Synaptic protein CSF levels relate to memory scores in individuals without dementia

Authors: Kirsten E. J. Wesenhagen, Diederick M. de Leeuw, Jori Tomassen, Johan Gobom, Isabelle Bos, Stephanie J. B. Vos, Pablo Martinez-Lage, Mikel Tainta, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Rik Vandenberghe, Yvonne Freund-Levi, Frans Verhey, Simon Lovestone, Johannes Streffer, Valerija Dobricic, Kaj Blennow, Philip Scheltens, August B. Smit, Lars Bertram, Charlotte E. Teunissen, Henrik Zetterberg, Betty M. Tijms, Pieter Jelle Visser, the Alzheimer’s Disease Neuroimaging Initiative

Source: Alzheimer’s Research & Therapy, Vol 17, Iss 1, Pp 1-15 (2025)

Subject Terms: Synaptic proteins, Cerebrospinal fluid proteomics, Memory performance, Early Alzheimer’s disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/47b19da867c743579995709d704bfaee

evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer’s disease

Authors: Jeffrey L. Cummings, Alireza Atri, Howard H. Feldman, Oskar Hansson, Mary Sano, Filip K. Knop, Peter Johannsen, Teresa León, Philip Scheltens

Source: Alzheimer’s Research & Therapy, Vol 17, Iss 1, Pp 1-12 (2025)

Subject Terms: Alzheimer’s disease, Clinical trial, Design, evoke, evoke+, Neuroinflammation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/52cae5cc33be41bab98ba355f84833d1

Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical trials for Alzheimer’s disease: a systematic review

Authors: Marlies Oosthoek, Lisa Vermunt, Arno de Wilde, Bram Bongers, Daniel Antwi-Berko, Philip Scheltens, Pieter van Bokhoven, Everard G. B. Vijverberg, Charlotte E. Teunissen

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)

Subject Terms: Alzheimer, Clinical trial, Fluid-based biomarker, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/ae49560852f74a098698937680d6a2cf

Plasma oligomer beta-amyloid is associated with disease severity and cerebral amyloid deposition in Alzheimer’s disease spectrum

Authors: Sheng-Min Wang, Dong Woo Kang, Yoo Hyun Um, Sunghwan Kim, Chang Uk Lee, Philip Scheltens, Hyun Kook Lim

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)

Subject Terms: Oligomerization, Blood-based biomarker, Beta amyloid, Mild cognitive impairment, Dementia, And Alzheimer’s disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/d9d24874c19c4c6faf3c569a77dd18f5

Interest in genetic susceptibility testing and disclosure of AD dementia risk in cognitively normal adults: a survey study

Authors: Lisa Waterink, Larissa A. Masselink, Sven J. van der Lee, Leonie N. C. Visser, Solange Cleutjens, Jetske van der Schaar, Argonde C. van Harten, Philip Scheltens, Sietske A. M. Sikkes, Wiesje M. van der Flier, Marissa D. Zwan

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)

Subject Terms: Genetic screening, APOE disclosure, Dementia risk, Recruitment, Research registry, Clinical trials, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/42b3b0c2cdb74855a9ee7e49bcdf3ba0

Recruitment of pre-dementia participants: main enrollment barriers in a longitudinal amyloid-PET study

Authors: Ilse Bader, Ilona Bader, Isadora Lopes Alves, David Vállez García, Bruno Vellas, Bruno Dubois, Mercè Boada, Marta Marquié, Daniele Altomare, Philip Scheltens, Rik Vandenberghe, Bernard Hanseeuw, Michael Schöll, Giovanni B. Frisoni, Frank Jessen, Agneta Nordberg, Miia Kivipelto, Craig W. Ritchie, Oriol Grau-Rivera, José Luis Molinuevo, Lisa Ford, Andrew Stephens, Rossella Gismondi, Juan Domingo Gispert, Gill Farrar, Frederik Barkhof, Pieter Jelle Visser, Lyduine E. Collij, on behalf of the AMYPAD consortium

Source: Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2023)

Subject Terms: Alzheimer’s disease, Preclinical, Recruitment, Enrollment barriers, Amyloid PET, Clinical trial, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/53ca117657b04d869c1e2fc37d173899

Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning

Authors: Alexander Neumann, Olena Ohlei, Fahri Küçükali, Isabelle J. Bos, Jigyasha Timsina, Stephanie Vos, Dmitry Prokopenko, Betty M. Tijms, Ulf Andreasson, Kaj Blennow, Rik Vandenberghe, Philip Scheltens, Charlotte E. Teunissen, Sebastiaan Engelborghs, Giovanni B. Frisoni, Oliver Blin, Jill C. Richardson, Régis Bordet, Alberto Lleó, Daniel Alcolea, Julius Popp, Thomas W. Marsh, Priyanka Gorijala, Christopher Clark, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Richard J. B. Dobson, Cristina Legido-Quigley, Christine Van Broeckhoven, Rudolph E. Tanzi, Mara ten Kate, Christina M. Lill, Frederik Barkhof, Carlos Cruchaga, Simon Lovestone, Johannes Streffer, Henrik Zetterberg, Pieter Jelle Visser, Kristel Sleegers, Lars Bertram, EMIF-AD & ADNI study group

Source: Genome Medicine, Vol 15, Iss 1, Pp 1-23 (2023)

Subject Terms: Alzheimer’s disease, Dementia, Biomarkers, Cerebrospinal fluid (CSF), Genome-wide association study (GWAS), Multivariate analysis, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/f26d48a8fac447809738ca263de2f029

α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies

Authors: Frederique J. Hart de Ruyter, Tjado H. J. Morrema, Jurre den Haan, Gina Gase, Jos W. R. Twisk, Johannes F. de Boer, Philip Scheltens, Femke H. Bouwman, Frank D. Verbraak, Annemieke J. M. Rozemuller, Jeroen J. M. Hoozemans

Source: npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-9 (2023)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2373-8057

Access URL: https://doaj.org/article/f133d6ba3b3b465b90db3046c23ce62f

Neurophysiological alterations in mice and humans carrying mutations in APP and PSEN1 genes

Authors: Fran C. van Heusden, Anne M. van Nifterick, Bryan C. Souza, Arthur S. C. França, Ilse M. Nauta, Cornelis J. Stam, Philip Scheltens, August B. Smit, Alida A. Gouw, Ronald E. van Kesteren

Source: Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-21 (2023)

Subject Terms: Translational network neuroscience, Autosomal dominant Alzheimer’s disease, Mouse models of Alzheimer’s disease, Local field potential (LFP) recordings, Functional brain imaging, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/f890c4d9a0874d4687c36487e129d99f

Altered brain metabolism in frontotemporal dementia and psychiatric disorders: involvement of the anterior cingulate cortex

Authors: Marie-Paule E. van Engelen, Sander C. J. Verfaillie, Annemieke Dols, Mardien L. Oudega, Ronald Boellaard, Sandeep S. V. Golla, Marijke den Hollander, Rik Ossenkoppele, Philip Scheltens, Bart N. M. van Berckel, Yolande A. L. Pijnenburg, Everard G. B. Vijverberg

Source: EJNMMI Research, Vol 13, Iss 1, Pp 1-14 (2023)

Subject Terms: FTD, Psychiatry, Diagnostics, Biomarkers, FDG PET, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://doaj.org/toc/2191-219X

Access URL: https://doaj.org/article/2e33ccec1e054043a8dbf5dff021fd33

Virtual neural network-guided optimization of non-invasive brain stimulation in Alzheimer's disease.

Authors: Janne J Luppi, Cornelis J Stam, Philip Scheltens, Willem de Haan

Source: PLoS Computational Biology, Vol 20, Iss 1, p e1011164 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011164&type=printable; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/59bcd154d5364b84a5c6b515877a8654

Resting-state oscillations reveal disturbed excitation–inhibition ratio in Alzheimer’s disease patients

Authors: Anne M. van Nifterick, Danique Mulder, Denise J. Duineveld, Marina Diachenko, Philip Scheltens, Cornelis J. Stam, Ronald E. van Kesteren, Klaus Linkenkaer-Hansen, Arjan Hillebrand, Alida A. Gouw

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/be3f5099a4854293838d27dbf4189468

Severe CTE and TDP-43 pathology in a former professional soccer player with dementia: a clinicopathological case report and review of the literature

Authors: Suzan van Amerongen, Suzie Kamps, Kyra K. M. Kaijser, Yolande A. L. Pijnenburg, Philip Scheltens, Charlotte E. Teunissen, Frederik Barkhof, Rik Ossenkoppele, Annemieke J. M. Rozemuller, Robert A. Stern, Jeroen J. M. Hoozemans, Everard G. B. Vijverberg

Source: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-15 (2023)

Subject Terms: Soccer, Association football, Repetitive head impacts, Chronic traumatic encephalopathy, Tauopathy, Neurodegeneration, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/dc8c2ff679664261987eb1889733fdb5

Steeper memory decline after COVID-19 lockdown measures

Authors: Els D. Bakker, Stéphanie L. van der Pas, Marissa D. Zwan, Freek Gillissen, Femke H. Bouwman, Philip Scheltens, Wiesje M. van der Flier, Ingrid S. van Maurik

Source: Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-9 (2023)

Subject Terms: COVID-19, Lockdown, Cognitive decline, Dementia, MCI, Subjective cognitive decline, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/60892e7a3e9d4f15b0cb6dbfeb2c441c

Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer’s disease polygenic risk score

Authors: Jori Tomassen, Anouk den Braber, Sven J. van der Lee, Lianne M. Reus, Elles Konijnenberg, Stephen F. Carter, Maqsood Yaqub, Bart N.M. van Berckel, Lyduine E. Collij, Dorret I. Boomsma, Eco J.C. de Geus, Philip Scheltens, Karl Herholz, Betty M. Tijms, Pieter Jelle Visser

Source: BMC Neurology, Vol 22, Iss 1, Pp 1-11 (2022)

Subject Terms: Preclinical Alzheimer’s disease, APOE genotype, Polygenic risk score, Amyloid-β, Cognitive decline, Neuropsychology, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2377

Access URL: https://doaj.org/article/de2470f34ab8427f961bab5f7eb68c5e

Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface

Authors: Lisa Vermunt, Marco Otte, Inge M. W. Verberk, Joep Killestein, Afina W. Lemstra, Wiesje M. van derFlier, Yolande A. L. Pijnenburg, Everard G. B. Vijverberg, Femke H. Bouwman, Gido Gravesteijn, Wilma D. J. van deBerg, Philip Scheltens, Argonde C. vanHarten, Eline A. J. Willemse, Charlotte E. Teunissen

Source: Annals of Clinical and Translational Neurology, Vol 9, Iss 11, Pp 1832-1837 (2022)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2328-9503

Access URL: https://doaj.org/article/bb2c5e3e1a0f400bab820db7e4aec1eb

Longitudinal change in ATN biomarkers in cognitively normal individuals

Authors: Jarith L. Ebenau, Denise Visser, Lior A. Kroeze, Mardou S. S. A. van Leeuwenstijn, Argonde C. van Harten, Albert D. Windhorst, Sandeep V. S. Golla, Ronald Boellaard, Philip Scheltens, Frederik Barkhof, Bart N. M. van Berckel, Wiesje M. van der Flier

Source: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/2a10f0eecc1f491fb787668eb12f36a8

Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration

Authors: Ying Jiang, John J. Alam, Stephen N. Gomperts, Paul Maruff, Afina W. Lemstra, Ursula A. Germann, Philip H. Stavrides, Sandipkumar Darji, Sandeep Malampati, James Peddy, Cynthia Bleiwas, Monika Pawlik, Anna Pensalfini, Dun-Sheng Yang, Shivakumar Subbanna, Balapal S. Basavarajappa, John F. Smiley, Amanda Gardner, Kelly Blackburn, Hui-May Chu, Niels D. Prins, Charlotte E. Teunissen, John E. Harrison, Philip Scheltens, Ralph A. Nixon

Source: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/435994d00b734e18a90ea82931cd1bac

Clinical Features of Patients with Alzheimer’s Disease and a History of Traumatic Brain Injury

Authors: Suzan van Amerongen, Dewi K. Caton, Yolande A.L. Pijnenburg, Philip Scheltens, Everard G.B. Vijverberg

Source: Dementia and Geriatric Cognitive Disorders Extra, Vol 12, Iss 3, Pp 122-130 (2022)

Subject Terms: alzheimer’s disease, traumatic brain injury, age of onset, cognition, neuropsychiatry, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://www.karger.com/Article/FullText/526243; https://doaj.org/toc/1664-5464

Access URL: https://doaj.org/article/9919b4a8fbea40bcaf6f26b5ee5697db

Rationale and design of the 'NEurodegeneration: Traumatic brain injury as Origin of the Neuropathology (NEwTON)' study: a prospective cohort study of individuals at risk for chronic traumatic encephalopathy

Authors: Suzan van Amerongen, Dewi K. Caton, Rik Ossenkoppele, Frederik Barkhof, Petra J. W. Pouwels, Charlotte E. Teunissen, Annemieke J. M. Rozemuller, Jeroen J. M. Hoozemans, Yolande A. L. Pijnenburg, Philip Scheltens, Everard G. B. Vijverberg

Source: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-11 (2022)

Subject Terms: Chronic traumatic encephalopathy, Repetitive head injury, Traumatic brain injury, Contact sports, Cognition, Neuropsychiatry, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/7f3b25d51d02424798ab23341170ce6c