Polypyrimidine tract binding protein 1 (PTBP1) contains a novel regulatory sequence, the rBH3, that binds the prosurvival protein MCL1

Authors: Carico, Christine, Cui, Jia, Acton, Alexus, Placzek, William J.

Source: In Journal of Biological Chemistry June 2023 299(6)

Myeloid Cell Leukemia 1 Small Molecule Inhibitor S63845 Synergizes with Cisplatin in Triple-Negative Breast Cancer.

Authors: Acton, Alexus¹ (AUTHOR), Placzek, William J.¹ (AUTHOR) placzek@uab.edu

Source: Cancers. Sep2023, Vol. 15 Issue 18, p4481. 16p.

Subject Terms: *PROTEINS, *APOPTOSIS, *CISPLATIN, *CELL proliferation, *RESEARCH funding, *CELL lines, *TRANSCRIPTION factors, *BREAST tumors, *CHEMICAL inhibitors

Reviewing PTBP1 Domain Modularity in the Pre-Genomic Era: A Foundation to Guide the Next Generation of Exploring PTBP1 Structure–Function Relationships.

Authors: Carico, Christine¹ (AUTHOR), Placzek, William J.¹ (AUTHOR) placzek@uab.edu

Source: International Journal of Molecular Sciences. Jul2023, Vol. 24 Issue 13, p11218. 16p.

Subject Terms: *RNA-binding proteins, *NUCLEOTIDE sequence, *NUCLEOTIDE sequencing, *CARRIER proteins

The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of α-synuclein

Authors: Underwood, Rachel, Wang, Bing, Carico, Christine, Whitaker, Robert H., Placzek, William J., Yacoubian, Talene A. ^*

Source: In Journal of Biological Chemistry 5 June 2020 295(23):8005-8016

Serum Cytokine Profile in IgA Nephropathy

Authors: Selbach, Friederike ¹, Maggiore, Umberto ², Gentile, Micaela ¹, Meliambro, Kristin ¹, Campbell, Kirk N. ¹, Tucholski, Janusz ³, Julian, Bruce A. ³, Placzek, William J. ³, Alibrandi, Sara ¹, Kim-Schulze, Seunghee ⁴, Lanau Martínez, Maria ⁵, Fernandez-Lorente, M Loreto ⁵, Manrique, Joaquin ⁵, Cravedi, Paolo ^{1, ∗}

Source: In Kidney Medicine February 2025 7(2)

Specific inhibition of DPY30 activity by ASH2L-derived peptides suppresses blood cancer cell growth

Authors: Shah, Kushani K., Whitaker, Robert H., Busby, Theodore, Hu, Jing, Shi, Bi, Wang, Zhenjia, Zang, Chongzhi, Placzek, William J., Jiang, Hao

Source: In Experimental Cell Research 15 September 2019 382(2)

Phylogenetic analysis of the MCL1 BH3 binding groove and rBH3 sequence motifs in the p53 and INK4 protein families.

Authors: McGriff, Anna¹ (AUTHOR), Placzek, William J.¹ (AUTHOR) placzek@uab.edu

Source: PLoS ONE. 1/25/2023, Vol. 18 Issue 1, p1-19. 19p.

Subject Terms: *P53 protein, *CYCLIN-dependent kinase inhibitors, *MYELOID cells, *FAMILIES, *AMPHIBIANS, *KINASE inhibitors, *CYCLINS

UBC9 Mutant Reveals the Impact of Protein Dynamics on Substrate Selectivity and SUMO Chain Linkages

Authors: Wright, Christine M., Whitaker, Robert H., Onuiri, Joshua E., Blackburn, Tessa, McGarity, Sierra, Bjornsti, Mary-Ann, Placzek, William J.

Source: Biochemistry. 58(6):621-632

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN619139092&indx=1&recIds=ETOCRN619139092

MCL1 binds and negatively regulates the transcriptional function of tumor suppressor p73

Authors: Widden, Hayley, Kaczmarczyk, Aneta, Subedi, Ashok, Whitaker, Robert H., Placzek, William J.

Source: Cell death and disease. 11(11)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183675775.0x000001&indx=1&recIds=ETOCvdc_100183675775.0x000001

MCL1 binding to the reverse BH3 motif of P18INK4C couples cell survival to cell proliferation

Authors: Whitaker, Robert H., Placzek, William J.

Source: Cell death and disease. 11(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164506887.0x000001&indx=1&recIds=ETOCvdc_100164506887.0x000001

The E3 Ubiquitin Ligase Siah2 Contributes to Castration-Resistant Prostate Cancer by Regulation of Androgen Receptor Transcriptional Activity

Authors: Qi, Jianfei, Tripathi, Manisha, Mishra, Rajeev, Sahgal, Natasha, Fazil, Ladan, Ettinger, Susan, Placzek, William J., Claps, Giuseppina, Chung, Leland W.K., Bowtell, David, Gleave, Martin, Bhowmick, Neil, Ronai, Ze’ev A.

Source: In Cancer Cell 18 March 2013 23(3):332-346

Identification of a Novel Mcl-1 Protein Binding Motif

Authors: Placzek, William J., Sturlese, Mattia, Wu, Bainan, Cellitti, Jason F., Wei, Jun, Pellecchia, Maurizio

Source: In Journal of Biological Chemistry 18 November 2011 286(46):39829-39835

NMR Structure and Functional Characterization of a Human Cancer-related Nucleoside Triphosphatase

Authors: Placzek, William J. ^†, Almeida, Marcius S. ^†, Wüthrich, Kurt

Source: In Journal of Molecular Biology 2007 367(3):788-801

Serum galactose-deficient-IgA1 and IgG autoantibodies correlate in patients with IgA nephropathy.

Authors: Placzek, William J.¹ placzek@uab.edu, Yanagawa, Hiroyuki², Makita, Yuko², Renfrow, Matthew B.¹, Julian, Bruce A.^3,4, Rizk, Dana V.³, Suzuki, Yusuke², Novak, Jan⁴, Suzuki, Hitoshi²

Source: PLoS ONE. 1/11/2018, Vol. 13 Issue 1, p1-9. 9p.

Subject Terms: *IGA glomerulonephritis, *BLOOD serum analysis, *AUTOANTIBODIES, *AUTOANTIGENS, *NEPHROLOGY, *DIAGNOSIS

Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members.

Authors: Cui, Jia¹ jiacui@uab.edu, Placzek, William J.¹ placzek@uab.edu

Source: International Journal of Molecular Sciences. Jan2018, Vol. 19 Issue 1, p308. 22p. 2 Diagrams, 3 Charts, 1 Graph.

Subject Terms: *B cell lymphoma, *LYMPHOMAS, *APOPTOSIS, *ANTINEOPLASTIC agents, *DRUG resistance in cancer cells

Transcriptional Activation of Tumor Suppressor p73 is Modulated by MCL1 Through a Novel Protein Interaction

Authors: Widden, Hayley, Kacmarczyk, Aneta, Whitaker, Robert H., Placzek, William J.

Source: FASEB journal. 34(S1):1-1

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140398905.0x000001&indx=1&recIds=ETOCvdc_100140398905.0x000001

The multiple mechanisms of MCL1 in the regulation of cell fate.

Authors: Widden, Hayley¹, Placzek, William J.¹ placzek@uab.edu

Source: Communications Biology. 9/2/2021, Vol. 4 Issue 1, p1-12. 12p.

Subject Terms: *MYELOID cells, *BCL-2 proteins, *CANCER treatment, *CELL proliferation, *DNA damage

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A cell-penetrating MARCKS mimetic selectively triggers cytolytic death in glioblastoma

Authors: Eustace, Nicholas J., Anderson, Joshua C., Warram, Jason M., Widden, Hayley N., Pedersen, Rune T., Alrefai, Hasan, Patel, Zeel, Hicks, Patricia H., Placzek, William J., Gillespie, G. Yancey, Hjelmeland, Anita B., Willey, Christopher D.

Source: Oncogene; November 2020, Vol. 39 Issue: 46 p6961-6974, 14p