A monoclonal antibody that recognizes a unique 13-residue epitope in the cytoplasmic tail of HLA-E

Authors: Verhaar, Elisha R., Gan, Jin, Buhl, Susan, Li, Ziao, Horowitz, Amir, Ploegh, Hidde L.

Source: In Molecular Immunology August 2024 172:56-67

Targeted delivery of an anti-inflammatory corticosteroid to Ly6C/G-positive cells abates severity of influenza A symptoms

Authors: Pishesha, Novalia, Harmand, Thibault, Carpenet, Claire, Liu, Xin, Bhan, Atul, Islam, Ashraful, van den Doel, Renate, Pinney, William, Ploegh, Hidde L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Oct . 119(43), 1-9.

Access URL: https://www.jstor.org/stable/27208901

Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut

Authors: Lynch, Jason P., González-Prieto, Coral, Reeves, Analise Z., Bae, Sena, Powale, Urmila, Godbole, Neha P., Tremblay, Jacqueline M., Schmidt, Florian I., Ploegh, Hidde L., Kansra, Vikram, Glickman, Jonathan N., Leong, John M., Shoemaker, Charles B., Garrett, Wendy S., Lesser, Cammie F.

Source: In Cell Host & Microbe 12 April 2023 31(4):634-649

A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants

Authors: Pishesha, Novalia, Harmand, Thibault J., Rothlauf, Paul W., Praest, Patrique, Alexander, Ryan K., van den Doel, Renate, Liebeskind, Mariel J., Vakaki, Maria A., McCaul, Nicholas, Wijne, Charlotte, Verhaar, Elisha, Pinney, William, Heston, Hailey, Bloyet, Louis-Marie, Pontelli, Marjorie Cornejo, Ilagan, Ma. Xenia G., Lebbink, Robert Jan, Buchser, William J., Wiertz, Emmanuel J. H. J., Whelan, Sean P. J., Ploegh, Hidde L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Nov 01. 118(44), 1-10.

Access URL: https://www.jstor.org/stable/27093603

An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity

Authors: Borriello, Francesco, Poli, Valentina, Shrock, Ellen, Spreafico, Roberto, Liu, Xin, Pishesha, Novalia, Carpenet, Claire, Chou, Janet, Di Gioia, Marco, McGrath, Marisa E., Dillen, Carly A., Barrett, Nora A., Lacanfora, Lucrezia, Franco, Marcella E., Marongiu, Laura, Iwakura, Yoichiro, Pucci, Ferdinando, Kruppa, Michael D., Ma, Zuchao, Lowman, Douglas W., Ensley, Harry E., Nanishi, Etsuro, Saito, Yoshine, O’Meara, Timothy R., Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Dowling, David J., Frieman, Matthew, Elledge, Stephen J., Levy, Ofer, Irvine, Darrell J., Ploegh, Hidde L., Williams, David L., Zanoni, Ivan

Source: In Cell 17 February 2022 185(4):614-629

ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function

Authors: Sugiyama, Takashi, Murao, Naoya, Kadowaki, Hisae, Takao, Keizo, Miyakawa, Tsuyoshi, Matsushita, Yosuke, Katagiri, Toyomasa, Futatsugi, Akira, Shinmyo, Yohei, Kawasaki, Hiroshi, Sakai, Juro, Shiomi, Kazutaka, Nakazato, Masamitsu, Takeda, Kohsuke, Mikoshiba, Katsuhiko, Ploegh, Hidde L., Ichijo, Hidenori, Nishitoh, Hideki

Source: In iScience 23 July 2021 24(7)

Nanobody-Targeted Conditional Antimicrobial Therapeutics

Authors: Ngambenjawong, Chayanon, Ko, Henry, Samad, Tahoura, Pishesha, Novalia, Ploegh, Hidde L., Bhatia, Sangeeta N.

Source: ACS Nano; March 2025, Vol. 19 Issue: 10 p9958-9970, 13p

HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses

Authors: Clayton, Kiera L., Mylvaganam, Geetha, Villasmil-Ocando, Alonso, Stuart, Heather, Maus, Marcela V., Rashidian, Mohammad, Ploegh, Hidde L., Walker, Bruce D.

Source: In Cell Host & Microbe 10 March 2021 29(3):435-447

Nanobodies in cancer

Authors: Verhaar, Elisha R., Woodham, Andrew W., Ploegh, Hidde L. ^*

Source: In Seminars in Immunology February 2021 52

Converting an Anti-Mouse CD4 Monoclonal Antibody into an scFv Positron Emission Tomography Imaging Agent for Longitudinal Monitoring of CD4^+ T Cells

Authors: Islam, Ashraful, Pishesha, Novalia, Harmand, Thibault J., Heston, Hailey, Woodham, Andrew W., Cheloha, Ross W., Bousbaine, Djenet, Rashidian, Mohammad, Ploegh, Hidde L.

Source: Journal of immunology. 207(5):1468-1477

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627363173&indx=1&recIds=ETOCRN627363173

Asparaginyl Ligase-Catalyzed One-Step Cell Surface Modification of Red Blood Cells

Authors: Harmand, Thibault J., Pishesha, Novalia, Rehm, Fabian B. H., Ma, Weiyi, Pinney, William B., Xie, Yushu J., Ploegh, Hidde L.

Source: ACS chemical biology. 16(7):1201-1207

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627069489&indx=1&recIds=ETOCRN627069489

Activation of a G protein-coupled receptor through indirect antibody-mediated tethering of ligandsElectronic supplementary information (ESI) available. See DOI: 10.1039/d1cb00118c

Authors: Cheloha, Ross W., Fischer, Fabian A., Gardella, Thomas J., Ploegh, Hidde L.

Source: RSC chemical biology. 2(6):1692-1700

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100148469261.0x000001&indx=1&recIds=ETOCvdc_100148469261.0x000001

Nanobodies as in vivo, non-invasive, imaging agents

Authors: Harmand, Thibault J., Islam, Ashraful, Pishesha, Novalia, Ploegh, Hidde L.

Source: RSC chemical biology. 2(3):685-701

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100147978738.0x000001&indx=1&recIds=ETOCvdc_100147978738.0x000001

Imaging the immune sequelae of infection with SARS‐CoV‐2 in nonhuman primates by using two nanobody PET‐tracers.

Authors: Koopman, Gerrit, Verhoeven, Tom, Mooij, Petra, Acar, Roja F., Harmand, Thibault, Flanagan, Laney, Bakker, Jaco, Böszörményi, Kinga P., Bontrop, Ronald E., Langermans, Jan A. M., Ploegh, Hidde L., Verschoor, Ernst J., Vugts, Danielle J., Pishesha, Novalia, Stammes, Marieke A.

Source: Journal of Medical Virology; Oct2024, Vol. 96 Issue 10, p1-11, 11p

Subject Terms: ANTIGEN presenting cells, POSITRON emission tomography, NASAL mucosa, EMPLOYEE recruitment, LUNG diseases

Antigen discovery tools for adaptive immune receptor repertoire research

Authors: Bousbaine, Djenet, Ploegh, Hidde L.

Source: In Current Opinion in Systems Biology December 2020 24:64-70

Exploring cellular biochemistry with nanobodies

Authors: Cheloha, Ross W., Harmand, Thibault J., Wijne, Charlotte, Schwartz, Thomas U., Ploegh, Hidde L. ^*

Source: In Journal of Biological Chemistry 6 November 2020 295(45):15307-15327

Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition

Authors: Priem, Bram, van Leent, Mandy M.T., Teunissen, Abraham J.P., Sofias, Alexandros Marios, Mourits, Vera P., Willemsen, Lisa, Klein, Emma D., Oosterwijk, Roderick S., Meerwaldt, Anu E., Munitz, Jazz, Prévot, Geoffrey, Vera Verschuur, Anna, Nauta, Sheqouia A., van Leeuwen, Esther M., Fisher, Elizabeth L., de Jong, Karen A.M., Zhao, Yiming, Toner, Yohana C., Soultanidis, Georgios, Calcagno, Claudia, Bomans, Paul H.H., Friedrich, Heiner, Sommerdijk, Nico, Reiner, Thomas, Duivenvoorden, Raphaël, Zupančič, Eva, Di Martino, Julie S., Kluza, Ewelina, Rashidian, Mohammad, Ploegh, Hidde L., Dijkhuizen, Rick M., Hak, Sjoerd, Pérez-Medina, Carlos, Bravo-Cordero, Jose Javier, de Winther, Menno P.J., Joosten, Leo A.B., van Elsas, Andrea, Fayad, Zahi A., Rialdi, Alexander, Torre, Denis, Guccione, Ernesto, Ochando, Jordi, Netea, Mihai G., Griffioen, Arjan W., Mulder, Willem J.M.

Source: In Cell 29 October 2020 183(3):786-801

Turnip yellow mosaic virus protease binds ubiquitin suboptimally to fine-tune its deubiquitinase activity

Authors: Fieulaine, Sonia ^*, Witte, Martin D., Theile, Christopher S., Ayach, Maya, Ploegh, Hidde L., Jupin, Isabelle, Bressanelli, Stéphane ^**

Source: In Journal of Biological Chemistry 2 October 2020 295(40):13769-13783

Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade

Authors: Rashidian, Mohammad, LaFleur, Martin W., Verschoor, Vincent L., Dongre, Anushka, Zhang, Yun, Nguyen, Thao H., Kolifrath, Stephen, Aref, Amir R., Lau, Christie J., Paweletz, Cloud P., Bu, Xia, Freeman, Gordon J., Barrasaf, M. Inmaculad, Weinberg, Robert A., Sharpe, Arlene H., Ploegh, Hidde L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Aug . 116(34), 16971-16980.

Access URL: https://www.jstor.org/stable/26850570

Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix : May 8, 2019.

Authors: Jailkhani, Noor, Ingram, Jessica R., Rashidian, Mohammad, Rickelt, Steffen, Tian, Chenxi, Mak, Howard, Jiang, Zhigang, Ploegh, Hidde L., Hynes, Richard O.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Jul 01. 116(28), 14181-14190.

Access URL: https://www.jstor.org/stable/26761002