Multiple configurations of EGFR exon 20 resistance mutations after first- and third-generation EGFR TKI treatment affect treatment options in NSCLC.

Authors: Michael E Goldberg, Meagan Montesion, Lauren Young, James Suh, Joel Greenbowe, Mark Kennedy, Giuseppe Giaccone, Wallace L Akerley, Afshin Dowlati, Benjamin C Creelan, James K Hicks, Paul J Hesketh, Karen L Kelly, Jonathan W Riess, Vincent A Miller, Philip J Stephens, Garrett M Frampton, Siraj Ali, Jeffrey P Gregg, Lee A Albacker

Source: PLoS ONE, Vol 13, Iss 11, p e0208097 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6258560?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/648ec5a7f1f64da7a4f700ccb8ad9657

Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion.

Authors: Lee A Albacker, Jeremy Wu, Peter Smith, Markus Warmuth, Philip J Stephens, Ping Zhu, Lihua Yu, Juliann Chmielecki

Source: PLoS ONE, Vol 12, Iss 11, p e0176181 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5679612?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/d48f7087d6474058b507fa193b52f668

Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome.

Authors: Susan M Gribble, Frances K Wiseman, Stephen Clayton, Elena Prigmore, Elizabeth Langley, Fengtang Yang, Sean Maguire, Beiyuan Fu, Diana Rajan, Olivia Sheppard, Carol Scott, Heidi Hauser, Philip J Stephens, Lucy A Stebbings, Bee Ling Ng, Tomas Fitzgerald, Michael A Quail, Ruby Banerjee, Kai Rothkamm, Victor L J Tybulewicz, Elizabeth M C Fisher, Nigel P Carter

Source: PLoS ONE, Vol 8, Iss 4, p e60482 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3626651?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/40d01f7c551e41a4a19b62b717840f84

Comparison of Time-Dependent Density-Functional Theory and Coupled Cluster Theory for the Calculation of the Optical Rotations of Chiral Molecules.

Authors: T. Daniel Crawford¹, Philip J. Stephens¹

Source: Journal of Physical Chemistry A. Feb2008, Vol. 112 Issue 6, p1339-1345. 7p.

Subject Terms: *OPTICAL rotatory dispersion, *OPTICAL polarization, *ORGANIC compounds, *ELECTRON configuration

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Clinical utility of tumor genomic profiling in patients with high plasma circulating tumor DNA burden or metabolically active tumors

Authors: Cathy Zhou, Zilong Yuan, Weijie Ma, Lihong Qi, Angelique Mahavongtrakul, Ying Li, Hong Li, Jay Gong, Reggie R. Fan, Jin Li, Michael Molmen, Travis A. Clark, Dean Pavlick, Garrett M. Frampton, Brady Forcier, Elizabeth H. Moore, David K. Shelton, Matthew Cooke, Siraj M. Ali, Vincent A. Miller, Jeffrey P. Gregg, Philip J. Stephens, Tianhong Li

Source: Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-13 (2018)

Subject Terms: Next-generation sequencing (NGS), Plasma, Cell-free DNA (cfDNA), Circulating tumor DNA (ctDNA), Genomic alterations (GAs), Maximum somatic allele frequency (MSAF), Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13045-018-0671-8; https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/f7a6b3e50e784343a7af265214bc7dc3

Severe nivolumab-induced pneumonitis preceding durable clinical remission in a patient with refractory, metastatic lung squamous cell cancer: a case report

Authors: Hong Li, Weijie Ma, Ken Y. Yoneda, Elizabeth H. Moore, Yanhong Zhang, Lee L. Q. Pu, Garrett M. Frampton, Michael Molmen, Philip J. Stephens, Tianhong Li

Source: Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-9 (2017)

Subject Terms: PD-1 inhibitor, Nivolumab, Cancer immunotherapy, Immune-related adverse event, Pneumonitis, Complete remission, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13045-017-0433-z; https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/283b024780d54370ab4b010b91270338

Genomic landscape of advanced basal cell carcinoma: Implications for precision treatment with targeted and immune therapies

Authors: Aaron M. Goodman, Shumei Kato, Philip R. Cohen, Amélie Boichard, Garrett Frampton, Vincent Miller, Philip J. Stephens, Gregory A. Daniels, Razelle Kurzrock

Source: OncoImmunology, Vol 7, Iss 3 (2018)

Subject Terms: basal cell carcinoma, immunotherapy, tumor mutational burden, pd-1, pd-l1, checkpoint blockade, biomarkers, therapeutic antibodies, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/87de5ce678674a5a8eb59c501286191b

Acquired Resistance of EGFR-Mutant Lung Adenocarcinomas to Afatinib plus Cetuximab Is Associated with Activation of mTORC1

Authors: Valentina Pirazzoli, Caroline Nebhan, Xiaoling Song, Anna Wurtz, Zenta Walther, Guoping Cai, Zhongming Zhao, Peilin Jia, Elisa de Stanchina, Erik M. Shapiro, Molly Gale, Ruonan Yin, Leora Horn, David P. Carbone, Philip J. Stephens, Vincent Miller, Scott Gettinger, William Pao, Katerina Politi

Source: Cell Reports, Vol 7, Iss 4, Pp 999-1008 (2014)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124714003015; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/86956aaf1ede481dad5ccf05981d0a99