Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions

Authors: Holm, Caroline Marcher, Topaktas, Asli B., Dannesboe, Johs, Pless, Stephan A., Heusser, Stephanie A.

Source: In Biophysical Journal 16 July 2024 123(14):2122-2135

Protein semisynthesis underscores the role of a conserved lysine in activation and desensitization of acid-sensing ion channels

Authors: Sarkar, Debayan, Galleano, Iacopo, Heusser, Stephanie Andrea, Ou, Sofie Yuewei, Uzun, Gül Refika, Khoo, Keith K., van der Heden van Noort, Gerbrand Jan, Harrison, Joseph Scott, Pless, Stephan Alexander

Source: In Cell Chemical Biology 16 May 2024 31(5):1000-1010

Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Na v 1.5

Authors: Galleano, Iacopo, Harms, Hendrik, Choudhury, Koushik, Khoo, Keith, Delemotte, Lucie, Pless, Stephan Alexander

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Aug . 118(33), 1-10.

Access URL: https://www.jstor.org/stable/27074820

The suitability of high throughput automated patch clamp for physiological applications

Authors: Obergrussberger, Alison, Rinke‐Weiß, Ilka, Goetze, Tom A., Rapedius, Markus, Brinkwirth, Nina, Becker, Nadine, Rotordam, Maria Giustina, Hutchison, Laura, Madau, Paola, Pau, Davide, Dalrymple, David, Braun, Nina, Friis, Søren, Pless, Stephan A., Fertig, Niels

Source: Journal of physiology. 600(2):277-297

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139001916.0x000001&indx=1&recIds=ETOCvdc_100139001916.0x000001

P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity

Authors: Gasparri, Federica, Sarkar, Debayan, Bielickaite, Sarune, Poulsen, Mette Homann, Hauser, Alexander Sebastian, Pless, Stephan Alexander

Source: British journal of pharmacology. 179(14):3859-3874

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153633097.0x000001&indx=1&recIds=ETOCvdc_100153633097.0x000001

Acid-sensing ion channels as potential therapeutic targets

Authors: Heusser, Stephanie A., Pless, Stephan A.

Source: In Trends in Pharmacological Sciences December 2021 42(12):1035-1050

The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons

Authors: Jehasse, Kevin, Massotte, Laurent, Hartmann, Sebastian, Vitello, Romain, Ringlet, Sofian, Vitello, Marie, Chua, Han Chow, Pless, Stephan A., Engel, Dominique, Liégeois, Jean-François, Lakaye, Bernard, Roeper, Jochen, Seutin, Vincent

Source: In Neuropharmacology 1 October 2021 197

Mechanism and site of action of big dynorphin on ASIC1a

Authors: Borg, Christian B., Braun, Nina, Heusser, Stephanie A., Bay, Yasmin, Weis, Daniel, Galleano, Iacopo, Lund, Camilla, Tian, Weihua, Haugaard-Kedström, Linda M., Bennett, Eric P., Lynagh, Timothy, Strømgaard, Kristian, Andersen, Jacob, Pless, Stephan A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Mar . 117(13), 7447-7454.

Access URL: https://www.jstor.org/stable/26929468

Evolutionarily Conserved Interactions within the Pore Domain of Acid-Sensing Ion Channels

Authors: Kasimova, Marina A., Lynagh, Timothy, Sheikh, Zeshan Pervez, Granata, Daniele, Borg, Christian Bernsen, Carnevale, Vincenzo, Pless, Stephan Alexander

Source: In Biophysical Journal 25 February 2020 118(4):861-872

Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes

Authors: Lynagh, Timothy, Mikhaleva, Yana, Colding, Janne M., Glover, Joel C., Pless, Stephan A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Aug . 115(33), 8430-8435.

Access URL: https://www.jstor.org/stable/26530255

High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics

Authors: Wulf, Matthias, Pless, Stephan Alexander

Source: In Cell Reports 6 February 2018 22(6):1615-1626

The sodium leak complex and friends: Identifying protein partners of the NALCN channelosome

Authors: Usher, Samuel, Pless, Stephan A.

Source: Biophysical journal. 122(S1):396a-397a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185948985.0x000001&indx=1&recIds=ETOCvdc_100185948985.0x000001

Molecular determinants for agonist recognition and discrimination in P2X2 receptors

Authors: Gasparri, Federica, Wengel, Jesper, Grutter, Thomas, Pless, Stephan A.

Source: Journal of general physiology. 151(7):898-911

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN620698888&indx=1&recIds=ETOCRN620698888

PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels

Authors: Kim, Robin Y., Pless, Stephan A., Kurata, Harley T.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Nov 01. 114(45), E9702-E9711.

Access URL: https://www.jstor.org/stable/26485752

Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore region.

Authors: Schott, Katharina, Usher, Samuel George, Serra, Oscar, Carnevale, Vincenzo, Pless, Stephan Alexander, Han Chow Chua

Source: Proceedings of the National Academy of Sciences of the United States of America; 5/28/2024, Vol. 121 Issue 22, p1-12, 26p

Subject Terms: BINDING sites, SODIUM channels, DRUG design, CALCIUM channels, AMINO acid residues

Human P2X7 receptor variants Gly150Arg and Arg276His polymorphisms have differential effects on risk association and cellular functions in pancreatic cancer.

Authors: Magni, Lara, Yu, Haoran, Christensen, Nynne M., Poulsen, Mette H., Frueh, Alexander, Deshar, Ganga, Johansen, Astrid Z., Johansen, Julia S., Pless, Stephan A., Jørgensen, Niklas R., Novak, Ivana

Source: Cancer Cell International; 4/25/2024, Vol. 24 Issue 1, p1-16, 16p

Subject Terms: CELL physiology, PANCREATIC cancer, CELL migration inhibition, CELL migration, SINGLE nucleotide polymorphisms, PANCREATIC duct

Unique Contributions of an Arginine Side Chain to Ligand Recognition in a Glutamate-gated Chloride Channel

Authors: Lynagh, Timothy, Komnatnyy, Vitaly V., Pless, Stephan A.

Source: In Journal of Biological Chemistry 3 March 2017 292(9):3940-3946

Unexplained cardiac arrest: a tale of conflicting interpretations of KCNQ1 genetic test results

Authors: Chua, Han Chow, Servatius, Helge, Asatryan, Babken, Schaller, André, Rieubland, Claudine, Noti, Fabian, Seiler, Jens, Roten, Laurent, Baldinger, Samuel H., Tanner, Hildegard, Fuhrer, Juerg, Haeberlin, Andreas, Lam, Anna, Pless, Stephan A., Medeiros-Domingo, Argelia

Source: Clinical research in cardiology. 107(8):670-678

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141531888.0x000001&indx=1&recIds=ETOCvdc_100141531888.0x000001

One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels

Authors: Yau, Michael C., Kim, Robin Y., Wang, Caroline K., Li, Jingru, Ammar, Tarek, Yang, Runying Y., Pless, Stephan A., Kurata, Harley T.

Source: Journal of general physiology. 150(10):1421-1431

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN617611970&indx=1&recIds=ETOCRN617611970

Four drug-sensitive subunits are required for maximal effect of a voltage sensor-targeted KCNQ opener

Authors: Wang, Alice W., Yau, Michael C., Wang, Caroline K., Sharmin, Nazlee, Yang, Runying Y., Pless, Stephan A., Kurata, Harley T.

Source: Journal of general physiology. 150(10):1432-1443

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN617611981&indx=1&recIds=ETOCRN617611981