-Dieter ^{1, 2, 11}, Schmueck-Henneresse, Michael ^{1, 2}, Reinke, Petra ^{1, 11}, Wagner, Dimitrios L. ^{1, 2, 11, 12, 13, ∗}

Source: In Molecular Therapy 5 March 2025 33(3):997-1013

Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases

Authors: Saggau, Carina ^{1, 30}, Bacher, Petra ^{1, 2, 30}, Esser, Daniela ³, Rasa, Mahdi ^{1, 4}, Meise, Silja ¹, Mohr, Nicola ¹, Kohlstedt, Nora ¹, Hutloff, Andreas ^{1, 2}, Schacht, Sarah-Sophie ¹, Dargvainiene, Justina ³, Martini, Gabriela Rios ^{1, 2}, Stürner, Klarissa H. ^{3, 5}, Schröder, Ina ³, Markewitz, Robert ³, Hartl, Johannes ⁶, Hastermann, Maria ⁷, Duchow, Ankelien ⁷, Schindler, Patrick ⁷, Becker, Mareike ^{8, 9}, Bautista, Carolin ¹⁰, Gottfreund, Judith ¹¹, Walter, Jörn ¹¹, Polansky, Julia K. ^{12, 13}, Yang, Mingxing ¹², Naghavian, Reza ^{14, 15}, Wendorff, Mareike ^{2, 16}, Schuster, Ev-Marie ¹⁷, Dahl, Andreas ¹⁸, Petzold, Andreas ¹⁸, Reinhardt, Susanne ¹⁸, Franke, Andre ², Wieczorek, Marek ¹⁹, Henschel, Lea ¹⁹, Berger, Daniel ¹⁹, Heine, Guido ²⁰, Holtsche, Maike ²¹, Häußler, Vivien ²², Peters, Christian ¹, Schmidt, Enno ²¹, Fillatreau, Simon ^{23, 24, 25}, Busch, Dirk H. ²⁶, Wandinger, Klaus-Peter ³, Schober, Kilian ^{17, 27}, Martin, Roland ^{14, 15, 28, 29}, Paul, Friedemann ^{7, 30}, Leypoldt, Frank ^{3, 5, 30}, Scheffold, Alexander ^{1, 30, 31, ∗}

Source: In Immunity 8 October 2024 57(10):2416-2432

The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation

Authors: Knoll, Rainer, Helbig, Elisa T., Dahm, Kilian, Bolaji, Olufemi, Hamm, Frederik, Dietrich, Oliver, van Uelft, Martina, Müller, Sophie, Bonaguro, Lorenzo, Schulte-Schrepping, Jonas, Petrov, Lev, Krämer, Benjamin, Kraut, Michael, Stubbemann, Paula, Thibeault, Charlotte, Brumhard, Sophia, Theis, Heidi, Hack, Gudrun, De Domenico, Elena, Nattermann, Jacob, Becker, Matthias, Beyer, Marc D., Hillus, David, Georg, Philipp, Loers, Constantin, Tiedemann, Janina, Tober-Lau, Pinkus, Lippert, Lena, Millet Pascual-Leone, Belén, Tacke, Frank, Rohde, Gernot, Suttorp, Norbert, Witzenrath, Martin, Saliba, Antoine-Emmanuel, Ulas, Thomas, Polansky, Julia K., Sawitzki, Birgit, Sander, Leif E., Schultze, Joachim L., Aschenbrenner, Anna C., Kurth, Florian

Source: In Cell 8 August 2024 187(16):4318-4335

Gene editing of CD3 epsilonto redirect regulatory T cells for adoptive T cell transfer

Authors: Du, Weijie, Noyan, Fatih, McCallion, Oliver, Drosdek, Vanessa, Kath, Jonas, Glaser, Viktor, Fuster-Garcia, Carla, Yang, Mingxing, Stein, Maik, Franke, Clemens, Pu, Yaolin, Weber, Olaf, Polansky, Julia K., Cathomen, Toni, Jaeckel, Elmar, Hester, Joanna, Issa, Fadi, Volk, Hans-Dieter, Schmueck-Henneresse, Michael, Reinke, Petra, Wagner, Dimitrios L.

Source: Molecular Therapy; March 2025, Vol. 33 Issue: 3 p997-1013, 17p

Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells

Authors: Truong, Kim-Long, Schlickeiser, Stephan, Vogt, Katrin, Boës, David, Stanko, Katarina, Appelt, Christine, Streitz, Mathias, Grütz, Gerald, Stobutzki, Nadja, Meisel, Christian, Iwert, Christina, Tomiuk, Stefan, Polansky, Julia, Pascher, Andreas, Babel, Nina, Stervbo, Ulrik, Sauer, Igor, Gerlach, Undine, Sawitzki, Birgit

Source: Nature communications. 10(1):1-15

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153410688.0x000001&indx=1&recIds=ETOCvdc_100153410688.0x000001

A comprehensive analysis of 195 DNA methylomes reveals shared and cell-specific features of partially methylated domains

Authors: Salhab, Abdulrahman, Nordström, Karl, Gasparoni, Gilles, Kattler, Kathrin, Ebert, Peter, Ramirez, Fidel, Arrigoni, Laura, Müller, Fabian, Polansky, Julia, Cadenas, Cristina, G.Hengstler, Jan, Lengauer, Thomas, Manke, Thomas, Walter, Jörn

Source: Genome biology. 19(1):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184304161.0x000001&indx=1&recIds=ETOCvdc_100184304161.0x000001

Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

Authors: Durek, Pawel, Nordström, Karl, Gasparoni, Gilles, Salhab, Abdulrahman, Kressler, Christopher, de Almeida, Melanie, Bassler, Kevin, Ulas, Thomas, Schmidt, Florian, Xiong, Jieyi, Glažar, Petar, Klironomos, Filippos, Sinha, Anupam, Kinkley, Sarah, Yang, Xinyi, Arrigoni, Laura, Amirabad, Azim Dehghani, Ardakani, Fatemeh Behjati, Feuerbach, Lars, Gorka, Oliver, Ebert, Peter, Müller, Fabian, Li, Na, Frischbutter, Stefan, Schlickeiser, Stephan, Cendon, Carla, Fröhler, Sebastian, Felder, Bärbel, Gasparoni, Nina, Imbusch, Charles D., Hutter, Barbara, Zipprich, Gideon, Tauchmann, Yvonne, Reinke, Simon, Wassilew, Georgi, Hoffmann, Ute, Richter, Andreas S., Sieverling, Lina, Chang, Hyun-Dong, Syrbe, Uta, Kalus, Ulrich, Eils, Jürgen, Brors, Benedikt, Manke, Thomas, Ruland, Jürgen, Lengauer, Thomas, Rajewsky, Nikolaus, Chen, Wei, Dong, Jun, Sawitzki, Birgit, Chung, Ho-Ryun, Rosenstiel, Philip, Schulz, Marcel H., Schultze, Joachim L., Radbruch, Andreas, Walter, Jörn, Hamann, Alf, Polansky, Julia K.

Source: In Immunity 15 November 2016 45(5):1148-1161

Imprinting of Skin/Inflammation Homing in CD4^+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene

Authors: Pink, Matthias, Ratsch, Boris A., Mardahl, Maibritt, Durek, Pawel, Polansky, Julia K., Karl, Martin, Baumgrass, Ria, Wallner, Stefan, Cadenas, Cristina, Gianmoena, Kathrin

Source: Journal of immunology. 197(8):3406-3414

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN608370259&indx=1&recIds=ETOCRN608370259

Single-cell profiling reveals age-associated immunity in atherosclerosis.

Authors: Smit, Virginia, Mol, Jill de, Schaftenaar, Frank H, Depuydt, Marie A C, Postel, Rimke J, Smeets, Diede, Verheijen, Fenne W M, Bogers, Laurens, Duijn, Janine van, Verwilligen, Robin A F, Grievink, Hendrika W, Kleijn, Mireia N A Bernabé, Ingen, Eva van, Jong, Maaike J M de, Goncalves, Lauren, Peeters, Judith A H M, Smeets, Harm J, Wezel, Anouk, Polansky, Julia K, Winther, Menno P J de

Source: Cardiovascular Research; Nov2023, Vol. 119 Issue 15, p2508-2521, 14p

Subject Terms: ATHEROSCLEROTIC plaque, IMMUNOSENESCENCE, ATHEROSCLEROSIS, WESTERN diet, IMMUNITY, ANTIGEN presentation, PLASMA cells, CARDIOVASCULAR diseases

The enhancer landscape predetermines the skeletal regeneration capacity of stromal cells.

Authors: Hochmann, Sarah, Ou, Kristy, Poupardin, Rodolphe, Mittermeir, Michaela, Textor, Martin, Ali, Salaheddine, Wolf, Martin, Ellinghaus, Agnes, Jacobi, Dorit, Elmiger, Juri A. J., Donsante, Samantha, Riminucci, Mara, Schäfer, Richard, Kornak, Uwe, Klein, Oliver, Schallmoser, Katharina, Schmidt-Bleek, Katharina, Duda, Georg N., Polansky, Julia K., Geissler, Sven

Source: Science Translational Medicine; 3/22/2023, Vol. 15 Issue 688, p1-15, 15p

Subject Terms: ENDOCHONDRAL ossification, MESENCHYMAL stem cells, STROMAL cells, CARTILAGE regeneration, BONE regeneration, WHITE adipose tissue, REGENERATION (Biology), UMBILICAL cord

IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity

Authors: Bahri, Rajia, Pateras, Ioannis S, D'Orlando, Orietta, Goyeneche-Patino, Diego A, Campbell, Michelle, Polansky, Julia K, Sandig, Hilary, Papaioannou, Marilena, Evangelou, Kostas, Foukas, Periklis G, Gorgoulis, Vassilis G, Bulfone-Paus, Silvia

Source: Oncoimmunology. 4(9)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100058863648.0x000001&indx=1&recIds=ETOCvdc_100058863648.0x000001

Targeted De-Methylation of the FOXP3-TSDR Is Sufficient to Induce Physiological FOXP3 Expression but Not a Functional Treg Phenotype.

Authors: Kressler, Christopher, Gasparoni, Gilles, Nordström, Karl, Hamo, Dania, Salhab, Abdulrahman, Dimitropoulos, Christoforos, Tierling, Sascha, Reinke, Petra, Volk, Hans-Dieter, Walter, Jörn, Hamann, Alf, Polansky, Julia K.

Source: Frontiers in Immunology; 1/7/2021, Vol. 11, pN.PAG-N.PAG, 13p

Subject Terms: PHENOTYPES, SUPPRESSOR cells, IMMUNOLOGICAL tolerance, T cells, CLONE cells

The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

Authors: Abrignani, Sergio, Adams, David, de Almeida, Melanie, Altucci, Lucia, Amin, Viren, Amit, Ido, Antonarakis, Stylianos E., Aparicio, Samuel, Arima, Takahiro, Arrigoni, Laura, Arts, Rob, Asnafi, Vahid, Esteller, Manel, Bae, Jae-Bum, Bassler, Kevin, Beck, Stephan, Berkman, Benjamin, Bernstein, Bradley E., Bilenky, Mikhail, Bird, Adrian, Bock, Christoph, Boehm, Bernhard, Bourque, Guillaume, Breeze, Charles E., Brors, Benedikt, Bujold, David, Burren, Oliver, Bussemakers, Marion J., Butterworth, Adam, Campo, Elias, Carrillo-de-Santa-Pau, Enrique, Chadwick, Lisa, Chan, Kui Ming, Chen, Wei, Cheung, Tom H., Chiapperino, Luca, Choi, Nak Hyen, Chung, Ho-Ryun, Clarke, Laura, Connors, Joseph M., Cronet, Philippe, Danesh, John, Dermitzakis, Manolis, Drewes, Gerard, Durek, Pawel, Dyke, Stephanie, Dylag, Tomasz, Eaves, Connie J., Ebert, Peter, Eils, Roland, Eils, Jürgen, Ennis, Catherine A., Enver, Tariq, Feingold, Elise A., Felder, Bärbel, Ferguson-Smith, Anne, Fitzgibbon, Jude, Flicek, Paul, Foo, Roger S.-Y., Fraser, Peter, Frontini, Mattia, Furlong, Eileen, Gakkhar, Sitanshu, Gasparoni, Nina, Gasparoni, Gilles, Geschwind, Daniel H., Glažar, Petar, Graf, Thomas, Grosveld, Frank, Guan, Xin-Yuan, Guigo, Roderic, Gut, Ivo G., Hamann, Alf, Han, Bok-Ghee, Harris, R. Alan, Heath, Simon, Helin, Kristian, Hengstler, Jan G., Heravi-Moussavi, Alireza, Herrup, Karl, Hill, Steven, Hilton, Jason A., Hitz, Benjamin C., Horsthemke, Bernhard, Hu, Ming, Hwang, Joo-Yeon, Ip, Nancy Y., Ito, Takashi, Javierre, Biola-Maria, Jenko, Sasa, Jenuwein, Thomas, Joly, Yann, Jones, Steven J.M., Kanai, Yae, Kang, Hee Gyung, Karsan, Aly, Kiemer, Alexandra K., Kim, Song Cheol, Kim, Bong-Jo, Kim, Hyeon-Hoe, Kimura, Hiroshi, Kinkley, Sarah, Klironomos, Filippos, Koh, In-Uk, Kostadima, Myrto, Kressler, Christopher, Kreuzhuber, Roman, Kundaje, Anshul, Küppers, Ralf, Larabell, Carolyn, Lasko, Paul, Lathrop, Mark, Lee, Daniel H.S., Lee, Suman, Lehrach, Hans, Leitão, Elsa, Lengauer, Thomas, Lernmark, Åke, Leslie, R. David, Leung, Gilberto K.K., Leung, Danny, Loeffler, Markus, Ma, Yussanne, Mai, Antonello, Manke, Thomas, Marcotte, Eric R., Marra, Marco A., Martens, Joost H.A., Martin-Subero, Jose Ignacio, Maschke, Karen, Merten, Christoph, Milosavljevic, Aleksandar, Minucci, Saverio, Mitsuyama, Totai, Moore, Richard A., Müller, Fabian, Mungall, Andrew J., Netea, Mihai G., Nordström, Karl, Norstedt, Irene, Okae, Hiroaki, Onuchic, Vitor, Ouellette, Francis, Ouwehand, Willem, Pagani, Massimiliano, Pancaldi, Vera, Pap, Thomas, Pastinen, Tomi, Patel, Ronak, Paul, Dirk S., Pazin, Michael J., Pelicci, Pier Giuseppe, Phillips, Anthony G., Polansky, Julia, Porse, Bo, Pospisilik, J. Andrew, Prabhakar, Shyam, Procaccini, Dena C., Radbruch, Andreas, Rajewsky, Nikolaus, Rakyan, Vardham, Reik, Wolf, Ren, Bing, Richardson, David, Richter, Andreas, Rico, Daniel, Roberts, David J., Rosenstiel, Philip, Rothstein, Mark, Salhab, Abdulrahman, Sasaki, Hiroyuki, Satterlee, John S., Sauer, Sascha, Schacht, Claudia, Schmidt, Florian, Schmitz, Gerd, Schreiber, Stefan, Schröder, Christopher, Schübeler, Dirk, Schultze, Joachim L., Schulyer, Ronald P., Schulz, Marcel, Seifert, Martin, Shirahige, Katsuhiko, Siebert, Reiner, Sierocinski, Thomas, Siminoff, Laura, Sinha, Anupam, Soranzo, Nicole, Spicuglia, Salvatore, Spivakov, Mikhail, Steidl, Christian, Strattan, J. Seth, Stratton, Michael, Südbeck, Peter, Sun, Hao, Suzuki, Narumi, Suzuki, Yutaka, Tanay, Amos, Torrents, David, Tyson, Frederick L., Ulas, Thomas, Ullrich, Sebastian, Ushijima, Toshikazu, Valencia, Alfonso, Vellenga, Edo, Vingron, Martin, Wallace, Chris, Wallner, Stefan, Walter, Jörn, Wang, Huating, Weber, Stephanie, Weiler, Nina, Weller, Andreas, Weng, Andrew, Wilder, Steven, Wiseman, Sam M., Wu, Angela R., Wu, Zhenguo, Xiong, Jieyi, Yamashita, Yasuhiro, Yang, Xinyi, Yap, Desmond Y., Yip, Kevin Y., Yip, Stephen, Yoo, Jae-Il, Zerbino, Daniel, Zipprich, Gideon, Stunnenberg, Hendrik G., Hirst, Martin

Source: In Cell 17 November 2016 167(5):1145-1149

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

Authors: Huehn, Jochen¹ jochen.huehn@helmholtz-hzi.de, Polansky, Julia K.¹, Hamann, Alf²

Source: Nature Reviews Immunology. Feb2009, Vol. 9 Issue 2, p83-89. 7p. 3 Diagrams, 1 Chart.

Subject Terms: *CELLS, *EPIGENESIS, *IMMUNOLOGICAL tolerance, *T cells, *CELL lines, *TRANSCRIPTION factors, *IMMUNE response, *ANIMALS, *CELL differentiation, *GENES, *HEMATOPOIESIS, *MICE, *PROTEINS, *THYMUS

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Foxp3 occupancy and regulation of key target genes during T-cell stimulation.

Authors: Marson, Alexander, Kretschmer, Karsten, Frampton, Garrett M., Jacobsen, Elizabeth S., Polansky, Julia K., MacIsaac, Kenzie D., Levine, Stuart S., Fraenkel, Ernest, von Boehmer, Harald, Young, Richard A.

Source: Nature. 2/22/2007, Vol. 445 Issue 7130, p931-935. 5p. 4 Diagrams.

Subjects: T-cell receptor genes, CYTOLOGICAL research, CYTOKINES, AUTOIMMUNITY, CELL proliferation, DNA