Meta-analysis of genome-wide association studies of stable warfarin dose in patients of African ancestry

Authors: Asiimwe, Innocent G., Blockman, Marc, Cavallari, Larisa H., Cohen, Karen, Cupido, Clint, Dandara, Collet, Davis, Brittney H., Jacobson, Barry, Johnson, Julie A., Lamorde, Mohammed, Limdi, Nita A., Morgan, Jennie, Mouton, Johannes P., Muyambo, Sarudzai, Nakagaayi, Doreen, Ndadza, Arinao, Okello, Emmy, Perera, Minoli A., Schapkaitz, Elise, Sekaggya-Wiltshire, Christine, Semakula, Jerome R., Tatz, Gayle, Waitt, Catriona, Yang, Guang, Zhang, Eunice J., Jorgensen, Andrea L., Pirmohamed, Munir

Source: In Blood Advances 22 October 2024 8(20):5248-5261

Pharmacogenetics for the prescriber

Authors: Pirmohamed, Munir

Source: In Medicine January 2024 52(1):11-14

A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study

Authors: Swen, Jesse J, van der Wouden, Cathelijne H, Manson, Lisanne EN, Abdullah-Koolmees, Heshu, Blagec, Kathrin, Blagus, Tanja, Böhringer, Stefan, Cambon-Thomsen, Anne, Cecchin, Erika, Cheung, Ka-Chun, Deneer, Vera HM, Dupui, Mathilde, Ingelman-Sundberg, Magnus, Jonsson, Siv, Joefield-Roka, Candace, Just, Katja S, Karlsson, Mats O, Konta, Lidija, Koopmann, Rudolf, Kriek, Marjolein, Lehr, Thorsten, Mitropoulou, Christina, Rial-Sebbag, Emmanuelle, Rollinson, Victoria, Roncato, Rossana, Samwald, Matthias, Schaeffeler, Elke, Skokou, Maria, Schwab, Matthias, Steinberger, Daniela, Stingl, Julia C, Tremmel, Roman, Turner, Richard M, van Rhenen, Mandy H, Dávila Fajardo, Cristina L, Dolžan, Vita, Patrinos, George P, Pirmohamed, Munir, Sunder-Plassmann, Gere, Toffoli, Giuseppe, Guchelaar, Henk-Jan

Source: Lancet. 401(10374):347-356

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195818671.0x000001&indx=1&recIds=ETOCvdc_100195818671.0x000001

The Implementation of Pharmacogenetics in the United Kingdom

Authors: McDermott, John H., Sharma, Videha, Keen, Jessica, Newman, William G., Pirmohamed, Munir

Source: Handbook of experimental pharmacology. 280:3-34

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633601535&indx=1&recIds=ETOCRN633601535

What the Product Label Does Not Tell You About Drug–Drug Interaction Management

Authors: Burger, David M., le Comte, Marianne, Smolders, Elise J., Jacobs, Tom G., ter Heine, Rob, Knibbe, Catherijne A.J., Pirmohamed, Munir

Source: Journal of clinical pharmacology. 63(11):1181-1185

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195613317.0x000001&indx=1&recIds=ETOCvdc_100195613317.0x000001

Prescribing in liver disease

Authors: Pirmohamed, Munir

Source: Medicine. 51(5):326-330

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190319625.0x000001&indx=1&recIds=ETOCvdc_100190319625.0x000001

Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype

Authors: Gammal, Roseann S., Pirmohamed, Munir, Somogyi, Andrew A., Morris, Sarah A., Formea, Christine M., Elchynski, Amanda L., Oshikoya, Kazeem A., McLeod, Howard L., Haidar, Cyrine E., Whirl‐Carrillo, Michelle, Klein, Teri E., Caudle, Kelly E., Relling, Mary V.

Source: Clinical pharmacology & therapeutics. 113(5):973-985

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189922593.0x000001&indx=1&recIds=ETOCvdc_100189922593.0x000001

Characterization of Drug-Specific CD4^+ T-Cells Reveals Possible Roles of HLA Class II in the Pathogenesis of Carbamazepine Hypersensitivity Reactions

Authors: Jaruthamsophon, Kanoot, Thomson, Paul J., Hammond, Sean, Zhang, Euice, Alfirevic, Ana, Sukasem, Chonlaphat, Naisbitt, Dean J., Pirmohamed, Munir

Source: Chemical research in toxicology. 36(5):757-768

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Exploring the impact of design criteria for reference sets on performance evaluation of signal detection algorithms: The case of drug–drug interactions

Authors: Kontsioti, Elpida, Maskell, Simon, Pirmohamed, Munir

Source: Pharmacoepidemiology and drug safety. 32(8):832-844

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186846079.0x000001&indx=1&recIds=ETOCvdc_100186846079.0x000001

Analysis of serum microRNA‐122 in a randomized controlled trial of N‐acetylcysteine for treatment of antituberculosis drug‐induced liver injury

Authors: Moosa, Muhammed Shiraz, Russomanno, Giusy, Dorfman, Jeffrey R., Gunter, Hannah, Patel, Chandni, Costello, Eithne, Carr, Dan, Maartens, Gary, Pirmohamed, Munir, Goldring, Christopher, Cohen, Karen

Source: British journal of clinical pharmacology. 89(6):1844-1851

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182220001.0x000001&indx=1&recIds=ETOCvdc_100182220001.0x000001

Clinical Relevance of Drug–Drug Interactions With Antibiotics as Listed in a National Medication Formulary: Results From Two Large Population‐Based Case‐Control Studies in Patients Aged 65–100 Years Using Linked English Primary Care and Hospital Data

Authors: Staa, Tjeerd Pieter, Pirmohamed, Munir, Sharma, Anita, Buchan, Iain, Ashcroft, Darren M.

Source: Clinical pharmacology & therapeutics. 113(2):423-434

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172693040.0x000001&indx=1&recIds=ETOCvdc_100172693040.0x000001

Role of fatty liver index in risk-stratifying comorbid disease outcomes in non-alcoholic fatty liver disease

Authors: Ho, Brian, Thompson, Andrew, Jorgensen, Andrea L, Pirmohamed, Munir

Source: In JHEP Reports December 2023 5(12)

TNF-α‒Mediated Keratinocyte Expression and Release of Matrix Metalloproteinase 9: Putative Mechanism of Pathogenesis in Stevens‒Johnson Syndrome/Toxic Epidermal Necrolysis

Authors: Olsson-Brown, Anna, Yip, Vincent, Ogiji, Emeka D., Jolly, Carol, Ressel, Lorenzo, Sharma, Anurag, Bergfeld, Wilma, Liu, Xuan, Khirwadkar, Nitin, Bellon, Teresa, Dickinson, Anne, Ahmed, Shaheda, Langton, Abigail, Watson, Rachel, Pirmohamed, Munir, Carr, Daniel F.

Source: In Journal of Investigative Dermatology June 2023 143(6):1023-1030

A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study

Authors: Buunk, Annemarie, Goossens, Hanneke, Baas, Gert, Algera, Maartje, Schuil-Vlassak, Evelyn, Ambagts, Thijs, De Hoog-Schouten, Leonie, Musaafir, Sara, Bosch, Roelof, Tjong, Carol, Steeman, Sanne, Van der Plas, Martine, Baldew, Glenn, Den Hollander, Iris, De Waal, Zacharias, Heijn, Aurele, Nelemans, Leen, Kouwen-Lubbers, Kirsten, Van Leeuwen, Maartje, Hoogenboom, Sacha, Van Doremalen, Jacobine, Ton, Célin, Beetstra, Bastien, Meijs, Veronique, Dikken, Jan, Dubero, Dasha, Slager, Mark, Houben, Tom, Kanis, Thomas, Overmars, Wietske, Nijenhuis, Marga, Steffens, Michael, Bergs, Ingmar, Karamperis, Kariofyllis, Siamoglou, Stavroula, Ivantsik, Ouliana, Samiou, Georgia-Chryssa, Kordou, Zoe, Tsermpini, Evira, Ferentinos, Panagiotis, Karaivazoglou, Aikaterini, Rigas, George, Gerasimou, Harilaos, Voukelatou, Georgia, Georgila, Eleni, Tsermpini, Evangelia Eirini, Mendrinou, Efrossyni, Chalikiopoulou, Konstantina, Kolliopoulou, Alexandra, Mitropoulos, Konstantinos, Stratopoulos, Apostolos, Liopetas, Ioannis, Tsikrika, Athina, Barba, Evangelia, Emmanouil, Georgia, Stamopoulou, Theano, Stathoulias, Andreas, Giannopoulos, Panagiotis, Kanellakis, Filippos, Bartsakoulia, Marina, Katsila, Theodora, Douzenis, Athanassios, Gourzis, Filippos, Assimakopoulos, Konstantinos, Bignucolo, Alessia, Dal Cin, Lisa, Comello, Francesco, Mezzalira, Silvia, Puglisi, Fabio, Spina, Michele, Foltran, Luisa, Guardascione, Michela, Buonadonna, Angela, Bartoletti, Michele, Corsetti, Serena, Ongaro, Elena, Da Ros, Lucia, Bolzonello, Silvia, Spazzapan, Simon, Freschi, Andrea, Di Nardo, Paola, Palazzari, Elisa, Navarria, Federico, Innocente, Roberto, Berretta, Massimiliano, D'Andrea, Mario, Angelini, Francesco, Diraimo, Tania, Favaretto, Adolfo, Dávila-Fajardo, Cristina Lucía, Díaz-Villamarín, Xando, Martínez-González, Luis Javier, Antúnez-Rodríguez, Alba, Moreno-Escobar, Eduardo, Fernández-Gómez, Ana Estefanía, García-Navas, Paloma, Bautista-Pavés, Alicia Bautista Pavés, Burillo-Gómez, Francisco, Villegas-Rodríguez, Inmaculada, Sánchez-Ramos, Jesús Gabriel, Antolinos-Pérez, Mª José, Rivera, Ricardo, Martínez-Huertas, Susana, Thomas-Carazo, Jesús, Yañez-Sanchez, Jose Julio, Blancas-López-Barajas, Mª Isabel, García-Orta, Rocío, González-Astorga, Beatriz, Rodríguez-González, Carlos José, Ruiz-Carazo, Francisco Javier, Pérez-Campos, Manuel, Cano-Herrera, Irene, Herrera, Rosa, Gil-Jiménez, Teresa, Delgado-Ureña, Mª Teresa, Triviño-Juarez, Jose Matías, Campos-Velázquez, Salustiano, Alcántara- Espadafor, Silvia, Moreno Aguilar, Maria Rosario, Ontiveros- Ortega, Maria Carmen, Carnerero-Córdoba, Lidia, Guerrero-Jiménez, Margarita, Legeren- Álvarez, Marta, Yélamos-Vargas, Marisol, Castillo-Pérez, Isabel, Aomar-Millán, Ismael, Anguita-Romero, Manuel, Sánchez-García, María José, Sequero-Lopez, Silvia, Faro-Miguez, Naya, López-Fernández, Silvia, Leyva-Ferrer, Rosario Nieves, Herrera-Gómez, Norberto, Pertejo-Manzano, Laura, Pérez-Gutierrez, Eva Mª, Martín-de la Higuera, Antonio J., Plaza-Carrera, Jose, Baena-Garzón, Flor, Toledo-Frías, Pablo, Cruz-Valero, Inés, Chacón-McWeeny, Verónica, Gallardo- Sánchez, Isabel, Arrebola, Antonio, Guillén-Zafra, Lucía, Ceballos-Torres, Ángel, Guardia-Mancilla, Plácido, Guirao-Arrabal, Emilio, Canterero-Hinojosa, Jesús, Velasco-Fuentes, Sara, Sánchez- Cano, Daniel, Aguilar-Jaldo, Mª del Pilar, Caballero-Borrego, Juan, Praznik, Monika, Slapšak, Urška, Voncina, Blaz, Rajter, Branka, Škrinjar, Andrej, Marjetic Ulcakar, Angelika, Zidanšek, Anja, Stegne Ignjatvic, Tea, Mazej Poredoš, Barbara, Vivod Pecnik, Živka, Poplas Susic, Tonka, Juteršek, Milojka, Klen, Jasna, Skoporc, Janja, Kotar, Tjaša, Petek Šter, Marija, Zvezdana Dernovšk, Mojca, Mlinšek, Gregor, Miklavcic, Petra, Plemenitaš Ilješ, Anja, Grašic Kuhar, Cvetka, Oblak, Irena, Stražišar, Branka, Štrbac, Danijela, Matos, Erika, Mencinger, Marina, Vrbnjak, Marko, Saje, Marko, Radovanovic, Mirjana, Jeras, Katja, Bukovec, Lucija, Terzic, Tea, Minichmayr, Iris, Nanah, Abdulaziz, Nielsen, Elisabet, Zou, Yuanxi, Lauschke, Volker, Johansson, Inger, Zhou, Yitian, Nordling, Åsa, Aigner, Christof, Dames-Ludwig, Marlies, Monteforte, Rossella, Sunder-Plassmann, Raute, Steinhauser, Corinna, Sengoelge, Guerkan, Winnicki, Wolfgang, Schmidt, Alice, Vasileios, Fragoulakis, Fontana, Vanessa, Hanson, Anita, Little, Margaret, Hornby, Rachael, Dello Russo, Cinzia, French, Stephanie, Hampson, Jamie, Gumustekin, Mukaddes, Anyfantis, George, Hampson, Lucy, Lewis, David, Westhead, Ruth, Prince, Clare, Rajasingam, Arjunan, Swen, Jesse J, van der Wouden, Cathelijne H ^*, Manson, Lisanne EN ^*, Abdullah-Koolmees, Heshu, Blagec, Kathrin, Blagus, Tanja, Böhringer, Stefan, Cambon-Thomsen, Anne, Cecchin, Erika, Cheung, Ka-Chun, Deneer, Vera HM, Dupui, Mathilde, Ingelman-Sundberg, Magnus, Jonsson, Siv, Joefield-Roka, Candace, Just, Katja S, Karlsson, Mats O, Konta, Lidija, Koopmann, Rudolf, Kriek, Marjolein, Lehr, Thorsten, Mitropoulou, Christina, Rial-Sebbag, Emmanuelle, Rollinson, Victoria, Roncato, Rossana, Samwald, Matthias, Schaeffeler, Elke, Skokou, Maria, Schwab, Matthias, Steinberger, Daniela, Stingl, Julia C, Tremmel, Roman, Turner, Richard M, van Rhenen, Mandy H, Dávila Fajardo, Cristina L, Dolžan, Vita, Patrinos, George P, Pirmohamed, Munir, Sunder-Plassmann, Gere, Toffoli, Giuseppe, Guchelaar, Henk-Jan ^*

Source: In The Lancet 4-10 February 2023 401(10374):347-356

Updates on the immunopathology and genomics of severe cutaneous adverse drug reactions

Authors: Gibson, Andrew, Deshpande, Pooja, Campbell, Chelsea N., Krantz, Matthew S., Mukherjee, Eric, Mockenhaupt, Maja, Pirmohamed, Munir, Palubinsky, Amy M., Phillips, Elizabeth J.

Source: In The Journal of Allergy and Clinical Immunology February 2023 151(2):289-300

Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study

Authors: Alexander, Daniel C, Asiimwe, Innocent G, Ball, Simon, Bennett, Frances, Borges, Maria Carolina, Butterworth, Adam, Chaturvedi, Nishi, Chopade, Sandesh, Clarkson, Christopher, Cox, Martin, Dale, Caroline, Denaxas, Spiros, Dunca, Diana, Engmann, Jorgen E, Fernandez-Sanles, Alba, Finan, Chris, Fitzpatrick, Natalie, Gallagher, Jean, Gonzalez-Izquierdo, Arturo, Gratton, Jasmine, Gross, Christian, Hemingway, Harry, Henry, Albert, Hidajat, Mira, Hingorani, Aroon, Hukerikar, Nikita, Jorgensen, Andrea, Joshi, Roshni, Katsoulis, Michail, Kuan, Valerie, Kumar, Rashmi, Lai, Alvina G, Langenberg, Claudia, Lawlor, Deborah, Mancini, Mary, Miller, Diane, Ogden, Margaret, Ozyigit, Eda B, Patel, Shilpa, Pirmohamed, Munir, Roberts, Amanda, Ryan, David, Schmidt, Amand F, Shah, Anoop D, Shah, Tina, Sofat, Reecha, Takhar, Rohan, Torralbo, Ana, Ullah, Ayath, Walker, Lauren E, Warwick, Alasdair, Wheeler, Eleanor, Wright, Victoria L, Wu, Honghan, Zwierzyna, Magdalena, Patalay, Praveetha, Nitsch, Dorothea, Mathur, Rohini, Partridge, Linda, Wong, Ian C K, Hingorani, Melanie, Hingorani, Aroon D

Source: In The Lancet Digital Health January 2023 5(1):e16-e27

Sequential Association Rule Mining Revisited: A Study Directed at Relational Pattern Mining for Multi-morbidity
SGAI International conference on artificial intelligence

Authors: Vincent-Paulraj, Alexandar, Burnside, Girvan, Coenen, Frans, Pirmohamed, Munir, Walker, Lauren

Source: Lecture notes in computer science. 13101:241-253

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN607269141&indx=1&recIds=ETOCCN607269141

CYP3A4*22 and bleeding risk in ticagrelor users.

Authors: Asiimwe, Innocent G.¹ (AUTHOR) i.asiimwe@liverpool.ac.uk, Pirmohamed, Munir¹ (AUTHOR) munirp@liverpool.ac.uk

Source: Basic & Clinical Pharmacology & Toxicology. Mar2024, Vol. 134 Issue 3, p311-314. 4p.

Subject Terms: *PRASUGREL, *TICAGRELOR, *HEMORRHAGE

Stable warfarin dose prediction in sub‐Saharan African patients: A machine‐learning approach and external validation of a clinical dose–initiation algorithm

Authors: Asiimwe, Innocent G., Blockman, Marc, Cohen, Karen, Cupido, Clint, Hutchinson, Claire, Jacobson, Barry, Lamorde, Mohammed, Morgan, Jennie, Mouton, Johannes P., Nakagaayi, Doreen, Okello, Emmy, Schapkaitz, Elise, Sekaggya‐Wiltshire, Christine, Semakula, Jerome R., Waitt, Catriona, Zhang, Eunice J., Jorgensen, Andrea L., Pirmohamed, Munir

Source: CPT: pharmacometrics & systems pharmacology. 11(1):20-29

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138997228.0x000001&indx=1&recIds=ETOCvdc_100138997228.0x000001

High‐mobility group box 1 as a predictive biomarker for drug‐resistant epilepsy: A proof‐of‐concept study

Authors: Walker, Lauren Elizabeth, Sills, Graeme John, Jorgensen, Andrea, Alapirtti, Tiina, Peltola, Jukka, Brodie, Martin J., Marson, Anthony Guy, Vezzani, Annamaria, Pirmohamed, Munir

Source: Epilepsia. 63(1):e1-e6

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138827791.0x000001&indx=1&recIds=ETOCvdc_100138827791.0x000001