Disruption of cotranscriptional splicing suggests RBM39 is a therapeutic target in acute lymphoblastic leukemia

Authors: Jin, Qi, Harris, Ethan, Myers, Jacquelyn A., Mehmood, Rashid, Cotton, Anitria, Shirnekhi, Hazheen K., Baggett, David W., Wen, Jeremy Qiang, Schild, Andrew B., Bhansali, Rahul S., Klein, Jonathon, Narina, Shilpa, Pieters, Tim, Yoshimi, Akihide, Pruett-Miller, Shondra M., Kriwacki, Richard, Abdel-Wahab, Omar, Malinge, Sebastien, Ntziachristos, Panagiotis, Obeng, Esther A., Crispino, John D.

Source: In Blood 5 December 2024 144(23):2417-2431

MYB rearrangements and over‐expression in T‐cell acute lymphoblastic leukemia

Authors: Bardelli, Valentina, Arniani, Silvia, Pierini, Valentina, Pierini, Tiziana, Di Giacomo, Danika, Gorello, Paolo, Moretti, Martina, Pellanera, Fabrizia, Elia, Loredana, Vitale, Antonella, Storlazzi, Clelia Tiziana, Tolomeo, Doron, Mastrodicasa, Elena, Caniglia, Maurizio, Chiaretti, Sabina, Ruggeri, Loredana, Roti, Giovanni, Schwab, Claire, Harrison, Christine J, Almeida, André, Pieters, Tim, Van Vlierberghe, Pieter, Mecucci, Cristina, La Starza, Roberta

Source: Genes, chromosomes & cancer. 60(7):482-488

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121092072.0x000001&indx=1&recIds=ETOCvdc_100121092072.0x000001

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

Authors: El Ashkar, Sara, Schwaller, Juerg, Pieters, Tim, Goossens, Steven, Demeulemeester, Jonas, Christ, Frauke, Van Belle, Siska, Juge, Sabine, Boeckx, Nancy, Engelman, Alan, Van Vlierberghe, Pieter, Debyser, Zeger ^*, De Rijck, Jan ^*

Source: In Blood 4 January 2018 131(1):95-107

3187 – IKAROS LOSS ENHANCES PRE-LEUKEMIC THYMOCYTE SELF-RENEWAL AND DRIVES T-ALL IN MICE

Authors: Van Trimpont, Maaike, T'Sas, Sara, Lammens, Tim, Van Vlierberghe, Pieter, Pieters, Tim, Goossens, Steven

Source: In Experimental Hematology August 2024 137 Supplement

Genetic characterization and therapeutic targeting of MYC‐rearranged T cell acute lymphoblastic leukaemia

Authors: Milani, Gloria, Matthijssens, Filip, Van Loocke, Wouter, Durinck, Kaat, Roels, Juliette, Peirs, Sofie, Thénoz, Morgan, Pieters, Tim, Reunes, Lindy, Lintermans, Beatrice, Vandamme, Niels, Lammens, Tim, Van Roy, Nadine, Van Nieuwerburgh, Filip, Deforce, Dieter, Schwab, Claire, Raimondi, Susana, Dalla Pozza, Luciano, Carroll, Andrew J., De Moerloose, Barbara, Benoit, Yves, Goossens, Steven, Berx, Geert, Harrison, Christine J., Basso, Giuseppe, Cavé, Hélène, Sutton, Rosemary, Asnafi, Vahid, Meijerink, Jules, Mullighan, Charles, Loh, Mignon, Van Vlierberghe, Pieter

Source: British journal of haematology. 185(1):169-174

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094130479.0x000001&indx=1&recIds=ETOCvdc_100094130479.0x000001

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies

Authors: Pieters, Tim, T'Sas, Sara, Demoen, Lisa, Almeida, André, Haenebalcke, Lieven, Matthijssens, Filip, Lemeire, Kelly, D'Hont, Jinke, Van Rockeghem, Frederique, Hochepied, Tino, Lintermans, Beatrice, Reunes, Lindy, Lammens, Tim, Berx, Geert, Haigh, Jody, Goossens, Steven, Van Vlierberghe, Pieter

Source: Scientific reports. 9(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186588647.0x000001&indx=1&recIds=ETOCvdc_100186588647.0x000001

Tet2 is a tumor suppressor in the preleukemic phase of T-cell acute lymphoblastic leukemia

Authors: De Coninck, Stien, Roels, Juliette, Lintermans, Béatrice, T’Sas, Sara, Taghon, Tom, Curtis, David J., Pieters, Tim, Goossens, Steven, Van Vlierberghe, Pieter

Source: In Blood Advances 11 June 2024 8(11):2646-2649

The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling

Authors: Li, Jin ^*, Riedt, Tamara ^*, Goossens, Steven ^*, Carrillo García, Carmen, Szczepanski, Sabrina, Brandes, Maria, Pieters, Tim, Dobrosch, Linne, Gütgemann, Ines, Farla, Natalie, Radaelli, Enrico, Hulpiau, Paco, Mallela, Nikhil, Fröhlich, Holger, La Starza, Roberta, Matteucci, Caterina, Chen, Tong, Brossart, Peter, Mecucci, Cristina, Huylebroeck, Danny, Haigh, Jody J., Janzen, Viktor

Source: In Blood 26 January 2017 129(4):460-472

Inactivation of p120 catenin in mice disturbs intrahepatic bile duct development and aggravates liver carcinogenesis

Authors: van Hengel, Jolanda, Van den Broeke, Celine, Pieters, Tim, Libbrecht, Louis, Hofmann, Ilse, van Roy, Frans

Source: In European Journal of Cell Biology December 2016 95(12):574-584

Novel biological insights in T-cell acute lymphoblastic leukemia

Authors: Durinck, Kaat, Goossens, Steven, Peirs, Sofie, Wallaert, Annelynn, Van Loocke, Wouter, Matthijssens, Filip, Pieters, Tim, Milani, Gloria, Lammens, Tim, Rondou, Pieter, Van Roy, Nadine, De Moerloose, Barbara, Benoit, Yves, Haigh, Jody, Speleman, Frank, Poppe, Bruce, Van Vlierberghe, Pieter

Source: In Experimental Hematology August 2015 43(8):625-639

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

Authors: Van der Meulen, Joni, Sanghvi, Viraj, Mavrakis, Konstantinos, Durinck, Kaat, Fang, Fang, Matthijssens, Filip, Rondou, Pieter, Rosen, Monica, Pieters, Tim, Vandenberghe, Peter, Delabesse, Eric, Lammens, Tim, De Moerloose, Barbara, Menten, Björn, Van Roy, Nadine, Verhasselt, Bruno, Poppe, Bruce, Benoit, Yves, Taghon, Tom, Melnick, Ari M., Speleman, Frank, Wendel, Hans-Guido, Van Vlierberghe, Pieter ^*

Source: In Blood 1 January 2015 125(1):13-21

Emerging Epigenetic and Posttranslational Mechanisms Controlling Resistance to Glucocorticoids in Acute Lymphoblastic Leukemia

Authors: Borin, Cristina, Pieters, Tim, Serafin, Valentina, Ntziachristos, Panagiotis

Source: HemaSphere. 7(7):e916-e916

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191712938.0x000001&indx=1&recIds=ETOCvdc_100191712938.0x000001

Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice.

Authors: Pieters, Tim^1,2,3 (AUTHOR), Sanders, Ellen^1,2,3 (AUTHOR), Tian, Huiyu^1,2,4 (AUTHOR), van Hengel, Jolanda^1,2,3 (AUTHOR), van Roy, Frans^1,2 (AUTHOR) frans.vanroy@ugent.be

Source: BMC Developmental Biology. 8/3/2020, Vol. 20 Issue 1, p1-18. 18p.

Subject Terms: *NEURAL crest, *NEURAL tube, *NEURAL tube defects, *CELL anatomy, *EMBRYONIC stem cells, *CATENINS

Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids

Authors: Lasolle, Hélène, Schiavo, Andrea, Tourneur, Adrien, Gillotay, Pierre, de Faria da Fonseca, Bárbara, Ceolin, Lucieli, Monestier, Olivier, Aganahi, Benilda, Chomette, Laura, Kizys, Marina Malta Letro, Haenebalcke, Lieven, Pieters, Tim, Goossens, Steven, Haigh, Jody, Detours, Vincent, Maia, Ana Luiza Silva, Costagliola, Sabine, Romitti, Mírian

Source: Oncogene; January 2024, Vol. 43 Issue: 3 p155-170, 16p

Myb drives B-cell neoplasms and myeloid malignancies in vivo

Authors: Pieters, Tim ^*, Almeida, André ^*, T'Sas, Sara, Lemeire, Kelly, Hochepied, Tino, Berx, Geert, Kentsis, Alex, Goossens, Steven ^*, Van Vlierberghe, Pieter ^{*, *}

Source: In Blood Advances 24 May 2022 6(10):2987-2991

Mutations in the histone methyltransferase Ezh2drive context-dependent leukemia in Xenopus tropicalis

Authors: Tulkens, Dieter, Boelens, Marthe, Naert, Thomas, Carron, Marjolein, Demuynck, Suzan, Dewaele, Sylviane, Van Isterdael, Gert, Creytens, David, Pieters, Tim, Goossens, Steven, Van Vlierberghe, Pieter, Vleminckx, Kris

Source: Leukemia; December 2023, Vol. 37 Issue: 12 p2404-2413, 10p

p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification

Authors: Pieters, Tim

Contributors: Goossens, Steven, Haenebalcke, Lieven, Stryjewska, Agata, Huylebroeck, Danny, Berx, Geert, Wirth, Dagmar, Hengel, Jolanda ˜vanœ, Andries, Vanessa, Lemeire, Kelly, Haigh, Jody J., Stemmler, Marc P., De Rycke, Riet, Roy, Frans Van, Hochepied, Tino

Availability: http://data.europeana.eu/aggregation/europeana/2048441/item_LWADA4YWRDK5GU7ZYOUXHDCTSEYRVZQO

SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry.

Authors: Decaesteker, Bieke, Louwagie, Amber, Loontiens, Siebe, De Vloed, Fanny, Bekaert, Sarah-Lee, Roels, Juliette, Vanhauwaert, Suzanne, De Brouwer, Sara, Sanders, Ellen, Berezovskaya, Alla, Denecker, Geertrui, D'haene, Eva, Van Haver, Stéphane, Van Loocke, Wouter, Van Dorpe, Jo, Creytens, David, Van Roy, Nadine, Pieters, Tim, Van Neste, Christophe, Fischer, Matthias

Source: Nature Communications; 3/7/2023, Vol. 14 Issue 1, p1-16, 16p

Subject Terms: SOX transcription factors, NEUROBLASTOMA, TRANSCRIPTION factors, HISTONE deacetylase, RECURRENT neural networks, GENE targeting, GENE amplification

A Dual Role of SOX11 Expression in the Formation of T-Cell Acute Lymphoblastic Leukemia in Mouse Models

Authors: De Almeida, André, T'Sas, Sara, Van Ammel, Els, Van Vlierberghe, Pieter, Pieters, Tim, Goossens, Steven

Source: In Blood 28 November 2023 142 Supplement 1:1406-1406

Jmjd3 Drives Immature T-Cell Lymphoblastic Leukemia

Authors: Borin, Cristina, Pieters, Tim, Van Vlierberghe, Pieter, Ntziachristos, Panagiotis

Source: In Blood 2 November 2023 142 Supplement 1:4341-4341