Sensory Dysfunction in ALS and Other Motor Neuron Diseases: Clinical Relevance, Histopathology, Neurophysiology, and Insights from Neuroimaging

Authors: Jana Kleinerova, Rangariroyashe H. Chipika, Ee Ling Tan, Yana Yunusova, Véronique Marchand-Pauvert, Jan Kassubek, Pierre-Francois Pradat, Peter Bede

Source: Biomedicines, Vol 13, Iss 3, p 559 (2025)

Subject Terms: amyotrophic lateral sclerosis, motor neuron disease, sensory, neuroimaging, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/13/3/559; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/fff3034538674132b996f825b098bf8a

Motor imagery in amyotrophic lateral Sclerosis: An fMRI study of postural control

Authors: Malek Abidi, Pierre-Francois Pradat, Nicolas Termoz, Annabelle Couillandre, Peter Bede, Giovanni de Marco

Source: NeuroImage: Clinical, Vol 35, Iss , Pp 103051- (2022)

Subject Terms: ALS, Connectivity, Neuroimaging, Motor imagery, DCM, fMRI, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213158222001164; https://doaj.org/toc/2213-1582

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Frontotemporal Pathology in Motor Neuron Disease Phenotypes: Insights From Neuroimaging

Authors: Mary Clare McKenna, Philippe Corcia, Philippe Couratier, We Fong Siah, Pierre-Francois Pradat, Peter Bede

Source: Frontiers in Neurology, Vol 12 (2021)

Subject Terms: ALS, MND, PLS, MRI, PET, SMA, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2021.723450/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/a780ce84d2634259b915115084cc3772

Editorial: Biomarkers and Clinical Indicators in Motor Neuron Disease

Authors: Peter Bede, Pierre-Francois Pradat

Source: Frontiers in Neurology, Vol 10 (2019)

Subject Terms: ALS, MND, PLS, SMA, SBMA, PPS, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fneur.2019.01318/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/7e03b8bc41084fbfaa2bb20d23e0eee9

Cursive Eye-Writing With Smooth-Pursuit Eye-Movement Is Possible in Subjects With Amyotrophic Lateral Sclerosis

Authors: Timothée Lenglet, Jonathan Mirault, Marie Veyrat-Masson, Aurélie Funkiewiez, Maria del Mar Amador, Gaelle Bruneteau, Nadine Le Forestier, Pierre-Francois Pradat, Francois Salachas, Yannick Vacher, Lucette Lacomblez, Jean Lorenceau

Source: Frontiers in Neuroscience, Vol 13 (2019)

Subject Terms: amyotrophic lateral sclerosis, assisted communication devices, smooth-pursuit eye movements, pilot clinical study, motor learning, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnins.2019.00538/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/87a44b4522da4f96abdbf415831a2581

Biomarkers of Spinal and Bulbar Muscle Atrophy (SBMA): A Comprehensive Review

Authors: Giorgia Querin, Peter Bede, Veronique Marchand-Pauvert, Pierre-Francois Pradat

Source: Frontiers in Neurology, Vol 9 (2018)

Subject Terms: SBMA, biomarkers, clinical trials, multisystem involvement, outcome measures, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fneur.2018.00844/full; https://doaj.org/toc/1664-2295

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Effect of ultrasound-mediated blood-spinal cord barrier opening on survival and motor function in females in an amyotrophic lateral sclerosis mouse modelResearch in context

Authors: Anne-Sophie Montero, Ilyes Aliouat, Matthieu Ribon, Michael Canney, Lauriane Goldwirt, Samia Mourah, Félix Berriat, Christian S. Lobsiger, Pierre-François Pradat, François Salachas, Gaëlle Bruneteau, Alexandre Carpentier, Séverine Boillée

Source: EBioMedicine, Vol 106, Iss , Pp 105235- (2024)

Subject Terms: Blood-spinal cord barrier (BSCB), Ultrasound, Amyotrophic lateral sclerosis (ALS), Motor neuron disease (MND), Lymphocytes, Neuroinflammation, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424002706; https://doaj.org/toc/2352-3964

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Spinal cord ischemia revealed by a Brown-Sequard syndrome and caused by a calcified thoracic disc extrusion with spontaneous regression: a case report and review of the literature

Authors: Sonja Petrovic, Nadine Le Forestier, Pierre-François Pradat, Hugues Pascal-Moussellard, Lydia Chougar

Source: Journal of Medical Case Reports, Vol 17, Iss 1, Pp 1-6 (2023)

Subject Terms: Spinal cord ischemia, Brown-Sequard syndrome, Disc herniation, Case report, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1752-1947

Access URL: https://doaj.org/article/1355dff62c7f46009c6822f64872927e

Theoretical discrimination index of postural instability in amyotrophic lateral sclerosis

Authors: Rodolphe Vallée, Alexandre Vallée, Jean-Noël Vallée, Malek Abidi, Annabelle Couillandre, Nicolas Termoz, Pierre-François Pradat, Giovanni de Marco

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d4da7aa3f81949d6a5d81e4261fbb738

Cerebellar pathology in motor neuron disease: neuroplasticity and neurodegeneration

Authors: Rangariroyashe H Chipika, Grainne Mulkerrin, Pierre-François Pradat, Aizuri Murad, Fabrice Ango, Cédric Raoul, Peter Bede

Source: Neural Regeneration Research, Vol 17, Iss 11, Pp 2335-2341 (2022)

Subject Terms: amyotrophic lateral sclerosis, ataxia, cerebellum, magnetic resonance imaging, motor neuron disease, neuroimaging, neuroplasticity, pathology, primary lateral sclerosis, pseudobulbar affect, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=11;spage=2335;epage=2341;aulast=Chipika; https://doaj.org/toc/1673-5374

Access URL: https://doaj.org/article/0c124dd66dd9441d83293b5c996d1dba

Neurofilament light and heterogeneity of disease progression in amyotrophic lateral sclerosis: development and validation of a prediction model to improve interventional trials

Authors: Simon Witzel, Felix Frauhammer, Petra Steinacker, David Devos, Pierre-François Pradat, Vincent Meininger, Steffen Halbgebauer, Patrick Oeckl, Joachim Schuster, Simon Anders, Johannes Dorst, Markus Otto, Albert C. Ludolph

Source: Translational Neurodegeneration, Vol 10, Iss 1, Pp 1-12 (2021)

Subject Terms: Neurofilament light, Prediction model, Disease progression, Amyotrophic lateral sclerosis, Interventional trials, Statistical power, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9158

Access URL: https://doaj.org/article/885330fea1d344a7b200e9e29d421b8e

The French national protocol for Kennedy’s disease (SBMA): consensus diagnostic and management recommendations

Authors: Pierre-François Pradat, Emilien Bernard, Philippe Corcia, Philippe Couratier, Christel Jublanc, Giorgia Querin, Capucine Morélot Panzini, François Salachas, Christophe Vial, Karim Wahbi, Peter Bede, Claude Desnuelle, on behalf of the French Kennedy’s Disease Writing Group

Source: Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-21 (2020)

Subject Terms: Kennedy disease, Spinal and bulbar muscular atrophy, Guidelines, Polyglutamine, Androgen receptor, Androgen insensitivity, Medicine

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13023-020-01366-z; https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/53385653b6f54dc88c82f8af909bb4bc

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Spinal Cord Imaging in Amyotrophic Lateral Sclerosis: Historical Concepts—Novel Techniques

Authors: Mohamed Mounir El Mendili, Giorgia Querin, Peter Bede, Pierre-François Pradat

Source: Frontiers in Neurology, Vol 10 (2019)

Subject Terms: ALS (Amyotrophic lateral sclerosis), MRI—magnetic resonance imaging, MND, spinal cord, neuroimaging, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fneur.2019.00350/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/d81b2994aa354e1b9462f67c46d95889

Machine Learning in Amyotrophic Lateral Sclerosis: Achievements, Pitfalls, and Future Directions

Authors: Vincent Grollemund, Pierre-François Pradat, Giorgia Querin, François Delbot, Gaétan Le Chat, Jean-François Pradat-Peyre, Peter Bede

Source: Frontiers in Neuroscience, Vol 13 (2019)

Subject Terms: amyotrophic lateral sclerosis, machine learning, diagnosis, prognosis, risk stratification, clustering, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnins.2019.00135/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/e1941acbcc3545d1ac86da1874f9ab59

The spinal and cerebral profile of adult spinal-muscular atrophy: A multimodal imaging study

Authors: Giorgia Querin, Mohamed-Mounir El Mendili, Timothée Lenglet, Anthony Behin, Tanya Stojkovic, François Salachas, David Devos, Nadine Le Forestier, Maria del Mar Amador, Rabab Debs, Lucette Lacomblez, Vincent Meninger, Gaëlle Bruneteau, Julien Cohen-Adad, Stéphane Lehéricy, Pascal Laforêt, Sophie Blancho, Habib Benali, Martin Catala, Menghan Li, Véronique Marchand-Pauvert, Jean-Yves Hogrel, Peter Bede, Pierre-François Pradat

Source: NeuroImage: Clinical, Vol 21, Iss , Pp - (2019)

Subject Terms: Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213158218303668; https://doaj.org/toc/2213-1582

Access URL: https://doaj.org/article/53e889b333a8466487f9b9fdfd3df598

Metabolomics Biomarkers: A Strategy Toward Therapeutics Improvement in ALS

Authors: Débora Lanznaster, Denis Reis de Assis, Philippe Corcia, Pierre-François Pradat, Hélène Blasco

Source: Frontiers in Neurology, Vol 9 (2018)

Subject Terms: ALS, metabolomics, pharmacometabolomics, therapeutic, creatinine, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fneur.2018.01126/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/8911e63f16414e439c121ebd5fa2bf68

A pharmaco-metabolomics approach in a clinical trial of ALS: Identification of predictive markers of progression.

Authors: Hélène Blasco, Franck Patin, Amandine Descat, Guillaume Garçon, Philippe Corcia, Patrick Gelé, Timothée Lenglet, Peter Bede, Vincent Meininger, David Devos, Jean François Gossens, Pierre-François Pradat

Source: PLoS ONE, Vol 13, Iss 6, p e0198116 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198116/1/pone.0198116.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210223%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210223T052556Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c140401770f14e59a8b9db2f746da5cf

Selective disruption of acetylcholine synthesis in subsets of motor neurons: A new model of late-onset motor neuron disease

Authors: Marie-José Lecomte, Chloé Bertolus, Julie Santamaria, Anne-Laure Bauchet, Marc Herbin, Françoise Saurini, Hidemi Misawa, Thierry Maisonobe, Pierre-François Pradat, Marika Nosten-Bertrand, Jacques Mallet, Sylvie Berrard

Source: Neurobiology of Disease, Vol 65, Iss , Pp 102-111 (2014)

Subject Terms: Motor neuron dysfunction, Late-onset neuromuscular defects, Post-polio, Aging, Animal model, Conditional knockout mice, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S096999611400028X; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/acd9959efca348019bb0a9f910325232