Acute stress triggers sex-dependent rapid alterations in the human small intestine microbiota composition.

Authors: Rodiño-Janeiro, Bruno K., Khannous-Lleiffe, Olfat, Pigrau, Marc, Willis, Jesse R., Salvo-Romero, Eloísa, Nieto, Adoración, Expósito, Elba, Fortea, Marina, Pardo-Camacho, Cristina, Albert-Bayo, Mercé, González-Castro, Ana María, Guagnozzi, Danila, Martínez, Cristina, Lobo, Beatriz, Vicario, María, Santos, Javier, Gabaldón, Toni, Alonso-Cotoner, Carmen

Source: Frontiers in Microbiology; 2025, p1-16, 16p

Subject Terms: SUBJECTIVE stress, SMALL intestine, IRRITABLE colon, GUT microbiome, ADRENOCORTICOTROPIC hormone

Lactobacilli Degrade Wheat Amylase Trypsin Inhibitors to Reduce Intestinal Dysfunction Induced by Immunogenic Wheat Proteins

Authors: Caminero, Alberto, McCarville, Justin L., Zevallos, Victor F., Pigrau, Marc, Yu, Xuechen B., Jury, Jennifer, Galipeau, Heather J., Clarizio, Alexandra V., Casqueiro, Javier, Murray, Joseph A., Collins, Stephen M., Alaedini, Armin, Bercik, Premysl, Schuppan, Detlef, Verdu, Elena F.

Source: In Gastroenterology June 2019 156(8):2266-2280

Acute Stress Regulates Sex-Related Molecular Responses in the Human Jejunal Mucosa: Implications for Irritable Bowel Syndrome.

Authors: Rodiño-Janeiro, Bruno K.^1,2 (AUTHOR), Pigrau, Marc^1,2 (AUTHOR), Salvo-Romero, Eloísa^1,2,3 (AUTHOR), Nieto, Adoración^1,2 (AUTHOR), Expósito, Elba^1,3 (AUTHOR), González-Castro, Ana M.^1,2,3 (AUTHOR), Galán, Carmen^1,2 (AUTHOR), de Torres, Inés^4,5 (AUTHOR), Pribic, Teodora^1,2 (AUTHOR), Hernández, Laura^1,2 (AUTHOR), Lobo, Beatriz^1,2,4 (AUTHOR), Fortea, Marina^1,3 (AUTHOR), Gallart, Milagros^1,2 (AUTHOR), Pardo-Camacho, Cristina^1,3 (AUTHOR), Guagnozzi, Danila^1,3,4,6 (AUTHOR), Santos, Javier^1,2,4,6 (AUTHOR) javier.santos@vhir.org, Alonso-Cotoner, Carmen^1,2,4,6 (AUTHOR) javier.santos@vhir.org

Source: Cells (2073-4409). Feb2023, Vol. 12 Issue 3, p423. 17p.

Subject Terms: *IRRITABLE colon, *GLUCOCORTICOID receptors, *GENE expression, *MUCOUS membranes, *PROTEIN expression, *TIGHT junctions

Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome

Authors: Pinto-Sanchez, Maria Ines, Hall, Geoffrey B., Ghajar, Kathy, Nardelli, Andrea, Bolino, Carolina, Lau, Jennifer T., Martin, Francois-Pierre, Cominetti, Ornella, Welsh, Christopher, Rieder, Amber, Traynor, Jenna, Gregory, Caitlin, De Palma, Giada, Pigrau, Marc, Ford, Alexander C., Macri, Joseph, Berger, Bernard, Bergonzelli, Gabriela, Surette, Michael G., Collins, Stephen M., Moayyedi, Paul, Bercik, Premysl

Source: In Gastroenterology August 2017 153(2):448-459

Downregulation of mucosal mast cell activation and immune response in diarrhoea‐irritable bowel syndrome by oral disodium cromoglycate: A pilot study

Authors: Lobo, Beatriz, Ramos, Laura, Martínez, Cristina, Guilarte, Mar, González‐Castro, Ana M, Alonso‐Cotoner, Carmen, Pigrau, Marc, Torres, Inés, Rodiño‐Janeiro, Bruno K, Salvo‐Romero, Eloisa, Fortea, Marina, Pardo‐Camacho, Cristina, Guagnozzi, Danila, Azpiroz, Fernando, Santos, Javier, Vicario, María

Source: United European Gastroenterology journal. 5(6):887-897

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112783800.0x000001&indx=1&recIds=ETOCvdc_100112783800.0x000001

Overexpression of corticotropin-releasing factor in intestinal mucosal eosinophils is associated with clinical severity in Diarrhea-Predominant Irritable Bowel Syndrome

Authors: Salvo-Romero, Eloísa, Martínez, Cristina, Lobo, Beatriz, Rodiño-Janeiro, Bruno K., Pigrau, Marc, Sánchez-Chardi, Alejandro D., González-Castro, Ana M., Fortea, Marina, Pardo-Camacho, Cristina, Nieto, Adoración, Expósito, Elba, Guagnozzi, Danila, Rodríguez-Urrutia, Amanda, de Torres, Inés, Farré, Ricard, Azpiroz, Fernando, Alonso-Cotoner, Carmen, Santos, Javier, Vicario, María

Source: Scientific reports. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188975591.0x000001&indx=1&recIds=ETOCvdc_100188975591.0x000001

Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress

Authors: Vicario, María, Guilarte, Mar, Alonso, Carmen, Yang, Pinchang, Martínez, Cristina, Ramos, Laura, Lobo, Beatriz, González, Ana, Guilà, Meritxell, Pigrau, Marc, Saperas, Esteban, Azpiroz, Fernando, Santos, Javier

Source: In Brain Behavior and Immunity 2010 24(7):1166-1175

Decreased TESK1-mediated cofilin 1 phosphorylation in the jejunum of IBS-D patients may explain increased female predisposition to epithelial dysfunction

Authors: Rodiño-Janeiro, Bruno K., Martínez, Cristina, Fortea, Marina, Lobo, Beatriz, Pigrau, Marc, Nieto, Adoración, González-Castro, Ana María, Salvo-Romero, Eloísa, Guagnozzi, Danila, Pardo-Camacho, Cristina, Iribarren, Cristina, Azpiroz, Fernando, Alonso-Cotoner, Carmen, Santos, Javier, Vicario, Maria

Source: Scientific reports. 8(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131371668.0x000001&indx=1&recIds=ETOCvdc_100131371668.0x000001

916 - Gut Microbiota-Diet Interactions in a Humanized Mouse Model of IBS: The Role of Intestinal Mast Cells

Authors: Shimbori, Chiko, De Palma, Giada, Reed, David E., Pigrau, Marc, Lu, Jun, Zhang, Yong, YU, YANG, Jiménez-Vargas, Nestor N., Sessenwein, Jessica, Lopez, Cintya D. Lopez, Polanco, Josue O. Jaramillo, Verdu, Elena F., Lomax, Alan E., Beyak, Michael, Collins, Stephen M., Vanner, Stephen, Bercik, Premysl

Source: Gastroenterology. 154(6):S-182-S-182

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100085558941.0x000001&indx=1&recIds=ETOCvdc_100085558941.0x000001

Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice.

Authors: De Palma, Giada, Shimbori, Chiko, Reed, David E., Yu, Yang, Rabbia, Virginia, Lu, Jun, Jimenez-Vargas, Nestor, Sessenwein, Jessica, Lopez-Lopez, Cintya, Pigrau, Marc, Jaramillo-Polanco, Josue, Zhang, Yong, Baerg, Lauren, Manzar, Ahmad, Pujo, Julien, Bai, Xiaopeng, Pinto-Sanchez, Maria Ines, Caminero, Alberto, Madsen, Karen, Surette, Michael G.

Source: Science Translational Medicine; 7/27/2022, Vol. 14 Issue 655, p1-12, 12p

Subject Terms: HISTAMINE receptors, GUT microbiome, HISTAMINE, HYPERALGESIA, VISCERAL pain, IRRITABLE colon

Mucosal Plasma Cell Activation and Proximity to Nerve Fibres Are Associated with Glycocalyx Reduction in Diarrhoea-Predominant Irritable Bowel Syndrome: Jejunal Barrier Alterations Underlying Clinical Manifestations.

Authors: Pardo-Camacho, Cristina, Ganda Mall, John-Peter, Martínez, Cristina, Pigrau, Marc, Expósito, Elba, Albert-Bayo, Mercé, Melón-Ardanaz, Elisa, Nieto, Adoración, Rodiño-Janeiro, Bruno, Fortea, Marina, Guagnozzi, Danila, Rodriguez-Urrutia, Amanda, Torres, Inés de, Santos-Briones, Ignacio, Azpiroz, Fernando, Lobo, Beatriz, Alonso-Cotoner, Carmen, Santos, Javier, González-Castro, Ana M., Vicario, Maria

Source: Cells (2073-4409); Jul2022, Vol. 11 Issue 13, pN.PAG-N.PAG, 19p

Subject Terms: IRRITABLE colon, PLASMA cells, SYMPTOMS, NEURONS, GLYCOCALYX, B cells, NERVES, IMMUNOGLOBULIN G

819 – Metabolism of Wheat Amylase Trypsin Inhibitors by Lactobacilli Ameliorates Gut Dysfunction Induced by Wheat Proteins

Authors: Fernandez, Alberto Caminero, McCarville, Justin, Zevallos, Victor F., Pigrau, Marc, Yu, Bella, Jury, Jennifer, Galipeau, Heather J., Casqueiro, Javier, Murray, Joseph A., Collins, Stephen M., Alaedini, Armin, Bercik, Premysl, Schuppan, Detlef, Verdu, Elena F.

Source: Gastroenterology. 156(6):S-174-S-175

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100080958180.0x000001&indx=1&recIds=ETOCvdc_100080958180.0x000001

157 - HÁBITOS ALIMENTARIOS EN ENTIDADES QUE CURSAN CON DIARREA CRÓNICA Y SU POTENCIAL IMPACTO EN LAS MANIFESTACIONES CLÍNICAS

Authors: Muñoz-Puig, Clara, Rueda-Farré, Ainara, Albert-Bayo, Mercé, Expósito, Elba, Alonso-Colomer, Carmen, Pigrau, Marc, Nieto, Adoración, Guagnozzi, Danila, Azpiroz, Fernando, Vicario, Maria, Santos, Javier, González-Castro, Ana Maria, Lobo, Beatriz

Source: In Gastroenterologia y Hepatologia March 2023 46 Supplement 3:S189-S189

Stress Induces Specific Gender-Related Molecular Alterations in Barrier Regulatory Genes in the Jejunal Mucosa of Healthy

Authors: Rodiño-Janeiro, Bruno Kotska, Pigrau, Marc, Nieto, Adoración, Pribic, Teodora, Hernández-Palet, Laura, Salvo-Romero, Eloísa, Gallart, Milagros, Lobo, Beatriz, González-Castro, Ana María, Fortea-Guillamón, Marina, Pardo-Camacho, Cristina, de Torres, Inés, Martinez, Cristina, Guagnozzi, Danila, Pérez-Berezo, Teresa, Azpiroz, Fernando, Vicario, María, Santos, Javier, Cotoner, Carmen Alonso

Source: Gastroenterology. 152(5):S720-S721

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100054006403.0x000001&indx=1&recIds=ETOCvdc_100054006403.0x000001

Peripheral Corticotropin-Releasing Factor Triggers Jejunal Mast Cell Activation and Abdominal Pain in Patients With Diarrhea-Predominant Irritable Bowel Syndrome.

Authors: Guilarte, Mar, Vicario, MarÃa, MartÃnez, Cristina, de Torres, Inés, Lobo, Beatriz, Pigrau, Marc, González-Castro, Ana, Rodiño-Janeiro, Bruno K., Salvo-Romero, EloÃsa, Fortea, Marina, Pardo-Camacho, Cristina, AntolÃn, MarÃa, Saperas, Esteban, Azpiroz, Fernando, Santos, Javier, Alonso-Cotoner, Carmen

Source: American Journal of Gastroenterology (Lippincott Williams & Wilkins); Dec2020, Vol. 115 Issue 12, p2047-2059, 13p

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Integrated Multi-Omic Analysis Reveals Female Predominance of Deregulated Mucosal Actin Depolymerization by Decreased Tesk1-Mediated CFL1-Phosphorylation in IBS-D

Authors: Rodiño-Janeiro, Bruno Kotska, Martinez, Cristina, Fortea-Guillamón, Marina, Lobo, Beatriz, Pigrau, Marc, González-Castro, Ana María, Salvo-Romero, Eloísa, Pardo-Camacho, Cristina, Iribarren, Cristina, Guagnozzi, Danila, Azpiroz, Fernando, Cotoner, Carmen Alonso, Santos, Javier, Vicario, María

Source: Gastroenterology. 152(5):S721-S721

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100061549662.0x000001&indx=1&recIds=ETOCvdc_100061549662.0x000001

Diet-Microbiota Interactions Underlie Symptoms' Generation in IBS

Authors: De Palma, Giada, Reed, David E., Pigrau, Marc, Lu, Jun, Sidani, Sacha, Zhang, Yong, Yu, Yang, Jiménez-Vargas, Nestor N., Sessenwein, Jessica, Lopez Lopez, Cintya D., Jaramillo Polanco, Josue O., Verdu, Elena F., Collins, Stephen M., Lomax, Alan E., Beyak, Michael, Vanner, Stephen, Bercik, Premysl

Source: Gastroenterology. 152(5):S160-S160

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100054022769.0x000001&indx=1&recIds=ETOCvdc_100054022769.0x000001

Nutritional Wheat Amylase Trypsin Inhibitors Exacerbate Gluten-Induced Pathology and Alter the Gut Microbiota in Mice

Authors: McCarville, Justin, Zevallos, Victor F., Fernandez, Alberto Caminero, Pigrau, Marc, Jury, Jennifer, Murray, Joseph A., Bercik, Premysl, Schuppan, Detlef, Verdu, Elena F.

Source: Gastroenterology. 152(5):S71-S71

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100054020103.0x000001&indx=1&recIds=ETOCvdc_100054020103.0x000001