Proteomic and metabolomic signatures of rectal tumor discriminate patients with different responses to preoperative radiotherapy

Authors: Anna Wojakowska, Lukasz Marczak, Marcin Zeman, Mykola Chekan, Ewa Zembala-Nożyńska, Krzysztof Polanski, Aleksander Strugała, Piotr Widlak, Monika Pietrowska

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: rectal cancer, radiotherapy, tissue, metabolomics, proteomics, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1323961/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/3f43c2ebf3f94730a7c3c985ab1dcc45

Proteomic profile of melanoma cell‐derived small extracellular vesicles in patients’ plasma: a potential correlate of melanoma progression

Authors: Monika Pietrowska, Aneta Zebrowska, Marta Gawin, Lukasz Marczak, Priyanka Sharma, Sujan Mondal, Justyna Mika, Joanna Polańska, Soldano Ferrone, John M. Kirkwood, Piotr Widlak, Theresa L. Whiteside

Source: Journal of Extracellular Vesicles, Vol 10, Iss 4, Pp n/a-n/a (2021)

Subject Terms: high‐resolution mass spectrometry (HRMS), melanoma cell‐derived exosomes (MTEX), proteomics, small extracellular vesicles (sEV), tumour‐derived exosomes (TEX), Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2001-3078

Access URL: https://doaj.org/article/85e7fb7698f447119cbb8d127eebe1e9

RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation

Authors: Katarzyna Szołtysek, Patryk Janus, Gracjana Zając, Tomasz Stokowy, Anna Walaszczyk, Wiesława Widłak, Bartosz Wojtaś, Bartłomiej Gielniewski, Simon Cockell, Neil D. Perkins, Marek Kimmel, Piotr Widlak

Source: BMC Genomics, Vol 19, Iss 1, Pp 1-13 (2018)

Subject Terms: Co-regulation, Integrative genomics, Radiation response, Transcription network, Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12864-018-5211-y; https://doaj.org/toc/1471-2164

Access URL: https://doaj.org/article/4937e296e2514ddba4026d0e4435d9ea

Proteomes of exosomes from HPV(+) or HPV(-) head and neck cancer cells: differential enrichment in immunoregulatory proteins

Authors: Sonja Ludwig, Lukasz Marczak, Priyanka Sharma, Agata Abramowicz, Marta Gawin, Piotr Widlak, Theresa L. Whiteside, Monika Pietrowska

Source: OncoImmunology, Vol 8, Iss 7 (2019)

Subject Terms: exosomes, head and neck cancer, human papillomavirus, proteomics, immune functions, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/e0a2c5c3f90e41438848888ffc445780

Metabolomic Signature Discriminates Normal Human Cornea from Keratoconus—A Pilot GC/MS Study

Authors: Anna Wojakowska, Monika Pietrowska, Piotr Widlak, Dariusz Dobrowolski, Edward Wylęgała, Dorota Tarnawska

Source: Molecules, Vol 25, Iss 12, p 2933 (2020)

Subject Terms: keratoconus, cornea, ocular metabolomics, GC/MS profiling, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/12/2933; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/6af98b027b3841a4b05382a2164a2c96

Partial-Body Irradiation in Patients with Prostate Cancer Treated with IMRT Has Little Effect on the Composition of Serum Proteome

Authors: Monika Pietrowska, Karol Jelonek, Joanna Polanska, Anna Wojakowska, Lukasz Marczak, Ewa Chawinska, Aleksanda Chmura, Wojciech Majewski, Leszek Miszczyk, Piotr Widlak

Source: Proteomes, Vol 3, Iss 3, Pp 117-131 (2015)

Subject Terms: IMRT, mass spectrometry, prostate cancer, radiation response, serum proteomics, Microbiology, QR1-502

File Description: electronic resource

Relation: http://www.mdpi.com/2227-7382/3/3/117; https://doaj.org/toc/2227-7382

Access URL: https://doaj.org/article/3fe8ee1ad0544a83808326fed678888c

Harmonization of exosome isolation from culture supernatants for optimized proteomics analysis.

Authors: Agata Abramowicz, Lukasz Marczak, Anna Wojakowska, Szczepan Zapotoczny, Theresa L Whiteside, Piotr Widlak, Monika Pietrowska

Source: PLoS ONE, Vol 13, Iss 10, p e0205496 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6209201?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/8a5e33bd311744ce8fd0ca96570fc8d4

Systemic Effects of Radiotherapy and Concurrent Chemo-Radiotherapy in Head and Neck Cancer Patients—Comparison of Serum Metabolome Profiles

Authors: Karol Jelonek, Aleksandra Krzywon, Patrycja Jablonska, Ewa M. Slominska, Ryszard T. Smolenski, Joanna Polanska, Tomasz Rutkowski, Jolanta Mrochem-Kwarciak, Krzysztof Skladowski, Piotr Widlak

Source: Metabolites, Vol 10, Iss 2, p 60 (2020)

Subject Terms: head and neck cancer, mass spectrometry, metabolomics, radiation response, chemotherapy response, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/10/2/60; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/86b3b163e9a141e1b7590898601ea566

Signal Partitioning Algorithm for Highly Efficient Gaussian Mixture Modeling in Mass Spectrometry.

Authors: Andrzej Polanski, Michal Marczyk, Monika Pietrowska, Piotr Widlak, Joanna Polanska

Source: PLoS ONE, Vol 10, Iss 7, p e0134256 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4521892?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/708c96c3cf854ad8bc04372b5e93cc05

An Optimized Method of Metabolite Extraction from Formalin-Fixed Paraffin-Embedded Tissue for GC/MS Analysis.

Authors: Anna Wojakowska, Łukasz Marczak, Karol Jelonek, Krzysztof Polanski, Piotr Widlak, Monika Pietrowska

Source: PLoS ONE, Vol 10, Iss 9, p e0136902 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4562636?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/7a64de027cf149b28911b78855aa1c51

Application of Metabolomics in Thyroid Cancer Research

Authors: Anna Wojakowska, Mykola Chekan, Piotr Widlak, Monika Pietrowska

Source: International Journal of Endocrinology, Vol 2015 (2015)

Subject Terms: Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://doaj.org/toc/1687-8337; https://doaj.org/toc/1687-8345

Access URL: https://doaj.org/article/1c11eb104055488784e498ae341d9428

Blood-based detection of MMP11 as a marker of prostate cancer progression regulated by the ALDH1A1-TGF-β1 signaling mechanism

Authors: Ielizaveta Gorodetska, Vasyl Lukiyanchuk, Marta Gawin, Myroslava Sliusar, Annett Linge, Fabian Lohaus, Tobias Hölscher, Kati Erdmann, Susanne Fuessel, Angelika Borkowetz, Anna Wojakowska, Daniel Fochtman, Mark Reardon, Ananya Choudhury, Yasmin Antonelli, Aldo Leal-Egaña, Ayse Sedef Köseer, Uğur Kahya, Jakob Püschel, Andrea Petzold, Daria Klusa, Claudia Peitzsch, Romy Kronstein-Wiedemann, Torsten Tonn, Lukasz Marczak, Christian Thomas, Piotr Widłak, Monika Pietrowska, Mechthild Krause, Anna Dubrovska

Source: Journal of Experimental & Clinical Cancer Research, Vol 44, Iss 1, Pp 1-25 (2025)

Subject Terms: Prostate cancer, Metastasis, Liquid biopsy, MMP11, ALDH1A1, TGF-β1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/39ad058654cc4db59d1c3aa2bbba94b4

Sources of variation in the serum metabolome of female participants of the HUNT2 study

Authors: Julia Debik, Katarzyna Mrowiec, Agata Kurczyk, Piotr Widłak, Karol Jelonek, Tone F. Bathen, Guro F. Giskeødegård

Source: Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/2a3c6853fb3e48d1959746cf31770b5d

Profiling of serum metabolome of breast cancer: multi-cancer features discriminate between healthy women and patients with breast cancer

Authors: Katarzyna Mrowiec, Julia Debik, Karol Jelonek, Agata Kurczyk, Lucyna Ponge, Agata Wilk, Marcela Krzempek, Guro F. Giskeødegård, Tone F. Bathen, Piotr Widłak

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: biomarker, breast cancer, high-resolution mass spectrometry, metabolomics, multicancer signature, serum metabolome, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1377373/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/6ffcb6adce7948709ed3aa30fe4cc712

Late Effects of Ionizing Radiation on the Ultrastructure of Hepatocytes and Activity of Lysosomal Enzymes in Mouse Liver Irradiated In Vivo

Authors: Małgorzata Łysek-Gładysińska, Anna Wieczorek, Anna Walaszczyk, Karol Jelonek, Monika Pietrowska, Piotr Widłak, Roland Kulik, Dorota Gabryś

Source: Metabolites, Vol 14, Iss 4, p 212 (2024)

Subject Terms: ionizing radiation, liver, hepatocytes, lysosomes, autophagic vacuoles, lysosomal hydrolases, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/14/4/212; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/8baf73fc98d94bda986271b809218e4c

Association of serum metabolome profile with the risk of breast cancer in participants of the HUNT2 study

Authors: Katarzyna Mrowiec, Agata Kurczyk, Karol Jelonek, Julia Debik, Guro F. Giskeødegård, Tone F. Bathen, Piotr Widłak

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: breast cancer, cancer risk, serum metabolome, metabolic profiling, population study, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1116806/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/1a34ba1283ff46d190468abd5dc17496

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Combining Low-Dose Computer-Tomography-Based Radiomics and Serum Metabolomics for Diagnosis of Malignant Nodules in Participants of Lung Cancer Screening Studies

Authors: Joanna Zyla, Michal Marczyk, Wojciech Prazuch, Magdalena Sitkiewicz, Agata Durawa, Malgorzata Jelitto, Katarzyna Dziadziuszko, Karol Jelonek, Agata Kurczyk, Edyta Szurowska, Witold Rzyman, Piotr Widłak, Joanna Polanska

Source: Biomolecules, Vol 14, Iss 1, p 44 (2023)

Subject Terms: classification models, integration, early detection, lung cancer, screening study, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/14/1/44; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/ec8c98bbebeb46d7ac1d8f30fc5a2f96

TGFβ+ small extracellular vesicles from head and neck squamous cell carcinoma cells reprogram macrophages towards a pro‐angiogenic phenotype

Authors: Nils Ludwig, Saigopalakrishna S. Yerneni, Juliana H. Azambuja, Monika Pietrowska, Piotr Widłak, Cynthia S. Hinck, Alicja Głuszko, Mirosław J. Szczepański, Teresa Kärmer, Isabella Kallinger, Daniela Schulz, Richard J. Bauer, Gerrit Spanier, Steffen Spoerl, Johannes K. Meier, Tobias Ettl, Beatrice M. Razzo, Torsten E. Reichert, Andrew P. Hinck, Theresa L. Whiteside

Source: Journal of Extracellular Vesicles, Vol 11, Iss 12, Pp n/a-n/a (2022)

Subject Terms: angiogenesis, exosomes, head and neck squamous cell carcinoma, macrophages, small extracellular vesicles, TGFβ, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2001-3078

Access URL: https://doaj.org/article/f088f547bd094054be588feb402afff5

The Metabolic Footprint of Systemic Effects in the Blood Caused by Radiotherapy and Inflammatory Conditions: A Systematic Review

Authors: Karol Jelonek, Katarzyna Mrowiec, Dorota Gabryś, Piotr Widłak

Source: Metabolites, Vol 13, Iss 9, p 1000 (2023)

Subject Terms: ionizing radiation, head and neck cancer, radiotherapy, inflammation, metabolomics, lipidomics, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/13/9/1000; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/8ef55ebe251f4e56ba81a575b9679d30