The value of neck adipose tissue as a predictor for metabolic risk in health and type 2 diabetes

Authors: Cresswell, Emily, Basty, Nicolas, Atabaki Pasdar, Naeimeh, Karpe, Fredrik, Pinnick, Katherine E.

Source: In Biochemical Pharmacology May 2024 223

HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution

Authors: Kuo, Feng-Chih, Neville, Matt J., Sabaratnam, Rugivan, Wesolowska-Andersen, Agata, Phillips, Daniel, Wittemans, Laura B.L., van Dam, Andrea D., Loh, Nellie Y., Todorčević, Marijana, Denton, Nathan, Kentistou, Katherine A., Joshi, Peter K., Christodoulides, Constantinos, Langenberg, Claudia, Collas, Philippe, Karpe, Fredrik, Pinnick, Katherine E.

Source: In Cell Reports 26 July 2022 40(4)

MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition

Authors: Hilton, Catriona ^a, Neville, Matt J. ^{a, b, ⁎}, Wittemans, Laura B.L. ^{d, f}, Todorcevic, Marijana ^a, Pinnick, Katherine E. ^a, Pulit, Sara L. ^{c, d, e}, Luan, Jian'an ^f, Kulyté, Agné ^g, Dahlman, Ingrid ^g, Wareham, Nicholas J. ^f, Lotta, Luca A. ^f, Arner, Peter ^g, Lindgren, Cecilia M. ^{c, d}, Langenberg, Claudia ^f, Karpe, Fredrik ^{a, b, ⁎}

Source: In eBioMedicine June 2019 44:467-475

Challenging metabolic tissues with fructose: tissue‐specific and sex‐specific responses

Authors: Pinnick, Katherine E., Hodson, Leanne

Source: Journal of physiology. 597(14):3527-3537

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100093749416.0x000001&indx=1&recIds=ETOCvdc_100093749416.0x000001

Measuring Human Lipid Metabolism Using Deuterium Labeling: In Vivo and In Vitro Protocols

Authors: Pinnick, Katherine E., Gunn, Pippa J., Hodson, Leanne

Source: Methods in molecular biology. 1862:83-96

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN617861249&indx=1&recIds=ETOCRN617861249

Bone morphogenetic protein 2 is a depot-specific regulator of human adipogenesis

Authors: Denton, Nathan F., Eghleilib, Mohamed, Al-Sharifi, Sama, Todorčević, Marijana, Neville, Matt J., Loh, Nellie, Drakesmith, Alexander, Karpe, Fredrik, Pinnick, Katherine E.

Source: International journal of obesity. 43(12):2458-2468

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193227518.0x000001&indx=1&recIds=ETOCvdc_100193227518.0x000001

Cartilage oligomeric matrix protein is differentially expressed in human subcutaneous adipose tissue and regulates adipogenesis

Authors: Denton, Nathan, Pinnick, Katherine E., Karpe, Fredrik

Source: Molecular metabolism. 16:172-179

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097790712.0x000001&indx=1&recIds=ETOCvdc_100097790712.0x000001

Role of developmental transcription factors in white, brown and beige adipose tissues

Authors: Hilton, Catriona, Karpe, Fredrik, Pinnick, Katherine E.

Source: In BBA - Molecular and Cell Biology of Lipids May 2015 1851(5):686-696

A cellular model for the investigation of depot specific human adipocyte biology

Authors: Todorčević, Marijana, Hilton, Catriona, McNeil, Catriona, Christodoulides, Constantinos, Hodson, Leanne, Karpe, Fredrik, Pinnick, Katherine E.

Source: Adipocyte. 6(1):40-55

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100050356137.0x000001&indx=1&recIds=ETOCvdc_100050356137.0x000001

Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation

Authors: Bensaad, Karim, Favaro, Elena, Lewis, Caroline A., Peck, Barrie, Lord, Simon, Collins, Jennifer M., Pinnick, Katherine E., Wigfield, Simon, Buffa, Francesca M., Li, Ji-Liang, Zhang, Qifeng, Wakelam, Michael J.O., Karpe, Fredrik, Schulze, Almut, Harris, Adrian L.

Source: In Cell Reports 9 October 2014 9(1):349-365

An optimised protocol for the investigation of insulin signalling in a human cell culture model of adipogenesis.

Authors: Gamwell, Jonathan M., Paphiti, Keanu, Hodson, Leanne, Karpe, Fredrik, Pinnick, Katherine E., Todorčević, Marijana

Source: Adipocyte; Dec2023, Vol. 12 Issue 1, p1-11, 11p

Subject Terms: HUMAN cell culture, CELL communication, ADIPOGENESIS, INSULIN, HUMAN stem cells

Modifying nutritional substrates induces macrovesicular lipid droplet accumulation and metabolic alterations in a cellular model of hepatic steatosis

Authors: Gunn, Pippa J., Pramfalk, Camilla, Millar, Val, Cornfield, Thomas, Hutchinson, Matthew, Johnson, Elspeth M., Nagarajan, Shilpa R., Troncoso‐Rey, Perla, Mithen, Richard F., Pinnick, Katherine E., Traka, Maria H., Green, Charlotte J., Hodson, Leanne

Source: Physiological reports. 8(13)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107620945.0x000001&indx=1&recIds=ETOCvdc_100107620945.0x000001

RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro

Authors: Loh, Nellie Y., Minchin, James E. N., Pinnick, Katherine E., Verma, Manu, Todorčević, Marijana, Denton, Nathan, Moustafa, Julia El-Sayed, Kemp, John P., Gregson, Celia L., Evans, David M., Neville, Matt J., Small, Kerrin S., McCarthy, Mark I., Mahajan, Anubha, Rawls, John F., Karpe, Fredrik, Christodoulides, Constantinos

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174598883.0x000001&indx=1&recIds=ETOCvdc_100174598883.0x000001

De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation

Authors: Collins, Jennifer M. ^*, Neville, Matt J. ^*, Pinnick, Katherine E. ^*, Hodson, Leanne ^*, Ruyter, Bente ^†, van Dijk, Theo H. ^§, Reijngoud, Dirk-Jan ^§, Fielding, Mark D. ^*, Frayn, Keith N. ^{1, *}

Source: In Journal of Lipid Research September 2011 52(9):1683-1692

Metformin maintains intrahepatic triglyceride content through increased hepatic de novo lipogenesis.

Authors: Green, Charlotte J., Marjot, Thomas, Walsby-Tickle, John, Charlton, Catriona, Cornfield, Thomas, Westcott, Felix, Pinnick, Katherine E., Moolla, Ahmad, Hazlehurst, Jonathan M., McCullagh, James, Tomlinson, Jeremy W., Hodson, Leanne

Source: European Journal of Endocrinology; Mar2022, Vol. 186 Issue 3, p367-377, 11p

Subject Terms: WEIGHT loss, NON-alcoholic fatty liver disease, METFORMIN, LIPID synthesis, TISSUE metabolism

Correction to: Bone morphogenetic protein 2 is a depot-specific regulator of human adipogenesis

Authors: Denton, Nathan F., Eghleilib, Mohamed, Al-Sharifi, Sama, Todorčević, Marijana, Neville, Matt J., Loh, Nellie, Drakesmith, Alexander, Karpe, Fredrik, Pinnick, Katherine E.

Source: International journal of obesity. 43(12):2593-2593

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193227330.0x000001&indx=1&recIds=ETOCvdc_100193227330.0x000001

Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin.

Authors: Lord, Simon R., Collins, Jennifer M., Cheng, Wei-Chen, Haider, Syed, Wigfield, Simon, Gaude, Edoardo, Fielding, Barbara A., Pinnick, Katherine E., Harjes, Ulrike, Segaran, Ashvina, Jha, Pooja, Hoefler, Gerald, Pollak, Michael N., Thompson, Alastair M., Roy, Pankaj G., English, Ruth., Adams, Rosie F., Frezza, Christian, Buffa, Francesca M., Karpe, Fredrik

Source: British Journal of Cancer; Jan2020, Vol. 122 Issue 2, p258-265, 8p, 1 Diagram, 4 Graphs

Subject Terms: PROTEIN kinases, RESEARCH, XENOGRAFTS, ANIMAL experimentation, RESEARCH methodology, DIABETES, CELL physiology, GENETIC disorders, EVALUATION research, MEDICAL cooperation, MITOCHONDRIA, COMPARATIVE studies, GENE expression profiling, GENES, RESEARCH funding, METFORMIN, LIPID metabolism disorders, FATTY acids, BREAST tumors, OXIDATION-reduction reaction, LIPID peroxidation (Biology), MICE, PHARMACODYNAMICS

Regional fat depot masses are influenced by protein-coding gene variants.

Authors: Neville, Matt J., Wittemans, Laura B. L., Pinnick, Katherine E., Todorčević, Marijana, Kaksonen, Risto, Pietiläinen, Kirsi H., Luan, Jian’an, Scott, Robert A., Wareham, Nicholas J., Langenberg, Claudia, Karpe, Fredrik

Source: PLoS ONE; 5/30/2019, Vol. 14 Issue 5, p1-17, 17p

Subject Terms: ADIPOSE tissues, DUAL-energy X-ray absorptiometry, WAIST-hip ratio, X-ray imaging, GENETIC code, MOLECULAR biology

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