Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis

Authors: Diehl, Carina ^{1, 2, 20}, Soberón, Valeria ^{1, 2, 3, 4, 20}, Baygün, Seren ^{1, 2, 3, 20}, Chu, Yuanyuan ^{1, 4, 20}, Mandelbaum, Jonathan ⁵, Kraus, Laura ^{1, 2}, Engleitner, Thomas ^{2, 3, 6}, Rudelius, Martina ⁷, Fangazio, Marco ⁵, Daniel, Christoph ⁸, Bortoluzzi, Sabrina ^{1, 2}, Helmrath, Sabine ^{1, 2}, Singroul, Pankaj ^{1, 2}, Gölling, Vanessa ^{1, 2}, Osorio Barrios, Francisco ^{1, 2}, Seyhan, Gönül ^{1, 2}, Oßwald, Lena ^{1, 2, 9}, Kober-Hasslacher, Maike ^{1, 4}, Zeng, Theodor ^{1, 2}, Öllinger, Rupert ^{2, 3, 6}, Afzali, Ali M. ¹⁰, Korn, Thomas ¹⁰, Honarpisheh, Mohsen ¹¹, Lech, Maciej ¹¹, Ul Ain, Qurrat ¹², Pircher, Joachim ^{12, 13}, Imširović, Vanna ¹⁴, Jelenčić, Vedrana ¹⁴, Wensveen, Felix M. ¹⁴, Passerini, Verena ¹⁵, Bärthel, Stefanie ^{2, 3, 16}, Bhagat, Govind ¹⁷, Dominguez-Sola, David ¹⁸, Saur, Dieter ^{2, 3, 16}, Steiger, Katja ^{3, 19}, Rad, Roland ^{2, 3, 6}, Pasqualucci, Laura ^{5, 17}, Weigert, Oliver ^{3, 15}, Schmidt-Supprian, Marc ^{1, 2, 3, 4, 21, ∗}

Source: In Immunity 14 January 2025 58(1):124-142

Aging platelets shift their hemostatic properties to inflammatory functions

Authors: Anjum, Afra ^{1, 2}, Mader, Magdalena ^{1, 2}, Mahameed, Shaan ¹, Muraly, Abhinaya ^{1, 2}, Denorme, Frederik ³, Kliem, Fabian P. ⁴, Rossaro, Dario ^{1, 2}, Agköl, Sezer ^{1, 2}, Di Fina, Lea ^{1, 2}, Mulkers, Maité ^{1, 2}, Laun, Lisa ^{1, 2}, Li, Lukas ¹, Kupper, Nadja ^{1, 2}, Yue, Keyang ^{1, 2}, Hoffknecht, Marie-Louise ^{1, 2}, Akhalkatsi, Anastassia ^{1, 2}, Loew, Quentin ^{1, 2}, Pircher, Joachim ^{1, 2}, Escaig, Raphael ^{1, 2}, Strasser, Erwin ⁵, Wichmann, Christian ⁵, Pekayvaz, Kami ^{1, 2}, Nieswandt, Bernhard ⁶, Schulz, Christian ^{1, 2, 7}, Robles, Maria S. ⁴, Kaiser, Rainer ^{1, 2}, Massberg, Steffen ^{1, 2}, Campbell, Robert ³, Nicolai, Leo ^{1, 2, ∗}

Source: In Blood December 2024

Jak2V617F clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk

Authors: Liu, Wenli, Pircher, Joachim, Schuermans, Art, Ul Ain, Qurrat, Zhang, Zhe, Honigberg, Michael C., Yalcinkaya, Mustafa, Nakao, Tetsushi, Pournamadri, Ashley, Xiao, Tong, Hajebrahimi, Mohammad Ali, Wasner, Lisa, Stegner, David, Petzold, Tobias, Natarajan, Pradeep, Massberg, Steffen, Tall, Alan R., Schulz, Christian, Wang, Nan

Source: In Blood 11 April 2024 143(15):1539-1550

Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease

Authors: Petzold, Tobias, Zhang, Zhe, Ballesteros, Iván, Saleh, Inas, Polzin, Amin, Thienel, Manuela, Liu, Lulu, Ul Ain, Qurrat, Ehreiser, Vincent, Weber, Christian, Kilani, Badr, Mertsch, Pontus, Götschke, Jeremias, Cremer, Sophie, Fu, Wenwen, Lorenz, Michael, Ishikawa-Ankerhold, Hellen, Raatz, Elisabeth, El-Nemr, Shaza, Görlach, Agnes, Marhuenda, Esther, Stark, Konstantin, Pircher, Joachim, Stegner, David, Gieger, Christian, Schmidt-Supprian, Marc, Gaertner, Florian, Almendros, Isaac, Kelm, Malte, Schulz, Christian, Hidalgo, Andrés, Massberg, Steffen

Source: In Immunity 13 December 2022 55(12):2285-2299

Molecular imaging of cardiac CXCR4 expression in a mouse model of acute myocardial infarction using a novel 68Ga-mCXCL12 PET tracer

Authors: Zacherl, Mathias Johannes ^a, Todica, Andrei ^a, Wängler, Carmen ^b, Schirrmacher, Ralf ^c, Hajebrahimi, Mohammad Ali ^d, Pircher, Joachim ^{d, e}, Li, Xiang ^f, Lindner, Simon ^a, Brendel, Matthias ^a, Bartenstein, Peter ^a, Massberg, Steffen ^{d, e}, Brunner, Stefan ^d, Lehner, Sebastian ^{a, g}, Hacker, Marcus ^{f, *}, Huber, Bruno C. ^d

Source: In Journal of Nuclear Cardiology December 2021 28(6):2965-2975

Eosinophil-platelet interactions promote atherosclerosis and stabilize thrombosis with eosinophil extracellular traps

Authors: Marx, Charlotte ^*, Novotny, Julia ^*, Salbeck, Danby, Zellner, Katie R., Nicolai, Leo, Pekayvaz, Kami, Kilani, Badr, Stockhausen, Sven, Bürgener, Niklas, Kupka, Danny, Stocker, Thomas J., Weckbach, Ludwig T., Pircher, Joachim, Moser, Markus, Joner, Michael, Desmet, Walter, Adriaenssens, Tom, Neumann, Franz-Josef, Gerschlick, Anthony H., ten Berg, Jurrien M., Lorenz, Michael, Stark, Konstantin

Source: In Blood 21 November 2019 134(21):1859-1872

Role of RXRβ in platelet function and arterial thrombosis

Authors: Lüsebrink, Enzo, Warm, Verena, Pircher, Joachim, Ehrlich, Andreas, Zhang, Zhe, Strecker, Jan, Chambon, Pierre, Massberg, Steffen, Schulz, Christian ^*, Petzold, Tobias

Source: In Journal of Thrombosis and Haemostasis September 2019 17(9):1489-1499

Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis

Authors: Heun, Yvonn, Pircher, Joachim, Czermak, Thomas, Bluem, Philipp, Hupel, Georg, Bohmer, Monica, Kraemer, Bjoern F., Pogoda, Kristin, Pfeifer, Alexander, Woernle, Markus, Ribeiro, Andrea, Hübner, Max, Kreth, Simone, Claus, Ralf A., Weis, Sebastian, Ungelenk, Luisa, Krötz, Florian, Pohl, Ulrich, Mannell, Hanna

Source: In EBioMedicine April 2019 42:120-132

Endothelial CD40 Mediates Microvascular von Willebrand Factor-Dependent Platelet Adhesion Inducing Inflammatory Venothrombosis in ADAMTS13 Knockout Mice

Authors: Tahir, Sibgha, Wagner, Andreas, Dietzel, Steffen, Mannell, Hanna, Pircher, Joachim, Weckbach, Ludwig, Hecker, Markus, Pohl, Ulrich

Source: Thrombosis and haemostasis. 120(3):466-476

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187790605.0x000001&indx=1&recIds=ETOCvdc_100187790605.0x000001

Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3

Authors: von Gamm, Matthias, Schaub, Annalisa, Jones, Alisha N., Wolf, Christine, Behrens, Gesine, Lichti, Johannes, Essig, Katharina, Macht, Anna, Pircher, Joachim, Ehrlich, Andreas

Source: Journal of experimental medicine. 216(7):1700-1723

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN620695165&indx=1&recIds=ETOCRN620695165

Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis

Authors: Weckbach, Ludwig T., Grabmaier, Ulrich, Uhl, Andreas, Gess, Sebastian, Boehm, Felicitas, Zehrer, Annette, Pick, Robert, Salvermoser, Melanie, Czermak, Thomas, Pircher, Joachim

Source: Journal of experimental medicine. 216(2):350-368

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN619056241&indx=1&recIds=ETOCRN619056241

Neutrophils promote venular thrombosis by shaping the rheological environment for platelet aggregation

Authors: Puhr-Westerheide, Daniel, Schink, Severin, Fabritius, Matthias, Mittmann, Laura, Hessenauer, Maximilian, Pircher, Joachim, Zuchtriegel, Gabriele, Uhl, Bernd, Holzer, Martin, Massberg, Steffen, Krombach, Fritz, Reichel, Christoph

Source: Scientific reports. 9(1):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190891643.0x000001&indx=1&recIds=ETOCvdc_100190891643.0x000001

Platelet–Neutrophil Crosstalk in Atherothrombosis

Authors: Pircher, Joachim, Engelmann, Bernd, Massberg, Steffen, Schulz, Christian

Source: Thrombosis and haemostasis. 119(8):1274-1282

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186819020.0x000001&indx=1&recIds=ETOCvdc_100186819020.0x000001

HIF-1α Dependent Wound Healing Angiogenesis In Vivo Can Be Controlled by Site-Specific Lentiviral Magnetic Targeting of SHP-2

Authors: Heun, Yvonn, Pogoda, Kristin, Anton, Martina, Pircher, Joachim, Pfeifer, Alexander, Woernle, Markus, Ribeiro, Andrea, Kameritsch, Petra, Mykhaylyk, Olga, Plank, Christian, Kroetz, Florian, Pohl, Ulrich, Mannell, Hanna

Source: In Molecular Therapy 5 July 2017 25(7):1616-1627

The Actin Regulator Coronin-1A Modulates Platelet Shape Change and Consolidates Arterial Thrombosis

Authors: Stocker, Thomas J., Pircher, Joachim, Skenderi, Artid, Ehrlich, Andreas, Eberle, Clemens, Megens, Remco T. A., Petzold, Tobias, Zhang, Zhe, Walzog, Barbara, Müller-Taubenberger, Annette

Source: Thrombosis and haemostasis. 118(12):2098-2111

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN618184582&indx=1&recIds=ETOCRN618184582

Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation

Authors: Pircher, Joachim, Czermak, Thomas, Ehrlich, Andreas, Eberle, Clemens, Gaitzsch, Erik, Margraf, Andreas, Grommes, Jochen, Saha, Prakash, Titova, Anna, Ishikawa-Ankerhold, Hellen, Stark, Konstantin, Petzold, Tobias, Stocker, Thomas, Weckbach, Ludwig, Novotny, Julia, Sperandio, Markus, Nieswandt, Bernhard, Smith, Alberto, Mannell, Hanna, Walzog, Barbara, Horst, David, Soehnlein, Oliver, Massberg, Steffen, Schulz, Christian

Source: Nature communications. 9(1):1-15

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132430782.0x000001&indx=1&recIds=ETOCvdc_100132430782.0x000001

The proteasome regulates collagen-induced platelet aggregation via nuclear-factor-kappa-B (NFĸB) activation

Authors: Grundler, Katharina, Rotter, Raffaela, Tilley, Sloane, Pircher, Joachim, Czermak, Thomas, Yakac, Mustaf, Gaitzsch, Erik, Massberg, Steffen, Krötz, Florian, Sohn, Hae-Young, Pohl, Ulrich, Mannell, Hanna, Kraemer, Bjoern F

Source: In Thrombosis Research December 2016 148:15-22

Effect and sustainability of a stepwise implemented multidisciplinary antimicrobial stewardship programme in a university hospital emergency department.

Authors: Arenz, Lukas, Porger, Annika, Michel, Michaela De, Weber, Alexandra, Jung, Jette, Horns, Heidi, Gscheidle, Sandra, Weiglein, Tobias, Pircher, Joachim, Becker-Lienau, Johanna, Horster, Sophia, Klein, Matthias, Draenert, Rika

Source: JAC-Antimicrobial Resistance; Feb2024, Vol. 6 Issue 1, p1-8, 8p

LL37 inhibits the inflammatory endothelial response induced by viral or endogenous DNA

Authors: Merkle, Monika, Pircher, Joachim, Mannell, Hanna, Krötz, Florian, Blüm, Philipp, Czermak, Thomas, Gaitzsch, Erik, Schneider, Christine, Köppel, Simone, Ribeiro, Andrea, Wörnle, Markus

Source: In Journal of Autoimmunity December 2015 65:19-29

Double-stranded DNA induces a prothrombotic phenotype in the vascular endothelium

Authors: Gaitzsch, Erik, Czermak, Thomas, Ribeiro, Andrea, Heun, Yvonn, Bohmer, Monica, Merkle, Monika, Mannell, Hanna, Schulz, Christian, Wörnle, Markus, Pircher, Joachim

Source: Scientific reports. 7(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174117480.0x000001&indx=1&recIds=ETOCvdc_100174117480.0x000001