Recommendations for recognizing, risk stratifying, treating, and managing children and adolescents with hypoglycemia

Authors: Stefano Zucchini, Stefano Tumini, Andrea Enzo Scaramuzza, Riccardo Bonfanti, Maurizio Delvecchio, Roberto Franceschi, Dario Iafusco, Lorenzo Lenzi, Enza Mozzillo, Stefano Passanisi, Claudia Piona, Ivana Rabbone, Novella Rapini, Andrea Rigamonti, Carlo Ripoli, Giuseppina Salzano, Silvia Savastio, Riccardo Schiaffini, Angela Zanfardino, Valentino Cherubini, Diabetes Study Group of the Italian Society for Pediatric Endocrinology Diabetes, Albino Claudia Accursia, Aloe Monica, Anzelotti Maria Teresa, Arnaldi Claudia, Barbetti Fabrizio, Bassi Marta, Berioli Maria Giulia, Bernardini Luca, Bertelli Enrica, Biagioni Martina, Bobbio Adriana, Bombaci Bruno, Bonfanti Riccardo, Bonura Clara, Bracciolini Giulia Patrizia, Bruzzese Mariella, Bruzzi Patrizia, Buono Pietro, Buscarino Piera, Cadario Francesco, Calcaterra Valeria, Calzi Elena, Cappa Marco, Cardani Roberta, Cardella Francesca, Cardinale Giuliana Marcella, Casertano Alberto, Castorani Valeria, Cauvin Vittoria, Cenciarelli Valentina, Ceruti Franco, Cherubini Valentino, Chiarelli Francesco, Chiari Giovanni, Cianfarani Stefano, Cicchetti Mario, Cipriano Paola, Cirillo Dante, Citriniti Felice, Coccioli Maria Susanna, Confetto Santino, Contreas Giovanna, Coro Anna, Correddu Antonella, Corsini Elisa, Crino’ Antonino, d’Annunzio Giuseppe, De Berardinis Fiorella, De Donno Valeria, De Filippo Gianpaolo, De Marco Rosaria, De Sanctis Luisa, Del Duca Elisabetta, Delvecchio Maurizio, Deodati Annalisa, Di Bonito Procolo, Di Candia Francesca, Faleschini Elena, Fattorusso Valentina, Favia Anna, Federico Giovanni, Felappi Barbara, Ferrari Mara, Ferrito Lucia, Fichera Graziella, Fontana Franco, Fornari Elena, Franceschi Roberto, Franco Francesca, Franzese Adriana, Frongia Anna Paola, Frontino Giulio, Gaiero Alberto, Galassi Sabrina Maria, Gallo Francesco, Gargantini Luigi, Giani Elisa, Gortan Anna Jolanda, Graziani Vanna, Grosso Caterina, Gualtieri Antonella, Guasti Monica, Guerraggio Lucia Paola, Guzzetti Chiara, Iafusco Dario, Iannicelli Gennaro, Iezzi Maria Laura, Ignaccolo Maria Giovanna, Innaurato Stefania, Inzaghi Elena, Iovane Brunella, Iughetti Lorenzo, Kaufmann Peter, La Loggia Alfonso, Lambertini Anna Giulia, Lapolla Rosa, Lasagni Anna, Lazzaro Nicola, Lazzeroni Pietro, Lenzi Lorenzo, Lera Riccardo, Levantini Gabriella, Lezzi Marilea, Lia Rosanna, Liguori Alice, Lo Presti Donatella, Lombardo Fortunato, Lonero Antonella, Longhi Silvia, Lorubbio Antonella, Lucchesi Sonia, Maccioni Rosella, Macedoni Maddalena, Macellaro Patrizia Cristiana, Madeo Simona Filomena, Maffeis Claudio, Mainetti Benedetta, Maltoni Giulio, Mameli Chiara, Mammì Francesco, Manca Bitti Maria Luisa, Mancioppi Valentina, Manco Melania, Marigliano Marco, Marino Monica, Marsciani Alberto, Matteoli Maria Cristina, Mazzali Elena, Minute Marta, Minuto Nicola, Monti Sara, Morandi Anita,, Morganti Gianfranco, Morotti Elisa, Mozzillo Enza, Musolino Gianluca, Olivieri Francesca, Ortolani Federica, Pampanini Valentina, Pardi Daniela, Pascarella Filomena, Pasquino Bruno, Passanisi Stefano, Patera Ippolita Patrizia, Pedini Annalisa, Pennati Maria Cristina, Peruzzi Sonia, Peverelli Paola, Pezzino Giulia, Piccini Barbara, Piccinno Elvira Eugenia Rosaria, Piona Claudia, Piredda Gavina, Piscopo Alessia, Pistone Carmelo, Pozzi Erica, Prandi Elena, Predieri Barbara, Prudente Sabrina, Pulcina Anna, Rabbone Ivana, Randazzo Emioli, Rapini Novella, Reinstadler Petra, Riboni Sara, Ricciardi Maria Rossella, Rigamonti Andrea, Ripoli Carlo, Rossi Virginia, Rossi Paolo, Rutigliano Irene, Sabbion Alberto, Salvatoni Alessandro, Salvo Caterina, Salzano Giuseppina, Sanseviero Mariateresa, Savastio Silvia, Savini Rosanna, Scanu Mariapiera, Scaramuzza Andrea Enzo, Schiaffini Riccardo, Schiavone Maurizio, Schieven Eleonardo, Scipione Mirella, Secco Andrea, Silvestri Francesca, Siri Giulia, Sogno Valin Paola, Sordelli Silvia, Spiri Daniele, Stagi Stefano, Stamati Filomena Andreina, Suprani Tosca, Talarico Valentina, Tiberi Valentina, Timpanaro Tiziana Antonia Lucia, Tinti Davide, Tirendi Antonina, Tomaselli Letizia Grazia, Toni Sonia, Torelli Cataldo, Tornese Gianluca, Trada Michela,, Trettene Adolfo Andrea, Tumini Stefano, Tumminelli Marilena, Valerio Giuliana, Vandelli Sara, Ventrici Claudia, Zampolli Maria, Zanatta Manuela, Zanfardino Angela, Zecchino Clara, Zonca Silvia, Zucchini Stefano

Source: Frontiers in Endocrinology, Vol 15 (2024)

Subject Terms: adolescents, automated insulin delivery, children, hypoglycemia, glucagon, oral glucose, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2024.1387537/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/04c5d7ea5bbf4c18b2fce4857d7be15d

Glycemia Risk Index as a Novel Metric to Evaluate the Safety of Glycemic Control in Children and Adolescents with Type 1 Diabetes: An Observational, Multicenter, Real-Life Cohort Study

Authors: Piona, Claudia, Marigliano, Marco, Roncarà, Chiara, Mozzillo, Enza, Di Candia, Francesca, Zanfardino, Angela, Iafusco, Dario, Maltoni, Giulio, Zucchini, Stefano, Piccinno, Elvira, Delvecchio, Maurizio, Passanisi, Stefano, Lombardo, Fortunato, Bonfanti, Riccardo, Maffeis, Claudio

Source: Diabetes technology & therapeutics. 25(7):507-512

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186732523.0x000001&indx=1&recIds=ETOCvdc_100186732523.0x000001

Cardiovascular Risk Factors in Children and Adolescents with Type 1 Diabetes Mellitus: The Role of Insulin Resistance and Associated Genetic Variants

Authors: Maguolo, Alice, Rioda, Marco, Zusi, Chiara, Emiliani, Federica, Olivieri, Francesca, Piona, Claudia, Marigliano, Marco, Orsi, Silvia, Morandi, Anita, Maffeis, Claudio

Source: Hormone research in pædiatrics. 96(3):306-315

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185356355.0x000001&indx=1&recIds=ETOCvdc_100185356355.0x000001

MiniMed 780G Six-Month Use in Children and Adolescents with Type 1 Diabetes: Clinical Targets and Predictors of Optimal Glucose Control

Authors: Lombardo, Fortunato, Passanisi, Stefano, Alibrandi, Angela, Bombaci, Bruno, Bonfanti, Riccardo, Delvecchio, Maurizio, Di Candia, Francesca, Mozzillo, Enza, Piccinno, Elvira, Piona, Claudia Anita, Rigamonti, Andrea, Scialabba, Francesco, Maffeis, Claudio, Salzano, Giuseppina

Source: Diabetes technology & therapeutics. 25(6):404-413

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184443938.0x000001&indx=1&recIds=ETOCvdc_100184443938.0x000001

Risk factors for pre-clinical atherosclerosis in adolescents with type 1 diabetes

Authors: Morandi, Anita, Piona, Claudia, Corradi, Massimiliano, Marigliano, Marco, Giontella, Alice, Orsi, Silvia, Emiliani, Federica, Tagetti, Angela, Marcon, Denise, Fava, Cristiano, Maffeis, Claudio

Source: In Diabetes Research and Clinical Practice April 2023 198

Continuous glucose monitoring use and glucose variability in very young children with type 1 diabetes (VibRate): A multinational prospective observational real‐world cohort study

Authors: Dovc, Klemen, Van Name, Michelle, Jenko Bizjan, Barbara, Rusak, Ewa, Piona, Claudia, Yesiltepe‐Mutlu, Gul, Mentink, Rosaline, Frontino, Giulio, Macedoni, Maddalena, Ferreira, Sofia Helena, Serra‐Caetano, Joana, Galhardo, Júlia, Pelicand, Julie, Silvestri, Francesca, Sherr, Jennifer, Chobot, Agata, Biester, Torben

Source: Diabetes, obesity & metabolism. 24(3):564-569

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140752867.0x000001&indx=1&recIds=ETOCvdc_100140752867.0x000001

Evaluation of HbA1c and glucose management indicator discordance in a population of children and adolescents with type 1 diabetes

Authors: Piona, Claudia, Marigliano, Marco, Mozzillo, Enza, Di Candia, Francesca, Zanfardino, Angela, Iafusco, Dario, Maltoni, Giulio, Zucchini, Stefano, Piccinno, Elvira, Maffeis, Claudio

Source: Pediatric diabetes. 23(1):84-89

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139258903.0x000001&indx=1&recIds=ETOCvdc_100139258903.0x000001

Proceedings of 21st ISPAD science school for physicians 2022

Authors: dos Santos, Tiago Jeronimo, Chobot, Agata, Piona, Claudia, Dovc, Klemen, Biester, Torben, Gajewska, Katarzyna Anna, Beaufort, Carine, Sumnik, Zdenek, Petruzelkova, Lenka

Source: Pediatric diabetes. 23(7):903-911

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175333835.0x000001&indx=1&recIds=ETOCvdc_100175333835.0x000001

Markers of subclinical vascular damage in young adults with type 1 diabetes mellitus: the role of central blood pressure

Authors: Marcon, Denise, Tagetti, Angela, Piona, Claudia, Giontella, Alice, Bortolotti, Stefano, Bonafini, Sara, Carletti, Lorenza, Morandi, Anita, Trombetta, Maddalena, Maffeis, Claudio, Fava, Cristiano

Source: Journal of hypertension. 40(12):2469-2475

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172930980.0x000001&indx=1&recIds=ETOCvdc_100172930980.0x000001

Sex differences in cardiovascular risk factors of children and adolescents with type 1 diabetes mellitus: A role for diet?

Authors: Maffeis, Claudio, Olivieri, Francesca, Peverelli, Paola, Cendon, Margherita, Tomasselli, Francesca, Tommasi, Mara, Trandev, Tatiana, Fornari, Elena, Piona, Claudia, Morandi, Anita, Maguolo, Alice

Source: Nutrition, metabolism, and cardiovascular diseases. 32(4):1045-1054

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100159620009.0x000001&indx=1&recIds=ETOCvdc_100159620009.0x000001

Twenty years of the International Society for Pediatric and Adolescent Diabetes Science Schools programs: Assessment of their impact on the participants' personal careers and networking development

Authors: Dos Santos, Tiago Jeronimo, Chobot, Agata, Laimon, Wafaa, Waldron, Sheridan, Piona, Claudia, Giani, Elisa, Dovc, Klemen, Macedoni, Maddalena, Mameli, Chiara, Cardona‐Hernandez, Roque, Aschemeier‐Fuchs, Bärbel, McGill, Margaret, Delamater, Alan M., Wood, Jamie, Calliari, Luís Eduardo, Scaramuzza, Andrea, De Beaufort, Carine, Lion, Sylvia, Danne, Thomas, Donaghue, Kim C.

Source: Pediatric diabetes. 23(5):536-544

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157125805.0x000001&indx=1&recIds=ETOCvdc_100157125805.0x000001

Hepatic lipogenesis marked by GCKR‐modulated triglycerides increases serum FGF21 in children/teens with obesity.

Authors: Maffeis, Claudio, Morandi, Anita, Zusi, Chiara, Olivieri, Francesca, Fornari, Elena, Cavarzere, Paolo, Piona, Claudia, Corradi, Massimiliano, Emiliani, Federica, Da Ros, Alessandro, Berni Canani, Roberto, Mantovani, Alessandro, Targher, Giovanni

Source: Diabetes, Obesity & Metabolism; Feb2025, Vol. 27 Issue 2, p825-834, 10p

Subject Terms: FIBROBLAST growth factors, ADOLESCENT obesity, MENDELIAN randomization, INSULIN resistance, BLOOD lipids

Glycemic Variability and Time in Range Are Associated with the Risk of Overweight and High LDL-Cholesterol in Children and Youths with Type 1 Diabetes.

Authors: Piona, Claudia¹ (AUTHOR), Marigliano, Marco¹ (AUTHOR), Mancioppi, Valentina¹ (AUTHOR), Mozzillo, Enza² (AUTHOR), Occhiati, Luisa² (AUTHOR), Zanfardino, Angela³ (AUTHOR), Iafusco, Dario³ (AUTHOR), Maltoni, Giulio⁴ (AUTHOR), Zucchini, Stefano⁴ (AUTHOR), Delvecchio, Maurizio⁵ (AUTHOR), Passanisi, Stefano⁶ (AUTHOR), Lombardo, Fortunato⁶ (AUTHOR), Maffeis, Claudio¹ (AUTHOR)

Source: Hormone Research in Paediatrics. 2025, Vol. 98 Issue 1, p59-65. 7p.

Subject Terms: *CONTINUOUS glucose monitoring, *TYPE 1 diabetes, *GLYCEMIC control, *CARDIOVASCULAR diseases risk factors, *LOGISTIC regression analysis

Oxidative stress in youth with type 1 diabetes: Not only a matter of gender, age, and glycemic control

Authors: Morandi, Anita, Corradi, Massimiliano, Orsi, Silvia, Piona, Claudia, Zusi, Chiara, Costantini, Silvia, Marigliano, Marco, Maffeis, Claudio

Source: In Diabetes Research and Clinical Practice September 2021 179

Relationships between HbA1c and continuous glucose monitoring metrics of glycaemic control and glucose variability in a large cohort of children and adolescents with type 1 diabetes

Authors: Piona, Claudia, Marigliano, Marco, Mozzillo, Enza, Rosanio, Francesco, Zanfardino, Angela, Iafusco, Dario, Maltoni, Giulio, Zucchini, Stefano, Piccinno, Elvira, Delvecchio, Maurizio, Maffeis, Claudio

Source: In Diabetes Research and Clinical Practice July 2021 177

Albuminuric and non-albuminuric reduced eGFR phenotypes in youth with type 1 diabetes: Factors associated with cardiometabolic risk

Authors: Di Bonito, Procolo, Mozzillo, Enza, Rosanio, Francesco M., Maltoni, Giulio, Piona, Claudia A., Franceschi, Roberto, Ripoli, Carlo, Ricciardi, Maria R., Tornese, Gianluca, Arnaldi, Claudia, Iovane, Brunella, Iafusco, Dario, Zanfardino, Angela, Suprani, Tosca, Savastio, Silvia, Cherubini, Valentino, Tiberi, Valentino, Piccinno, Elvira, Schiaffini, Riccardo, Delvecchio, Maurizio, Casertano, Alberto, Maffeis, Claudio, Franzese, Adriana

Source: In Nutrition, Metabolism and Cardiovascular Diseases 30 June 2021 31(7):2033-2041

Long chain fatty acids metabolism and cardiovascular risk factors in youth with type 1 diabetes

Authors: Morandi, Anita, Piona, Claudia, Bonafini, Sara, Marigliano, Marco, Tomasselli, Francesca, Tagetti, Angela, Marcon, Denise, Costantini, Silvia, Fava, Cristiano, Maffeis, Claudio

Source: In Nutrition, Metabolism and Cardiovascular Diseases 4 January 2021 31(1):297-305

Are we confident that final‐year medical students know at least basics about diabetes?: A preliminary report from the multicenter, survey‐based Diabetes Know‐Me study

Authors: Chobot, Agata, Gosławska, Zuzanna, Giani, Elisa, Boddu, Sirisha Kusuma, Mysliwiec, Malgorzata, Odeh, Rasha, Piona, Claudia, Polanska, Joanna, Tsai, Meng‐Che, Beaufort, Carine, Dovc, Klemen

Source: Pediatric diabetes. 22(6):850-853

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127395020.0x000001&indx=1&recIds=ETOCvdc_100127395020.0x000001

High Glycemic Variability Is Associated with Worse Continuous Glucose Monitoring Metrics in Children and Adolescents with Type 1 Diabetes

Authors: Piona, Claudia, Marigliano, Marco, Mozzillo, Enza, Di Candia, Francesca, Zanfardino, Angela, Iafusco, Dario, Maltoni, Giulio, Zucchini, Stefano, Delvecchio, Maurizio, Maffeis, Claudio

Source: Hormone research in pædiatrics. 94(9/10):369-373

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140805841.0x000001&indx=1&recIds=ETOCvdc_100140805841.0x000001

In vivo confocal microscopy study of corneal nerve alterations in children and youths with Type 1 diabetes

Authors: Cozzini, Tiziano, Piona, Claudia, Marchini, Giorgio, Merz, Tommaso, Brighenti, Tommaso, Bonetto, Jacopo, Marigliano, Marco, Olivieri, Francesca, Maffeis, Claudio, Pedrotti, Emilio

Source: Pediatric diabetes. 22(5):780-786

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100151888011.0x000001&indx=1&recIds=ETOCvdc_100151888011.0x000001