A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies

Authors: Chia-Chi Lin, Elena Garralda, Patrick Schöffski, David S. Hong, Lillian L. Siu, Miguel Martin, Michela Maur, Rina Hui, Ross A Soo, Joanne Chiu, Tian Zhang, Brigette Ma, Chrisann Kyi, Daniel SW Tan, Philippe A. Cassier, John Sarantopoulos, Andrew Weickhardt, Richard D. Carvajal, Jennifer Spratlin, Taito Esaki, Fréderic Rolland, Wallace Akerley, Barbara Deschler-Baier, Lawrence Rispoli, Tanay S. Samant, Niladri Roy Chowdhury, Daniel Gusenleitner, Eunice L. Kwak, Vasileios Askoxylakis, Filippo De Braud

Source: OncoImmunology, Vol 13, Iss 1 (2024)

Subject Terms: Efficacy, ieramilimab, LAG-3 inhibitor, safety, spartalizumab, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/fba32163599d40e7abcb0008f2589a1a

The NF-κB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancer

Authors: Allison Voisin, Maud Plaschka, Marlène Perrin-Niquet, Julie Twardowski, Insaf Boutemine, Baptiste Eluard, Guilhem Lalle, Pierre Stéphan, Khaled Bouherrou, Laurie Tonon, Roxane Pommier, Anthony Ferrari, Ulf Klein, Mélanie Wencker, Véronique Baud, Philippe A. Cassier, Yenkel Grinberg-Bleyer

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: CD8 + T cells, NF-KappaB, cancer, immunotherapy, LCMV, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1379777/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/cb478953a89049eead0106dbe604bf78

Phase Ib study of combinations of avadomide (CC‐122), CC‐223, CC‐292, and rituximab in patients with relapsed/refractory diffuse large B‐cell lymphoma

Authors: Vincent Ribrag, Julio C. Chavez, Carola Boccomini, Jason Kaplan, Jason C. Chandler, Armando Santoro, Paolo Corradini, Ian W. Flinn, Ranjana Advani, Philippe A. Cassier, Randeep Sangha, Vaishalee P. Kenkre, Iris Isufi, Shailaja Uttamsingh, Patrick R. Hagner, Anita K. Gandhi, Frank Shen, Sophie Michelliza, Harald Haeske, Kristen Hege, Michael Pourdehnad, John Kuruvilla

Source: eJHaem, Vol 3, Iss 1, Pp 139-153 (2022)

Subject Terms: new drug development, non‐Hodgkin lymphoma, phase 1 clinical trials, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2688-6146

Access URL: https://doaj.org/article/96c484da7911405ebd05aa9e00d581f2

Model Informed Dosing Regimen and Phase I Results of the Anti‐PD‐1 Antibody Budigalimab (ABBV‐181)

Authors: John Powderly, Alexander Spira, Shunsuke Kondo, Toshihiko Doi, Jason J. Luke, Drew Rasco, Bo Gao, Minna Tanner, Philippe A. Cassier, Anas Gazzah, Antoine Italiano, Diego Tosi, Daniel E. Afar, Apurvasena Parikh, Benjamin Engelhardt, Stefan Englert, Stacie L. Lambert, Sreeneeranj Kasichayanula, Sven Mensing, Rajeev Menon, Gregory Vosganian, Anthony Tolcher

Source: Clinical and Translational Science, Vol 14, Iss 1, Pp 277-287 (2021)

Subject Terms: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

Access URL: https://doaj.org/article/2e9537a22ea94fefa65b2b3c6cd4e048

Precision medicine for patients with gastro-oesophageal cancer: A subset analysis of the ProfiLER program

Authors: Philippe A. Cassier, Clémentine Peyramaure, Valery Attignon, Lauriane Eberst, Camille Pacaud, Sandrine Boyault, Françoise Desseigne, Mathieu Sarabi, Pierre Guibert, Pauline Rochefort, Nathalie Marques, Michel Rivoire, Aurélien Dupré, Patrice Peyrat, Catherine Terret, Isabelle Ray-Coquard, Clélia Coutzac, David Pérol, Jean-Yves Blay, Olivier Trédan, Christelle de la Fouchardière

Source: Translational Oncology, Vol 15, Iss 1, Pp 101266- (2022)

Subject Terms: Oesophageal cancer, Gastric cancer, Molecular alterations, molecular-targeted agents, NGS, CGH, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1936523321002576; https://doaj.org/toc/1936-5233

Access URL: https://doaj.org/article/af51f8a698dc4ce7a25e81ac463e3700

Safety, pharmacokinetics, and efficacy of budigalimab with rovalpituzumab tesirine in patients with small cell lung cancer

Authors: Emiliano Calvo, Alexander Spira, María de Miguel, Shunsuke Kondo, Anas Gazzah, Michael Millward, Hans Prenen, Sylvie Rottey, Lydia Warburton, Tuomo Alanko, Philippe A. Cassier, Kiyotaka Yoh, Antoine Italiano, Victor Moreno, Katriina Peltola, Takashi Seto, Ryo Toyozawa, Daniel E. Afar, Stefan Englert, Philip Komarnitsky, Stacie Lambert, Apurvasena Parikh, Gregory Vosganian, Bo Gao

Source: Cancer Treatment and Research Communications, Vol 28, Iss , Pp 100405- (2021)

Subject Terms: Lung cancer, Immunotherapy, Small-molecule agent, Clinical trial, Antibody-drug conjugate, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2468294221001039; https://doaj.org/toc/2468-2942

Access URL: https://doaj.org/article/e1966145ff134f7d8b7360173186cc8e

Combining chemotherapeutic agents and netrin‐1 interference potentiates cancer cell death

Authors: Andrea Paradisi, Marion Creveaux, Benjamin Gibert, Guillaume Devailly, Emeline Redoulez, David Neves, Elsa Cleyssac, Isabelle Treilleux, Christian Klein, Gerhard Niederfellner, Philippe A. Cassier, Agnès Bernet, Patrick Mehlen

Source: EMBO Molecular Medicine, Vol 5, Iss 12, Pp 1821-1834 (2013)

Subject Terms: cancer therapy, DCC, dependence receptor, netrin‐1, p53, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/9e1bf643b90540ad9b57b1bd4832139a

Mifepristone for ectopic ACTH secretion in metastatic endocrine carcinomas: report of two cases.

Authors: Philippe A Cassier¹

Source: European Journal of Endocrinology. Jun2008, Vol. 158 Issue 6, p935-938. 4p.

Subject Terms: *BIOLOGICAL transport, *ABSORPTION (Physiology), *BODY fluid flow, *ENDOCRINE diseases

Identification of microenvironment features associated with primary resistance to anti-PD-1/PD-L1 + antiangiogenesis in gastric cancer through spatial transcriptomics and plasma proteomics

Authors: Sophie Cousin, Jean-Philippe Guégan, Kohei Shitara, Lola Jade Palmieri, Jean Philippe Metges, Simon Pernot, Shota Fukuoka, Shohei Koyama, Hiroyoshi Nishikawa, Carine A. Bellera, Antoine Adenis, Carlos A. Gomez-Roca, Philippe Alexandre Cassier, Antoine Hollebecque, Coralie Cantarel, Michèle Kind, Isabelle Soubeyran, Lucile Vanhersecke, Alban Bessede, Antoine Italiano

Source: Molecular Cancer, Vol 23, Iss 1, Pp 1-11 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/092395fd8b914e7cbe0ceb717ec9a6b5

Phase I study of ABBV-428, a mesothelin-CD40 bispecific, in patients with advanced solid tumors

Authors: Fabrice Barlesi, Steven Kao, Philippe A Cassier, Hua Fang, Frances Fan, Kathryn Allaire, Shiming Ye, Debra T Chao, William R Henner, Joel S Hayflick, Michael A McDevitt

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/2/e002015.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/20dbdf5be81c4b86b9fc3af9b764237c

Tocilizumab for the treatment of paraneoplastic inflammatory syndrome associated with angiomatoid fibrous histiocytoma

Authors: Jean-Yves Blay, Lauriane Eberst, Philippe A Cassier, Mehdi Brahmi, Franck Tirode

Source: ESMO Open, Vol 5, Iss 3 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://esmoopen.bmj.com/content/5/3/e000756.full; https://doaj.org/toc/2059-7029

Access URL: https://doaj.org/article/7de98426096448a09b656dd2aaab8acf

A first-in-human study investigating biodistribution, safety and recommended dose of a new radiolabeled MAb targeting FZD10 in metastatic synovial sarcoma patients

Authors: Anne-Laure Giraudet, Philippe Alexandre Cassier, Chicaco Iwao-Fukukawa, Gwenaelle Garin, Jean-Noël Badel, David Kryza, Sylvie Chabaud, Laurence Gilles-Afchain, Gilles Clapisson, Claude Desuzinges, David Sarrut, Adrien Halty, Antoine Italiano, Masaharu Mori, Takuya Tsunoda, Toyomasa Katagiri, Yusuke Nakamura, Laurent Alberti, Claire Cropet, Simon Baconnier, Sandrine Berge-Montamat, David Pérol, Jean-Yves Blay

Source: BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018)

Subject Terms: Synovial sarcoma, Radioimmunotherapy, Theranostic, First-in-human trial, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-018-4544-x; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/f7e4c42b865f4a648c225b6c01e4f105

Part I of GANNET53: A European Multicenter Phase I/II Trial of the Hsp90 Inhibitor Ganetespib Combined With Weekly Paclitaxel in Women With High-Grade, Platinum-Resistant Epithelial Ovarian Cancer—A Study of the GANNET53 Consortium

Authors: Isabelle Ray-Coquard, Ioana Braicu, Regina Berger, Sven Mahner, Jalid Sehouli, Eric Pujade-Lauraine, Philippe Alexandre Cassier, Ute Martha Moll, Hanno Ulmer, Karin Leunen, Alain Gustave Zeimet, Christian Marth, Ignace Vergote, Nicole Concin

Source: Frontiers in Oncology, Vol 9 (2019)

Subject Terms: recurrent ovarian carcinoma, p53 mutation, Hsp90 inhibitors, ganetespib, platinum-resistance, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2019.00832/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/8601cb9f6b384df886c2d55dca630015

New developments in treatment of ovarian carcinoma: focus on trabectedin

Authors: Philippe A Cassier, Aude Duret, Olivier Trédan, et al

Source: Cancer Management and Research, Vol 2010, Iss default, Pp 233-242 (2010)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.dovepress.com/new-developments-in-treatment-of-ovarian-carcinoma-focus-on-trabectedi-a5420; https://doaj.org/toc/1179-1322

Access URL: https://doaj.org/article/26737dab2a254aa5b152d35994591e61

Trabectedin and its potential in the treatment of soft tissue sarcoma

Authors: Philippe A Cassier, Armelle Dufresne, Jean-Yves Blay, Jérôme Fayette

Source: Therapeutics and Clinical Risk Management, Vol 2008, Iss Issue 1, Pp 109-116 (2008)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.dovepress.com/trabectedin-and-its-potential-in-the-treatment-of-soft-tissue-sarcoma-a1290; https://doaj.org/toc/1176-6336; https://doaj.org/toc/1178-203X

Access URL: https://doaj.org/article/7765f5567f9a41e6b4d227e91ca6a144

Multi-purpose utility of circulating plasma DNA testing in patients with advanced cancers.

Authors: Geraldine Perkins, Timothy A Yap, Lorna Pope, Amy M Cassidy, Juliet P Dukes, Ruth Riisnaes, Christophe Massard, Philippe A Cassier, Susana Miranda, Jeremy Clark, Katie A Denholm, Khin Thway, David Gonzalez De Castro, Gerhardt Attard, L Rhoda Molife, Stan B Kaye, Udai Banerji, Johann S de Bono

Source: PLoS ONE, Vol 7, Iss 11, p e47020 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144797/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/3dec2081d85c4d8ca5a5e0e4c2fc16a1