DGCR2 targeting affibody molecules for delivery of drugs and imaging reagents to human beta cells

Authors: Pierre Cheung, Jonas Persson, Bo Zhang, Svitlana Vasylovska, Joey Lau, Sofie Invast, Olle Korsgren, Stefan Ståhl, John Löfblom, Olof Eriksson

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-14 (2025)

Subject Terms: Affibody molecule, Beta cells, DGCR2, Drug delivery, Imaging reagents, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/8f0942c421404379986b2157178d93c5

PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil

Authors: Faïza Maloum-Rami, Pierre Cheung, Gunnar Antoni, Zhe Jin, Olof Eriksson, Daniel Espes

Source: EJNMMI Research, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: GABAA receptors, PET imaging, Endocrine-cell mass imaging, Flumazenil, Subunits, Type 1 diabetes, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://doaj.org/toc/2191-219X

Access URL: https://doaj.org/article/3edfc8c9823444cf8097dcc5e1ddafd2

Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells

Authors: Pierre Cheung, Julia Thorngren, Bo Zhang, Svitlana Vasylovska, Francesco Lechi, Jonas Persson, Stefan Ståhl, John Löfblom, Olle Korsgren, Jonas Eriksson, Joey Lau, Olof Eriksson

Source: EJNMMI Research, Vol 13, Iss 1, Pp 1-12 (2023)

Subject Terms: Affibody molecule, Stem cells, Diabetes, DGCR2, PET, Fluorine-18 chemistry, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://doaj.org/toc/2191-219X

Access URL: https://doaj.org/article/9bc788183687432ebdda01b90d26bed0

Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule

Authors: Olivia Wegrzyniak, Francesco Lechi, Bogdan Mitran, Pierre Cheung, Athanasios Bitzios, Jonas Persson, John Löfblom, Helena Nordström, Jonas Eriksson, Fredrik Y. Frejd, Olle Korsgren, Bo Zhang, Olof Eriksson

Source: iScience, Vol 27, Iss 5, Pp 109688- (2024)

Subject Terms: Health sciences, Health technology, Natural sciences, Biological sciences, Biochemistry, Biological sciences research methodologies, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224009106; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/fad25e6180594e048184d89a8e877f10

Imaging of fibrogenesis in the liver by [18F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β

Authors: Olivia Wegrzyniak, Bo Zhang, Johanna Rokka, Maria Rosestedt, Bogdan Mitran, Pierre Cheung, Emmi Puuvuori, Sofie Ingvast, Jonas Persson, Helena Nordström, John Löfblom, Fredrik Pontén, Fredrik Y. Frejd, Olle Korsgren, Jonas Eriksson, Olof Eriksson

Source: EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-18 (2023)

Subject Terms: PET imaging, Platelet derived growth factor receptor, Hepatic stellate cells, Fibrogenesis, Liver fibrosis, Medical physics. Medical radiology. Nuclear medicine, R895-920, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2365-421X

Access URL: https://doaj.org/article/84daea9b1f234c4eacb9912e8eedc172

[18F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44

Authors: Pierre Cheung, Mohammad A. Amin, Bo Zhang, Francesco Lechi, Olle Korsgren, Jonas Eriksson, Luke R. Odell, Olof Eriksson

Source: Pharmaceutics, Vol 15, Iss 2, p 499 (2023)

Subject Terms: 18F-labelling, beta-cell mass, diabetes, GPR44, CRTH2, islet imaging, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/15/2/499; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/627424c53a45442bbbeb53570903b0a7

The Drosophila melanogaster Levodopa-Induced Depression Model Exhibits Negative Geotaxis Deficits and Differential Gene Expression in Males and Females

Authors: Thiago C. Moulin, Federico Ferro, Angela Hoyer, Pierre Cheung, Michael J. Williams, Helgi B. Schiöth

Source: Frontiers in Neuroscience, Vol 15 (2021)

Subject Terms: major depression, L-Dopa, negative geotaxis, CG4269, CG6821, climbing behavior, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2021.653470/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/5b7df746a3d546eeb801f4648fd3352e

The Current State of Beta-Cell-Mass PET Imaging for Diabetes Research and Therapies

Authors: Pierre Cheung, Olof Eriksson

Source: Biomedicines, Vol 9, Iss 12, p 1824 (2021)

Subject Terms: beta-cell mass, diabetes, positron emission tomography, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/9/12/1824; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/722d33eac0cf43ac9a2ba661a440d767

PET Imaging of GPR44 by Antagonist [11C]MK-7246 in Pigs

Authors: Pierre Cheung, Bo Zhang, Emmi Puuvuori, Sergio Estrada, Mohammad A. Amin, Sofie Ye, Olle Korsgren, Luke R. Odell, Jonas Eriksson, Olof Eriksson

Source: Biomedicines, Vol 9, Iss 4, p 434 (2021)

Subject Terms: pancreas imaging, diabetes, biomarker, PET, PTGDR2, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/9/4/434; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/a98421e8f5e64dde94a575e5283caa46