Repurposing the Whole Expression Transcriptome Assay for the Genetic Diagnosis of T-Cell Acute Lymphoblastic Leukemia and Lymphoma

Authors: Bardelli, Valentina ^∗, Arniani, Silvia ^∗, Pierini, Valentina ^∗, Nardelli, Carlotta ^∗, Matteucci, Caterina ^∗, Lema Fernandez, Anair Graciela ^∗, Crocioni, Maria ^∗, Cerrano, Marco ^†, Salutari, Prassede ^‡, Papayanidis, Cristina ^§, Trappolini, Silvia ^¶, Giglio, Fabio ^‖, Mastaglio, Sara ^∗∗, Zappasodi, Patrizia ^††, Pasciolla, Crescenza ^‡‡, Defina, Marzia ^§§, Piccini, Matteo ^¶¶, Lanzarone, Giuseppe ^‖‖, Di Giacomo, Danika ^{∗, ∗∗∗}, Sica, Simona ^†††, Montefiori, Lindsey E. ^‡‡‡, Mullighan, Charles G. ^‡‡‡, Mecucci, Cristina ^∗, La Starza, Roberta ^{∗, ∗}

Source: In The Journal of Molecular Diagnostics January 2025

High grade B-cell lymphoma with MYC, BCL2 and/or BCL6 rearrangements: unraveling the genetic landscape of a rare aggressive subtype of non-Hodgkin lymphoma

Authors: Ferrari, Anna, Arniani, Silvia, Crescenzi, Barbara, Ascani, Stefano, Flenghi, Leonardo, Pierini, Valentina, Moretti, Martina, Beacci, Donatella, Romoli, Silvia, Bardelli, Valentina, Calistri, Daniele, Martinelli, Giovanni, Mecucci, Cristina, La Starza, Roberta

Source: Leukemia & lymphoma. 63(6):1356-1362

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154927818.0x000001&indx=1&recIds=ETOCvdc_100154927818.0x000001

14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia

Authors: Di Giacomo, Danika ^*, La Starza, Roberta ^*, Gorello, Paolo, Pellanera, Fabrizia, Kalender Atak, Zeynep, De Keersmaecker, Kim, Pierini, Valentina, Harrison, Christine J., Arniani, Silvia, Moretti, Martina, Testoni, Nicoletta, De Santis, Giovanna, Roti, Giovanni, Matteucci, Caterina, Bassan, Renato, Vandenberghe, Peter, Aerts, Stein, Cools, Jan, Bornhauser, Beat, Bourquin, Jean-Pierre, Piazza, Rocco, Mecucci, Cristina ^*

Source: In Blood 2 September 2021 138(9):773-784

MYB rearrangements and over‐expression in T‐cell acute lymphoblastic leukemia

Authors: Bardelli, Valentina, Arniani, Silvia, Pierini, Valentina, Pierini, Tiziana, Di Giacomo, Danika, Gorello, Paolo, Moretti, Martina, Pellanera, Fabrizia, Elia, Loredana, Vitale, Antonella, Storlazzi, Clelia Tiziana, Tolomeo, Doron, Mastrodicasa, Elena, Caniglia, Maurizio, Chiaretti, Sabina, Ruggeri, Loredana, Roti, Giovanni, Schwab, Claire, Harrison, Christine J, Almeida, André, Pieters, Tim, Van Vlierberghe, Pieter, Mecucci, Cristina, La Starza, Roberta

Source: Genes, chromosomes & cancer. 60(7):482-488

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121092072.0x000001&indx=1&recIds=ETOCvdc_100121092072.0x000001

Identification and genetic characterization of a NUP98-HHEX molecular rearrangement in a pediatric acute myeloid leukemia

Authors: Sorel, Nathalie, Raimbault, Anna, Brizard, Françoise, Depaire, Thibault, Pierini, Valentina, Dupraz, Christelle, Millot, Frédéric, Mecucci, Cristina, Chomel, Jean-Claude

Source: Leukemia & lymphoma. 62(14):3531-3535

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136544580.0x000001&indx=1&recIds=ETOCvdc_100136544580.0x000001

Epigenetic Modeling of Jumping Translocations of 1q Heterochromatin in Acute Myeloid Leukemia After 5'‐Azacytidine Treatment.

Authors: Lema Fernandez, Anair Graciela, Nardelli, Carlotta, Pierini, Valentina, Crescenzi, Barbara, Pellanera, Fabrizia, Matteucci, Caterina, Crocioni, Maria, Arniani, Silvia, Di Battista, Valeria, Quintini, Martina, Mondanelli, Giada, Orabona, Ciriana, Gorello, Paolo, Mecucci, Cristina

Source: Genes, Chromosomes & Cancer; Nov2024, Vol. 63 Issue 11, p1-11, 11p

Design of a Comprehensive Fluorescence in Situ Hybridization Assay for Genetic Classification of T-Cell Acute Lymphoblastic Leukemia

Authors: La Starza, Roberta, Pierini, Valentina, Pierini, Tiziana, Nofrini, Valeria, Matteucci, Caterina, Arniani, Silvia, Moretti, Martina, Lema Fernandez, Anair G., Pellanera, Fabrizia, Di Giacomo, Danika, Storlazzi, Tiziana C., Vitale, Antonella, Gorello, Paolo, Sammarelli, Gabriella, Roti, Giovanni, Basso, Giuseppe, Chiaretti, Sabina, Foà, Robin, Schwab, Claire, Harrison, Christine J., Van Vlierberghe, Pieter, Mecucci, Cristina

Source: In The Journal of Molecular Diagnostics May 2020 22(5):629-639

Identification of two independent clones underlying the co‐existence of myelodysplastic syndrome with excess of blasts type 2 and isolated 5q‐ and smouldering multiple myeloma

Authors: Quintini, Martina, Arniani, Silvia, Ascani, Stefano, Camerini, Chiara, Crescenzi, Barbara, Di Battista, Valeria, Moretti, Martina, Pellanera, Fabrizia, Pierini, Valentina, Mecucci, Cristina

Source: Cytopathology. 31(1):59-62

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100149865985.0x000001&indx=1&recIds=ETOCvdc_100149865985.0x000001

A distinct epigenetic program underlies the 1;7 translocation in myelodysplastic syndromes

Authors: Fernandez, Anair, Crescenzi, Barbara, Pierini, Valentina, Battista, Valeria, Barba, Gianluca, Pellanera, Fabrizia, Giacomo, Danika, Roti, Giovanni, Piazza, Rocco, Adelman, Emmalee, Figueroa, Maria, Mecucci, Cristina

Source: Leukemia. 33(10):2481-2494

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190817990.0x000001&indx=1&recIds=ETOCvdc_100190817990.0x000001

A novel t(X;21)(p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in myelodysplastic syndromes and acute myeloid leukemias.

Authors: Mavridou, Elena, Lema Fernandez, Anair Graciela, Nardelli, Carlotta, Pierini, Valentina, Quintini, Martina, Arniani, Silvia, Di Giacomo, Danika, Crescenzi, Barbara, Matteucci, Caterina, Sambani, Constantina, Mecucci, Cristina

Source: Genes, Chromosomes & Cancer; Apr2024, Vol. 63 Issue 4, p1-9, 9p

Linking genomic lesions with minimal residual disease improves prognostic stratification in children with T-cell acute lymphoblastic leukaemia

Authors: La Starza, Roberta, Lettieri, Antonella, Pierini, Valentina, Nofrini, Valeria, Gorello, Paolo, Songia, Simona, Crescenzi, Barbara, te Kronnie, Geertruy, Giordan, Marco, Leszl, Anna, Valsecchi, Maria Grazia, Aversa, Franco, Basso, Giuseppe, Biondi, Andrea, Conter, Valentino, Cazzaniga, Giovanni, Mecucci, Cristina

Source: In Leukemia Research August 2013 37(8):928-935

New somatic TERT promoter variants enhance the Telomerase activity in Glioblastoma

Authors: Pierini, Tiziana, Nardelli, Carlotta, Lema Fernandez, Anair Graciela, Pierini, Valentina, Pellanera, Fabrizia, Nofrini, Valeria, Gorello, Paolo, Moretti, Martina, Arniani, Silvia, Roti, Giovanni, Giovenali, Paolo, Lupattelli, Marco, Metro, Giulio, Molica, Carmen, Castrioto, Corrado, Corinaldesi, Rodolfo, Laurenti, Maria Elena, Ascani, Stefano, Mecucci, Cristina, La Starza, Roberta

Source: Acta neuropathologica communications. 8(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172014077.0x000001&indx=1&recIds=ETOCvdc_100172014077.0x000001

FISH analysis reveals frequent co-occurrence of 4q24/ TET2 and 5q and/or 7q deletions

Authors: La Starza, Roberta, Crescenzi, Barbara, Nofrini, Valeria, Barba, Gianluca, Matteucci, Caterina, Brandimarte, Lucia, Pierini, Valentina, Testoni, Nicoletta, Musto, Pellegrino, Paolini, Stefania, Gianfelici, Valentina, Storlazzi, Clelia T., Pierini, Antonio, Berchicci, Laura, Gorello, Paolo, Mecucci, Cristina

Source: In Leukemia Research 2012 36(1):37-41

Involvement of a member of the histone cluster 1 at 6p21 in NUP98-positive MDS/AML

Authors: Di Giacomo, Danika, Pierini, Valentina, La Starza, Roberta, Borlenghi, Erika, Pellanera, Fabrizia, Lema Fernandez, Anair Graciela, Bellotti, Daniela, Lamorgese, Cinzia, Rossi, Giuseppe, Mecucci, Cristina

Source: Leukemia & lymphoma. 58(11):2765-2767

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100049436822.0x000001&indx=1&recIds=ETOCvdc_100049436822.0x000001

Acute leukemia with PICALM–MLLT10 fusion gene: diagnostic and treatment struggle

Authors: Savage, Natasha M., Kota, Vamsi, Manaloor, Elizabeth J., Kulharya, Anita S., Pierini, Valentina, Mecucci, Cristina, Ustun, Celalettin

Source: In Cancer Genetics and Cytogenetics 2010 202(2):129-132

Leukemic recombinations involving heterochromatin in myeloproliferative disorders with t(1;9)

Authors: Sambani, Constantina, La Starza, Roberta, Pierini, Valentina, Vandenberghe, Peter, Gonzales-Aguilera, Juan J., Rigana, Helen, Koumbi, Daphne, Manola, Kalliopi N., Stavropoulou, Chryssa, Georgakakos, Vasileios N., Pagoni, Maria, Wlodarska, Iwona, Mecucci, Cristina

Source: In Cancer Genetics and Cytogenetics 2005 162(1):45-49

Chromothripsis is a frequent event and underlies typical genetic changes in early T-cell precursor lymphoblastic leukemia in adults

Authors: Arniani, Silvia, Pierini, Valentina, Pellanera, Fabrizia, Matteucci, Caterina, Di Giacomo, Danika, Bardelli, Valentina, Quintini, Martina, Mavridou, Elena, Lema Fernandez, Anair Graciela, Nardelli, Carlotta, Moretti, Martina, Gorello, Paolo, Crescenzi, Barbara, Romoli, Silvia, Beacci, Donatella, Cerrano, Marco, Fracchiolla, Nicola, Sica, Simona, Forghieri, Fabio, Giglio, Fabio, Dargenio, Michela, Elia, Loredana, La Starza, Roberta, Mecucci, Cristina

Source: Leukemia; November 2022, Vol. 36 Issue: 11 p2577-2585, 9p

Genomic and clinical findings in myeloid neoplasms with PDGFRB rearrangement.

Authors: Di Giacomo, Danika, Quintini, Martina, Pierini, Valentina, Pellanera, Fabrizia, La Starza, Roberta, Gorello, Paolo, Matteucci, Caterina, Crescenzi, Barbara, Fiumara, Paolo Fabio, Veltroni, Marinella, Borlenghi, Erika, Albano, Francesco, Forghieri, Fabio, Maccaferri, Monica, Bettelli, Francesca, Luppi, Mario, Cuneo, Antonio, Rossi, Giuseppe, Mecucci, Cristina

Source: Annals of Hematology; Feb2022, Vol. 101 Issue 2, p297-307, 11p

Subject Terms: PLATELET-derived growth factor receptors, GENE rearrangement, SINGLE nucleotide polymorphisms, PROTEIN-tyrosine kinases

Blast crisis Ph+chronic myeloid leukemia with NUP98/HOXA13 up-regulating MSI2.

Authors: Giacomo, Danika Di¹ danikadigiacomo@libero.it, Pierini, Valentina¹ pierinivalentina@yahoo.it, Barba, Gianluca¹ barbag76@hotmail.com, Ceccarelli, Veronica² cvery73@yahoo.it, Vecchini, Alba² alba.vecchini@unipg.it, Mecucci, Cristina¹ cristina.mecucci@unipg.it

Source: Molecular Cytogenetics (17558166). 2014, Vol. 7 Issue 1, p2-13. 12p.

Subject Terms: *MYELOID leukemia, *GENETIC regulation, *HEMATOLOGY, *GENE fusion, *GENE expression, *PROGNOSIS

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