An intranasal nanoparticle vaccine elicits protective immunity against Mycobacterium tuberculosis

Authors: Sefat, K M Samiur Rahman ^{a, 1}, Kumar, Monish ^{a, 1}, Kehl, Stephanie ^b, Kulkarni, Rohan ^a, Leekha, Ankita ^a, Paniagua, Melisa-Martinez ^a, Ackart, David F. ^c, Jones, Nicole ^b, Spencer, Charles ^b, Podell, Brendan K ^c, Ouellet, Hugues ^b, Varadarajan, Navin ^{a, ⁎}

Source: In Vaccine 17 September 2024 42(22)

The Many Hosts of Mycobacteria 9 (MHM9): A conference report

Authors: Klever, Abigail Marie, Alexander, Kathleen A., Almeida, Deepak, Anderson, Matthew Z., Ball, Ray L., Beamer, Gillian, Boggiatto, Paola, Buikstra, Jane E., Chandler, Bruce, Claeys, Tiffany A., Concha, Aislinn E., Converse, Paul J., Derbyshire, Keith M., Dobos, Karen M., Dupnik, Kathryn M., Endsley, Janice J., Endsley, Mark A., Fennelly, Kevin, Franco-Paredes, Carlos, Hagge, Deanna A., Hall-Stoodley, Luanne, Hayes, Don, Jr., Hirschfeld, Katherine, Hofman, Courtney A., Honda, Jennifer R., Hull, Natalie M., Kramnik, Igor, Lacourciere, Karen, Lahiri, Ramanuj, Lamont, Elise A., Larsen, Michelle H., Lemaire, Timothy, Lesellier, Sandrine, Lee, Naomi R., Lowry, Christopher A., Mahfooz, Najmus S., McMichael, Temet M., Merling, Marlena R., Miller, Michele A., Nagajyothi, Jyothi F., Nelson, Elizabeth, Nuermberger, Eric L., Pena, Maria T., Perea, Claudia, Podell, Brendan K., Pyle, Charlie J., Quinn, Fred D., Rajaram, Murugesan V.S., Mejia, Oscar Rosas, Rothoff, Michelle, Sago, Saydie A., Salvador, Liliana C.M., Simonson, Andrew W., Spencer, John S., Sreevatsan, Srinand, Subbian, Selvakumar, Sunstrum, James, Tobin, David M., Vijayan, K.K.Vidya, Wright, Caelan T.O., Robinson, Richard T.

Source: In Tuberculosis September 2023 142

Immunogenicity and protection against Mycobacterium avium with a heterologous RNA prime and protein boost vaccine regimen

Authors: Rais, Maham, Abdelaal, Hazem, Reese, Valerie A., Ferede, Debora, Larsen, Sasha E., Pecor, Tiffany, Erasmus, Jesse H., Archer, Jacob, Khandhar, Amit P., Cooper, Sarah K., Podell, Brendan K., Reed, Steven G., Coler, Rhea N., Baldwin, Susan L.

Source: In Tuberculosis January 2023 138

Mucosal exposure to non-tuberculous mycobacteria elicits B cell-mediated immunity against pulmonary tuberculosis

Authors: Dutt, Taru S., Karger, Burton R., Fox, Amy, Youssef, Nathan, Dadhwal, Rhythm, Ali, Malik Zohaib, Patterson, Johnathan, Creissen, Elizabeth, Rampacci, Elisa, Cooper, Sarah K., Podell, Brendan K., Gonzalez-Juarrero, Mercedes, Obregon-Henao, Andres, Henao-Tamayo, Marcela

Source: In Cell Reports 13 December 2022 41(11)

The DosR regulon of Mycobacterium avium and adaptation to hypoxia.

Authors: Belardinelli, Juan M., Avanzi, Charlotte, Martin, Kelsey E., Lam, Ha, Dragset, Marte S., Wheat, William H., Podell, Brendan K., Gonzalez-Juarrero, Mercedes, Jackson, Mary

Source: Frontiers in Cellular & Infection Microbiology; 2025, p1-14, 14p

Subject Terms: MYCOBACTERIUM tuberculosis, TUBERCULOSIS, NITRIC oxide, LUNGS, PSYCHOLOGICAL stress, MYCOBACTERIA, MYCOBACTERIUM avium

Immune cell infiltration and modulation of the blood-brain barrier in a guinea pig model of tuberculosis: Observations without evidence of bacterial dissemination to the brain.

Authors: Latham, Amanda S., Geer, Charlize E., Ackart, David F., Weninger, Kristin N., Gross, Chase C., Podell, Brendan K., Basaraba, Randall J., Moreno, Julie A.

Source: PLoS ONE; 12/31/2024, Vol. 19 Issue 12, p1-30, 30p

Subject Terms: AQUAPORINS, MYCOBACTERIUM tuberculosis, NEUROLOGICAL disorders, GUINEA pigs, PNEUMONIA, BLOOD-brain barrier, LUNGS

BCG-Prime and boost with Esx-5 secretion system deletion mutant leads to better protection against clinical strains of Mycobacterium tuberculosis

Authors: Tiwari, Sangeeta, Dutt, Taru S., Chen, Bing, Chen, Mei, Kim, John, Dai, Annie Zhi, Lukose, Regy, Shanley, Crystal, Fox, Amy, Karger, Burton R., Porcelli, Steven A., Chan, John, Podell, Brendan K., Obregon-Henao, Andres, Orme, Ian M., Jacobs, William R., Henao-Tamayo, Marcela

Source: Vaccine. 38(45):7156-7165

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135901608.0x000001&indx=1&recIds=ETOCvdc_100135901608.0x000001

Small Animal Models for Human Immunodeficiency Virus (HIV), Hepatitis B, and Tuberculosis: Proceedings of an NIAID Workshop

Authors: Akkina, Ramesh, Barber, Daniel L., Bility, Moses T., Bissig, Karl-Dimiter, Burwitz, Benjamin J., Eichelberg, Katrin, Endsley, Janice J., Garcia, J. Victor, Hafner, Richard, Karakousis, Petros C., Korba, Brent E., Koshy, Rajen, Lambros, Chris, Menne, Stephan, Nuermberger, Eric L., Ploss, Alexander, Podell, Brendan K., Poluektova, Larisa Y., Sanders-Beer, Brigitte E., Subbian, Selvakumar, Wahl, Angela

Source: Current HIV research. 18(1):19-28

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157206573.0x000001&indx=1&recIds=ETOCvdc_100157206573.0x000001

ELISA-R: an R-based method for robust ELISA data analysis.

Authors: Dutt, Taru S., Spencer, John S., Karger, Burton R., Fox, Amy, Obregon-Henao, Andres, Podell, Brendan K., Anderson, G. Brooke, Henao-Tamayo, Marcela

Source: Frontiers in Immunology; 2024, p1-9, 9p

Subject Terms: MYCOBACTERIUM leprae, BACTERIAL antigens, VACCINE effectiveness, ENZYME-linked immunosorbent assay, MYCOBACTERIUM tuberculosis

Heterogeneity in immune cell composition is associated with Mycobacterium tuberculosis replication at the granuloma level.

Authors: Cooper, Sarah K., Ackart, David Forrest, Lanni, Faye, Henao-Tamayo, Marcela, Anderson, G. Brooke, Podell, Brendan K.

Source: Frontiers in Immunology; 2024, p01-13, 13p

Subject Terms: MYCOBACTERIUM tuberculosis, B cells, T cells, IN situ hybridization, CELL populations

Protective interplay: Mycobacterium tuberculosis diminishes SARS-CoV-2 severity through innate immune priming.

Authors: Williams, Brittany D., Ferede, Debora, Abdelaal, Hazem F. M., Berube, Bryan J., Podell, Brendan K., Larsen, Sasha E., Baldwin, Susan L., Coler, Rhea N.

Source: Frontiers in Immunology; 2024, p01-15, 15p

Subject Terms: MYCOBACTERIUM tuberculosis, SARS-CoV-2, COVID-19, BACTERIAL diseases, COVID-19 pandemic

Impact of immunopathology on the antituberculous activity of pyrazinamide

Authors: Blanc, Landry, Sarathy, Jansy Passiflora, Cabrera, Nadine Alvarez, O Brien, Paul, Dias-Freedman, Isabela, Mina, Marizel, Sacchettini, James, Savic, Radojka M., Gengenbacher, Martin, Podell, Brendan K.

Source: Journal of experimental medicine. 215(8):1975-1986

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN616981090&indx=1&recIds=ETOCRN616981090

Increased Severity of Tuberculosis in Guinea Pigs with Type 2 Diabetes: A Model of Diabetes-Tuberculosis Comorbidity

Authors: Podell, Brendan K., Ackart, David F., Obregon-Henao, Andres, Eck, Sarah P., Henao-Tamayo, Marcela, Richardson, Michael, Orme, Ian M., Ordway, Diane J., Basaraba, Randall J.

Source: In The American Journal of Pathology April 2014 184(4):1104-1118

Effects of Mycobacterium vaccae NCTC 11659 and Lipopolysaccharide Challenge on Polarization of Murine BV-2 Microglial Cells.

Authors: Desmond, Luke W., Holbrook, Evan M., Wright, Caelan T. O., Zambrano, Cristian A., Stamper, Christopher E., Bohr, Adam D., Frank, Matthew G., Podell, Brendan K., Moreno, Julie A., MacDonald, Andrew S., Reber, Stefan O., Hernández-Pando, Rogelio, Lowry, Christopher A.

Source: International Journal of Molecular Sciences; Jan2024, Vol. 25 Issue 1, p474, 20p

Subject Terms: LIPOPOLYSACCHARIDES, REVERSE transcriptase polymerase chain reaction, MICROGLIA, GENE expression, COMPLEMENT receptors, MYCOBACTERIUM

Digital Image Analysis of Heterogeneous Tuberculosis Pulmonary Pathology in Non-Clinical Animal Models using Deep Convolutional Neural Networks

Authors: Asay, Bryce C., Edwards, Blake Blue, Andrews, Jenna, Ramey, Michelle E., Richard, Jameson D., Podell, Brendan K., Gutiérrez, Juan F. Muñoz, Frank, Chad B., Magunda, Forgivemore, Robertson, Gregory T., Lyons, Michael, Ben-Hur, Asa, Lenaerts, Anne J.

Source: Scientific reports. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174704714.0x000001&indx=1&recIds=ETOCvdc_100174704714.0x000001

Metformin enhances protection in guinea pigs chronically infected with Mycobacterium tuberculosis

Authors: Frenkel, Jessica D. Haugen, Ackart, David F., Todd, Alexandra K., DiLisio, James E., Hoffman, Siana, Tanner, Samantha, Kiran, Dilara, Murray, Megan, Chicco, Adam, Obregón-Henao, Andrés, Podell, Brendan K., Basaraba, Randall J.

Source: Scientific reports. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174695933.0x000001&indx=1&recIds=ETOCvdc_100174695933.0x000001

Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers

Authors: Furlani, Robert E., Richardson, Mike A., Podell, Brendan K., Ackart, David F., Haugen, Jessica D., Melander, Roberta J., Basaraba, Randall J., Melander, Christian

Source: Bioorganic & medicinal chemistry letters. 25(21):4820-4823

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100064270381.0x000001&indx=1&recIds=ETOCvdc_100064270381.0x000001

Gliosis, misfolded protein aggregation, and neuronal loss in a guinea pig model of pulmonary tuberculosis.

Authors: Latham, Amanda S., Geer, Charlize E., Ackart, David F., Anderson, Isla K., Vittoria, Kaley M., Podell, Brendan K., Basaraba, Randall J., Moreno, Julie A.

Source: Frontiers in Neuroscience; 2023, p01-17, 17p

Subject Terms: TUBERCULOSIS, GUINEA pigs, MYCOBACTERIUM tuberculosis, MYCOBACTERIAL diseases, PATHOLOGICAL physiology

Preparation Strategies of the Anti-Mycobacterial Drug Bedaquiline for Intrapulmonary Routes of Administration.

Authors: Maloney, Sara E., Stewart, Ian E., Podell, Brendan K., Gary, Hadley E., Mecham, Jeffrey B., Berube, Bryan J., Baldwin, Susan L., Coler, Rhea N., Hickey, Anthony J.

Source: Pharmaceuticals (14248247); May2023, Vol. 16 Issue 5, p729, 12p

Subject Terms: ADENOSINE triphosphatase, RESPIRATORY therapy, PARTICULATE matter, MYCOBACTERIUM tuberculosis, GUINEA pigs, SPRAY drying

Company/Entity: WORLD Health Organization

Standardized guinea pig model for Q fever vaccine reactogenicity.

Authors: Baeten, Laurie A.¹, Podell, Brendan K.², Sluder, Ann E.³ asluder@mgh.harvard.edu, Garritsen, Anja⁴, Bowen, Richard A.¹, Poznansky, Mark C.³

Source: PLoS ONE. 10/12/2018, Vol. 13 Issue 10, p1-19. 19p.

Subject Terms: *COXIELLA burnetii, *ANIMAL models in research, *Q fever, *INTRADERMAL injections, *PATHOGENIC bacteria, *VACCINATION