Decoding KRAS mutation in non-small cell lung cancer patients receiving immunotherapy: A retrospective institutional comparison and literature review

Authors: Urtecho, S. Berenice ^a, Provenzano, Leonardo ^{b, ⁎}, Spagnoletti, Andrea ^b, Bottiglieri, Achille ^b, Pircher, Chiara ^b, Massa, Giacomo ^b, Sposetti, Caterina ^{b, c}, Proto, Claudia ^b, Brambilla, Marta ^b, Occhipinti, Mario ^b, Mazzeo, Laura ^{b, d}, Beninato, Teresa ^b, Leporati, Rita ^b, Giani, Claudia ^b, Cavalli, Chiara ^b, Serino, Roberta ^b, Prina, Marco Meazza ^e, Bassetti, Anna ^b, Nasca, Vincenzo ^b, di Mauro, Rosa Maria ^b, Abate, Alice ^b, Manglaviti, Sara ^b, Dumitrascu, Andra Diana ^b, Liberti, Giorgia Di ^b, Cassano, Teresa Serra ^b, Ganzinelli, Monica ^b, Wu, Sulin ^f, Garassino, Marina Chiara ^{b, f}, de Braud, Filippo G.M. ^{b, c, g}, Russo, Giuseppe Lo ^b, Prelaj, Arsela ^{b, d}

Source: In Lung Cancer January 2025 199

Ramucirumab plus paclitaxel as switch maintenance versus continuation of first-line oxaliplatin-based chemotherapy in patients with advanced HER2-negative gastric or gastro-oesophageal junction cancer (ARMANI): a randomised, open-label, multicentre, phase 3 trial

Authors: Randon, Giovanni ^a, Lonardi, Sara ^b, Fassan, Matteo ^{c, d}, Palermo, Federica ^a, Tamberi, Stefano ^e, Giommoni, Elisa ^f, Ceccon, Carlotta ^c, Di Donato, Samantha ^g, Fornaro, Lorenzo ^h, Brunetti, Oronzo ⁱ, De Vita, Ferdinando ^j, Bittoni, Alessandro ^k, Chini, Claudio ^l, Spallanzani, Andrea ^m, Nappo, Floriana ^b, Bethaz, Valerie ⁿ, Strippoli, Antonia ^o, Latiano, Tiziana ^p, Cardellino, Giovanni Gerardo ^q, Giuliani, Francesco ^{i, r}, Morano, Federica ^a, Niger, Monica ^a, Raimondi, Alessandra ^a, Prisciandaro, Michele ^a, Pircher, Chiara Carlotta ^a, Sciortino, Carolina ^a, Marchesi, Silvia ^a, Garattini, Silvio Ken ^{a, q}, Airò, Giulia ^{a, s}, Miceli, Rosalba ^t, Di Bartolomeo, Maria ^a, Pietrantonio, Filippo ^{a, *}

Source: In The Lancet Oncology December 2024 25(12):1539-1550

A multicenter phase 2 single arm study of cabozantinib in patients with advanced or unresectable renal cell carcinoma pre-treated with one immune-checkpoint inhibitor: The BREAKPOINT trial (Meet-Uro trial 03)

Authors: Procopio, Giuseppe, Claps, Mélanie, Pircher, Chiara, Porcu, Luca, Sepe, Pierangela, Guadalupi, Valentina, De Giorgi, Ugo, Bimbatti, Davide, Nolè, Franco, Carrozza, Francesco

Source: Tumori. 109(1):129-137

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632758179&indx=1&recIds=ETOCRN632758179

Exploring the Role of Immunotherapy-Based Treatments for Advanced Non–Small-Cell Lung Cancer With Novel Driver Alterations

Authors: Brambilla, Marta, Beninato, Teresa, Piemontese, Anna, Mazzeo, Laura, Pircher, Chiara Carlotta, Manglaviti, Sara, Ambrosini, Paolo, Signorelli, Diego, Lorenzini, Daniele, Prelaj, Arsela, Ferrara, Roberto, Proto, Claudia, Lo Russo, Giuseppe, Pizzutilo, Elio Gregory, Ganzinelli, Monica, Grande, Ilaria, Capone, Iolanda, Di Mauro, Rosa Maria, Conca, Elena, Dumitrascu, Andra Diana, Zanella, Caterina, Leporati, Rita, Rota, Simone, Garassino, Marina Chiara, Marchetti, Paolo, de Braud, Filippo Maria, Occhipinti, Mario

Source: In Clinical Lung Cancer November 2023 24(7):631-640

Platinum sensitivity in patients with IDH1/2 mutated vs wild‐type intrahepatic cholangiocarcinoma: A propensity score‐based study

Authors: Niger, Monica, Nichetti, Federico, Casadei‐Gardini, Andrea, Rizzato, Mario Domenico, Pircher, Chiara, Bini, Marta, Franza, Andrea, Rimini, Margherita, Burgio, Valentina, Sposetti, Caterina, Fornaro, Lorenzo, Rapposelli, Ilario Giovanni, D'Amico, Francesco Enrico, Aprile, Giuseppe, Vivaldi, Caterina, Frassineti, Giovanni Luca, Milione, Massimo, Leoncini, Giuseppe, Cappetta, Alessandro, Vasile, Enrico, Fassan, Matteo, Morano, Federica, Perrone, Federica, Tamborini, Elena, Pruneri, Giancarlo, Lonardi, Sara, Mazzaferro, Vincenzo, Pietrantonio, Filippo, Di Bartolomeo, Maria, de Braud, Filippo

Source: International journal of cancer. 151(8):1310-1320

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187494279.0x000001&indx=1&recIds=ETOCvdc_100187494279.0x000001

MGMT inactivation as a new biomarker in patients with advanced biliary tract cancers

Authors: Niger, Monica, Nichetti, Federico, Casadei‐Gardini, Andrea, Morano, Federica, Pircher, Chiara, Tamborini, Elena, Perrone, Federica, Canale, Matteo, Lipka, Daniel B., Vingiani, Andrea, Agnelli, Luca, Dobberkau, Anna, Hüllein, Jennifer, Korell, Felix, Heilig, Christoph E., Pusceddu, Sara, Corti, Francesca, Droz, Michele, Ulivi, Paola, Prisciandaro, Michele, Antista, Maria, Bini, Marta, Cattaneo, Laura, Milione, Massimo, Glimm, Hanno, Köhler, Bruno C., Pruneri, Giancarlo, Hübschmann, Daniel, Fröhling, Stefan, Mazzaferro, Vincenzo, Pietrantonio, Filippo, Di Bartolomeo, Maria, Braud, Filippo

Source: Molecular oncology. 16(14):2733-2746

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167236486.0x000001&indx=1&recIds=ETOCvdc_100167236486.0x000001

Individual patient data (IPD) pooled analysis on the optimal therapeutic management of patients with microsatellite instability-high (MSI) resectable gastroesophageal adenocarcinoma (GEA).

Authors: Raimondi, Alessandra, Tine', Gabriele, Tougeron, David, Lonardi, Sara, Ricagno, Gianmarco, Cardellino, Giovanni Gerardo, Nappo, Floriana, De Vita, Ferdinando, Nankivell, Matthew Guy, Cunningham, David, Lee, Jeeyun, Kang, Won Ki, Cheong, Jae-Ho, Choi, Yoon Young, Polymeropoulos, Alessio, Pircher, Chiara Carlotta, Miceli, Rosalba, Piessen, Guillaume, Andre, Thierry, Pietrantonio, Filippo

Source: Journal of Clinical Oncology; 2025 Supplement 4, Vol. 43, p455-455, 188p

Multidrug regimens for treatment of older patients with metastatic pancreatic cancer

Authors: Macchini, Marina, Chiaravalli, Marta, Pircher, Chiara, Zanon, Silvia, Peretti, Umberto, Mazza, Elena, Valente, Maria Maddalena, Fugazza, Clara, Gianni, Luca, Reni, Michele

Source: In Digestive and Liver Disease January 2021 53(1):117-121

Locoregional Treatment in Intrahepatic Cholangiocarcinoma: Which Treatment for Which Patient?

Authors: Bourien, Héloïse¹ (AUTHOR) h.bourien@rennes.unicancer.fr, Pircher, Chiara Carlotta² (AUTHOR) chiara.pircher@istitutotumori.mi.it, Guiu, Boris³ (AUTHOR) b-guiu@chu-montpellier.fr, Lamarca, Angela^4,5,6 (AUTHOR) angela.lamarca@nhs.net, Valle, Juan W^5,6 (AUTHOR), Niger, Monica² (AUTHOR) monica.niger@istitutotumori.mi.it, Edeline, Julien¹ (AUTHOR)

Source: Cancers. Sep2023, Vol. 15 Issue 17, p4217. 38p.

Subject Terms: *CHOLANGIOCARCINOMA, *RADIO frequency therapy, *CANCER relapse, *EVIDENCE-based medicine, *CATHETER ablation, *MICROWAVES, *RADIOTHERAPY, *BILE ducts, *ONCOLOGISTS, *DISEASE complications, BILE duct tumors

Molecular Characterization and Clinical Relevance of MGMT‐Silenced Pancreatic Cancer.

Authors: Nichetti, Federico, Silvestri, Marco, Agnelli, Luca, Franza, Andrea, Pircher, Chiara, Rota, Simone, Ambrosini, Paolo, Fotia, Giuseppe, Hüllein, Jennifer, Randon, Giovanni, Lajer, Panna, Perrone, Federica, Tamborini, Elena, Leoncini, Giuseppe, Coppa, Jorgelina, Busset, Michele Droz Dit, Pusceddu, Sara, Milione, Massimo, Morano, Federica, Pietrantonio, Filippo

Source: Cancer Medicine; Dec2024, Vol. 13 Issue 23, p1-12, 12p

Subject Terms: PANCREATIC cancer, O6-Methylguanine-DNA Methyltransferase, DRUG target, RAS oncogenes, OVERALL survival

Nab-paclitaxel plus gemcitabine with or without capecitabine and cisplatin in metastatic pancreatic adenocarcinoma (PACT-19): a randomised phase 2 trial

Authors: Reni, Michele, Zanon, Silvia, Peretti, Umberto, Chiaravalli, Marta, Barone, Diletta, Pircher, Chiara, Balzano, Gianpaolo, Macchini, Marina, Romi, Silvia, Gritti, Elena, Mazza, Elena, Nicoletti, Roberto, Doglioni, Claudio, Falconi, Massimo, Gianni, Luca

Source: In The Lancet Gastroenterology & Hepatology October 2018 3(10):691-697

A randomised phase 2 trial of nab-paclitaxel plus gemcitabine with or without capecitabine and cisplatin in locally advanced or borderline resectable pancreatic adenocarcinoma

Authors: Reni, Michele, Zanon, Silvia, Balzano, Gianpaolo, Passoni, Paolo, Pircher, Chiara, Chiaravalli, Marta, Fugazza, Clara, Ceraulo, Domenica, Nicoletti, Roberto, Arcidiacono, Paolo Giorgio, Macchini, Marina, Peretti, Umberto, Castoldi, Renato, Doglioni, Claudio, Falconi, Massimo, Partelli, Stefano, Gianni, Luca

Source: In European Journal of Cancer October 2018 102:95-102

Safety and efficacy of preoperative or postoperative chemotherapy for resectable pancreatic adenocarcinoma (PACT-15): a randomised, open-label, phase 2–3 trial

Authors: Reni, Michele, Balzano, Gianpaolo, Zanon, Silvia, Zerbi, Alessandro, Rimassa, Lorenza, Castoldi, Renato, Pinelli, Domenico, Mosconi, Stefania, Doglioni, Claudio, Chiaravalli, Marta, Pircher, Chiara, Arcidiacono, Paolo Giorgio, Torri, Valter, Maggiora, Paola, Ceraulo, Domenica, Falconi, Massimo, Gianni, Luca

Source: In The Lancet Gastroenterology & Hepatology June 2018 3(6):413-423

Acquired Resistance Mechanisms to PD-L1 Blockade in a Patient With Microsatellite Instability-High Extrahepatic Cholangiocarcinoma

Authors: Niger, Monica, Nichetti, Federico, Dell'Angelo, Francesca, Cappelletti, Vera, Pircher, Chiara, Vismara, Marta, Cotsoglou, Christian, Bhoori, Sherrie, Vingiani, Andrea, Di Bartolomeo, Maria, Pietrantonio, Filippo, de Braud, Filippo, Pruneri, Giancarlo, Daidone, Maria Grazia, Mazzaferro, Vincenzo

Source: JCO precision oncology. 6

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165733975.0x000001&indx=1&recIds=ETOCvdc_100165733975.0x000001

Negative Ultraselection of Patients With RAS/BRAF Wild-Type, Microsatellite-Stable Metastatic Colorectal Cancer Receiving Anti–EGFR-Based Therapy

Authors: Randon, Giovanni, Maddalena, Giulia, Germani, Marco Maria, Pircher, Chiara Carlotta, Manca, Paolo, Bergamo, Francesca, Giordano, Mirella, Sposetti, Caterina, Montagna, Aldo, Vetere, Guglielmo, Zambelli, Luca, Rasola, Cosimo, Boccaccino, Alessandra, Pagani, Filippo, Ambrosini, Margherita, Massafra, Marco, Fontanini, Gabriella, Milione, Massimo, Fassan, Matteo, Cremolini, Chiara, Lonardi, Sara, Pietrantonio, Filippo

Source: JCO precision oncology. 6

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152760485.0x000001&indx=1&recIds=ETOCvdc_100152760485.0x000001

A phase II/III randomized clinical trial of CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative chemotherapy versus immediate resection in patIents with resecTable BiliarY Tract Cancers (BTC) at high risk for recurrence: PURITY study.

Authors: Niger, Monica, Nichetti, Federico, Fornaro, Lorenzo, Pircher, Chiara, Morano, Federica, Palermo, Federica, Rimassa, Lorenza, Pressiani, Tiziana, Berardi, Rossana, Gardini, Andrea Casadei, Sperti, Elisa, Salvatore, Lisa, Melisi, Davide, Bergamo, Francesca, Siena, Salvatore, Mosconi, Stefania, Longarini, Raffaella, Arcangeli, Giuseppina, Corallo, Salvatore, Delliponti, Laura

Source: BMC Cancer; 4/8/2024, Vol. 24 Issue 1, p1-10, 10p

A phase II study evaluating the efficacy of enzalutamide and the role of liquid biopsy for evaluation of ARv7 in mCRPC patients with measurable metastases including visceral disease (Excalibur study).

Authors: Sepe, Pierangela, Procopio, Giuseppe, Pircher, Chiara Carlotta, Basso, Umberto, Caffo, Orazio, Cappelletti, Vera, Claps, Melanie, De Giorgi, Ugo, Fratino, Lucia, Guadalupi, Valentina, Miodini, Patrizia, De Marco, Cinzia, Perrucci, Bruno, Mennitto, Alessia, Santini, Daniele, Spina, Francesco, Stellato, Marco, de Braud, Filippo, Verzoni, Elena

Source: Therapeutic Advances in Medical Oncology; 1/22/2024, p1-11, 11p

Clinical and prognostic characteristics of early onset metastatic pancreatic cancer.

Authors: Pretta, Andrea, Giampieri, Riccardo, Nichetti, Federico, Ziranu, Pina, Lupi, Alessio, Cimbro, Erika, Andena, Paola, Felicetti, Cristiano, Pircher, Chiara Carlotta, Gusmaroli, Eleonora, Donisi, Clelia, Balconi, Francesca, Mariani, Stefano, Lai, Eleonora, Puzzoni, Marco, Pusceddu, Valeria, Berardi, Rossana, Niger, Monica, Scartozzi, Mario

Source: Journal of Clinical Oncology; 2024 Supplement 3, Vol. 42, p702-702, 117p

Comparison between different therapeutic sequences in patients affected by metastatic pancreatic ductal adenocarcinoma.

Authors: Pretta, Andrea, Giampieri, Riccardo, Nichetti, Federico, Ziranu, Pina, Lupi, Alessio, Moledda, Giusy, Andena, Paola, Felicetti, Cristiano, D'Agata, Alessandra Pia, Pircher, Chiara Carlotta, Codipietro, Claudia, Rota, Simone, Rizzo, Daiana, Sanna, Giorgia, Lai, Eleonora, Puzzoni, Marco, Pusceddu, Valeria, Berardi, Rossana, Niger, Monica, Scartozzi, Mario

Source: Journal of Clinical Oncology; 2024 Supplement 3, Vol. 42, p674-674, 117p

Safety and antitumor activity of metformin plus lanreotide in patients with advanced gastro-intestinal or lung neuroendocrine tumors: the phase Ib trial MetNET2.

Authors: Pusceddu, Sara, Corti, Francesca, Prinzi, Natalie, Nichetti, Federico, Ljevar, Silva, Busico, Adele, Cascella, Tommaso, Leporati, Rita, Oldani, Simone, Pircher, Chiara Carlotta, Coppa, Jorgelina, Resi, Veronica, Milione, Massimo, Maccauro, Marco, Miceli, Rosalba, Tamborini, Elena, Perrone, Federica, Spreafico, Carlo, Niger, Monica, Morano, Federica

Source: Journal of Hematology & Oncology; 12/14/2023, Vol. 16 Issue 1, p1-5, 5p

Subject Terms: ANTINEOPLASTIC agents, NEUROENDOCRINE tumors, LUNG tumors, METFORMIN, PRECOCIOUS puberty, PEOPLE with diabetes, INTESTINAL tumors